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Aliases for HOXB8 Gene

Aliases for HOXB8 Gene

  • Homeobox B8 2 3 5
  • Homeobox Protein Hox-2.4 3 4
  • Homeobox Protein Hox-2D 3 4
  • Homeo Box B8 2 3
  • HOX2D 3 4
  • Homeobox Protein Hox-B8 3
  • Homeo Box 2D 3
  • Hox-2.4 3
  • HOX2 3

External Ids for HOXB8 Gene

Previous HGNC Symbols for HOXB8 Gene

  • HOX2
  • HOX2D

Previous GeneCards Identifiers for HOXB8 Gene

  • GC17M046401
  • GC17M049170
  • GC17M047030
  • GC17M047164
  • GC17M044044
  • GC17M046688
  • GC17M042058

Summaries for HOXB8 Gene

Entrez Gene Summary for HOXB8 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB8 Gene

HOXB8 (Homeobox B8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXD8.

UniProtKB/Swiss-Prot for HOXB8 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB8 Gene

Additional gene information for HOXB8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB8 Gene

Genomics for HOXB8 Gene

GeneHancer (GH) Regulatory Elements for HOXB8 Gene

Promoters and enhancers for HOXB8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I048608 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.6 1638 10 HDGF PKNOX1 CLOCK ARNT SIN3A FEZF1 ZNF2 ZNF213 ZNF207 ZNF143 HOXB8 PIR62254 HOXB7 ENSG00000263412 HOXB2 SUMO2P17 SNX11 HOXB9 CALCOCO2 SCRN2
GH17I048538 Promoter/Enhancer 3 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.3 +41.9 41946 68.8 FEZF1 IRF4 YY1 ZNF213 ZNF143 SP3 MEF2D ZNF610 GLIS1 NBN HOXB2 HOXB3 HOXB6 HOXB4 HOXB5 PIR47329 PIR34300 UBE2Z SP2 ENSG00000264701
GH17I048623 Promoter/Enhancer 2 EPDnew FANTOM5 ENCODE dbSUPER 4.9 -11.5 -11538 6.4 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 POLR2B ZNF766 CBX5 ZNF213 HOXB9 ENSG00000264701 ENSG00000230532 CDK5RAP3 PRAC2 PRAC1 HOXB13 LOC105371811 HOXB2 HOXB8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HOXB8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HOXB8 gene promoter:

Genomic Locations for HOXB8 Gene

Genomic Locations for HOXB8 Gene
chr17:48,611,377-48,615,112
(GRCh38/hg38)
Size:
3,736 bases
Orientation:
Minus strand
chr17:46,688,739-46,692,478
(GRCh37/hg19)

Genomic View for HOXB8 Gene

Genes around HOXB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB8 Gene

Proteins for HOXB8 Gene

  • Protein details for HOXB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17481-HXB8_HUMAN
    Recommended name:
    Homeobox protein Hox-B8
    Protein Accession:
    P17481
    Secondary Accessions:
    • Q9H1I2

    Protein attributes for HOXB8 Gene

    Size:
    243 amino acids
    Molecular mass:
    27574 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB8 Gene

Post-translational modifications for HOXB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB8 Gene

No data available for DME Specific Peptides for HOXB8 Gene

Domains & Families for HOXB8 Gene

Gene Families for HOXB8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for HOXB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17481

UniProtKB/Swiss-Prot:

HXB8_HUMAN :
  • Belongs to the Antp homeobox family.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXB8: view

Function for HOXB8 Gene

Molecular function for HOXB8 Gene

GENATLAS Biochemistry:
homeo box B8(2D),homologous to mouse Hox-2.4,Drosophila Antp,Ubx,abd-A,involved in the establishment of anteroposterior polarity of the anterior mouse limb,controlled by SHH through a negative feedback loop
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Phenotypes From GWAS Catalog for HOXB8 Gene

Gene Ontology (GO) - Molecular Function for HOXB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB8: view
genes like me logo Genes that share phenotypes with HOXB8: view

Animal Models for HOXB8 Gene

MGI Knock Outs for HOXB8:

Clone Products

  • Addgene plasmids for HOXB8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB8 Gene

Localization for HOXB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXB8 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HOXB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with HOXB8: view

Pathways & Interactions for HOXB8 Gene

SuperPathways for HOXB8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007625 grooming behavior IEA --
genes like me logo Genes that share ontologies with HOXB8: view

No data available for Pathways by source and SIGNOR curated interactions for HOXB8 Gene

Drugs & Compounds for HOXB8 Gene

No Compound Related Data Available

Transcripts for HOXB8 Gene

mRNA/cDNA for HOXB8 Gene

Unigene Clusters for HOXB8 Gene

Homeobox B8:
Representative Sequences:

Clone Products

  • Addgene plasmids for HOXB8

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB8 Gene

No ASD Table

Relevant External Links for HOXB8 Gene

GeneLoc Exon Structure for
HOXB8
ECgene alternative splicing isoforms for
HOXB8

Expression for HOXB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOXB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB8 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x24.4), Kidney - Cortex (x8.2), and Cervix - Endocervix (x4.8).

Protein differential expression in normal tissues from HIPED for HOXB8 Gene

This gene is overexpressed in Colon muscle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB8 Gene



Protein tissue co-expression partners for HOXB8 Gene

NURSA nuclear receptor signaling pathways regulating expression of HOXB8 Gene:

HOXB8

SOURCE GeneReport for Unigene cluster for HOXB8 Gene:

Hs.514292

Evidence on tissue expression from TISSUES for HOXB8 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with HOXB8: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB8 Gene

Orthologs for HOXB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HOXB8 33 34
  • 97.39 (n)
cow
(Bos Taurus)
Mammalia LOC100337349 33
  • 96.71 (n)
rat
(Rattus norvegicus)
Mammalia Hoxb8 33
  • 95.47 (n)
mouse
(Mus musculus)
Mammalia Hoxb8 33 16 34
  • 95.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB8 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB8 33
  • 83.82 (n)
lizard
(Anolis carolinensis)
Reptilia HOXB8 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb8 33
  • 80.28 (n)
Str.10287 33
zebrafish
(Danio rerio)
Actinopterygii hoxb8a 33 34
  • 73.06 (n)
hoxb8b 34
  • 63 (a)
OneToMany
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Ubx 34
  • 21 (a)
ManyToMany
abd-A 34
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mab-5 34
  • 31 (a)
ManyToMany
lin-39 34
  • 27 (a)
ManyToMany
Species where no ortholog for HOXB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HOXB8 Gene

ENSEMBL:
Gene Tree for HOXB8 (if available)
TreeFam:
Gene Tree for HOXB8 (if available)

Paralogs for HOXB8 Gene

genes like me logo Genes that share paralogs with HOXB8: view

Variants for HOXB8 Gene

Sequence variations from dbSNP and Humsavar for HOXB8 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000062421 -- 48,620,539(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000072656 -- 48,612,023(-) T/C downstream_transcript_variant
rs1000123927 -- 48,621,676(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000367738 -- 48,617,958(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000541350 -- 48,620,758(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HOXB8 Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv2676919 CNV deletion 23128226
esv2758694 CNV gain 17122850
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897

Variation tolerance for HOXB8 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB8 Gene

Disorders for HOXB8 Gene

Additional Disease Information for HOXB8

No disorders were found for HOXB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXB8 Gene

Publications for HOXB8 Gene

  1. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K … Matsuo N (Teratology 2002) 3 4 58
  2. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott MP (Cell 1992) 2 3 58
  3. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine PJ … Shows TB (Genomics 1990) 2 3 58
  4. Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. (PMID: 2570724) Giampaolo A … Simeone A (Differentiation; research in biological diversity 1989) 3 4 58
  5. Organization of human class I homeobox genes. (PMID: 2576652) Boncinelli E … Simeone A (Genome 1989) 3 4 58

Products for HOXB8 Gene

  • Addgene plasmids for HOXB8

Sources for HOXB8 Gene

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