Aliases for HOXA13 Gene
External Ids for HOXA13 Gene
Previous HGNC Symbols for HOXA13 Gene
Previous GeneCards Identifiers for HOXA13 Gene
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXA13 Gene
HOXA13 (Homeobox A13) is a Protein Coding gene. Diseases associated with HOXA13 include Hand-Foot-Genital Syndrome and Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is HOXC13.
UniProtKB/Swiss-Prot for HOXA13 Gene
Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.