Aliases for HOMEZ Gene

Aliases for HOMEZ Gene

  • Homeobox And Leucine Zipper Encoding 2 3 5
  • KIAA1443 2 3 4
  • Homeodomain Leucine Zipper-Containing Factor 3 4
  • Homeobox And Leucine Zipper Protein Homez 3 4

External Ids for HOMEZ Gene

Previous HGNC Symbols for HOMEZ Gene

  • KIAA1443

Previous GeneCards Identifiers for HOMEZ Gene

  • GC14M022813
  • GC14M023742
  • GC14M003859

Summaries for HOMEZ Gene

GeneCards Summary for HOMEZ Gene

HOMEZ (Homeobox And Leucine Zipper Encoding) is a Protein Coding gene. Diseases associated with HOMEZ include Ventricular Septal Defect. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ZHX3.

UniProtKB/Swiss-Prot Summary for HOMEZ Gene

Additional gene information for HOMEZ Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOMEZ Gene

Genomics for HOMEZ Gene

GeneHancer (GH) Regulatory Elements for HOMEZ Gene

Promoters and enhancers for HOMEZ Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOMEZ on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOMEZ

Top Transcription factor binding sites by QIAGEN in the HOMEZ gene promoter:
  • AREB6
  • CUTL1
  • Lmo2
  • Pax-4a
  • Sp1
  • STAT1

Genomic Locations for HOMEZ Gene

Genomic Locations for HOMEZ Gene
chr14:23,272,422-23,299,447
(GRCh38/hg38)
Size:
27,026 bases
Orientation:
Minus strand
chr14:23,741,666-23,768,656
(GRCh37/hg19)
Size:
26,991 bases
Orientation:
Minus strand

Genomic View for HOMEZ Gene

Genes around HOMEZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOMEZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOMEZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOMEZ Gene

Proteins for HOMEZ Gene

  • Protein details for HOMEZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX15-HOMEZ_HUMAN
    Recommended name:
    Homeobox and leucine zipper protein Homez
    Protein Accession:
    Q8IX15
    Secondary Accessions:
    • A1L445
    • B4DZ80
    • F8WCA3
    • Q6P049
    • Q86XB6
    • Q9P2A5

    Protein attributes for HOMEZ Gene

    Size:
    550 amino acids
    Molecular mass:
    61240 Da
    Quaternary structure:
    • Homodimer or heterodimer (Potential). Interacts with HOXC8.
    SequenceCaution:
    • Sequence=AAN76991.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA92681.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HOMEZ Gene

    Alternative splice isoforms for HOMEZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOMEZ Gene

Post-translational modifications for HOMEZ Gene

  • Ubiquitination at Lys230
  • Modification sites at PhosphoSitePlus

Other Protein References for HOMEZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOMEZ Gene

Domains & Families for HOMEZ Gene

Gene Families for HOMEZ Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOMEZ Gene

Suggested Antigen Peptide Sequences for HOMEZ Gene

GenScript: Design optimal peptide antigens:
  • Homeodomain leucine zipper-containing factor (HOMEZ_HUMAN)
genes like me logo Genes that share domains with HOMEZ: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HOMEZ Gene

Function for HOMEZ Gene

Molecular function for HOMEZ Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional regulator.

Phenotypes From GWAS Catalog for HOMEZ Gene

Gene Ontology (GO) - Molecular Function for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0003714 transcription corepressor activity IBA 21873635
genes like me logo Genes that share ontologies with HOMEZ: view
genes like me logo Genes that share phenotypes with HOMEZ: view

Animal Models for HOMEZ Gene

MGI Knock Outs for HOMEZ:
  • Homez Homez<tm1e(KOMP)Wtsi>

Animal Model Products

Clone Products

  • Addgene plasmids for HOMEZ

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOMEZ Gene

Localization for HOMEZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOMEZ Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOMEZ gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IDA,IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with HOMEZ: view

Pathways & Interactions for HOMEZ Gene

PathCards logo

SuperPathways for HOMEZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HOMEZ: view

No data available for Pathways by source and SIGNOR curated interactions for HOMEZ Gene

Drugs & Compounds for HOMEZ Gene

(1) Drugs for HOMEZ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HOMEZ: view

Transcripts for HOMEZ Gene

mRNA/cDNA for HOMEZ Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for HOMEZ

Alternative Splicing Database (ASD) splice patterns (SP) for HOMEZ Gene

No ASD Table

Relevant External Links for HOMEZ Gene

GeneLoc Exon Structure for
HOMEZ

Expression for HOMEZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOMEZ Gene

Protein differential expression in normal tissues from HIPED for HOMEZ Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOMEZ Gene



Protein tissue co-expression partners for HOMEZ Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOMEZ

SOURCE GeneReport for Unigene cluster for HOMEZ Gene:

Hs.632332

mRNA Expression by UniProt/SwissProt for HOMEZ Gene:

Q8IX15-HOMEZ_HUMAN
Tissue specificity: Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.

Evidence on tissue expression from TISSUES for HOMEZ Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with HOMEZ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOMEZ Gene

Orthologs for HOMEZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOMEZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOMEZ 31 30
  • 98.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HOMEZ 31 30
  • 90.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HOMEZ 30
  • 90.18 (n)
KIAA1443 31
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Homez 30
  • 81.6 (n)
mouse
(Mus musculus)
Mammalia Homez 17 31 30
  • 80.21 (n)
oppossum
(Monodelphis domestica)
Mammalia HOMEZ 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOMEZ 31
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOMEZ 31
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii homez 31
  • 18 (a)
OneToMany
HOMEZ (1 of 2) 31
  • 14 (a)
OneToMany
Species where no ortholog for HOMEZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOMEZ Gene

ENSEMBL:
Gene Tree for HOMEZ (if available)
TreeFam:
Gene Tree for HOMEZ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOMEZ: view image

Paralogs for HOMEZ Gene

Paralogs for HOMEZ Gene

genes like me logo Genes that share paralogs with HOMEZ: view

Variants for HOMEZ Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOMEZ Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs10131813 - p.Ala278Thr

Additional dbSNP identifiers (rs#s) for HOMEZ Gene

Structural Variations from Database of Genomic Variants (DGV) for HOMEZ Gene

Variant ID Type Subtype PubMed ID
esv2763062 CNV gain 21179565

Variation tolerance for HOMEZ Gene

Residual Variation Intolerance Score: 52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.30; 96.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOMEZ Gene

Human Gene Mutation Database (HGMD)
HOMEZ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOMEZ

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOMEZ Gene

Disorders for HOMEZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for HOMEZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ventricular septal defect
  • interventricular septal defect
- elite association - COSMIC cancer census association via MalaCards
Search HOMEZ in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HOMEZ

genes like me logo Genes that share disorders with HOMEZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOMEZ Gene

Publications for HOMEZ Gene

  1. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PMID: 12925734) Bayarsaihan D … Ruddle FH (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for HOMEZ Gene

Sources for HOMEZ Gene