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Aliases for HOTAIRM1 Gene

Subcategory (RNA class) for HOTAIRM1 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for HOTAIRM1 Gene

  • HOXA Transcript Antisense RNA, Myeloid-Specific 1 2 3 5
  • HOXA Transcript Antisense RNA, Myeloid-Specific 1 (Non-Protein Coding) 2 3
  • HOXA Cluster Antisense RNA 1 (Non-Protein Coding) 2 3
  • Hox Transcript Antisense RNA, Myeloid-Specific 1 (Non-Protein Coding) 2
  • HOX Antisense Intergenic RNA Myeloid 1 3
  • Non-Protein Coding RNA 179 2
  • NCRNA00179 3
  • HOXA1-AS1 3
  • HOXA-AS1 3

External Ids for HOTAIRM1 Gene

Previous GeneCards Identifiers for HOTAIRM1 Gene

  • GC00U924339
  • GC07P027137

Summaries for HOTAIRM1 Gene

Entrez Gene Summary for HOTAIRM1 Gene

  • This non-coding locus is located in the HOX gene cluster. Transcription of this locus is induced by retinoic acid, and transcripts likely function in regulation of myelopoiesis through transcriptional activation of several genes in the HOXA cluster, in addition to several beta-2 integrins. [provided by RefSeq, Jan 2013]

GeneCards Summary for HOTAIRM1 Gene

HOTAIRM1 (HOXA Transcript Antisense RNA, Myeloid-Specific 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with HOTAIRM1 include Leukemia and Pancreatic Ductal Adenocarcinoma.

Additional gene information for HOTAIRM1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOTAIRM1 Gene

Genomics for HOTAIRM1 Gene

GeneHancer (GH) Regulatory Elements for HOTAIRM1 Gene

Promoters and enhancers for HOTAIRM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J027095 Promoter/Enhancer 3.4 VISTA UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 43.5 +42.5 42548 86.3 MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 ZNF610 HOXA2 HOXA9 HOXA10 HOXA1 HOXA3 HOXA6 HOXA4 HOXA5 HOXA7 HNRNPA2B1
GH07J026862 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.1 -231.5 -231533 3.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SKAP2 HOTAIRM1 HMGB3P20 TPM3P4 RPL23P7 PSMC1P2 HNRNPA2B1 HOXA-AS3 HOXA4 HOXA3
GH07J027030 Enhancer 0.9 Ensembl ENCODE 54.9 -64.1 -64129 2 PKNOX1 RB1 SIN3A CEBPG ZNF384 FEZF1 ZIC2 POLR2A ETV6 L3MBTL2 HOTAIRM1 SKAP2 HOXA1 HOXA2 HOXA-AS2 HOXA3 TPM3P4 NHP2P2
GH07J026855 Enhancer 1.3 Ensembl ENCODE dbSUPER 36.8 -238.1 -238099 4.8 HDAC1 PKNOX1 FEZF1 ZBTB40 TCF12 GLIS2 EGR1 ZNF366 EGR2 ZNF362 HOTAIRM1 HOXA5 HOXA-AS3 HOXA4 HOXA3 HOXA6 HOXA1 HOXA2 HOXA-AS2 SKAP2
GH07J027046 Enhancer 0.7 Ensembl ENCODE 26.6 -48.4 -48369 1.1 JUND MAFF JUN FOSL2 NHP2P2 HOTAIRM1 HOXA1 HOXA2 HOXA-AS2 HOXA3 SKAP2 TPM3P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HOTAIRM1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HOTAIRM1 Gene

Genomic Locations for HOTAIRM1 Gene
chr7:27,095,647-27,100,265
(GRCh38/hg38)
Size:
4,619 bases
Orientation:
Plus strand
chr7:27,135,266-27,139,884
(GRCh37/hg19)

Genomic View for HOTAIRM1 Gene

Genes around HOTAIRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOTAIRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOTAIRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOTAIRM1 Gene

Proteins for HOTAIRM1 Gene

Post-translational modifications for HOTAIRM1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HOTAIRM1 Gene

Domains & Families for HOTAIRM1 Gene

Gene Families for HOTAIRM1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HOTAIRM1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HOTAIRM1 Gene

Function for HOTAIRM1 Gene

Phenotypes From GWAS Catalog for HOTAIRM1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HOTAIRM1 Gene

Localization for HOTAIRM1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HOTAIRM1 Gene

Pathways & Interactions for HOTAIRM1 Gene

SuperPathways for HOTAIRM1 Gene

No Data Available

Interacting Proteins for HOTAIRM1 Gene

Gene Ontology (GO) - Biological Process for HOTAIRM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HOTAIRM1 Gene

Drugs & Compounds for HOTAIRM1 Gene

No Compound Related Data Available

Transcripts for HOTAIRM1 Gene

mRNA/cDNA for HOTAIRM1 Gene

(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(8) RNA Central transcripts :

Unigene Clusters for HOTAIRM1 Gene

HOXA transcript antisense RNA, myeloid-specific 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOTAIRM1 Gene

No ASD Table

Relevant External Links for HOTAIRM1 Gene

GeneLoc Exon Structure for
HOTAIRM1
ECgene alternative splicing isoforms for
HOTAIRM1

Expression for HOTAIRM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOTAIRM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HOTAIRM1 Gene:

HOTAIRM1

SOURCE GeneReport for Unigene cluster for HOTAIRM1 Gene:

Hs.445239
genes like me logo Genes that share expression patterns with HOTAIRM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOTAIRM1 Gene

Orthologs for HOTAIRM1 Gene

Evolution for HOTAIRM1 Gene

ENSEMBL:
Gene Tree for HOTAIRM1 (if available)
TreeFam:
Gene Tree for HOTAIRM1 (if available)

No data available for Orthologs for HOTAIRM1 Gene

Paralogs for HOTAIRM1 Gene

No data available for Paralogs for HOTAIRM1 Gene

Variants for HOTAIRM1 Gene

Sequence variations from dbSNP and Humsavar for HOTAIRM1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1022228508 uncertain-significance, Athabaskan brainstem dysgenesis, Bosley-Salih-Alorainy syndrome 27,095,697(+) A/G upstream_transcript_variant
rs104894017 pathogenic, Bosley-Salih-Alorainy syndrome 27,095,829(+) G/C upstream_transcript_variant
rs104894018 pathogenic, Athabaskan brainstem dysgenesis 27,095,837(+) G/A/C upstream_transcript_variant
rs10951154 benign, Microtia, hearing impairment, and cleft palate 27,095,695(+) C/T upstream_transcript_variant
rs117630421 likely-benign, Microtia, hearing impairment, and cleft palate, Bosley-Salih-Alorainy syndrome, Athabaskan brainstem dysgenesis 27,100,618(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HOTAIRM1 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
dgv11244n54 CNV loss 21841781
esv3612654 CNV loss 21293372
nsv606464 CNV loss 21841781
nsv7393 OTHER inversion 18451855

Additional Variant Information for HOTAIRM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOTAIRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HOTAIRM1 Gene

Disorders for HOTAIRM1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for HOTAIRM1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leukemia
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
acute promyelocytic leukemia
  • apl
glioblastoma
  • glioblastoma multiforme
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HOTAIRM1

genes like me logo Genes that share disorders with HOTAIRM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOTAIRM1 Gene

Publications for HOTAIRM1 Gene

  1. A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. (PMID: 19144990) Zhang X … Newburger PE (Blood 2009) 2 3 58
  2. Reciprocal regulation of chromatin state and architecture by HOTAIRM1 contributes to temporal collinear HOXA gene activation. (PMID: 28180285) Wang XQ … Dostie J (Nucleic acids research 2017) 3 58
  3. The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway. (PMID: 27740626) Chen ZH … Chen YQ (Cell death and differentiation 2017) 3 58
  4. HOTAIRM1 as a potential biomarker for diagnosis of colorectal cancer functions the role in the tumour suppressor. (PMID: 27307307) Wan L … Zhang H (Journal of cellular and molecular medicine 2016) 3 58
  5. PU.1 controls the expression of long noncoding RNA HOTAIRM1 during granulocytic differentiation. (PMID: 27146823) Wei S … Wang K (Journal of hematology & oncology 2016) 3 58

Products for HOTAIRM1 Gene

Sources for HOTAIRM1 Gene

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