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Aliases for HNRNPUL2 Gene

Aliases for HNRNPUL2 Gene

  • Heterogeneous Nuclear Ribonucleoprotein U Like 2 2 3 5
  • Scaffold-Attachment Factor A2 3 4
  • HNRPUL2 3 4
  • SAF-A2 3 4
  • Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 2 3
  • Heterogeneous Nuclear Ribonucleoprotein U-Like 2 2

External Ids for HNRNPUL2 Gene

Previous HGNC Symbols for HNRNPUL2 Gene

  • HNRPUL2

Previous GeneCards Identifiers for HNRNPUL2 Gene

  • GC11M062236
  • GC11M062482
  • GC11M058810
  • GC11M062493

Summaries for HNRNPUL2 Gene

GeneCards Summary for HNRNPUL2 Gene

HNRNPUL2 (Heterogeneous Nuclear Ribonucleoprotein U Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include kinase activity. An important paralog of this gene is HNRNPUL2-BSCL2.

Additional gene information for HNRNPUL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL2 Gene

Genomics for HNRNPUL2 Gene

GeneHancer (GH) Regulatory Elements for HNRNPUL2 Gene

Promoters and enhancers for HNRNPUL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I062724 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.2 215 6.2 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC SSRP1 TTC9C HNRNPUL2 HNRNPUL2-BSCL2 NXF1 GANAB INTS5 CSKMT LOC105369332 MTA2 EML3
GH11I062750 Enhancer 0.4 ENCODE 12 -23.7 -23725 0.4 PRDM10 ZNF384 GC11M062817 PIR44039 PIR37929 TTC9C HNRNPUL2 HNRNPUL2-BSCL2 TAF6L SLC3A2 SNHG1 SNORD22
GH11I062852 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.6 -128.5 -128452 5.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SNHG1 SLC3A2 ENSG00000278527 GC11M062911 GC11M062920 GC11M062923 GC11M062930 SNORD27 SNORD28 SNORD29
GH11I062712 Enhancer 0.9 ENCODE dbSUPER 0.4 +13.5 13459 3.5 FOXA2 MAX RAD21 YY1 FOSL1 ZNF316 CBFA2T2 ZNF600 NFE2 RXRA PIR38618 TTC9C UBXN1 LBHD1 LRRN4CL POLR2G GANAB B3GAT3 UQCC3 ROM1
GH11I062722 Enhancer 0.6 ENCODE 0.4 +5.2 5181 0.2 CTCF SAP130 TEAD1 ARID4B SIN3A MNT RAD21 TEAD3 ZNF157 ZBTB33 HNRNPUL2 PIR38618 HNRNPUL2-BSCL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HNRNPUL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HNRNPUL2 gene promoter:

Genomic Locations for HNRNPUL2 Gene

Genomic Locations for HNRNPUL2 Gene
chr11:62,712,625-62,727,385
(GRCh38/hg38)
Size:
14,761 bases
Orientation:
Minus strand
chr11:62,480,097-62,494,857
(GRCh37/hg19)

Genomic View for HNRNPUL2 Gene

Genes around HNRNPUL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPUL2 Gene

Proteins for HNRNPUL2 Gene

  • Protein details for HNRNPUL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1KMD3-HNRL2_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 2
    Protein Accession:
    Q1KMD3
    Secondary Accessions:
    • Q8N3B3

    Protein attributes for HNRNPUL2 Gene

    Size:
    747 amino acids
    Molecular mass:
    85105 Da
    Quaternary structure:
    • Binds to MLF1 and retains it in the nucleus.

neXtProt entry for HNRNPUL2 Gene

Post-translational modifications for HNRNPUL2 Gene

  • Ubiquitination at isoforms=273, posLast=406406, isoforms=471, isoforms=553, and isoforms=601
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPUL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPUL2 Gene

Domains & Families for HNRNPUL2 Gene

Gene Families for HNRNPUL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HNRNPUL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPUL2: view

No data available for UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Function for HNRNPUL2 Gene

Gene Ontology (GO) - Molecular Function for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with HNRNPUL2: view

Phenotypes for HNRNPUL2 Gene

genes like me logo Genes that share phenotypes with HNRNPUL2: view

Animal Model Products

CRISPR Products

miRNA for HNRNPUL2 Gene

miRTarBase miRNAs that target HNRNPUL2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPUL2 Gene

Localization for HNRNPUL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPUL2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with HNRNPUL2: view

Pathways & Interactions for HNRNPUL2 Gene

SuperPathways for HNRNPUL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HNRNPUL2: view

No data available for Pathways by source and SIGNOR curated interactions for HNRNPUL2 Gene

Drugs & Compounds for HNRNPUL2 Gene

No Compound Related Data Available

Transcripts for HNRNPUL2 Gene

mRNA/cDNA for HNRNPUL2 Gene

Unigene Clusters for HNRNPUL2 Gene

Heterogeneous nuclear ribonucleoprotein U-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL2 Gene

No ASD Table

Relevant External Links for HNRNPUL2 Gene

GeneLoc Exon Structure for
HNRNPUL2
ECgene alternative splicing isoforms for
HNRNPUL2

Expression for HNRNPUL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPUL2 Gene

Protein differential expression in normal tissues from HIPED for HNRNPUL2 Gene

This gene is overexpressed in Tlymphocyte (9.9), Peripheral blood mononuclear cells (7.1), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPUL2 Gene



Protein tissue co-expression partners for HNRNPUL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPUL2 Gene:

HNRNPUL2

SOURCE GeneReport for Unigene cluster for HNRNPUL2 Gene:

Hs.657058

Evidence on tissue expression from TISSUES for HNRNPUL2 Gene

  • Heart(2.5)
  • Spleen(2.5)
  • Nervous system(2.5)
  • Kidney(2.3)
  • Intestine(2.2)
  • Lung(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with HNRNPUL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPUL2 Gene

Orthologs for HNRNPUL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPUL2 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 96 (a)
OneToMany
HNRNPUL2 33
  • 94.96 (n)
cow
(Bos Taurus)
Mammalia HNRNPUL2 33 34
  • 94.33 (n)
rat
(Rattus norvegicus)
Mammalia Hnrnpul2 33
  • 92.26 (n)
mouse
(Mus musculus)
Mammalia Hnrnpul2 33 16 34
  • 92.13 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 60 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpul2 33
  • 61.47 (n)
Str.17711 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11697 33
zebrafish
(Danio rerio)
Actinopterygii HNRNPUL2 34
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30122 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.11 34
  • 8 (a)
OneToMany
Species where no ortholog for HNRNPUL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPUL2 Gene

ENSEMBL:
Gene Tree for HNRNPUL2 (if available)
TreeFam:
Gene Tree for HNRNPUL2 (if available)

Paralogs for HNRNPUL2 Gene

Paralogs for HNRNPUL2 Gene

(4) SIMAP similar genes for HNRNPUL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HNRNPUL2: view

Variants for HNRNPUL2 Gene

Sequence variations from dbSNP and Humsavar for HNRNPUL2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000314782 -- 62,713,697(-) C/T 3_prime_UTR_variant
rs1000387734 -- 62,716,705(-) G/A intron_variant
rs1000417515 -- 62,716,363(-) A/G intron_variant
rs1000457536 -- 62,719,624(-) G/A intron_variant
rs1000707265 -- 62,727,479(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL2 Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855
nsv555174 CNV gain 21841781

Variation tolerance for HNRNPUL2 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPUL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPUL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Disorders for HNRNPUL2 Gene

Additional Disease Information for HNRNPUL2

No disorders were found for HNRNPUL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPUL2 Gene

Publications for HNRNPUL2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 58
  3. BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E … Raught B (Molecular & cellular proteomics : MCP 2015) 3 58
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58

Products for HNRNPUL2 Gene

Sources for HNRNPUL2 Gene

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