In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate ge... See more...

Aliases for HOXA10 Gene

Aliases for HOXA10 Gene

  • Homeobox A10 2 3 5
  • Homeobox Protein Hox-A10 3 4
  • Homeobox Protein Hox-1.8 3 4
  • Homeobox Protein Hox-1H 3 4
  • Homeo Box A10 2 3
  • HOX1H 3 4
  • PL 3 4
  • Homeobox Protein HOXA10 3
  • Homeobox Protein 1H 3
  • HOX1.8 3
  • HOXA10 5
  • HOX1 3

External Ids for HOXA10 Gene

Previous HGNC Symbols for HOXA10 Gene

  • HOX1H
  • HOX1

Previous GeneCards Identifiers for HOXA10 Gene

  • GC07M026854
  • GC07M026918
  • GC07M026952
  • GC07M026983
  • GC07M027176
  • GC07M027210
  • GC07M027202
  • GC07M027174
  • GC07M027189
  • GC07M027199
  • GC07M027229

Summaries for HOXA10 Gene

Entrez Gene Summary for HOXA10 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for HOXA10 Gene

HOXA10 (Homeobox A10) is a Protein Coding gene. Diseases associated with HOXA10 include Adenomyosis and Ovarian Clear Cell Adenocarcinoma. Among its related pathways are Transcriptional misregulation in cancer and Signaling events mediated by HDAC Class III. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding and histone deacetylase binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot Summary for HOXA10 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.

Gene Wiki entry for HOXA10 Gene

Additional gene information for HOXA10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXA10 Gene

Genomics for HOXA10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HOXA10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXA10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOXA10

Top Transcription factor binding sites by QIAGEN in the HOXA10 gene promoter:
  • ATF-2
  • c-Jun
  • p53

Genomic Locations for HOXA10 Gene

Genomic Locations for HOXA10 Gene
chr7:27,170,592-27,180,261
(GRCh38/hg38)
Size:
9,670 bases
Orientation:
Minus strand
chr7:27,210,210-27,219,880
(GRCh37/hg19)
Size:
9,671 bases
Orientation:
Minus strand

Genomic View for HOXA10 Gene

Genes around HOXA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA10 Gene

Proteins for HOXA10 Gene

  • Protein details for HOXA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31260-HXA10_HUMAN
    Recommended name:
    Homeobox protein Hox-A10
    Protein Accession:
    P31260
    Secondary Accessions:
    • O43370
    • O43605
    • Q15949
    • Q504T1

    Protein attributes for HOXA10 Gene

    Size:
    410 amino acids
    Molecular mass:
    42414 Da
    Quaternary structure:
    • Interacts with SIRT2; the interaction is direct.
    SequenceCaution:
    • Sequence=AAB96917.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH13971.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAB86198.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for HOXA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOXA10 Gene

Post-translational modifications for HOXA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HOXA10

No data available for DME Specific Peptides for HOXA10 Gene

Domains & Families for HOXA10 Gene

Gene Families for HOXA10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOXA10 Gene

Suggested Antigen Peptide Sequences for HOXA10 Gene

GenScript: Design optimal peptide antigens:
  • PL (HXA10_HUMAN)
  • cDNA, FLJ92804, Homo sapiens homeo box A10 (HOXA10), transcript variant 2, mRNA (Q504T1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31260

UniProtKB/Swiss-Prot:

HXA10_HUMAN :
  • Belongs to the Abd-B homeobox family.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXA10: view

Function for HOXA10 Gene

Molecular function for HOXA10 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.
GENATLAS Biochemistry:
homeo box A10(1H),homologous to mouse Hox-1.8,expressed in the secretory endometrium

Phenotypes From GWAS Catalog for HOXA10 Gene

Gene Ontology (GO) - Molecular Function for HOXA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 21471217
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 21471217
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 18692240
genes like me logo Genes that share ontologies with HOXA10: view
genes like me logo Genes that share phenotypes with HOXA10: view

Animal Models for HOXA10 Gene

MGI Knock Outs for HOXA10:

Animal Model Products

CRISPR Products

miRNA for HOXA10 Gene

miRTarBase miRNAs that target HOXA10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXA10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXA10 Gene

Localization for HOXA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXA10 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOXA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IDA 15213244
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA 15213244
genes like me logo Genes that share ontologies with HOXA10: view

Pathways & Interactions for HOXA10 Gene

genes like me logo Genes that share pathways with HOXA10: view

Pathways by source for HOXA10 Gene

1 BioSystems pathway for HOXA10 Gene
1 KEGG pathway for HOXA10 Gene

SIGNOR curated interactions for HOXA10 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HOXA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 8972230
GO:0007283 spermatogenesis TAS,IEA --
GO:0007338 single fertilization IEA --
genes like me logo Genes that share ontologies with HOXA10: view

Drugs & Compounds for HOXA10 Gene

(7) Drugs for HOXA10 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcitriol Approved Nutra Target TNF-α and IL-1β production inhibitor, Vitamin D receptor (VDR) agonist 175

(4) Additional Compounds for HOXA10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HOXA10: view

Transcripts for HOXA10 Gene

mRNA/cDNA for HOXA10 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXA10

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA10 Gene

No ASD Table

Relevant External Links for HOXA10 Gene

GeneLoc Exon Structure for
HOXA10

Expression for HOXA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA10 Gene

This gene is overexpressed in Uterus (x7.7), Muscle - Skeletal (x5.7), Colon - Sigmoid (x4.2), and Cervix - Endocervix (x4.1).

Protein differential expression in normal tissues from HIPED for HOXA10 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HOXA10 Gene



Protein tissue co-expression partners for HOXA10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOXA10

SOURCE GeneReport for Unigene cluster for HOXA10 Gene:

Hs.110637

Evidence on tissue expression from TISSUES for HOXA10 Gene

  • Muscle(4.5)
  • Nervous system(4.4)
  • Intestine(2.9)
  • Kidney(2.4)
  • Blood(2.2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with HOXA10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA10 Gene

Orthologs for HOXA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXA10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HOXA10 30 31
  • 99.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HOXA10 31
  • 93 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia HOXA10 30 31
  • 92.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100909714 30
  • 86.26 (n)
Mouse
(Mus musculus)
Mammalia Hoxa10 30 17 31
  • 86.16 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HOXA10 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HOXA10 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 76 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
HOXA10 30
  • 75.86 (n)
Lizard
(Anolis carolinensis)
Reptilia HOXA10 31
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hoxa10 30
  • 69.1 (n)
Zebrafish
(Danio rerio)
Actinopterygii hoxa10b 30 31
  • 59.94 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 21 (a)
OneToMany
Species where no ortholog for HOXA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HOXA10 Gene

ENSEMBL:
Gene Tree for HOXA10 (if available)
TreeFam:
Gene Tree for HOXA10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOXA10: view image

Paralogs for HOXA10 Gene

(14) SIMAP similar genes for HOXA10 Gene using alignment to 2 proteins:

  • HXA10_HUMAN
  • Q5I0Y5_HUMAN
genes like me logo Genes that share paralogs with HOXA10: view

Variants for HOXA10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOXA10 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
714346 Benign: not provided 27,173,943(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for HOXA10 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXA10 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
nsv5675 CNV insertion 18451855
nsv606465 CNV loss 21841781
nsv606468 CNV loss 21841781
nsv7393 OTHER inversion 18451855
nsv824042 CNV gain 20364138

Variation tolerance for HOXA10 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXA10 Gene

Human Gene Mutation Database (HGMD)
HOXA10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA10 Gene

Disorders for HOXA10 Gene

MalaCards: The human disease database

(19) MalaCards diseases for HOXA10 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HOXA10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HOXA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXA10 Gene

Publications for HOXA10 Gene

  1. HOXA10 mutations in congenital absence of uterus and vagina. (PMID: 17482600) Lalwani S … Gray MR (Fertility and sterility 2008) 3 23 41
  2. Genetic alterations of HOXA10 and their effect on the severity of endometriosis in a Taiwanese population. (PMID: 18339267) Wu HH … Tsai HD (Reproductive biomedicine online 2008) 3 23 41
  3. Homeobox HOXA10 gene analysis in cryptorchidism. (PMID: 14960020) Bertini V … Simi P (Journal of pediatric endocrinology & metabolism : JPEM 2004) 3 23 41
  4. Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. (PMID: 7906121) Castronovo V … Sobel M (Biochemical pharmacology 1994) 3 4 23
  5. A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells. (PMID: 1676505) Lowney P … Largman C (Nucleic acids research 1991) 3 4 23

Products for HOXA10 Gene

Sources for HOXA10 Gene