Aliases for HOXB2 Gene
External Ids for HOXB2 Gene
Previous HGNC Symbols for HOXB2 Gene
Previous GeneCards Identifiers for HOXB2 Gene
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB2 Gene
HOXB2 (Homeobox B2) is a Protein Coding gene. Diseases associated with HOXB2 include Omphalocele and Pancreatic Cancer. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA2.
UniProtKB/Swiss-Prot Summary for HOXB2 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.