Aliases for HOXB4 Gene
External Ids for HOXB4 Gene
Previous HGNC Symbols for HOXB4 Gene
Previous GeneCards Identifiers for HOXB4 Gene
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB4 Gene
HOXB4 (Homeobox B4) is a Protein Coding gene. Diseases associated with HOXB4 include Omphalocele and Leukemia, Acute Myeloid. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXC4.
UniProtKB/Swiss-Prot Summary for HOXB4 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.