In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate g... See more...

Aliases for HOXA9 Gene

Aliases for HOXA9 Gene

  • Homeobox A9 2 3 5
  • Homeobox Protein Hox-1G 3 4
  • Homeobox Protein Hox-A9 3 4
  • HOX1G 3 4
  • Homeodomain Protein HOXA9 3
  • Homeo Box A9 2
  • HOX1.7 3
  • ABD-B 3
  • HOX1 3

External Ids for HOXA9 Gene

Previous HGNC Symbols for HOXA9 Gene

  • HOX1G
  • HOX1

Previous GeneCards Identifiers for HOXA9 Gene

  • GC07U990049
  • GC07M026844
  • GC07M026910
  • GC07M026945
  • GC07M026946
  • GC07M026975
  • GC07M027168
  • GC07M027213
  • GC07M027214
  • GC07M027219
  • GC07M027230
  • GC07M027254

Summaries for HOXA9 Gene

Entrez Gene Summary for HOXA9 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for HOXA9 Gene

HOXA9 (Homeobox A9) is a Protein Coding gene. Diseases associated with HOXA9 include Myeloid Leukemia and Leukemia. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is ENSG00000257184.

UniProtKB/Swiss-Prot Summary for HOXA9 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.

Gene Wiki entry for HOXA9 Gene

Additional gene information for HOXA9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXA9 Gene

Genomics for HOXA9 Gene

GeneHancer (GH) Regulatory Elements for HOXA9 Gene

Promoters and enhancers for HOXA9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXA9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOXA9

Top Transcription factor binding sites by QIAGEN in the HOXA9 gene promoter:
  • c-Myb
  • MyoD
  • p53
  • Sp1

Genomic Locations for HOXA9 Gene

Genomic Locations for HOXA9 Gene
chr7:27,162,438-27,175,180
(GRCh38/hg38)
Size:
12,743 bases
Orientation:
Minus strand
chr7:27,202,054-27,210,117
(GRCh37/hg19)
Size:
8,064 bases
Orientation:
Minus strand

Genomic View for HOXA9 Gene

Genes around HOXA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA9 Gene

Proteins for HOXA9 Gene

  • Protein details for HOXA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31269-HXA9_HUMAN
    Recommended name:
    Homeobox protein Hox-A9
    Protein Accession:
    P31269
    Secondary Accessions:
    • O43369
    • O43429
    • Q99820

    Protein attributes for HOXA9 Gene

    Size:
    272 amino acids
    Molecular mass:
    30172 Da
    Quaternary structure:
    • Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.
    SequenceCaution:
    • Sequence=AAC50364.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HOXA9 Gene

Post-translational modifications for HOXA9 Gene

  • Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HOXA9
  • Boster Bio Antibodies for HOXA9

No data available for DME Specific Peptides for HOXA9 Gene

Domains & Families for HOXA9 Gene

Gene Families for HOXA9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOXA9 Gene

Blocks:
  • Lambda and other repressor helix-turn-helix signature
  • Hox9 activation region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOXA9 Gene

GenScript: Design optimal peptide antigens:
  • Homeobox protein Hox-1G (HXA9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31269

UniProtKB/Swiss-Prot:

HXA9_HUMAN :
  • Belongs to the Abd-B homeobox family.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXA9: view

Function for HOXA9 Gene

Molecular function for HOXA9 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.
GENATLAS Biochemistry:
homeo box A9(1G),with two alternatively spliced isoforms,including either exon AB or CD,homologous to mouse Hox-1.7,Drosophila abd-B,fused with NUP98 in acute myeloid leukemia with translocation t(7;11),see AML2

Phenotypes From GWAS Catalog for HOXA9 Gene

Gene Ontology (GO) - Molecular Function for HOXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0019899 enzyme binding IPI 22269951
genes like me logo Genes that share ontologies with HOXA9: view
genes like me logo Genes that share phenotypes with HOXA9: view

Animal Models for HOXA9 Gene

MGI Knock Outs for HOXA9:

Animal Model Products

CRISPR Products

miRNA for HOXA9 Gene

miRTarBase miRNAs that target HOXA9

Transcription Factor Targets for HOXA9 Gene

Selected GeneGlobe predicted Target genes for HOXA9
Targeted motifs for HOXA9 Gene
HOMER Transcription Factor Regulatory Elements motif HOXA9
  • Consensus sequence: GGCCATAAATCA Submotif: canonical Cell Type: HSC GEO ID: GSE33509

Clone Products

  • Addgene plasmids for HOXA9

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for HOXA9 Gene

Localization for HOXA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXA9 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HOXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IDA --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with HOXA9: view

Pathways & Interactions for HOXA9 Gene

PathCards logo

SuperPathways for HOXA9 Gene

genes like me logo Genes that share pathways with HOXA9: view

Pathways by source for HOXA9 Gene

1 KEGG pathway for HOXA9 Gene

SIGNOR curated interactions for HOXA9 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HOXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 8563754
GO:0007283 spermatogenesis IEA --
GO:0007338 single fertilization IEA --
genes like me logo Genes that share ontologies with HOXA9: view

Drugs & Compounds for HOXA9 Gene

(2) Drugs for HOXA9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HOXA9: view

Transcripts for HOXA9 Gene

mRNA/cDNA for HOXA9 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for HOXA9

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2:
SP3:

Relevant External Links for HOXA9 Gene

GeneLoc Exon Structure for
HOXA9

Expression for HOXA9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA9 Gene

This gene is overexpressed in Kidney - Cortex (x5.8) and Fallopian Tube (x5.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOXA9

Evidence on tissue expression from TISSUES for HOXA9 Gene

  • Bone marrow(4.6)
  • Intestine(4.3)
  • Blood(2)
genes like me logo Genes that share expression patterns with HOXA9: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA9 Gene

Orthologs for HOXA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXA9 31 30
  • 99.14 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 97 (a)
OneToMany
HOXA9 30
  • 94.24 (n)
cow
(Bos Taurus)
Mammalia HOXA9 31 30
  • 93.87 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Hoxa9 17 31 30
  • 92.87 (n)
rat
(Rattus norvegicus)
Mammalia Hoxa9l 30
  • 92.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 89 (a)
ManyToMany
-- 31
  • 81 (a)
ManyToMany
-- 31
  • 81 (a)
ManyToMany
LOC100858551 30
  • 79.23 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 95 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa9 30
  • 71.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia hoxa9-A 30
zebrafish
(Danio rerio)
Actinopterygii hoxa9b 31
  • 48 (a)
ManyToMany
hoxa9a 31 31
  • 42 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 18 (a)
OneToMany
Species where no ortholog for HOXA9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXA9 Gene

ENSEMBL:
Gene Tree for HOXA9 (if available)
TreeFam:
Gene Tree for HOXA9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOXA9: view image

Paralogs for HOXA9 Gene

Paralogs for HOXA9 Gene

(5) SIMAP similar genes for HOXA9 Gene using alignment to 2 proteins:

  • HXA9_HUMAN
  • A8MVF3_HUMAN
genes like me logo Genes that share paralogs with HOXA9: view

Variants for HOXA9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOXA9 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
787701 Benign: not provided 27,163,795(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs35991882 Uncertain Significance: not provided 27,163,754(-) T/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for HOXA9 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXA9 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
nsv606465 CNV loss 21841781
nsv606468 CNV loss 21841781
nsv7393 OTHER inversion 18451855
nsv824042 CNV gain 20364138

Variation tolerance for HOXA9 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXA9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXA9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA9 Gene

Disorders for HOXA9 Gene

MalaCards: The human disease database

(13) MalaCards diseases for HOXA9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myeloid leukemia
  • leukemia myelogenous
leukemia
  • leukemias
acute leukemia
  • stem cell leukaemia
myelodysplastic syndrome
  • mds
chronic myelomonocytic leukemia
  • leukemia, myelomonocytic, chronic
- elite association - COSMIC cancer census association via MalaCards
Search HOXA9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HXA9_HUMAN
  • Note=A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98.
  • Note=A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.

Additional Disease Information for HOXA9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HOXA9: view

No data available for Genatlas for HOXA9 Gene

Publications for HOXA9 Gene

  1. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). (PMID: 12649177) Barbouti A … Fioretos T (Cancer research 2003) 3 4 23 54
  2. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. (PMID: 8563754) Borrow J … Housman DE (Nature genetics 1996) 3 4 23 54
  3. HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules. (PMID: 22269951) Bandyopadhyay S … Dicorleto PE (Molecular and cellular biology 2012) 3 4 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. (PMID: 20389018) Gilbert PM … Weaver VM (The Journal of clinical investigation 2010) 3 23 54

Products for HOXA9 Gene

Sources for HOXA9 Gene