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Aliases for HOMEZ Gene

Aliases for HOMEZ Gene

  • Homeobox And Leucine Zipper Encoding 2 3 5
  • KIAA1443 2 3 4
  • Homeodomain Leucine Zipper-Containing Factor 3 4
  • Homeobox And Leucine Zipper Protein Homez 3

External Ids for HOMEZ Gene

Previous HGNC Symbols for HOMEZ Gene

  • KIAA1443

Previous GeneCards Identifiers for HOMEZ Gene

  • GC14M022813
  • GC14M023742
  • GC14M003859

Summaries for HOMEZ Gene

GeneCards Summary for HOMEZ Gene

HOMEZ (Homeobox And Leucine Zipper Encoding) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ZHX3.

UniProtKB/Swiss-Prot for HOMEZ Gene

  • May function as a transcriptional regulator.

Additional gene information for HOMEZ Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOMEZ Gene

Genomics for HOMEZ Gene

GeneHancer (GH) Regulatory Elements for HOMEZ Gene

Promoters and enhancers for HOMEZ Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J023284 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 678.2 +13.7 13696 3.4 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 HOMEZ PIR53909 ACIN1 PRMT5 IPO4 RNF31 NGDN THTPA TSSK4 RABGGTA
GH14J023297 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 661.3 -1.3 -1253 5.5 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 HOMEZ BCL2L2 PIR57322 PPP1R3E ACIN1 RNF31 RNA5SP383 PRMT5 RBM23 LOC102724814
GH14J024270 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 30.4 -973.4 -973379 5.4 MLX ZFP64 DMAP1 IRF4 SLC30A9 ZNF213 ZNF143 SP3 NFYC SSRP1 LOC102725044 RABGGTA IPO4 TSSK4 RNF31 HOMEZ KHNYN NOP9 NGDN DHRS1
GH14J022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27 +319.5 319541 7.6 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 AJUBA ACIN1 NGDN HAUS4 PRMT5 C14orf93 RBM23 LOC102724814 PABPN1 MMP14
GH14J024113 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.1 -815.4 -815393 3.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 DCAF11 NRL RNF31 KHNYN RNA5SP383 IPO4 TM9SF1 TINF2 TSSK4 NFATC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOMEZ on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HOMEZ gene promoter:
  • STAT1
  • Sp1
  • Lmo2
  • AREB6
  • Pax-4a
  • CUTL1

Genomic Locations for HOMEZ Gene

Genomic Locations for HOMEZ Gene
27,026 bases
Minus strand
26,991 bases
Minus strand

Genomic View for HOMEZ Gene

Genes around HOMEZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOMEZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOMEZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOMEZ Gene

Proteins for HOMEZ Gene

  • Protein details for HOMEZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox and leucine zipper protein Homez
    Protein Accession:
    Secondary Accessions:
    • A1L445
    • B4DZ80
    • F8WCA3
    • Q6P049
    • Q86XB6
    • Q9P2A5

    Protein attributes for HOMEZ Gene

    550 amino acids
    Molecular mass:
    61240 Da
    Quaternary structure:
    • Homodimer or heterodimer (Potential). Interacts with HOXC8.
    • Sequence=AAN76991.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HOMEZ Gene

    Alternative splice isoforms for HOMEZ Gene


neXtProt entry for HOMEZ Gene

Post-translational modifications for HOMEZ Gene

  • Ubiquitination at Lys230
  • Modification sites at PhosphoSitePlus

Other Protein References for HOMEZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOMEZ Gene

Domains & Families for HOMEZ Gene

Gene Families for HOMEZ Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOMEZ Gene

Suggested Antigen Peptide Sequences for HOMEZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HOMEZ: view

No data available for UniProtKB/Swiss-Prot for HOMEZ Gene

Function for HOMEZ Gene

Molecular function for HOMEZ Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional regulator.

Phenotypes From GWAS Catalog for HOMEZ Gene

Gene Ontology (GO) - Molecular Function for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0003714 transcription corepressor activity IBA --
genes like me logo Genes that share ontologies with HOMEZ: view
genes like me logo Genes that share phenotypes with HOMEZ: view

Animal Models for HOMEZ Gene

MGI Knock Outs for HOMEZ:
  • Homez Homez<tm1e(KOMP)Wtsi>

Animal Model Products

Clone Products

  • Addgene plasmids for HOMEZ

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOMEZ Gene

Localization for HOMEZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOMEZ Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOMEZ gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with HOMEZ: view

Pathways & Interactions for HOMEZ Gene

SuperPathways for HOMEZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HOMEZ: view

No data available for Pathways by source and SIGNOR curated interactions for HOMEZ Gene

Drugs & Compounds for HOMEZ Gene

(1) Drugs for HOMEZ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HOMEZ: view

Transcripts for HOMEZ Gene

mRNA/cDNA for HOMEZ Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(203) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOMEZ Gene

Homeobox and leucine zipper encoding:
Representative Sequences:

Clone Products

  • Addgene plasmids for HOMEZ

Alternative Splicing Database (ASD) splice patterns (SP) for HOMEZ Gene

No ASD Table

Relevant External Links for HOMEZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOMEZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOMEZ Gene

Protein differential expression in normal tissues from HIPED for HOMEZ Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOMEZ Gene

Protein tissue co-expression partners for HOMEZ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HOMEZ Gene:


SOURCE GeneReport for Unigene cluster for HOMEZ Gene:


mRNA Expression by UniProt/SwissProt for HOMEZ Gene:

Tissue specificity: Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.

Evidence on tissue expression from TISSUES for HOMEZ Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with HOMEZ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOMEZ Gene

Orthologs for HOMEZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOMEZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HOMEZ 34 33
  • 98.93 (n)
(Canis familiaris)
Mammalia HOMEZ 34 33
  • 90.88 (n)
(Bos Taurus)
Mammalia HOMEZ 33
  • 90.18 (n)
KIAA1443 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Homez 33
  • 81.6 (n)
(Mus musculus)
Mammalia Homez 16 34 33
  • 80.21 (n)
(Monodelphis domestica)
Mammalia HOMEZ 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia HOMEZ 34
  • 59 (a)
(Anolis carolinensis)
Reptilia HOMEZ 34
  • 48 (a)
(Danio rerio)
Actinopterygii homez 34
  • 18 (a)
HOMEZ (1 of 2) 34
  • 14 (a)
Species where no ortholog for HOMEZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOMEZ Gene

Gene Tree for HOMEZ (if available)
Gene Tree for HOMEZ (if available)
Evolutionary constrained regions (ECRs) for HOMEZ: view image

Paralogs for HOMEZ Gene

Paralogs for HOMEZ Gene

genes like me logo Genes that share paralogs with HOMEZ: view

Variants for HOMEZ Gene

Sequence variations from dbSNP and Humsavar for HOMEZ Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000044977 -- 23,274,675(-) A/C 3_prime_UTR_variant
rs1000078309 -- 23,282,744(-) T/C intron_variant
rs1000168744 -- 23,273,942(-) A/G 3_prime_UTR_variant
rs1000323310 -- 23,280,082(-) G/A intron_variant
rs1000342342 -- 23,285,979(-) C/G 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for HOMEZ Gene

Variant ID Type Subtype PubMed ID
esv2763062 CNV gain 21179565

Variation tolerance for HOMEZ Gene

Residual Variation Intolerance Score: 52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.30; 96.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOMEZ Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOMEZ Gene

Disorders for HOMEZ Gene

Additional Disease Information for HOMEZ

No disorders were found for HOMEZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOMEZ Gene

Publications for HOMEZ Gene

  1. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PMID: 12925734) Bayarsaihan D … Ruddle FH (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for HOMEZ Gene

  • Addgene plasmids for HOMEZ

Sources for HOMEZ Gene

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