Aliases for HOMER1 Gene
External Ids for HOMER1 Gene
Previous GeneCards Identifiers for HOMER1 Gene
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOMER1 Gene
HOMER1 (Homer Scaffolding Protein 1) is a Protein Coding gene. Diseases associated with HOMER1 include Ogden Syndrome. Among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include identical protein binding and receptor binding. An important paralog of this gene is HOMER3.
UniProtKB/Swiss-Prot for HOMER1 Gene
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.