Aliases for HOMER1 Gene
External Ids for HOMER1 Gene
Previous GeneCards Identifiers for HOMER1 Gene
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOMER1 Gene
HOMER1 (Homer Scaffold Protein 1) is a Protein Coding gene. Diseases associated with HOMER1 include Phelan-Mcdermid Syndrome and Bipolar Disorder. Among its related pathways are Circadian entrainment and BDNF-TrkB Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and signaling receptor binding. An important paralog of this gene is HOMER2.
UniProtKB/Swiss-Prot Summary for HOMER1 Gene
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).