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Aliases for HOOK2 Gene

Aliases for HOOK2 Gene

  • Hook Microtubule Tethering Protein 2 2 3 5
  • Protein Hook Homolog 2 3 4
  • H-Hook2 3 4
  • HHK2 3 4
  • Hook Homolog 2 (Drosophila) 2
  • Hook Homolog 2 3
  • HK2 3

External Ids for HOOK2 Gene

Previous GeneCards Identifiers for HOOK2 Gene

  • GC19M013005
  • GC19M013096
  • GC19M012719
  • GC19M012734
  • GC19M012873
  • GC19M012446
  • GC19M012766
  • GC19M012769
  • GC19M012815
  • GC19M012770
  • GC19M012771
  • GC19M012772
  • GC19M012773
  • GC19M012774
  • GC19M012787
  • GC19M012789
  • GC19M012801

Summaries for HOOK2 Gene

Entrez Gene Summary for HOOK2 Gene

  • Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

GeneCards Summary for HOOK2 Gene

HOOK2 (Hook Microtubule Tethering Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is HOOK3.

UniProtKB/Swiss-Prot for HOOK2 Gene

  • Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.

Gene Wiki entry for HOOK2 Gene

Additional gene information for HOOK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOOK2 Gene

Genomics for HOOK2 Gene

GeneHancer (GH) Regulatory Elements for HOOK2 Gene

Promoters and enhancers for HOOK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012774 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.2 +95.3 95334 6.2 SP1 ZFX ELF3 CTCF ZKSCAN8 MNT SIX5 CBFA2T2 ZNF148 NKRF GC19P012779 HOOK2 CCDC130 WDR83OS ZNF44 ZNF564 ZNF700 ZNF136 ZNF799 TRIR
GH19J012872 Promoter/Enhancer 1.2 Ensembl ENCODE 600.7 -0.6 -634 0.9 MLLT1 SP1 KLF14 KLF9 SP2 CTCF RFX1 EGR1 HDGF TRIM28 HOOK2 GC19P012877 MAST1
GH19J012943 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 6.2 -74.2 -74172 6.8 SP1 ZFX ELF3 MNT CBFA2T2 ZNF148 NKRF POLR2A MLLT1 CEBPG RAD23A ZNF136 CCDC130 TRMT1 ZNF442 ZNF625 DHPS MRI1 ZNF844 RPS6P25
GH19J012757 Enhancer 1.1 ENCODE dbSUPER 12.7 +114.9 114877 1.1 CTCF ZKSCAN8 MNT GTF2F1 NCOA6 RAD21 KAT8 ZBTB8A ZIC2 ZNF143 JUNB HOOK2 TRIR GET3 TNPO2 MAST1 RNASEH2A RTBDN WDR83OS WDR83
GH19J013160 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -294.6 -294555 13.8 ZNF652 SP1 ZFX ELF3 MNT ZNF148 NKRF POLR2A MLLT1 ZNF121 CCDC130 ZNF44 ZNF791 ZNF799 ZNF564 WDR83OS DCAF15 MRI1 ZNF442 TRMT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOOK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HOOK2 gene promoter:
  • AREB6
  • Egr-1
  • NF-kappaB1
  • p53
  • SRF
  • SRF (504 AA)

Genomic Locations for HOOK2 Gene

Genomic Locations for HOOK2 Gene
chr19:12,763,003-12,872,740
(GRCh38/hg38)
Size:
109,738 bases
Orientation:
Minus strand
chr19:12,873,817-12,983,554
(GRCh37/hg19)
Size:
109,738 bases
Orientation:
Minus strand

Genomic View for HOOK2 Gene

Genes around HOOK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOOK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOOK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOOK2 Gene

Proteins for HOOK2 Gene

  • Protein details for HOOK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ED9-HOOK2_HUMAN
    Recommended name:
    Protein Hook homolog 2
    Protein Accession:
    Q96ED9
    Secondary Accessions:
    • O60562

    Protein attributes for HOOK2 Gene

    Size:
    719 amino acids
    Molecular mass:
    83207 Da
    Quaternary structure:
    • Self-associates (PubMed:18799622). Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3 (PubMed:18799622). May interact directly with AKTIP/FTS, HOOK1 and HOOK3 (PubMed:18799622). Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (PubMed:18799622). Interacts with CNTRL (PubMed:17140400). Interacts with microtubules (PubMed:11238449). Interacts with ZC3H14 (PubMed:19273536). Interacts with LRGUK (via guanylate kinase-like domain) (By similarity). Interacts with CCDC181 (By similarity).

    Alternative splice isoforms for HOOK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOOK2 Gene

Post-translational modifications for HOOK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HOOK2 Gene

Domains & Families for HOOK2 Gene

Gene Families for HOOK2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HOOK2 Gene

Suggested Antigen Peptide Sequences for HOOK2 Gene

GenScript: Design optimal peptide antigens:
  • Protein Hook homolog 2 (HOOK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96ED9

UniProtKB/Swiss-Prot:

HOOK2_HUMAN :
  • Belongs to the hook family.
Family:
  • Belongs to the hook family.
genes like me logo Genes that share domains with HOOK2: view

Function for HOOK2 Gene

Molecular function for HOOK2 Gene

UniProtKB/Swiss-Prot Function:
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.

Phenotypes From GWAS Catalog for HOOK2 Gene

Gene Ontology (GO) - Molecular Function for HOOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008017 microtubule binding IBA 21873635
GO:0042802 identical protein binding IPI 18799622
GO:0051959 dynein light intermediate chain binding IBA 21873635
genes like me logo Genes that share ontologies with HOOK2: view
genes like me logo Genes that share phenotypes with HOOK2: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for HOOK2 - Now 50% OFF >
  • * HOOK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * HOOK2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for HOOK2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HOOK2 Gene

Localization for HOOK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOOK2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome (PubMed:17540036). Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosome, or mitochondria (PubMed:17540036). Often found in close association with microtubules (PubMed:17540036). Localizes to the manchette in elongating spermatids (By similarity). {ECO:0000250 UniProtKB:Q7TMK6, ECO:0000269 PubMed:17540036}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOOK2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IBA,IDA 17140400
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with HOOK2: view

Pathways & Interactions for HOOK2 Gene

PathCards logo

SuperPathways for HOOK2 Gene

No Data Available

SIGNOR curated interactions for HOOK2 Gene

Activates:

Gene Ontology (GO) - Biological Process for HOOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis TAS 9927460
GO:0007032 endosome organization IMP 18799622
GO:0007040 lysosome organization IMP 18799622
GO:0008333 endosome to lysosome transport IMP 18799622
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with HOOK2: view

No data available for Pathways by source for HOOK2 Gene

Drugs & Compounds for HOOK2 Gene

No Compound Related Data Available

Transcripts for HOOK2 Gene

mRNA/cDNA for HOOK2 Gene

Unigene Clusters for HOOK2 Gene

Hook homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for HOOK2 - Now 50% OFF >
  • * HOOK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * HOOK2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for HOOK2

Alternative Splicing Database (ASD) splice patterns (SP) for HOOK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - - -
SP2:
SP3: - - - - -
SP4: -
SP5:
SP6: - -
SP7: -
SP8:
SP9:
SP10:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for HOOK2 Gene

GeneLoc Exon Structure for
HOOK2
ECgene alternative splicing isoforms for
HOOK2

Expression for HOOK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOOK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOOK2 Gene

This gene is overexpressed in Pituitary (x4.2).

Protein differential expression in normal tissues from HIPED for HOOK2 Gene

This gene is overexpressed in Bone (63.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOOK2 Gene



NURSA nuclear receptor signaling pathways regulating expression of HOOK2 Gene:

HOOK2

SOURCE GeneReport for Unigene cluster for HOOK2 Gene:

Hs.30792

Evidence on tissue expression from TISSUES for HOOK2 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with HOOK2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOOK2 Gene

Orthologs for HOOK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOOK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOOK2 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOOK2 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOOK2 35 34
  • 89.09 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hook2 34
  • 83.71 (n)
mouse
(Mus musculus)
Mammalia Hook2 17 35 34
  • 83.52 (n)
oppossum
(Monodelphis domestica)
Mammalia HOOK2 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOOK2 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOOK2 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hook2 34
  • 63.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1897 34
zebrafish
(Danio rerio)
Actinopterygii hook2 35 34
  • 64.55 (n)
OneToOne
zgc66419 34
fruit fly
(Drosophila melanogaster)
Insecta hk 35
  • 31 (a)
OneToMany
Species where no ortholog for HOOK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOOK2 Gene

ENSEMBL:
Gene Tree for HOOK2 (if available)
TreeFam:
Gene Tree for HOOK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOOK2: view image

Paralogs for HOOK2 Gene

Paralogs for HOOK2 Gene

(11) SIMAP similar genes for HOOK2 Gene using alignment to 9 proteins:

  • HOOK2_HUMAN
  • K7EJ48_HUMAN
  • K7EJ65_HUMAN
  • K7EJA7_HUMAN
  • K7EK29_HUMAN
  • K7EMG7_HUMAN
  • K7EMR5_HUMAN
  • K7ENU5_HUMAN
  • K7EQA2_HUMAN
genes like me logo Genes that share paralogs with HOOK2: view

Variants for HOOK2 Gene

Sequence variations from dbSNP and Humsavar for HOOK2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000203641 -- 12,766,879(-) G/A/C/T intron_variant
rs1000217245 -- 12,763,973(-) T/G intron_variant
rs1000249954 -- 12,779,222(-) C/T upstream_transcript_variant
rs1000891444 -- 12,777,440(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001137810 -- 12,776,272(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HOOK2 Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
esv2667754 CNV deletion 23128226
nsv1160586 CNV duplication 26073780
nsv953977 CNV deletion 24416366

Variation tolerance for HOOK2 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.34; 85.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOOK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOOK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOOK2 Gene

Disorders for HOOK2 Gene

Additional Disease Information for HOOK2

No disorders were found for HOOK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOOK2 Gene

Publications for HOOK2 Gene

  1. Genetic analysis of hook, a gene required for endocytic trafficking in drosophila. (PMID: 9927460) Krämer H … Phistry M (Genetics 1999) 2 3 4 58
  2. SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans. (PMID: 19273536) Guthrie CR … Kraemer BC (Human molecular genetics 2009) 3 4 58
  3. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PMID: 18799622) Xu L … Harper JW (Molecular biology of the cell 2008) 3 4 58
  4. Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. (PMID: 17140400) Szebenyi G … Krämer H (Traffic (Copenhagen, Denmark) 2007) 3 4 58
  5. Hook2 contributes to aggresome formation. (PMID: 17540036) Szebenyi G … Krämer H (BMC cell biology 2007) 3 4 58

Products for HOOK2 Gene

Sources for HOOK2 Gene

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