Aliases for HOXA11 Gene
External Ids for HOXA11 Gene
Previous HGNC Symbols for HOXA11 Gene
Previous GeneCards Identifiers for HOXA11 Gene
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXA11 Gene
HOXA11 (Homeobox A11) is a Protein Coding gene. Diseases associated with HOXA11 include Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia 1 and Radio-Ulnar Synostosis-Amegakaryocytic Thrombocytopenia Syndrome. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXC11.
UniProtKB/Swiss-Prot Summary for HOXA11 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.