Aliases for HOOK1 Gene
External Ids for HOOK1 Gene
Previous GeneCards Identifiers for HOOK1 Gene
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOOK1 Gene
HOOK1 (Hook Microtubule Tethering Protein 1) is a Protein Coding gene. Diseases associated with HOOK1 include Water-Clear Cell Adenoma and Clear Cell Adenoma. Gene Ontology (GO) annotations related to this gene include identical protein binding and actin binding. An important paralog of this gene is HOOK3.
UniProtKB/Swiss-Prot Summary for HOOK1 Gene
Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622).