HOXA-AS2 Gene (RNA Gene)

HOXA Cluster Antisense RNA 2

GC07P027107
GIFtS:
17
This gene produces a long non-coding RNA that promotes cell proliferation. This transcript may interact with enhancer of zeste homolog 2 Polycomb repressive complex to repress gene expression. [provided by RefSeq, Dec 2017] See more...

Aliases for HOXA-AS2 Gene

Data sources for HOXA-AS2 Gene:

Subcategory (RNA class) for HOXA-AS2 Gene

lncRNA

Aliases for HOXA-AS2 Gene

External Ids for HOXA-AS2 Gene

Previous GeneCards Identifiers for HOXA-AS2 Gene

  • GC07P027151

Summaries for HOXA-AS2 Gene

Entrez Gene Summary for HOXA-AS2 Gene

  • This gene produces a long non-coding RNA that promotes cell proliferation. This transcript may interact with enhancer of zeste homolog 2 Polycomb repressive complex to repress gene expression. [provided by RefSeq, Dec 2017]

GeneCards Summary for HOXA-AS2 Gene

HOXA-AS2 (HOXA Cluster Antisense RNA 2) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with HOXA-AS2 include Gallbladder Cancer and High Grade Glioma.

Additional gene information for HOXA-AS2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXA-AS2 Gene

Genomics for HOXA-AS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HOXA-AS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXA-AS2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for HOXA-AS2 Gene

Latest Assembly
chr7:27,107,777-27,139,583
(GRCh38/hg38)
Size:
31,807 bases
Orientation:
Plus strand

Previous Assembly
chr7:27,161,538-27,168,379
(GRCh37/hg19 by Entrez Gene)
Size:
6,842 bases
Orientation:
Plus strand

chr7:27,147,396-27,173,921
(GRCh37/hg19 by Ensembl)
Size:
26,526 bases
Orientation:
Plus strand

Genomic View for HOXA-AS2 Gene

Genes around HOXA-AS2 on UCSC Golden Path with GeneCards custom track
HOXA-AS2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
HOXA-AS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXA-AS2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HOXA-AS2 Gene

Proteins for HOXA-AS2 Gene

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  1. Antibodies for research
  2. Protein products for research
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Post-translational modifications for HOXA-AS2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HOXA-AS2 Gene

Domains & Families for HOXA-AS2 Gene

Gene Families for HOXA-AS2 Gene

HGNC:
genes like me logo Genes that share domains with HOXA-AS2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HOXA-AS2 Gene

Function for HOXA-AS2 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for HOXA-AS2 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HOXA-AS2 Gene

Localization for HOXA-AS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXA-AS2 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HOXA-AS2 Gene

Pathways & Interactions for HOXA-AS2 Gene

PathCards logo

SuperPathways for HOXA-AS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXA-AS2 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for HOXA-AS2 Gene

Drugs & Compounds for HOXA-AS2 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for HOXA-AS2 Gene

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Non-coding RNA (ncRNA) Transcripts from RNAcentral for HOXA-AS2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00002C1618_9606 lncRNA 991 4

Ensembl: ENST00000523364 (view in UCSC) ,

LncBook: HSALNT0120340,

LNCipedia: HOXA-AS2:7,

NONCODE: NONHSAT119675.2,

URS000020E00C_9606 lncRNA 800 4

Ensembl: ENST00000521159 (view in UCSC) ,

LncBook: HSALNT0120344,

LNCipedia: HOXA-AS2:11,

NONCODE: NONHSAT119678.2,

URS00004F59FF_9606 lncRNA 630 4

Ensembl: ENST00000593438 (view in UCSC) ,

LncBook: HSALNT0120338,

LNCipedia: HOXA-AS2:6,

NONCODE: NONHSAT119674.2,

URS000007A468_9606 lncRNA 583 4

Ensembl: ENST00000517641 (view in UCSC) ,

LncBook: HSALNT0120343,

LNCipedia: HOXA-AS2:10,

NONCODE: NONHSAT119677.2,

URS00005887DF_9606 lncRNA 496 4

Ensembl: ENST00000524048 (view in UCSC) ,

LncBook: HSALNT0120347,

LNCipedia: HOXA-AS2:13,

NONCODE: NONHSAT119680.2,

HOXA-AS2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for HOXA-AS2 Gene

7 NCBI additional mRNA sequence :

CRISPR products for research

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA-AS2 Gene

No ASD Table

Relevant External Links for HOXA-AS2 Gene

GeneLoc Exon Structure for
HOXA-AS2

Expression for HOXA-AS2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXA-AS2 Gene

mRNA expression in normal human tissues for HOXA-AS2 Gene
mRNA expression by GTEx for HOXA-AS2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOXA-AS2

SOURCE GeneReport for Unigene cluster for HOXA-AS2 Gene:

Hs.714774
genes like me logo Genes that share expression patterns with HOXA-AS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA-AS2 Gene

Orthologs for HOXA-AS2 Gene

Evolution for HOXA-AS2 Gene

ENSEMBL:
Gene Tree for HOXA-AS2 (if available)
TreeFam:
Gene Tree for HOXA-AS2 (if available)

No data available for Orthologs for HOXA-AS2 Gene

Paralogs for HOXA-AS2 Gene

No data available for Paralogs for HOXA-AS2 Gene

Variants for HOXA-AS2 Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HOXA-AS2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HOXA-AS2 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
dgv11244n54 CNV loss 21841781
nsv5674 CNV deletion 18451855
nsv606464 CNV loss 21841781
nsv606465 CNV loss 21841781
nsv7393 OTHER inversion 18451855

Additional Variant Information for HOXA-AS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXA-AS2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for HOXA-AS2 Gene

Disorders for HOXA-AS2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for HOXA-AS2 Gene - From: LNC and COP

Disorder Aliases PubMed IDs
gallbladder cancer
  • gallbladder ca
high grade glioma
  • glial cell tumor
acute promyelocytic leukemia
  • apl
melanoma
  • malignant melanoma
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HOXA-AS2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HOXA-AS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXA-AS2 Gene

Publications for HOXA-AS2 Gene

  1. HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells. (PMID: 23649634) Zhao H … Newburger PE (Journal of cellular biochemistry 2013) 2 3 74
  2. Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis. (PMID: 29310118) Gao Y … Xue Y (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3 74
  3. Long noncoding RNA HOXA-AS2 represses P21 and KLF2 expression transcription by binding with EZH2, LSD1 in colorectal cancer. (PMID: 28112720) Ding J … Wang K (Oncogenesis 2017) 3 74
  4. Upregulation of long non-coding RNA HOXA-AS2 promotes proliferation and induces epithelial-mesenchymal transition in gallbladder carcinoma. (PMID: 28388535) Zhang P … Gao Y (Oncotarget 2017) 3 74
  5. Long non-coding RNA HOXA-AS2 promotes proliferation and invasion of breast cancer by acting as a miR-520c-3p sponge. (PMID: 28545023) Fang Y … Zhang Q (Oncotarget 2017) 3 74

ExternalLinks

View latest publications for HOXA-AS2 gene in Mastermind

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Sources for HOXA-AS2 Gene