This non-coding locus is located in the HOX gene cluster. Transcription of this locus is induced by retinoic acid, and transcripts likely function in regulation of myelopoiesis through transcriptional activation of several genes in the HOXA cluster, in addition to several beta-2 integrins. [provided by RefSeq, Jan 2013] See more...

Aliases for HOTAIRM1 Gene

Subcategory (RNA class) for HOTAIRM1 Gene

lncRNA

Number of RNA Genes sources:

4 / 14

Aliases for HOTAIRM1 Gene

  • HOXA Transcript Antisense RNA, Myeloid-Specific 1 2 3 5
  • HOXA Transcript Antisense RNA, Myeloid-Specific 1 (Non-Protein Coding) 2 3
  • HOXA Cluster Antisense RNA 1 (Non-Protein Coding) 2 3
  • HOTAIRM1 2 168
  • Hox Transcript Antisense RNA, Myeloid-Specific 1 (Non-Protein Coding) 2
  • HOX Antisense Intergenic RNA Myeloid 1 3
  • Non-Protein Coding RNA 179 2
  • NONHSAG047181 92
  • HSALNG0056850 167
  • NCRNA00179 3
  • HOXA1-AS1 3
  • HOXA-AS1 3

External Ids for HOTAIRM1 Gene

Previous GeneCards Identifiers for HOTAIRM1 Gene

  • GC00U924339
  • GC07P027137

Summaries for HOTAIRM1 Gene

Entrez Gene Summary for HOTAIRM1 Gene

  • This non-coding locus is located in the HOX gene cluster. Transcription of this locus is induced by retinoic acid, and transcripts likely function in regulation of myelopoiesis through transcriptional activation of several genes in the HOXA cluster, in addition to several beta-2 integrins. [provided by RefSeq, Jan 2013]

GeneCards Summary for HOTAIRM1 Gene

HOTAIRM1 (HOXA Transcript Antisense RNA, Myeloid-Specific 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with HOTAIRM1 include Leukemia and Pancreatic Ductal Adenocarcinoma.

Rfam classification for HOTAIRM1 Gene

  • HOX antisense intergenic RNA myeloid 1 conserved region 3
  • HOX antisense intergenic RNA myeloid 1 conserved region 4
  • HOX antisense intergenic RNA myeloid 1 conserved region 2
  • HOX antisense intergenic RNA myeloid 1 conserved region 5
  • HOX antisense intergenic RNA myeloid 1 conserved region 1

Additional gene information for HOTAIRM1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for HOTAIRM1 Gene

Genomics for HOTAIRM1 Gene

GeneHancer (GH) Regulatory Elements for HOTAIRM1 Gene

Promoters and enhancers for HOTAIRM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J027094 Enhancer 0.4 Ensembl 505.7 -1.3 -1346 0.2 CBX8 RNF2 EZH2 SUZ12 HOTAIRM1 ENSG00000276528 HOXA1 piR-56037-047
GH07J027095 Promoter/Enhancer 3 VISTA UCNEbase EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 43.5 +42.5 42514 86.3 EP300 HNRNPK ZNF217 CTCF ZSCAN5C TCF12 POLR2G USF1 NCOR1 PHF8 HOXA2 HOXA9 HOXA10 HOXA1 HOXA3 HOXA6 HOXA4 HOXA5 HOXA7 HNRNPA2B1
GH07J026909 Enhancer 0.9 Ensembl ENCODE 62.4 -184.3 -184346 4.6 TEAD4 TEAD1 NR2F2 SMARCC1 CTCF FOS FOSL2 CEBPB JUN SPI1 HOTAIRM1 SKAP2 HOXA2 HOXA-AS2 HOXA3 piR-48772-025 RPL7AP38
GH07J026862 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 22.1 -231.8 -231847 4 ZNF217 SIN3A TCF12 NRF1 USF1 POLR2G SP1 GTF2E2 PHF8 PHB2 SKAP2 lnc-EVX1-8 lnc-HOXA1-1 HOTAIRM1 HOXA5 HOXA-AS3 HOXA4 HOXA3 HOXA6 HOXA1
GH07J026855 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 36.8 -238.1 -238099 4.8 CTBP1 ZNF341 NCOR1 NFIC ZBTB17 ZNF384 MAFF ZFHX2 TAL1 MAFK HOTAIRM1 HOXA5 HOXA-AS3 HOXA4 HOXA3 HOXA6 HOXA1 HOXA2 HOXA-AS2 SKAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOTAIRM1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HOTAIRM1 Gene

Genomic Locations for HOTAIRM1 Gene
chr7:27,095,647-27,100,265
(GRCh38/hg38)
Size:
4,619 bases
Orientation:
Plus strand
chr7:27,135,266-27,139,884
(GRCh37/hg19)
Size:
4,619 bases
Orientation:
Plus strand

Genomic View for HOTAIRM1 Gene

Genes around HOTAIRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOTAIRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOTAIRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOTAIRM1 Gene

Proteins for HOTAIRM1 Gene

Post-translational modifications for HOTAIRM1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HOTAIRM1 Gene

Domains & Families for HOTAIRM1 Gene

Gene Families for HOTAIRM1 Gene

genes like me logo Genes that share domains with HOTAIRM1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HOTAIRM1 Gene

Function for HOTAIRM1 Gene

Phenotypes From GWAS Catalog for HOTAIRM1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HOTAIRM1 Gene

Localization for HOTAIRM1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOTAIRM1 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HOTAIRM1 Gene

Pathways & Interactions for HOTAIRM1 Gene

PathCards logo

SuperPathways for HOTAIRM1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for HOTAIRM1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for HOTAIRM1 Gene

Drugs & Compounds for HOTAIRM1 Gene

No Compound Related Data Available

Transcripts for HOTAIRM1 Gene

mRNA/cDNA for HOTAIRM1 Gene

16 RNACentral transcripts :
2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
6 NONCODE transcripts :
1 ENA transcripts :
3 LncBook transcripts :
11 LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOTAIRM1 Gene

No ASD Table

Relevant External Links for HOTAIRM1 Gene

GeneLoc Exon Structure for
HOTAIRM1

Expression for HOTAIRM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOTAIRM1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOTAIRM1

SOURCE GeneReport for Unigene cluster for HOTAIRM1 Gene:

Hs.445239
genes like me logo Genes that share expression patterns with HOTAIRM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOTAIRM1 Gene

Orthologs for HOTAIRM1 Gene

Evolution for HOTAIRM1 Gene

ENSEMBL:
Gene Tree for HOTAIRM1 (if available)
TreeFam:
Gene Tree for HOTAIRM1 (if available)

No data available for Orthologs for HOTAIRM1 Gene

Paralogs for HOTAIRM1 Gene

No data available for Paralogs for HOTAIRM1 Gene

Variants for HOTAIRM1 Gene

Additional dbSNP identifiers (rs#s) for HOTAIRM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOTAIRM1 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
dgv11244n54 CNV loss 21841781
esv3612654 CNV loss 21293372
nsv606464 CNV loss 21841781
nsv7393 OTHER inversion 18451855

Additional Variant Information for HOTAIRM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOTAIRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for HOTAIRM1 Gene

Disorders for HOTAIRM1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for HOTAIRM1 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
leukemia
  • leukemias
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
malignant glioma
  • glial cell tumor
astrocytoma
  • astrocytic tumor
acute promyelocytic leukemia
  • apl
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HOTAIRM1

genes like me logo Genes that share disorders with HOTAIRM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOTAIRM1 Gene

Publications for HOTAIRM1 Gene

  1. A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. (PMID: 19144990) Zhang X … Newburger PE (Blood 2009) 2 3 54
  2. Downregulation of long noncoding RNA HOTAIRM1 variant 1 contributes to osteoarthritis via regulating miR-125b/BMPR2 axis and activating JNK/MAPK/ERK pathway. (PMID: 30551410) Xiao Y … Ma X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3 54
  3. Long Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1-HOXA1 Axis Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Lung Cancer. (PMID: 29662483) Tian X … Wang S (Frontiers in immunology 2018) 3 54
  4. LncRNA HOTAIRM1 inhibits the progression of hepatocellular carcinoma by inhibiting the Wnt signaling pathway. (PMID: 30070317) Zhang Y … Liu J (European review for medical and pharmacological sciences 2018) 3 54
  5. Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme. (PMID: 30376874) Li Q … Hong X (Journal of experimental & clinical cancer research : CR 2018) 3 54

Products for HOTAIRM1 Gene

Sources for HOTAIRM1 Gene