External Ids for HOXB13 Gene
Previous GeneCards Identifiers for HOXB13 Gene
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB13 Gene
HOXB13 (Homeobox B13) is a Protein Coding gene. Diseases associated with HOXB13 include Prostate Cancer and Spinal Cord Ependymoma. Among its related pathways are Regulation of Androgen receptor activity and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXA13.
UniProtKB/Swiss-Prot for HOXB13 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536).