This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided b... See more...

Aliases for HOXB2 Gene

Aliases for HOXB2 Gene

  • Homeobox B2 2 3 5
  • Homeobox Protein Hox-2.8 3 4
  • Homeobox Protein Hox-2H 3 4
  • Homeobox Protein Hox-B2 3 4
  • Homeo Box B2 2 3
  • HOX2H 3 4
  • K8 3 4
  • K8 Home Protein 3
  • Homeo Box 2H 3
  • Hox-2.8 3
  • HOX2 3

External Ids for HOXB2 Gene

Previous HGNC Symbols for HOXB2 Gene

  • HOX2
  • HOX2H

Previous GeneCards Identifiers for HOXB2 Gene

  • GC17M046331
  • GC17M049100
  • GC17M046962
  • GC17M047094
  • GC17M043975
  • GC17M046620
  • GC17M041989

Summaries for HOXB2 Gene

Entrez Gene Summary for HOXB2 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB2 Gene

HOXB2 (Homeobox B2) is a Protein Coding gene. Diseases associated with HOXB2 include Omphalocele and Pancreatic Cancer. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA2.

UniProtKB/Swiss-Prot Summary for HOXB2 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB2 Gene

Additional gene information for HOXB2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXB2 Gene

Genomics for HOXB2 Gene

GeneHancer (GH) Regulatory Elements for HOXB2 Gene

Promoters and enhancers for HOXB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXB2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOXB2

Top Transcription factor binding sites by QIAGEN in the HOXB2 gene promoter:
  • CBF(2)
  • Egr-3
  • FOXO4
  • Hlf
  • IRF-1
  • ITF-2
  • Lmo2
  • N-Myc
  • POU3F2
  • Tal-1beta

Genomic Locations for HOXB2 Gene

Genomic Locations for HOXB2 Gene
chr17:48,540,894-48,545,031
(GRCh38/hg38)
Size:
4,138 bases
Orientation:
Minus strand
chr17:46,618,256-46,623,441
(GRCh37/hg19)
Size:
5,186 bases
Orientation:
Minus strand

Genomic View for HOXB2 Gene

Genes around HOXB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB2 Gene

Proteins for HOXB2 Gene

  • Protein details for HOXB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14652-HXB2_HUMAN
    Recommended name:
    Homeobox protein Hox-B2
    Protein Accession:
    P14652
    Secondary Accessions:
    • P10913
    • P17485

    Protein attributes for HOXB2 Gene

    Size:
    356 amino acids
    Molecular mass:
    37914 Da
    Quaternary structure:
    • Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.

neXtProt entry for HOXB2 Gene

Post-translational modifications for HOXB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXB2 Gene

Domains & Families for HOXB2 Gene

Gene Families for HOXB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOXB2 Gene

Blocks:
  • Lambda and other repressor helix-turn-helix signature
  • Homeobox protein, antennapedia type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOXB2 Gene

GenScript: Design optimal peptide antigens:
  • Homeobox B2, isoform CRA_b (D3DTV2_HUMAN)
  • K8 (HXB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14652

UniProtKB/Swiss-Prot:

HXB2_HUMAN :
  • Belongs to the Antp homeobox family. Proboscipedia subfamily.
Family:
  • Belongs to the Antp homeobox family. Proboscipedia subfamily.
genes like me logo Genes that share domains with HOXB2: view

Function for HOXB2 Gene

Molecular function for HOXB2 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
GENATLAS Biochemistry:
homeo box B2(2H),homologous to mouse Hox-2.8,Drosophila pb

Phenotypes From GWAS Catalog for HOXB2 Gene

Gene Ontology (GO) - Molecular Function for HOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IC --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
genes like me logo Genes that share ontologies with HOXB2: view
genes like me logo Genes that share phenotypes with HOXB2: view

Animal Models for HOXB2 Gene

MGI Knock Outs for HOXB2:

Animal Model Products

CRISPR Products

miRNA for HOXB2 Gene

Clone Products

  • Addgene plasmids for HOXB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB2 Gene

Localization for HOXB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXB2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with HOXB2: view

Pathways & Interactions for HOXB2 Gene

genes like me logo Genes that share pathways with HOXB2: view

Gene Ontology (GO) - Biological Process for HOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0002011 morphogenesis of an epithelial sheet IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 7876223
GO:0008015 blood circulation TAS 7876223
genes like me logo Genes that share ontologies with HOXB2: view

No data available for SIGNOR curated interactions for HOXB2 Gene

Drugs & Compounds for HOXB2 Gene

(3) Additional Compounds for HOXB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HOXB2: view

Transcripts for HOXB2 Gene

mRNA/cDNA for HOXB2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for HOXB2

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB2 Gene

No ASD Table

Relevant External Links for HOXB2 Gene

GeneLoc Exon Structure for
HOXB2

Expression for HOXB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HOXB2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOXB2

SOURCE GeneReport for Unigene cluster for HOXB2 Gene:

Hs.514289

Evidence on tissue expression from TISSUES for HOXB2 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with HOXB2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB2 Gene

Orthologs for HOXB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB2 31 30
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HOXB2 31 30
  • 88.11 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HOXB2 31 30
  • 88.01 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb2 17 31 30
  • 82.72 (n)
rat
(Rattus norvegicus)
Mammalia Hoxb2 30
  • 82.44 (n)
oppossum
(Monodelphis domestica)
Mammalia HOXB2 31
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB2 31
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB2 31 30
  • 68.91 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXB2 31
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb2 30
  • 64.55 (n)
zebrafish
(Danio rerio)
Actinopterygii hoxb2a 31 30 30
  • 63.38 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pb 31
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
OneToMany
Species where no ortholog for HOXB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB2 Gene

ENSEMBL:
Gene Tree for HOXB2 (if available)
TreeFam:
Gene Tree for HOXB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOXB2: view image

Paralogs for HOXB2 Gene

(2) SIMAP similar genes for HOXB2 Gene using alignment to 2 proteins:

  • HXB2_HUMAN
  • D3DTV2_HUMAN
genes like me logo Genes that share paralogs with HOXB2: view

Variants for HOXB2 Gene

Additional dbSNP identifiers (rs#s) for HOXB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXB2 Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv2758694 CNV gain 17122850
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897
nsv953922 CNV deletion 24416366

Variation tolerance for HOXB2 Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOXB2 Gene

Disorders for HOXB2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HOXB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
omphalocele
  • omphalocoele
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search HOXB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HOXB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HOXB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB2 Gene

Publications for HOXB2 Gene

  1. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. (PMID: 20195514) Pillas D … Jarvelin MR (PLoS genetics 2010) 3 23 41 54
  2. The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. (PMID: 10595394) Case SS … Lloyd JA (DNA and cell biology 1999) 3 4 23 54
  3. Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. (PMID: 7876223) Vieille-Grosjean I … Huber P (The Journal of biological chemistry 1995) 3 4 23 54
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 41 54
  5. HOXB2 as a novel prognostic indicator for stage I lung adenocarcinomas. (PMID: 17805056) Inamura K … Ishikawa Y (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2007) 3 23 54

Products for HOXB2 Gene

Sources for HOXB2 Gene