Subcategory (RNA class) for HOTAIR Gene
Number of RNA Genes sources:
Aliases for HOTAIR Gene
External Ids for HOTAIR Gene
Previous GeneCards Identifiers for HOTAIR Gene
This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes. It functions through an RNA product, which binds lysine specific demethylase 1 (LSD1) and Polycomb repressive complex 2 (PRC2), and serves as a scaffold to assemble these regulators at the HOXD gene cluster, thereby promoting epigenetic repression of HOXD. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2019]
GeneCards Summary for HOTAIR Gene
HOTAIR (HOX Transcript Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with HOTAIR include Gastric Cardia Adenocarcinoma and Gastrointestinal System Cancer. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.