This gene produces a long RNA in antisense to the HOXA gene cluster. This transcript may regulate expression of HOXA genes in cis. This gene is upregulated in tumors and is implicated in the promotion of cell proliferation. [provided by RefSeq, Dec 2017] See more...

Aliases for HOTTIP Gene

Data sources for HOTTIP Gene:

Subcategory (RNA class) for HOTTIP Gene

lncRNA

Aliases for HOTTIP Gene

External Ids for HOTTIP Gene

Previous HGNC Symbols for HOTTIP Gene

  • NCRNA00213

Previous GeneCards Identifiers for HOTTIP Gene

  • GC07P027246
  • GC07P027249
  • GC07P027251
  • GC07P027257

Summaries for HOTTIP Gene

Entrez Gene Summary for HOTTIP Gene

  • This gene produces a long RNA in antisense to the HOXA gene cluster. This transcript may regulate expression of HOXA genes in cis. This gene is upregulated in tumors and is implicated in the promotion of cell proliferation. [provided by RefSeq, Dec 2017]

GeneCards Summary for HOTTIP Gene

HOTTIP (HOXA Distal Transcript Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with HOTTIP include Pancreatic Ductal Adenocarcinoma and Tongue Squamous Cell Carcinoma.

Rfam classification for HOTTIP Gene

  • HOXA transcript at the distal tip, conserved region 1
  • HOXA transcript at the distal tip, conserved region 2
  • HOXA transcript at the distal tip, conserved region 3
  • HOXA transcript at the distal tip, conserved region 4

Additional gene information for HOTTIP Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for HOTTIP Gene

Genomics for HOTTIP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HOTTIP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOTTIP on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for HOTTIP Gene

Latest Assembly
chr7:27,198,574-27,207,757
(GRCh38/hg38)
Size:
9,184 bases
Orientation:
Plus strand

Previous Assembly
chr7:27,240,040-27,246,878
(GRCh37/hg19 by Entrez Gene)
Size:
6,839 bases
Orientation:
Plus strand

chr7:27,238,194-27,246,878
(GRCh37/hg19 by Ensembl)
Size:
8,685 bases
Orientation:
Plus strand

Genomic View for HOTTIP Gene

Genes around HOTTIP on UCSC Golden Path with GeneCards custom track
HOTTIP in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
HOTTIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOTTIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOTTIP Gene

Proteins for HOTTIP Gene

Post-translational modifications for HOTTIP Gene

No Post-translational modifications

No data available for DME Specific Peptides for HOTTIP Gene

Domains & Families for HOTTIP Gene

Gene Families for HOTTIP Gene

genes like me logo Genes that share domains with HOTTIP: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HOTTIP Gene

Function for HOTTIP Gene

Phenotypes From GWAS Catalog for HOTTIP Gene

CRISPR products for research

miRNA for HOTTIP Gene

miRTarBase miRNAs that target HOTTIP

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HOTTIP Gene

Localization for HOTTIP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOTTIP gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HOTTIP Gene

Pathways & Interactions for HOTTIP Gene

PathCards logo

SuperPathways for HOTTIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOTTIP Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for HOTTIP Gene

Drugs & Compounds for HOTTIP Gene

No Compound Related Data Available

Transcripts for HOTTIP Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for HOTTIP Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075E1E7_9606 lncRNA 4665 4

RefSeq: NR_037843,

LncBook: HSALNT0120390,

LNCipedia: HOTTIP:3,

NONCODE: NONHSAT211845.1,

URS00003AFF17_9606 lncRNA 2287 4

Ensembl: ENST00000472494 (view in UCSC) ,

LncBook: HSALNT0120394,

LNCipedia: HOTTIP:5,

NONCODE: NONHSAT119718.2,

URS00002F876F_9606 lncRNA 783 4

Ensembl: ENST00000421733 (view in UCSC) ,

LncBook: HSALNT0120381,

LNCipedia: HOTTIP:1,

NONCODE: NONHSAT119716.2,

URS0000D617C6_9606 lncRNA 3343 2

Ensembl: ENST00000521028 (view in UCSC) ,

LNCipedia: HOTTIP:10,

URS0000D6509B_9606 lncRNA 1287 1

Ensembl: ENST00000605136 (view in UCSC) ,

HOTTIP in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for HOTTIP Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for HOTTIP Gene

No ASD Table

Relevant External Links for HOTTIP Gene

GeneLoc Exon Structure for
HOTTIP

Expression for HOTTIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOTTIP Gene

mRNA differential expression in normal tissues according to GTEx for HOTTIP Gene

This gene is overexpressed in Colon - Transverse (x15.4), Cervix - Endocervix (x8.3), Cervix - Ectocervix (x7.9), Prostate (x7.7), Vagina (x6.2), and Bladder (x5.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOTTIP

SOURCE GeneReport for Unigene cluster for HOTTIP Gene:

Hs.199486
genes like me logo Genes that share expression patterns with HOTTIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOTTIP Gene

Orthologs for HOTTIP Gene

Evolution for HOTTIP Gene

ENSEMBL:
Gene Tree for HOTTIP (if available)
TreeFam:
Gene Tree for HOTTIP (if available)

No data available for Orthologs for HOTTIP Gene

Paralogs for HOTTIP Gene

No data available for Paralogs for HOTTIP Gene

Variants for HOTTIP Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HOTTIP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HOTTIP Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
nsv519583 CNV gain 19592680
nsv5675 CNV insertion 18451855
nsv606468 CNV loss 21841781
nsv606469 CNV loss 21841781
nsv7393 OTHER inversion 18451855
nsv824042 CNV gain 20364138

Additional Variant Information for HOTTIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOTTIP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for HOTTIP Gene

Disorders for HOTTIP Gene

MalaCards: The human disease database

(18) MalaCards diseases for HOTTIP Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
tongue squamous cell carcinoma
  • squamous cell carcinoma of tongue
hirschsprung disease 1
  • hirschsprung disease, susceptibility to, 1
small cell cancer of the lung
  • sclc1
osteogenic sarcoma
  • osteosarcoma; osrc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HOTTIP

genes like me logo Genes that share disorders with HOTTIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOTTIP Gene

Publications for HOTTIP Gene

  1. Long non-coding RNA HOTTIP promotes BCL-2 expression and induces chemoresistance in small cell lung cancer by sponging miR-216a. (PMID: 29367594) Sun Y … Guo L (Cell death & disease 2018) 3 74
  2. LncRNA HOTTIP-Mediated HOXA11 Expression Promotes Cell Growth, Migration and Inhibits Cell Apoptosis in Breast Cancer. (PMID: 29415429) Sun Y … Zhu W (International journal of molecular sciences 2018) 3 74
  3. Long noncoding RNA HOTTIP promotes endothelial cell proliferation and migration via activation of the Wnt/β-catenin pathway. (PMID: 29058802) Liao B … Dong S (Journal of cellular biochemistry 2018) 3 74
  4. LncRNA HOTTIP promotes papillary thyroid carcinoma cell proliferation, invasion and migration by regulating miR-637. (PMID: 29474928) Yuan Q … Lu X (The international journal of biochemistry & cell biology 2018) 3 74
  5. Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1. (PMID: 29274585) Liu T … He K (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 74

Products for HOTTIP Gene

Sources for HOTTIP Gene