Aliases for HOXB5 Gene
External Ids for HOXB5 Gene
Previous HGNC Symbols for HOXB5 Gene
Previous GeneCards Identifiers for HOXB5 Gene
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB5 Gene
HOXB5 (Homeobox B5) is a Protein Coding gene. Diseases associated with HOXB5 include High Grade Ependymoma and Mowat-Wilson Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is HOXA5.
UniProtKB/Swiss-Prot Summary for HOXB5 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.