Aliases for HOMER2 Gene
External Ids for HOMER2 Gene
Previous GeneCards Identifiers for HOMER2 Gene
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]
GeneCards Summary for HOMER2 Gene
HOMER2 (Homer Scaffold Protein 2) is a Protein Coding gene. Diseases associated with HOMER2 include Deafness, Autosomal Dominant 68 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are FoxO signaling pathway and Protein-protein interactions at synapses. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is HOMER1.
UniProtKB/Swiss-Prot for HOMER2 Gene
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005).