Aliases for HOOK3 Gene
External Ids for HOOK3 Gene
Previous GeneCards Identifiers for HOOK3 Gene
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
GeneCards Summary for HOOK3 Gene
HOOK3 (Hook Microtubule Tethering Protein 3) is a Protein Coding gene. Diseases associated with HOOK3 include Small Intestine Neuroendocrine Neoplasm and Small Intestine Benign Neoplasm. Gene Ontology (GO) annotations related to this gene include identical protein binding and microtubule binding. An important paralog of this gene is HOOK1.
UniProtKB/Swiss-Prot Summary for HOOK3 Gene
Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).