Aliases for HNRNPUL2 Gene
Aliases for HNRNPUL2 Gene
External Ids for HNRNPUL2 Gene
- HGNC: 25451
- Entrez Gene: 221092
- Ensembl: ENSG00000214753
- UniProtKB: Q1KMD3
Previous HGNC Symbols for HNRNPUL2 Gene
- HNRPUL2
Previous GeneCards Identifiers for HNRNPUL2 Gene
- GC11M062236
- GC11M062482
- GC11M058810
- GC11M062493
Summaries for HNRNPUL2 Gene
GeneCards Summary for HNRNPUL2 Gene
HNRNPUL2 (Heterogeneous Nuclear Ribonucleoprotein U Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include kinase activity. An important paralog of this gene is HNRNPUL2-BSCL2.
Additional gene information for HNRNPUL2 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL2 Gene
Genomics for HNRNPUL2 Gene
GeneHancer (GH) Regulatory Elements for HNRNPUL2 Gene
Promoters and enhancers for HNRNPUL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HNRNPUL2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for HNRNPUL2 Gene
Genomic Locations for HNRNPUL2 Gene
- chr11:62,712,625-62,727,385
- (GRCh38/hg38)
- Size:
- 14,761 bases
- Orientation:
- Minus strand
- chr11:62,480,097-62,494,857
- (GRCh37/hg19)
Genomic View for HNRNPUL2 Gene
Genes around HNRNPUL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3 by Ensembl
- 11q12.3 by Entrez Gene
- 11q12.3 by HGNC
HNRNPUL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPUL2 Gene
Proteins for HNRNPUL2 Gene
-
Protein details for HNRNPUL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q1KMD3-HNRL2_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein U-like protein 2
- Protein Accession:
- Q1KMD3
- Q8N3B3
Protein attributes for HNRNPUL2 Gene
- Size:
- 747 amino acids
- Molecular mass:
- 85105 Da
- Quaternary structure:
-
- Binds to MLF1 and retains it in the nucleus.
Protein Expression for HNRNPUL2 Gene
Post-translational modifications for HNRNPUL2 Gene
Other Protein References for HNRNPUL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HNRNPUL2
- Novus Biologicals Antibodies for HNRNPUL2
-
Abcam antibodies for HNRNPUL2
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Protein Products
-
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Assay Products
No data available for DME Specific Peptides for HNRNPUL2 Gene
Domains & Families for HNRNPUL2 Gene
Gene Families for HNRNPUL2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for HNRNPUL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPUL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HNRNPUL2 Gene
Function for HNRNPUL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
Phenotypes for HNRNPUL2 Gene
- GenomeRNAi human phenotypes for HNRNPUL2:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPUL2
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miRNA for HNRNPUL2 Gene
- miRTarBase miRNAs that target HNRNPUL2
miRNA Products
- Search ViGene Biosciences for HNRNPUL2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HNRNPUL2
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- genomics-online: shRNA clones - Search results for available HNRNPUL2 gene related products
-
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Clone Products
-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HNRNPUL2 gene related products
- orf clones - Search results for available HNRNPUL2 gene related products
- Applied Biological Materials Clones for HNRNPUL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HNRNPUL2
-
ViGene Biosciences adenoviral particle packaged cDNA for HNRNPUL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPUL2 gene
-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPUL2 Gene
Localization for HNRNPUL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0016020 | membrane | HDA,IDA | 19946888 |
Pathways & Interactions for HNRNPUL2 Gene
No Data Available
Interacting Proteins for HNRNPUL2 Gene
Selected Interacting proteins:
ENSP00000301785
Q1KMD3-HNRL2_HUMAN
for HNRNPUL2 Gene via
STRING
IID
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for HNRNPUL2 Gene
Transcripts for HNRNPUL2 Gene
mRNA/cDNA for HNRNPUL2 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (779) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPUL2 Gene
- Heterogeneous nuclear ribonucleoprotein U-like 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPUL2
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- Applied Biological Materials CRISPR for HNRNPUL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPUL2
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miRNA Products
- Search ViGene Biosciences for HNRNPUL2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HNRNPUL2
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- genomics-online: shRNA clones - Search results for available HNRNPUL2 gene related products
-
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Clone Products
-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HNRNPUL2 gene related products
- orf clones - Search results for available HNRNPUL2 gene related products
- Applied Biological Materials Clones for HNRNPUL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HNRNPUL2 Gene
This gene is overexpressed in Tlymphocyte (9.9), Peripheral blood mononuclear cells (7.1), and Lymph node (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPUL2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HNRNPUL2 Gene:
HNRNPUL2SOURCE GeneReport for Unigene cluster for HNRNPUL2 Gene:
Hs.657058Evidence on tissue expression from TISSUES for HNRNPUL2 Gene
- Heart(2.5)
- Spleen(2.5)
- Nervous system(2.5)
- Kidney(2.3)
- Intestine(2.2)
- Lung(2.2)
- Muscle(2.2)
Primer Products
-
OriGene qPCR primer pairs for HNRNPUL2
- genomics-online: primer clones - Search results for available HNRNPUL2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPUL2 Gene
Orthologs for HNRNPUL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPUL2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| HNRNPUL2 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | HNRNPUL2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hnrnpul2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Hnrnpul2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hnrnpul2 33 |
|
||
| Str.17711 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11697 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | HNRNPUL2 34 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG30122 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y41E3.11 34 |
|
OneToMany |
- Species where no ortholog for HNRNPUL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HNRNPUL2 Gene
(4) SIMAP similar genes for HNRNPUL2 Gene using alignment to 2 proteins:
Variants for HNRNPUL2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000314782 | -- | 62,713,697(-) | C/T | 3_prime_UTR_variant | |
| rs1000387734 | -- | 62,716,705(-) | G/A | intron_variant | |
| rs1000417515 | -- | 62,716,363(-) | A/G | intron_variant | |
| rs1000457536 | -- | 62,719,624(-) | G/A | intron_variant | |
| rs1000707265 | -- | 62,727,479(-) | C/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.78;
47.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HNRNPUL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HNRNPUL2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPUL2 Gene
Disorders for HNRNPUL2 Gene
Additional Disease Information for HNRNPUL2
No disorders were found for HNRNPUL2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPUL2 Gene
Publications for HNRNPUL2 Gene
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 58
- BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E … Raught B (Molecular & cellular proteomics : MCP 2015) 3 58
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
Products for HNRNPUL2 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for HNRNPUL2
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- ViGene Biosciences adenoviral particle packaged cDNA for HNRNPUL2 gene
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- genomics-online: cdna clones - Search results for available HNRNPUL2 gene related products
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Sources for HNRNPUL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
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- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems