This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008] See more...

Aliases for HOMER1 Gene

Aliases for HOMER1 Gene

  • Homer Scaffold Protein 1 2 3 5
  • Homer Scaffolding Protein 1 2 3
  • Homer Protein Homolog 1 3 4
  • Homer-1 3 4
  • SYN47 3 4
  • Homer, Neuronal Immediate Early Gene, 1 3
  • Homer Homolog 1 (Drosophila) 2
  • Homer Homolog 1 3
  • HOMER1A 3
  • HOMER1B 3
  • HOMER1C 3
  • HOMER 3
  • Ves-1 3

External Ids for HOMER1 Gene

Previous GeneCards Identifiers for HOMER1 Gene

  • GC05M078910
  • GC05M078708
  • GC05M078753
  • GC05M078755
  • GC05M078705
  • GC05M073877

Summaries for HOMER1 Gene

Entrez Gene Summary for HOMER1 Gene

  • This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOMER1 Gene

HOMER1 (Homer Scaffold Protein 1) is a Protein Coding gene. Diseases associated with HOMER1 include Phelan-Mcdermid Syndrome and Bipolar Disorder. Among its related pathways are Circadian entrainment and BDNF-TrkB Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and signaling receptor binding. An important paralog of this gene is HOMER2.

UniProtKB/Swiss-Prot Summary for HOMER1 Gene

  • Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).

Gene Wiki entry for HOMER1 Gene

Additional gene information for HOMER1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOMER1 Gene

Genomics for HOMER1 Gene

GeneHancer (GH) Regulatory Elements for HOMER1 Gene


GeneHancers around HOMER1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOMER1

Top Transcription factor binding sites by QIAGEN in the HOMER1 gene promoter:
  • GATA-1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for HOMER1 Gene

Genomic Locations for HOMER1 Gene
chr5:79,372,636-79,514,134
(GRCh38/hg38)
Size:
141,499 bases
Orientation:
Minus strand
chr5:78,668,459-78,810,040
(GRCh37/hg19)
Size:
141,582 bases
Orientation:
Minus strand

Genomic View for HOMER1 Gene

Genes around HOMER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOMER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOMER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOMER1 Gene

Proteins for HOMER1 Gene

  • Protein details for HOMER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YM7-HOME1_HUMAN
    Recommended name:
    Homer protein homolog 1
    Protein Accession:
    Q86YM7
    Secondary Accessions:
    • B2R688
    • O96003
    • Q86YM5

    Protein attributes for HOMER1 Gene

    Size:
    354 amino acids
    Molecular mass:
    40277 Da
    Quaternary structure:
    • Tetramer; this tetrameric structure is critical for forming the high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Interacts with SHANK1; forms high-order polymerized complex with a mesh-like network structure, at least composed of SHANK1, HOMER1 and DLGAP1; the complex formation is SHANK1 multimerization dependent.Interacts with SHANK1; forms high-order polymerized complex with a mesh-like network structure, at least composed of SHANK1, HOMER1 and DLGAP1; the complex formation is SHANK1 multimerization dependent (By similarity). Interacts with NFATC4 (PubMed:18218901).

    Alternative splice isoforms for HOMER1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOMER1 Gene

Post-translational modifications for HOMER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOMER1 Gene

No data available for DME Specific Peptides for HOMER1 Gene

Domains & Families for HOMER1 Gene

Gene Families for HOMER1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HOMER1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOMER1 Gene

GenScript: Design optimal peptide antigens:
  • Homer protein homolog 1 (HOME1_HUMAN)
  • Homer homolog 1 (Drosophila) (Q5U5K4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86YM7

UniProtKB/Swiss-Prot:

HOME1_HUMAN :
  • The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. The coiled-Coil domain forms an antiparallel tetrameric arrangement (By similarity).
  • Belongs to the Homer family.
Domain:
  • The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. The coiled-Coil domain forms an antiparallel tetrameric arrangement (By similarity).
Family:
  • Belongs to the Homer family.
genes like me logo Genes that share domains with HOMER1: view

Function for HOMER1 Gene

Molecular function for HOMER1 Gene

UniProtKB/Swiss-Prot Function:
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).

Phenotypes From GWAS Catalog for HOMER1 Gene

Gene Ontology (GO) - Molecular Function for HOMER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0035256 G protein-coupled glutamate receptor binding IBA 21873635
GO:0035591 signaling adaptor activity IC 14505576
GO:0044325 ion channel binding IPI 14505576
genes like me logo Genes that share ontologies with HOMER1: view
genes like me logo Genes that share phenotypes with HOMER1: view

Animal Models for HOMER1 Gene

MGI Knock Outs for HOMER1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOMER1 Gene

Localization for HOMER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOMER1 Gene

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, dendritic spine. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOMER1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HOMER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA 21873635
GO:0014069 postsynaptic density IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HOMER1: view

Pathways & Interactions for HOMER1 Gene

genes like me logo Genes that share pathways with HOMER1: view

Pathways by source for HOMER1 Gene

2 KEGG pathways for HOMER1 Gene
1 Cell Signaling Technology pathway for HOMER1 Gene

Gene Ontology (GO) - Biological Process for HOMER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003009 skeletal muscle contraction IEA --
GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway TAS 9808459
GO:0007216 G protein-coupled glutamate receptor signaling pathway IBA 21873635
GO:0007268 chemical synaptic transmission TAS 9808458
GO:0009967 positive regulation of signal transduction IC 14505576
genes like me logo Genes that share ontologies with HOMER1: view

No data available for SIGNOR curated interactions for HOMER1 Gene

Drugs & Compounds for HOMER1 Gene

(2) Drugs for HOMER1 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levodopa Approved Pharma Agonist 461
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with HOMER1: view

Transcripts for HOMER1 Gene

mRNA/cDNA for HOMER1 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOMER1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - -
SP3: - - - -
SP4:

Relevant External Links for HOMER1 Gene

GeneLoc Exon Structure for
HOMER1

Expression for HOMER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOMER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOMER1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.5) and Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for HOMER1 Gene

This gene is overexpressed in Brain (18.7), Lung (16.9), Fetal Brain (10.3), and Frontal cortex (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOMER1 Gene



Protein tissue co-expression partners for HOMER1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOMER1

SOURCE GeneReport for Unigene cluster for HOMER1 Gene:

Hs.591761

Evidence on tissue expression from TISSUES for HOMER1 Gene

  • Nervous system(4.8)
  • Pancreas(4.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with HOMER1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOMER1 Gene

Orthologs for HOMER1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOMER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOMER1 31 30
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HOMER1 31 30
  • 96.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HOMER1 31 30
  • 94.26 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOMER1 31
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Homer1 17 31 30
  • 91.15 (n)
rat
(Rattus norvegicus)
Mammalia Homer1 30
  • 89.55 (n)
oppossum
(Monodelphis domestica)
Mammalia HOMER1 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOMER1 31 30
  • 88.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOMER1 31
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia homer1 30
  • 82.49 (n)
zebrafish
(Danio rerio)
Actinopterygii HOMER1 31
  • 80 (a)
OneToOne
homer1 30
  • 70.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta homer 31
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToMany
Species where no ortholog for HOMER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOMER1 Gene

ENSEMBL:
Gene Tree for HOMER1 (if available)
TreeFam:
Gene Tree for HOMER1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOMER1: view image

Paralogs for HOMER1 Gene

Paralogs for HOMER1 Gene

(2) SIMAP similar genes for HOMER1 Gene using alignment to 3 proteins:

  • HOME1_HUMAN
  • Q5U5K4_HUMAN
  • Q86YM6_HUMAN
genes like me logo Genes that share paralogs with HOMER1: view

Variants for HOMER1 Gene

Additional dbSNP identifiers (rs#s) for HOMER1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOMER1 Gene

Variant ID Type Subtype PubMed ID
esv2730351 CNV deletion 23290073
esv2730352 CNV deletion 23290073
esv2730353 CNV deletion 23290073
esv3381279 CNV insertion 20981092
esv3605531 CNV gain 21293372
esv3890659 CNV gain 25118596
nsv1126063 CNV deletion 24896259
nsv462218 CNV gain 19166990
nsv472347 CNV novel sequence insertion 20440878
nsv598742 CNV gain 21841781

Variation tolerance for HOMER1 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOMER1 Gene

Human Gene Mutation Database (HGMD)
HOMER1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOMER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOMER1 Gene

Disorders for HOMER1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for HOMER1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
phelan-mcdermid syndrome
  • phmds
bipolar disorder
  • major affective disorder 1
autism
  • autistic disorder
fragile x syndrome
  • fxs
pervasive developmental disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HOMER1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HOMER1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOMER1 Gene

Publications for HOMER1 Gene

  1. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. (PMID: 9808458) Xiao B … Worley PF (Neuron 1998) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. No association of alcohol dependence with HOMER 1 and 2 genetic variants. (PMID: 20333726) Preuss UW … Zill P (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41 54
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 41 54
  5. HOMER1 promoter analysis in Parkinson's disease: association study with psychotic symptoms. (PMID: 19648775) De Luca V … Quattrone A (Neuropsychobiology 2009) 3 41 54

Products for HOMER1 Gene

Sources for HOMER1 Gene