This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of ... See more...

Aliases for HOXB3 Gene

Aliases for HOXB3 Gene

  • Homeobox B3 2 3 5
  • Homeobox Protein Hox-2.7 3 4
  • Homeobox Protein Hox-2G 3 4
  • Homeobox Protein Hox-B3 3 4
  • HOX2G 3 4
  • Homeo Box 2G 3
  • Homeo Box B3 2
  • Hox-2.7 3
  • HOX2 3

External Ids for HOXB3 Gene

Previous HGNC Symbols for HOXB3 Gene

  • HOX2
  • HOX2G

Previous GeneCards Identifiers for HOXB3 Gene

  • GC17M046338
  • GC17M049107
  • GC17M046969
  • GC17M047101
  • GC17M043983
  • GC17M046626
  • GC17M041996

Summaries for HOXB3 Gene

Entrez Gene Summary for HOXB3 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB3 Gene

HOXB3 (Homeobox B3) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is HOXA3.

UniProtKB/Swiss-Prot Summary for HOXB3 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB3 Gene

Additional gene information for HOXB3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXB3 Gene

Genomics for HOXB3 Gene

GeneHancer (GH) Regulatory Elements for HOXB3 Gene

Promoters and enhancers for HOXB3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXB3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOXB3

Top Transcription factor binding sites by QIAGEN in the HOXB3 gene promoter:
  • ATF-2
  • c-Jun
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5

Genomic Locations for HOXB3 Gene

Genomic Locations for HOXB3 Gene
chr17:48,548,870-48,604,912
(GRCh38/hg38)
Size:
56,043 bases
Orientation:
Minus strand
chr17:46,626,232-46,682,274
(GRCh37/hg19)
Size:
56,043 bases
Orientation:
Minus strand

Genomic View for HOXB3 Gene

Genes around HOXB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB3 Gene

Proteins for HOXB3 Gene

  • Protein details for HOXB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14651-HXB3_HUMAN
    Recommended name:
    Homeobox protein Hox-B3
    Protein Accession:
    P14651
    Secondary Accessions:
    • A8K567
    • B7Z5N8
    • B7Z5P8
    • B7ZAD0
    • D3DTV3
    • O95615
    • P17484

    Protein attributes for HOXB3 Gene

    Size:
    431 amino acids
    Molecular mass:
    44340 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HOXB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOXB3 Gene

Post-translational modifications for HOXB3 Gene

  • Glycosylation at Asn122
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

No data available for DME Specific Peptides for HOXB3 Gene

Domains & Families for HOXB3 Gene

Gene Families for HOXB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOXB3 Gene

Blocks:
  • Lambda and other repressor helix-turn-helix signature
  • Homeobox protein, antennapedia type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOXB3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51054, highly similar to Homeobox protein Hox-B3 (B7Z5N8_HUMAN)
  • cDNA, FLJ79144, highly similar to Homeobox protein Hox-B3 (B7ZAD0_HUMAN)
  • Homeobox protein Hox-2G (HXB3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14651

UniProtKB/Swiss-Prot:

HXB3_HUMAN :
  • Belongs to the Antp homeobox family.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXB3: view

Function for HOXB3 Gene

Molecular function for HOXB3 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
GENATLAS Biochemistry:
homeo box B3(2G),homologous to mouse Hox-2.7,Drosophila Zen

Phenotypes From GWAS Catalog for HOXB3 Gene

Gene Ontology (GO) - Molecular Function for HOXB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 7913891
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IC --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with HOXB3: view
genes like me logo Genes that share phenotypes with HOXB3: view

Animal Models for HOXB3 Gene

MGI Knock Outs for HOXB3:

Animal Model Products

CRISPR Products

miRNA for HOXB3 Gene

miRTarBase miRNAs that target HOXB3

Clone Products

  • Addgene plasmids for HOXB3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB3 Gene

Localization for HOXB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXB3 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HOXB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with HOXB3: view

Pathways & Interactions for HOXB3 Gene

genes like me logo Genes that share pathways with HOXB3: view

SIGNOR curated interactions for HOXB3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HOXB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001525 angiogenesis IEP 17972163
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with HOXB3: view

Drugs & Compounds for HOXB3 Gene

No Compound Related Data Available

Transcripts for HOXB3 Gene

mRNA/cDNA for HOXB3 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for HOXB3

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB3 Gene

No ASD Table

Relevant External Links for HOXB3 Gene

GeneLoc Exon Structure for
HOXB3

Expression for HOXB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB3 Gene

This gene is overexpressed in Colon - Sigmoid (x4.2) and Esophagus - Gastroesophageal Junction (x4.2).

Protein differential expression in normal tissues from HIPED for HOXB3 Gene

This gene is overexpressed in Brain (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HOXB3 Gene



Protein tissue co-expression partners for HOXB3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOXB3

SOURCE GeneReport for Unigene cluster for HOXB3 Gene:

Hs.654560

Evidence on tissue expression from TISSUES for HOXB3 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with HOXB3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB3 Gene

Orthologs for HOXB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB3 31 30
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HOXB3 31 30
  • 94.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HOXB3 31 30
  • 92.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb3 17 31 30
  • 91.09 (n)
rat
(Rattus norvegicus)
Mammalia Hoxb3 30
  • 90.91 (n)
oppossum
(Monodelphis domestica)
Mammalia HOXB3 31
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB3 31 30
  • 71.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXB3 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb3 30
  • 69.61 (n)
Str.15450 30
zebrafish
(Danio rerio)
Actinopterygii hoxb3a 31 30 30
  • 68.41 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 18 (a)
OneToMany
Species where no ortholog for HOXB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB3 Gene

ENSEMBL:
Gene Tree for HOXB3 (if available)
TreeFam:
Gene Tree for HOXB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOXB3: view image

Paralogs for HOXB3 Gene

(11) SIMAP similar genes for HOXB3 Gene using alignment to 6 proteins:

  • HXB3_HUMAN
  • B7Z5N8_HUMAN
  • B7ZAD0_HUMAN
  • C9J2I3_HUMAN
  • F8VXG0_HUMAN
  • F8W1L2_HUMAN

Pseudogenes.org Pseudogenes for HOXB3 Gene

genes like me logo Genes that share paralogs with HOXB3: view

Variants for HOXB3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOXB3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs2229304 - p.Pro82Thr

Additional dbSNP identifiers (rs#s) for HOXB3 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXB3 Gene

Variant ID Type Subtype PubMed ID
dgv1478n106 CNV deletion 24896259
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv1007307 CNV deletion 20482838
esv2758694 CNV gain 17122850
nsv1118763 CNV deletion 24896259
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897
nsv953922 CNV deletion 24416366

Variation tolerance for HOXB3 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB3 Gene

Disorders for HOXB3 Gene

Additional Disease Information for HOXB3

No disorders were found for HOXB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXB3 Gene

Publications for HOXB3 Gene

  1. Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. (PMID: 19854132) Palakurthy RK … Green MR (Molecular cell 2009) 3 23 54
  2. HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. (PMID: 17972163) Chung N … Rha HK (Molecular biology reports 2009) 3 23 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context. (PMID: 9774637) Viganò MA … Mavilio F (Molecular and cellular biology 1998) 3 23 54
  5. Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells. (PMID: 9556594) Guazzi S … Boncinelli E (The Journal of biological chemistry 1998) 3 23 54

Products for HOXB3 Gene

Sources for HOXB3 Gene