Aliases for HOOK2 Gene
External Ids for HOOK2 Gene
Previous GeneCards Identifiers for HOOK2 Gene
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
GeneCards Summary for HOOK2 Gene
HOOK2 (Hook Microtubule Tethering Protein 2) is a Protein Coding gene. Diseases associated with HOOK2 include Breast Medullary Carcinoma and Well-Differentiated Liposarcoma. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is HOOK3.
UniProtKB/Swiss-Prot Summary for HOOK2 Gene
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.