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Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004] See more...
Aliases for HOOK3 Gene
Aliases for HOOK3 Gene
External Ids for HOOK3 Gene
- HGNC: 23576
- NCBI Entrez Gene: 84376
- Ensembl: ENSG00000168172
- OMIM®: 607825
- UniProtKB/Swiss-Prot: Q86VS8
Previous GeneCards Identifiers for HOOK3 Gene
- GC12M9A0079
- GC08P042821
- GC08P042492
- GC08P042769
- GC08P042871
- GC08P041277
Summaries for HOOK3 Gene
-
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
GeneCards Summary for HOOK3 Gene
HOOK3 (Hook Microtubule Tethering Protein 3) is a Protein Coding gene. Diseases associated with HOOK3 include Small Intestine Neuroendocrine Neoplasm and Small Intestine Benign Neoplasm. Gene Ontology (GO) annotations related to this gene include identical protein binding and microtubule binding. An important paralog of this gene is HOOK1.
UniProtKB/Swiss-Prot Summary for HOOK3 Gene
-
Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).
Additional gene information for HOOK3 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOOK3 Gene
Genomics for HOOK3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HOOK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HOOK3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOOK3
- Top Transcription factor binding sites by QIAGEN in the HOOK3 gene promoter:
-
- PPAR-alpha
- STAT1
- STAT1alpha
- STAT1beta
- STAT2
- STAT3
- STAT4
- STAT5A
- STAT5B
- STAT6
Genomic Locations for HOOK3 Gene
Latest Assembly
- chr8:42,896,946-43,030,535
- (GRCh38/hg38)
- Size:
- 133,590 bases
- Orientation:
- Plus strand
Previous Assembly
- chr8:42,752,121-42,885,678
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 133,558 bases
- Orientation:
- Plus strand
Genomic View for HOOK3 Gene
Genes around HOOK3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p11.21 by HGNC
- 8p11.21 by Entrez Gene
- 8p11.21 by Ensembl
HOOK3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOOK3 Gene
Proteins for HOOK3 Gene
-
Protein details for HOOK3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86VS8-HOOK3_HUMAN
- Recommended name:
- Protein Hook homolog 3
- Protein Accession:
- Q86VS8
- D3DSY8
- Q8NBH0
- Q9BY13
Protein attributes for HOOK3 Gene
- Size:
- 718 amino acids
- Molecular mass:
- 83126 Da
- Quaternary structure:
-
- Interacts with Salmonella typhimurium spiC (By similarity). Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK1 and HOOK2. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (PubMed:18799622). Interacts with MSR1, and this association is stimulated by ligand binding to MSR1 (PubMed:17237231). Interacts with microtubules (PubMed:11238449). Interacts with dynein intermediate chain and dynactin (DCTN1) (PubMed:25035494). Interacts with CCDC181 (By similarity). Interacts with LRGUK (By similarity).
- SequenceCaution:
-
- Sequence=AAH48304.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for HOOK3 Gene
Post-translational modifications for HOOK3 Gene
Other Protein References for HOOK3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- NSJ Bioreagents HOOK3 Antibody
- Novus Biologicals Antibodies for HOOK3
- Invitrogen Antibodies for HOOK3 (AFLGC-HOOK3)
-
Biorbyt antibodies for HOOK3
-
Custom Antibody ServicesProSci Antibodies for HOOK3
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOOK3
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for HOOK3
- Origene Custom Protein Services for HOOK3
Assay products for research
No data available for DME Specific Peptides for HOOK3 Gene
Domains & Families for HOOK3 Gene
Gene Families for HOOK3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for HOOK3 Gene
Suggested Antigen Peptide Sequences for HOOK3 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein Hook homolog 3 (HOOK3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86VS8- Family:
-
- Belongs to the hook family.
Function for HOOK3 Gene
Molecular function for HOOK3 Gene
- UniProtKB/Swiss-Prot Function:
- Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).
Phenotypes From GWAS Catalog for HOOK3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17237231 |
| GO:0008017 | microtubule binding | IEA,IDA | 11238449 |
| GO:0034452 | dynactin binding | IDA | 27482052 |
| GO:0042802 | identical protein binding | IPI | 18799622 |
| GO:0045503 | dynein light chain binding | IPI | 27482052 |
Phenotypes for HOOK3 Gene
- MGI mutant phenotypes for HOOK3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOOK3:
Animal Models for HOOK3 Gene
- MGI Knock Outs for HOOK3:
-
- Hook3 Hook3<tm1b(NCOM)Mfgc>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HOOK3 - Starting at $85 >
- * HOOK3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HOOK3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HOOK3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOOK3
miRNA for HOOK3 Gene
- miRTarBase miRNAs that target HOOK3
-
- mmu-miR-181a-5p (MIRT014331)
- hsa-miR-192-5p (MIRT026745)
- hsa-miR-615-3p (MIRT039786)
- hsa-miR-181a-3p (MIRT046999)
- hsa-miR-181a-5p (MIRT047303)
- hsa-miR-17-5p (MIRT244587)
- hsa-miR-20a-5p (MIRT244588)
- hsa-miR-93-5p (MIRT244589)
- hsa-miR-106a-5p (MIRT244590)
- hsa-miR-106b-5p (MIRT244592)
- hsa-miR-302a-3p (MIRT244593)
- hsa-miR-302b-3p (MIRT244594)
- hsa-miR-302c-3p (MIRT244595)
- hsa-miR-302d-3p (MIRT244596)
- hsa-miR-372-3p (MIRT244597)
- hsa-miR-373-3p (MIRT244598)
- hsa-miR-20b-5p (MIRT244599)
- hsa-miR-520e (MIRT244600)
- hsa-miR-520a-3p (MIRT244602)
- hsa-miR-526b-3p (MIRT244603)
- hsa-miR-520b (MIRT244605)
- hsa-miR-520c-3p (MIRT244606)
- hsa-miR-519d-3p (MIRT244608)
- hsa-miR-520d-3p (MIRT244610)
- hsa-miR-302e (MIRT244615)
- hsa-miR-4662a-5p (MIRT442186)
- hsa-miR-6787-3p (MIRT442187)
- hsa-miR-212-3p (MIRT442188)
- hsa-miR-132-3p (MIRT442189)
- hsa-miR-372-5p (MIRT536766)
- hsa-miR-371a-5p (MIRT536767)
- hsa-miR-616-5p (MIRT536768)
- hsa-miR-373-5p (MIRT536769)
- hsa-miR-371b-5p (MIRT536770)
- hsa-miR-3613-3p (MIRT536771)
- hsa-miR-5692a (MIRT536772)
- mmu-miR-1196-5p (MIRT583064)
- mmu-miR-10b-5p (MIRT583065)
- mmu-miR-10a-5p (MIRT583066)
- mmu-miR-342-3p (MIRT589811)
- mmu-miR-377-3p (MIRT589812)
- mmu-miR-466i-3p (MIRT589813)
- mmu-miR-362-3p (MIRT589814)
- mmu-miR-329-3p (MIRT589815)
- mmu-miR-3067-5p (MIRT594901)
- mmu-miR-466o-3p (MIRT600781)
- mmu-miR-466m-3p (MIRT600782)
- mmu-miR-466f-3p (MIRT603013)
- hsa-miR-2681-5p (MIRT612889)
- hsa-miR-3529-3p (MIRT612890)
- hsa-miR-578 (MIRT612891)
- hsa-miR-3683 (MIRT612892)
- hsa-miR-1273c (MIRT612893)
- hsa-miR-640 (MIRT657314)
- hsa-miR-378a-5p (MIRT657315)
- hsa-miR-6821-3p (MIRT657316)
- hsa-miR-3653-5p (MIRT657317)
- hsa-miR-6790-3p (MIRT657318)
- hsa-miR-6513-3p (MIRT657319)
- hsa-miR-1224-3p (MIRT657320)
- hsa-miR-8079 (MIRT657321)
- hsa-miR-1245a (MIRT657322)
- hsa-miR-6844 (MIRT667940)
- hsa-miR-2052 (MIRT667941)
- hsa-miR-4508 (MIRT670724)
- hsa-miR-6780a-5p (MIRT670725)
- hsa-miR-6779-5p (MIRT670726)
- hsa-miR-3689c (MIRT670727)
- hsa-miR-3689b-3p (MIRT670728)
- hsa-miR-3689a-3p (MIRT670729)
- hsa-miR-30b-3p (MIRT670730)
- hsa-miR-1273h-5p (MIRT670731)
- hsa-miR-4314 (MIRT670732)
- hsa-miR-7977 (MIRT670733)
- hsa-miR-6806-5p (MIRT670734)
- hsa-miR-3178 (MIRT670735)
- hsa-miR-6799-5p (MIRT670736)
- hsa-miR-6883-5p (MIRT670737)
- hsa-miR-6785-5p (MIRT670738)
- hsa-miR-4728-5p (MIRT670739)
- hsa-miR-149-3p (MIRT670740)
- hsa-miR-7106-5p (MIRT670741)
- hsa-miR-5787 (MIRT670742)
- hsa-miR-4505 (MIRT670743)
- hsa-miR-24-3p (MIRT670744)
- hsa-miR-4284 (MIRT670745)
- hsa-miR-4486 (MIRT670746)
- hsa-miR-6506-5p (MIRT670747)
- hsa-miR-619-5p (MIRT670748)
- hsa-miR-3192-5p (MIRT670749)
- hsa-miR-4646-5p (MIRT670750)
- hsa-miR-204-3p (MIRT670751)
- hsa-miR-330-5p (MIRT670752)
- hsa-miR-326 (MIRT670753)
- hsa-miR-383-3p (MIRT670754)
- hsa-miR-4478 (MIRT670755)
- hsa-miR-4419b (MIRT670756)
- hsa-miR-3929 (MIRT670757)
- hsa-miR-514a-5p (MIRT670758)
- hsa-miR-665 (MIRT673628)
- hsa-miR-5089-5p (MIRT687914)
- hsa-let-7e-3p (MIRT687915)
- hsa-let-7d-3p (MIRT687916)
- hsa-miR-5589-5p (MIRT687917)
- hsa-miR-4731-5p (MIRT687918)
- hsa-miR-6778-3p (MIRT687919)
- hsa-miR-4638-5p (MIRT687920)
- hsa-miR-1307-3p (MIRT687921)
- hsa-miR-150-5p (MIRT687922)
- hsa-miR-7107-5p (MIRT687923)
- hsa-miR-1234-3p (MIRT687924)
- hsa-miR-186-3p (MIRT687925)
- hsa-miR-520h (MIRT687926)
- hsa-miR-520g-3p (MIRT687927)
- hsa-miR-512-3p (MIRT687928)
- hsa-miR-4777-5p (MIRT702814)
- hsa-miR-526a (MIRT702815)
- hsa-miR-523-5p (MIRT702816)
- hsa-miR-522-5p (MIRT702817)
- hsa-miR-520c-5p (MIRT702818)
- hsa-miR-519c-5p (MIRT702819)
- hsa-miR-519b-5p (MIRT702820)
- hsa-miR-519a-5p (MIRT702821)
- hsa-miR-518f-5p (MIRT702822)
- hsa-miR-518e-5p (MIRT702823)
- hsa-miR-518d-5p (MIRT702824)
- hsa-miR-2115-5p (MIRT702825)
- hsa-miR-4305 (MIRT702826)
- hsa-miR-770-5p (MIRT702827)
- hsa-miR-4712-5p (MIRT702828)
- hsa-miR-5586-5p (MIRT702829)
- hsa-miR-1273e (MIRT702830)
- hsa-miR-650 (MIRT702831)
- hsa-miR-3612 (MIRT702832)
- hsa-miR-6499-3p (MIRT702833)
- hsa-miR-2467-3p (MIRT702834)
- hsa-miR-219b-3p (MIRT702835)
- hsa-miR-17-3p (MIRT702836)
- hsa-miR-1247-3p (MIRT702837)
- hsa-miR-6511a-5p (MIRT702838)
- hsa-miR-1910-3p (MIRT702839)
- hsa-miR-302f (MIRT702840)
- hsa-miR-527 (MIRT718760)
- hsa-miR-518a-5p (MIRT718761)
- hsa-miR-27b-5p (MIRT718762)
- hsa-miR-556-5p (MIRT718763)
- hsa-miR-541-3p (MIRT733852)
- hsa-miR-1827 (MIRT738110)
- hsa-miR-25-5p (MIRT739379)
- hsa-miR-3664-3p (MIRT742024)
- hsa-miR-4327 (MIRT744100)
- hsa-miR-4433a-3p (MIRT744354)
- hsa-miR-4459 (MIRT744803)
- hsa-miR-4649-3p (MIRT746481)
- hsa-miR-4695-5p (MIRT747179)
- hsa-miR-4722-5p (MIRT747598)
- hsa-miR-4768-3p (MIRT748621)
- hsa-miR-485-5p (MIRT749065)
- hsa-miR-510-5p (MIRT749730)
- hsa-miR-512-5p (MIRT749756)
- hsa-miR-6087 (MIRT751907)
- hsa-miR-6808-5p (MIRT756569)
- hsa-miR-6884-5p (MIRT758507)
- hsa-miR-6893-5p (MIRT758713)
- hsa-miR-7160-5p (MIRT759319)
- hsa-miR-940 (MIRT760810)
- hsa-miR-4537 (MIRT770162)
- hsa-miR-510-3p (MIRT773319)
- hsa-miR-5585-5p (MIRT774745)
- hsa-miR-1273f (MIRT783304)
- hsa-miR-1289 (MIRT783399)
- hsa-miR-129-5p (MIRT783507)
- hsa-miR-1304-3p (MIRT783677)
- hsa-miR-134-3p (MIRT783754)
- hsa-miR-143-3p (MIRT783803)
- hsa-miR-3136-3p (MIRT784626)
- hsa-miR-3198 (MIRT784814)
- hsa-miR-3664-5p (MIRT785078)
- hsa-miR-4294 (MIRT785617)
- hsa-miR-4309 (MIRT785687)
- hsa-miR-452-5p (MIRT786164)
- hsa-miR-4534 (MIRT786209)
- hsa-miR-4639-3p (MIRT786256)
- hsa-miR-4676-3p (MIRT786382)
- hsa-miR-4708-5p (MIRT786474)
- hsa-miR-4770 (MIRT786688)
- hsa-miR-6088 (MIRT788030)
- hsa-miR-6514-5p (MIRT788346)
- hsa-miR-663b (MIRT788419)
- hsa-miR-6794-3p (MIRT788768)
- hsa-miR-7108-5p (MIRT789403)
- hsa-miR-7114-5p (MIRT789421)
- hsa-miR-7155-3p (MIRT789440)
- hsa-miR-8055 (MIRT789683)
- hsa-miR-8082 (MIRT789835)
- hsa-miR-892c-3p (MIRT789924)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HOOK3
- Browse OriGene Inhibitory RNA Products For HOOK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOOK3
Clone products for research
- Applied Biological Materials (abm): Clones for HOOK3 - Starting at $45 >
- * HOOK3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for HOOK3
- Addgene plasmids for HOOK3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HOOK3
Cell Lines for research
-
Horizon Cell Lines for HOOK3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOOK3 Gene
Localization for HOOK3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOOK3 Gene
- Cytoplasm, cytoskeleton. Golgi apparatus. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase (PubMed:11238449). Localizes to the manchette in elongating spermatids (By similarity). {ECO:0000250 UniProtKB:Q8BUK6, ECO:0000269 PubMed:11238449}.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| cytoskeleton | 4 |
| cytosol | 4 |
| nucleus | 3 |
| endosome | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Centriolar satellite (3)
- Golgi apparatus (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000242 | pericentriolar material | IEA,ISS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005801 | cis-Golgi network | IDA | 11238449 |
| GO:0005813 | centrosome | IEA,ISS | -- |
Pathways & Interactions for HOOK3 Gene
Interacting Proteins for HOOK3 Gene
Selected Interacting proteins:
Q86VS8-HOOK3_HUMAN
ENSP00000305699
for HOOK3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for HOOK3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007032 | endosome organization | IMP | 18799622 |
| GO:0007040 | lysosome organization | IMP | 18799622 |
| GO:0008333 | endosome to lysosome transport | IMP | 18799622 |
| GO:0015031 | protein transport | IEA | -- |
| GO:0022027 | interkinetic nuclear migration | IEA,ISS | -- |
No data available for Pathways by source for HOOK3 Gene
Transcripts for HOOK3 Gene
mRNA/cDNA for HOOK3 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000307602 14348 nts (view in UCSC)
- ENST00000524839 558 nts (view in UCSC)
- ENST00000526882 598 nts (view in UCSC)
- ENST00000527306 2325 nts (view in UCSC)
- ENST00000533338 774 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HOOK3 - Starting at $85 >
- * HOOK3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HOOK3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HOOK3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOOK3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HOOK3
- Browse OriGene Inhibitory RNA Products For HOOK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOOK3
Clone products for research
- Applied Biological Materials (abm): Clones for HOOK3 - Starting at $45 >
- * HOOK3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for HOOK3
- Addgene plasmids for HOOK3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HOOK3
Relevant External Links for HOOK3 Gene
- GeneLoc Exon Structure for
- HOOK3
Expression for HOOK3 Gene
This gene is overexpressed in Bone (41.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOOK3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOOK3
SOURCE GeneReport for Unigene cluster for HOOK3 Gene:
Hs.162852Evidence on tissue expression from TISSUES for HOOK3 Gene
- Nervous system(4.7)
- Liver(4.4)
- Intestine(4.4)
Primer products for research
-
OriGene qPCR primer pairs for HOOK3
-
OriGene qPCR primer pairs and template standards for HOOK3
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOOK3 Gene
Orthologs for HOOK3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HOOK3 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | HOOK3 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HOOK3 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Hook3 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hook3 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | HOOK3 29 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HOOK3 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HOOK3 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hook3 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | HOOK3 30 |
|
OneToOne | |
| Dr.5440 29 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | hk 29 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | HOOK_ANOGA 29 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4526 29 |
|
- Species where no ortholog for HOOK3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HOOK3 Gene
- ENSEMBL:
- Gene Tree for HOOK3 (if available)
- TreeFam:
- Gene Tree for HOOK3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HOOK3: view image
- Alliance of Genome Resources:
- Additional Orthologs for HOOK3
Paralogs for HOOK3 Gene
Variants for HOOK3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOOK3 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140588505 | Benign: not provided | 42,973,284(+) |
A/G NM_032410.4(HOOK3):c.1123-5A>G |
INTRON | |
| rs1563293555 | Likely Pathogenic: Short stature | 42,930,130(+) |
T/G NM_032410.4(HOOK3):c.225T>G (p.Asn75Lys) |
MISSENSE | |
| rs747141054 | Likely Pathogenic: Short stature | 42,973,316(+) |
G/A NM_032410.4(HOOK3):c.1150G>A (p.Glu384Lys) |
MISSENSE | |
| VAR_035710 | A breast cancer sample |
p.Gln221Arg |
|||
| rs34131505 | -- |
p.Tyr670Ser |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1916461 | CNV | deletion | 18987734 |
| esv3891387 | CNV | gain | 25118596 |
| nsv1032781 | CNV | gain | 25217958 |
| nsv480663 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
6.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.95;
19.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HOOK3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOOK3 Gene
Disorders for HOOK3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| small intestine neuroendocrine neoplasm |
|
|
| small intestine benign neoplasm |
|
|
| dystonia 6, torsion |
|
|
| hermansky-pudlak syndrome 9 |
|
|
| spinal muscular atrophy with lower extremity predominance |
|
|
Search HOOK3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HOOK3
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HOOK3 Gene
Publications for HOOK3 Gene
- The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. (PMID: 17237231) Sano H … Kuroki Y (The Journal of biological chemistry 2007) 2 3 4 22
- The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PMID: 11238449) Walenta JH … Krämer H (The Journal of cell biology 2001) 3 4 22
- An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PMID: 18799622) Xu L … Harper JW (Molecular biology of the cell 2008) 3 4
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for HOOK3 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for HOOK3
- Origene Custom Protein Services for HOOK3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HOOK3
- Browse OriGene Inhibitory RNA Products For HOOK3
- OriGene qPCR primer pairs for HOOK3
- OriGene qPCR primer pairs and template standards for HOOK3
- OriGene CRISPR knockouts for HOOK3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HOOK3
- Sino Biological Human cDNA Clone for HOOK3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HOOK3
- Novus Biologicals proteins and lysates for HOOK3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for HOOK3 (AFLGC-HOOK3)
- VectorBuilder Custom and pre-made DNA vectors for HOOK3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HOOK3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HOOK3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HOOK3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HOOK3
- Addgene plasmids for HOOK3
- antibodies-online: Show 5 available HOOK3 Antibodies ranked by validation data
- Compare Top HOOK3 Antibodies
- antibodies-online: Search results for available HOOK3 related products ranked by validation data
- antibodies-online: Show 6 available HOOK3 Proteins ranked by validation data
- Compare Top HOOK3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for HOOK3
- Search Santa Cruz Biotechnology (SCBT) for HOOK3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HOOK3
- Custom Antibody ServicesProSci Antibodies for HOOK3
- Search for HOOK3 Proteins at ProSci
- Horizon Cell Lines for HOOK3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HOOK3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HOOK3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HOOK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOOK3
- Biorbyt antibodies for HOOK3
Sources for HOOK3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources