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Aliases for HOXA7 Gene

Aliases for HOXA7 Gene

  • Homeobox A7 2 3 5
  • Homeobox Protein Hox 1.1 3 4
  • Homeo Box A7 2 3
  • HOX1A 3 4
  • Homeobox Protein HOX-1A 3
  • Homeobox Protein Hox-A7 3
  • Homeobox Protein Hox-1A 4
  • HOX1.1 3
  • ANTP 3
  • HOX1 3

External Ids for HOXA7 Gene

Previous HGNC Symbols for HOXA7 Gene

  • HOX1A
  • HOX1

Previous GeneCards Identifiers for HOXA7 Gene

  • GC07M026836
  • GC07M026936
  • GC07M026967
  • GC07M027159
  • GC07M027193

Summaries for HOXA7 Gene

Entrez Gene Summary for HOXA7 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA7 Gene

HOXA7 (Homeobox A7) is a Protein Coding gene. Diseases associated with HOXA7 include Oculoauricular Syndrome and Clivus Chordoma. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is HOXB7.

UniProtKB/Swiss-Prot for HOXA7 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXA7 Gene

Additional gene information for HOXA7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA7 Gene

Genomics for HOXA7 Gene

GeneHancer (GH) Regulatory Elements for HOXA7 Gene

Promoters and enhancers for HOXA7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J027095 Promoter/Enhancer 3.4 VISTA UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 652.7 +19.7 19741 86.3 MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 ZNF610 HOXA2 HOXA9 HOXA10 HOXA1 HOXA3 HOXA6 HOXA4 HOXA5 HOXA7 HNRNPA2B1
GH07J027661 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11 -505.0 -504967 3.3 HNRNPUL1 PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 HIBADH EIF4HP1 HOXA7 HOXA3 LOC105375211
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXA7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HOXA7 gene promoter:
  • p53
  • c-Myb
  • Sp1
  • deltaCREB
  • CREB
  • C/EBPalpha

Genomic Locations for HOXA7 Gene

Genomic Locations for HOXA7 Gene
chr7:27,153,716-27,157,936
(GRCh38/hg38)
Size:
4,221 bases
Orientation:
Minus strand
chr7:27,193,335-27,197,555
(GRCh37/hg19)
Size:
4,221 bases
Orientation:
Minus strand

Genomic View for HOXA7 Gene

Genes around HOXA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA7 Gene

Proteins for HOXA7 Gene

  • Protein details for HOXA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31268-HXA7_HUMAN
    Recommended name:
    Homeobox protein Hox-A7
    Protein Accession:
    P31268
    Secondary Accessions:
    • A4D191
    • O43368
    • O43486
    • O95655
    • Q9NSC8
    • Q9UDM1

    Protein attributes for HOXA7 Gene

    Size:
    230 amino acids
    Molecular mass:
    25355 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXA7 Gene

Post-translational modifications for HOXA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HOXA7
  • Boster Bio Antibodies for HOXA7

No data available for DME Specific Peptides for HOXA7 Gene

Domains & Families for HOXA7 Gene

Gene Families for HOXA7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for HOXA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31268

UniProtKB/Swiss-Prot:

HXA7_HUMAN :
  • Belongs to the Antp homeobox family.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXA7: view

Function for HOXA7 Gene

Molecular function for HOXA7 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
GENATLAS Biochemistry:
homeo box A7(1A),homologous to mouse Hox-1.1,Drosophila Antp,Ubx,abd-A,expressed in erythroleukemic cell line

Phenotypes From GWAS Catalog for HOXA7 Gene

Gene Ontology (GO) - Molecular Function for HOXA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 11435435
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 11435435
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with HOXA7: view
genes like me logo Genes that share phenotypes with HOXA7: view

Animal Models for HOXA7 Gene

MGI Knock Outs for HOXA7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXA7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXA7 Gene

Localization for HOXA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXA7 gene
Compartment Confidence
nucleus 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOXA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 11435435
GO:0005654 nucleoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with HOXA7: view

Pathways & Interactions for HOXA7 Gene

SuperPathways for HOXA7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11435435
GO:0001525 angiogenesis IEP 17972163
GO:0001953 negative regulation of cell-matrix adhesion IDA 14704364
GO:0002686 negative regulation of leukocyte migration IDA 14704364
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HOXA7: view

No data available for Pathways by source and SIGNOR curated interactions for HOXA7 Gene

Drugs & Compounds for HOXA7 Gene

No Compound Related Data Available

Transcripts for HOXA7 Gene

mRNA/cDNA for HOXA7 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXA7 Gene

Homeobox A7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXA7

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA7 Gene

No ASD Table

Relevant External Links for HOXA7 Gene

GeneLoc Exon Structure for
HOXA7
ECgene alternative splicing isoforms for
HOXA7

Expression for HOXA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOXA7 Gene

mRNA differential expression in normal tissues according to GTEx for HOXA7 Gene

This gene is overexpressed in Adrenal Gland (x4.6) and Fallopian Tube (x4.1).

Protein differential expression in normal tissues from HIPED for HOXA7 Gene

This gene is overexpressed in Urine (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HOXA7 Gene



Protein tissue co-expression partners for HOXA7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HOXA7 Gene:

HOXA7

SOURCE GeneReport for Unigene cluster for HOXA7 Gene:

Hs.610216

Evidence on tissue expression from TISSUES for HOXA7 Gene

  • Nervous system(2.7)
  • Muscle(2.4)
  • Kidney(2.3)
  • Stomach(2)
genes like me logo Genes that share expression patterns with HOXA7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA7 Gene

Orthologs for HOXA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXA7 34 33
  • 99.57 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HOXA7 34 33
  • 96.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HOXA7 34 33
  • 93.23 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxa7 16 34 33
  • 92.17 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909678 33
  • 92.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXA7 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXA7 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXA7 34 34 34 33
  • 81.65 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HOXA7 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa7 33
  • 76.5 (n)
Str.10310 33
African clawed frog
(Xenopus laevis)
Amphibia hox36 33
fruit fly
(Drosophila melanogaster)
Insecta Antp 34 35
  • 25 (a)
OneToMany
Species where no ortholog for HOXA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HOXA7 Gene

ENSEMBL:
Gene Tree for HOXA7 (if available)
TreeFam:
Gene Tree for HOXA7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOXA7: view image

Paralogs for HOXA7 Gene

(14) SIMAP similar genes for HOXA7 Gene using alignment to 2 proteins:

  • HXA7_HUMAN
  • E5RHM9_HUMAN
genes like me logo Genes that share paralogs with HOXA7: view

Variants for HOXA7 Gene

Sequence variations from dbSNP and Humsavar for HOXA7 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000292300 -- 27,158,142(-) T/C upstream_transcript_variant
rs1000360737 -- 27,156,224(-) C/A/T coding_sequence_variant, missense_variant
rs1000568757 -- 27,156,976(-) C/T upstream_transcript_variant
rs1000580191 -- 27,156,738(-) G/A upstream_transcript_variant
rs1002304049 -- 27,157,693(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HOXA7 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
dgv11244n54 CNV loss 21841781
nsv526526 CNV loss 19592680
nsv5674 CNV deletion 18451855
nsv606465 CNV loss 21841781
nsv7393 OTHER inversion 18451855
nsv824042 CNV gain 20364138

Variation tolerance for HOXA7 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXA7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA7 Gene

Disorders for HOXA7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HOXA7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
oculoauricular syndrome
  • ocacs
clivus chordoma
  • chordoma of clivus
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards
Search HOXA7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HOXA7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HOXA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXA7 Gene

Publications for HOXA7 Gene

  1. Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation. (PMID: 11435435) La Celle PT … Polakowska RR (The Journal of biological chemistry 2001) 3 4 22 58
  2. Sequence analysis and tissue specific expression of human HOXA7. (PMID: 10911612) Kim MH … Park HW (Molecular biotechnology 2000) 3 4 22 58
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
  4. HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. (PMID: 17972163) Chung N … Rha HK (Molecular biology reports 2009) 3 22 58
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58

Products for HOXA7 Gene

Sources for HOXA7 Gene

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