This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and ... See more...

Aliases for HOXB4 Gene

Aliases for HOXB4 Gene

  • Homeobox B4 2 3 5
  • Homeobox Protein Hox-2.6 3 4
  • Homeobox Protein Hox-2F 3 4
  • Homeobox Protein Hox-B4 3 4
  • Homeo Box B4 2 3
  • HOX2F 3 4
  • Homeo Box 2F 3
  • HOX-2.6 3
  • HOX2 3

External Ids for HOXB4 Gene

Previous HGNC Symbols for HOXB4 Gene

  • HOX2
  • HOX2F

Previous GeneCards Identifiers for HOXB4 Gene

  • GC17M046364
  • GC17M049133
  • GC17M046995
  • GC17M047127
  • GC17M047128
  • GC17M044007
  • GC17M046652
  • GC17M042021

Summaries for HOXB4 Gene

Entrez Gene Summary for HOXB4 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB4 Gene

HOXB4 (Homeobox B4) is a Protein Coding gene. Diseases associated with HOXB4 include Omphalocele and Leukemia, Acute Myeloid. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXC4.

UniProtKB/Swiss-Prot Summary for HOXB4 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB4 Gene

Additional gene information for HOXB4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXB4 Gene

Genomics for HOXB4 Gene

GeneHancer (GH) Regulatory Elements for HOXB4 Gene

Promoters and enhancers for HOXB4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXB4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOXB4

Top Transcription factor binding sites by QIAGEN in the HOXB4 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F-2
  • E2F-3a
  • E2F-4

Genomic Locations for HOXB4 Gene

Genomic Locations for HOXB4 Gene
chr17:48,575,507-48,578,381
(GRCh38/hg38)
Size:
2,875 bases
Orientation:
Minus strand
chr17:46,652,869-46,657,473
(GRCh37/hg19)
Size:
4,605 bases
Orientation:
Minus strand

Genomic View for HOXB4 Gene

Genes around HOXB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB4 Gene

Proteins for HOXB4 Gene

  • Protein details for HOXB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17483-HXB4_HUMAN
    Recommended name:
    Homeobox protein Hox-B4
    Protein Accession:
    P17483
    Secondary Accessions:
    • Q9NTA0

    Protein attributes for HOXB4 Gene

    Size:
    251 amino acids
    Molecular mass:
    27604 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB4 Gene

Post-translational modifications for HOXB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXB4 Gene

Domains & Families for HOXB4 Gene

Gene Families for HOXB4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOXB4 Gene

Blocks:
  • Homeobox protein, antennapedia type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOXB4 Gene

GenScript: Design optimal peptide antigens:
  • Homeobox protein Hox-2F (HXB4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17483

UniProtKB/Swiss-Prot:

HXB4_HUMAN :
  • Belongs to the Antp homeobox family. Deformed subfamily.
Family:
  • Belongs to the Antp homeobox family. Deformed subfamily.
genes like me logo Genes that share domains with HOXB4: view

Function for HOXB4 Gene

Molecular function for HOXB4 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
GENATLAS Biochemistry:
homeo box B4(2F),homologous to mouse Hox-2.6,Drosophila Dfd

LifeMap Function Summary for HOXB4 Gene

HOXB4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for HOXB4 Gene

Gene Ontology (GO) - Molecular Function for HOXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with HOXB4: view
genes like me logo Genes that share phenotypes with HOXB4: view

Animal Models for HOXB4 Gene

MGI Knock Outs for HOXB4:

Animal Model Products

CRISPR Products

miRNA for HOXB4 Gene

miRTarBase miRNAs that target HOXB4
Targeted motifs for HOXB4 Gene
HOMER Transcription Factor Regulatory Elements motif HOXB4
  • Consensus sequence: TGATTRATGGCY Submotif: canonical Cell Type: ES GEO ID: GSE34014

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXB4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HOXB4 Gene

Localization for HOXB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXB4 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
plasma membrane 2
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with HOXB4: view

Pathways & Interactions for HOXB4 Gene

genes like me logo Genes that share pathways with HOXB4: view

Gene Ontology (GO) - Biological Process for HOXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001501 skeletal system development IBA 21873635
GO:0002011 morphogenesis of an epithelial sheet IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with HOXB4: view

No data available for SIGNOR curated interactions for HOXB4 Gene

Drugs & Compounds for HOXB4 Gene

(2) Additional Compounds for HOXB4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HOXB4: view

Transcripts for HOXB4 Gene

mRNA/cDNA for HOXB4 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXB4

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB4 Gene

No ASD Table

Relevant External Links for HOXB4 Gene

GeneLoc Exon Structure for
HOXB4

Expression for HOXB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB4 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x4.8) and Colon - Sigmoid (x4.2).

Protein differential expression in normal tissues from HIPED for HOXB4 Gene

This gene is overexpressed in Nasal epithelium (42.4) and Tlymphocyte (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOXB4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOXB4

SOURCE GeneReport for Unigene cluster for HOXB4 Gene:

Hs.664706

Evidence on tissue expression from TISSUES for HOXB4 Gene

  • Bone marrow(2.3)
genes like me logo Genes that share expression patterns with HOXB4: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB4 Gene

Orthologs for HOXB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB4 31 30
  • 99.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HOXB4 31 30
  • 96.94 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb4 17 31 30
  • 95.32 (n)
rat
(Rattus norvegicus)
Mammalia Hoxb4 30
  • 94.3 (n)
dog
(Canis familiaris)
Mammalia HOXB4 31 30
  • 93.33 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXB4 31
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB4 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB4 30
  • 74.5 (n)
lizard
(Anolis carolinensis)
Reptilia HOXB4 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb4 30
  • 66.83 (n)
zebrafish
(Danio rerio)
Actinopterygii hoxb4a 31 30 30
  • 69.12 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Scr 32
  • 72 (a)
Dfd 31 32
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToMany
Species where no ortholog for HOXB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB4 Gene

ENSEMBL:
Gene Tree for HOXB4 (if available)
TreeFam:
Gene Tree for HOXB4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOXB4: view image

Paralogs for HOXB4 Gene

(11) SIMAP similar genes for HOXB4 Gene using alignment to 1 proteins:

  • HXB4_HUMAN
genes like me logo Genes that share paralogs with HOXB4: view

Variants for HOXB4 Gene

Additional dbSNP identifiers (rs#s) for HOXB4 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXB4 Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv1007307 CNV deletion 20482838
esv2758694 CNV gain 17122850
nsv819832 CNV gain 19587683
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897

Variation tolerance for HOXB4 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOXB4 Gene

Disorders for HOXB4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HOXB4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
omphalocele
  • omphalocoele
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards
Search HOXB4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HOXB4

genes like me logo Genes that share disorders with HOXB4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB4 Gene

Publications for HOXB4 Gene

  1. Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2. (PMID: 11085749) Giannola DM … Emerson SG (The Journal of experimental medicine 2000) 3 4 23 54
  2. Generation of mesenchymal stromal cells from HOXB4-expressing human embryonic stem cells. (PMID: 19878058) Liu YP … Hematti P (Cytotherapy 2009) 3 23 54
  3. [Analysis on promoter CpG methylation and expression of HOXB4 gene in cord blood CD34(+) cells and peripheral blood mononuclear cells]. (PMID: 19549386) Zheng CL … Lu M (Zhongguo shi yan xue ye xue za zhi 2009) 3 23 54
  4. The HOXB4 homeoprotein differentially promotes ex vivo expansion of early human lymphoid progenitors. (PMID: 17962697) Haddad R … Amsellem S (Stem cells (Dayton, Ohio) 2008) 3 23 54
  5. Effects of HOXB4 overexpression on ex vivo expansion and immortalization of hematopoietic cells from different species. (PMID: 17510218) Zhang XB … Kiem HP (Stem cells (Dayton, Ohio) 2007) 3 23 54

Products for HOXB4 Gene

Sources for HOXB4 Gene