Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004] See more...

Aliases for HOOK3 Gene

Aliases for HOOK3 Gene

  • Hook Microtubule Tethering Protein 3 2 3 5
  • Protein Hook Homolog 3 3 4
  • H-Hook3 3 4
  • HHK3 3 4
  • Hook Homolog 3 (Drosophila) 2
  • Hook Homolog 3 3
  • HK3 3

External Ids for HOOK3 Gene

Previous GeneCards Identifiers for HOOK3 Gene

  • GC12M9A0079
  • GC08P042821
  • GC08P042492
  • GC08P042769
  • GC08P042871
  • GC08P041277

Summaries for HOOK3 Gene

Entrez Gene Summary for HOOK3 Gene

  • Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

GeneCards Summary for HOOK3 Gene

HOOK3 (Hook Microtubule Tethering Protein 3) is a Protein Coding gene. Diseases associated with HOOK3 include Small Intestine Neuroendocrine Neoplasm and Small Intestine Benign Neoplasm. Gene Ontology (GO) annotations related to this gene include identical protein binding and microtubule binding. An important paralog of this gene is HOOK1.

UniProtKB/Swiss-Prot Summary for HOOK3 Gene

  • Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).

Gene Wiki entry for HOOK3 Gene

Additional gene information for HOOK3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOOK3 Gene

Genomics for HOOK3 Gene

GeneHancer (GH) Regulatory Elements for HOOK3 Gene

Promoters and enhancers for HOOK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J042893 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 508 -0.7 -682 6.4 HNRNPK EP300 ZSCAN5C SIN3A NRF1 TCF12 POLR2G PHF8 ZFX CTCF THAP1 HOOK3 MIR4469 RNF170 FNTA HE855963 RF00017-7012
GH08J043019 Promoter 0.3 EPDnew 500.1 +122.5 122498 0.1 ENSG00000254673 HOOK3 lnc-FNTA-1 RF00017-7018
GH08J042841 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 19 -54.0 -54009 3.5 ZBTB40 ZNF217 EP300 SIN3A TCF12 USF1 POLR2G SP1 NCOR1 GTF2E2 ENSG00000286837 THAP1 lnc-RNF170-2 ENSG00000254165 IKBKB HOOK3 HGSNAT RNF170 FNTA RF00017-7012
GH08J043054 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 17.3 +160.3 160289 5.2 HNRNPK ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A NRF1 TCF12 POLR2G USF1 FNTA HGSNAT ENSG00000254165 IKBKB HOOK3 ENSG00000254673 ENSG00000254198 RNF170 POMK THAP1
GH08J043139 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 5.5 +243.9 243886 4 EP300 CTCF SIN3A POLR2G PHF8 JUND FOS ZFX ZNF639 ZIC2 HGSNAT piR-52079-197 FNTA HOOK3 RF00017-7018 piR-50444-453
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOOK3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOOK3

Top Transcription factor binding sites by QIAGEN in the HOOK3 gene promoter:
  • PPAR-alpha
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for HOOK3 Gene

Genomic Locations for HOOK3 Gene
chr8:42,896,890-43,030,539
(GRCh38/hg38)
Size:
133,650 bases
Orientation:
Plus strand
chr8:42,752,033-42,885,682
(GRCh37/hg19)
Size:
133,650 bases
Orientation:
Plus strand

Genomic View for HOOK3 Gene

Genes around HOOK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOOK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOOK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOOK3 Gene

Proteins for HOOK3 Gene

  • Protein details for HOOK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VS8-HOOK3_HUMAN
    Recommended name:
    Protein Hook homolog 3
    Protein Accession:
    Q86VS8
    Secondary Accessions:
    • D3DSY8
    • Q8NBH0
    • Q9BY13

    Protein attributes for HOOK3 Gene

    Size:
    718 amino acids
    Molecular mass:
    83126 Da
    Quaternary structure:
    • Interacts with Salmonella typhimurium spiC (By similarity). Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK1 and HOOK2. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (PubMed:18799622). Interacts with MSR1, and this association is stimulated by ligand binding to MSR1 (PubMed:17237231). Interacts with microtubules (PubMed:11238449). Interacts with dynein intermediate chain and dynactin (DCTN1) (PubMed:25035494). Interacts with CCDC181 (By similarity). Interacts with LRGUK (By similarity).
    SequenceCaution:
    • Sequence=AAH48304.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HOOK3 Gene

neXtProt entry for HOOK3 Gene

Post-translational modifications for HOOK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOOK3 Gene

Antibody Products

  • Boster Bio Antibodies for HOOK3
  • Santa Cruz Biotechnology (SCBT) Antibodies for HOOK3

No data available for DME Specific Peptides for HOOK3 Gene

Domains & Families for HOOK3 Gene

Gene Families for HOOK3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for HOOK3 Gene

Blocks:
  • Calponin-like actin-binding
  • HOOK
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOOK3 Gene

GenScript: Design optimal peptide antigens:
  • Protein Hook homolog 3 (HOOK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86VS8

UniProtKB/Swiss-Prot:

HOOK3_HUMAN :
  • Belongs to the hook family.
Family:
  • Belongs to the hook family.
genes like me logo Genes that share domains with HOOK3: view

Function for HOOK3 Gene

Molecular function for HOOK3 Gene

UniProtKB/Swiss-Prot Function:
Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).

Phenotypes From GWAS Catalog for HOOK3 Gene

Gene Ontology (GO) - Molecular Function for HOOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17237231
GO:0008017 microtubule binding IDA,IBA 11238449
GO:0034452 dynactin binding IDA 27482052
GO:0042802 identical protein binding IPI 18799622
GO:0045503 dynein light chain binding IPI 27482052
genes like me logo Genes that share ontologies with HOOK3: view
genes like me logo Genes that share phenotypes with HOOK3: view

Animal Models for HOOK3 Gene

MGI Knock Outs for HOOK3:
  • Hook3 Hook3<tm1b(NCOM)Mfgc>

Animal Model Products

CRISPR Products

miRNA for HOOK3 Gene

miRTarBase miRNAs that target HOOK3

Clone Products

  • Addgene plasmids for HOOK3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOOK3 Gene

Localization for HOOK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOOK3 Gene

Cytoplasm, cytoskeleton. Golgi apparatus. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase (PubMed:11238449). Localizes to the manchette in elongating spermatids (By similarity). {ECO:0000250 UniProtKB:Q8BUK6, ECO:0000269 PubMed:11238449}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOOK3 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 4
cytosol 4
nucleus 3
endosome 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (3)
  • Golgi apparatus (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material ISS --
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0005801 cis-Golgi network IDA 11238449
GO:0005813 centrosome IEA,ISS --
genes like me logo Genes that share ontologies with HOOK3: view

Pathways & Interactions for HOOK3 Gene

PathCards logo

SuperPathways for HOOK3 Gene

No Data Available

SIGNOR curated interactions for HOOK3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HOOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007032 endosome organization IMP 18799622
GO:0007040 lysosome organization IMP 18799622
GO:0008333 endosome to lysosome transport IMP 18799622
GO:0015031 protein transport IEA --
GO:0022027 interkinetic nuclear migration ISS,IEA --
genes like me logo Genes that share ontologies with HOOK3: view

No data available for Pathways by source for HOOK3 Gene

Drugs & Compounds for HOOK3 Gene

No Compound Related Data Available

Transcripts for HOOK3 Gene

mRNA/cDNA for HOOK3 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for HOOK3

Alternative Splicing Database (ASD) splice patterns (SP) for HOOK3 Gene

No ASD Table

Relevant External Links for HOOK3 Gene

GeneLoc Exon Structure for
HOOK3

Expression for HOOK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOOK3 Gene

Protein differential expression in normal tissues from HIPED for HOOK3 Gene

This gene is overexpressed in Bone (41.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOOK3 Gene



Protein tissue co-expression partners for HOOK3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOOK3

SOURCE GeneReport for Unigene cluster for HOOK3 Gene:

Hs.162852

Evidence on tissue expression from TISSUES for HOOK3 Gene

  • Nervous system(4.5)
  • Intestine(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with HOOK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOOK3 Gene

Orthologs for HOOK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOOK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOOK3 31 30
  • 99.86 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 97 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HOOK3 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOOK3 31 30
  • 93.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hook3 17 31 30
  • 90.44 (n)
rat
(Rattus norvegicus)
Mammalia Hook3 30
  • 90.25 (n)
cow
(Bos Taurus)
Mammalia HOOK3 31 30
  • 90.06 (n)
OneToOne
chicken
(Gallus gallus)
Aves HOOK3 31 30
  • 83.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOOK3 31
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hook3 30
  • 77.78 (n)
zebrafish
(Danio rerio)
Actinopterygii HOOK3 31
  • 73 (a)
OneToOne
Dr.5440 30
fruit fly
(Drosophila melanogaster)
Insecta hk 31 32 30
  • 46.94 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta HOOK_ANOGA 30
  • 46.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.4526 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4526 30
Species where no ortholog for HOOK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOOK3 Gene

ENSEMBL:
Gene Tree for HOOK3 (if available)
TreeFam:
Gene Tree for HOOK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOOK3: view image

Paralogs for HOOK3 Gene

Paralogs for HOOK3 Gene

(2) SIMAP similar genes for HOOK3 Gene using alignment to 4 proteins:

  • HOOK3_HUMAN
  • H0YDK4_HUMAN
  • H0YDM4_HUMAN
  • H0YE69_HUMAN
genes like me logo Genes that share paralogs with HOOK3: view

Variants for HOOK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOOK3 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
770193 Benign: not provided 42,973,284(+) A/G INTRON_VARIANT
rs1563293555 Likely Pathogenic: Short stature 42,930,130(+) T/G MISSENSE_VARIANT
rs747141054 Likely Pathogenic: Short stature 42,973,316(+) G/A MISSENSE_VARIANT
VAR_035710 A breast cancer sample p.Gln221Arg
rs34131505 - p.Tyr670Ser

Additional dbSNP identifiers (rs#s) for HOOK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOOK3 Gene

Variant ID Type Subtype PubMed ID
esv1916461 CNV deletion 18987734
esv3891387 CNV gain 25118596
nsv1032781 CNV gain 25217958
nsv480663 CNV novel sequence insertion 20440878

Variation tolerance for HOOK3 Gene

Residual Variation Intolerance Score: 6.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOOK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOOK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOOK3 Gene

Disorders for HOOK3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for HOOK3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
small intestine neuroendocrine neoplasm
  • small intestine neuroendocrine tumor
small intestine benign neoplasm
  • neoplasm of small intestine
dystonia 6, torsion
  • dyt6
hermansky-pudlak syndrome 9
  • albinism with hemorrhagic diathesis and pigmented reticuloendothelial cells
primary autosomal recessive microcephaly
  • mcph
- elite association - COSMIC cancer census association via MalaCards
Search HOOK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HOOK3

genes like me logo Genes that share disorders with HOOK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOOK3 Gene

Publications for HOOK3 Gene

  1. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. (PMID: 17237231) Sano H … Kuroki Y (The Journal of biological chemistry 2007) 2 3 4 23 54
  2. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PMID: 11238449) Walenta JH … Krämer H (The Journal of cell biology 2001) 3 4 23 54
  3. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PMID: 18799622) Xu L … Harper JW (Molecular biology of the cell 2008) 3 4 54
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for HOOK3 Gene

Sources for HOOK3 Gene