Aliases for HNRNPUL2 Gene

Aliases for HNRNPUL2 Gene

  • Heterogeneous Nuclear Ribonucleoprotein U Like 2 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 2 3 4
  • Scaffold-Attachment Factor A2 3 4
  • HNRPUL2 3 4
  • SAF-A2 3 4
  • Heterogeneous Nuclear Ribonucleoprotein U-Like 2 2
  • DKFZp762N1910 2
  • HNRNPUL2 5

External Ids for HNRNPUL2 Gene

Previous HGNC Symbols for HNRNPUL2 Gene

  • HNRPUL2

Previous GeneCards Identifiers for HNRNPUL2 Gene

  • GC11M062236
  • GC11M062482
  • GC11M058810
  • GC11M062493

Summaries for HNRNPUL2 Gene

GeneCards Summary for HNRNPUL2 Gene

HNRNPUL2 (Heterogeneous Nuclear Ribonucleoprotein U Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include kinase activity. An important paralog of this gene is HNRNPUL2-BSCL2.

Additional gene information for HNRNPUL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPUL2 Gene

Genomics for HNRNPUL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HNRNPUL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J062724 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.1 56 6.8 SP1 HNRNPL CREB1 PRDM10 ZNF629 TFE3 IKZF1 RFX5 KDM1A ZNF692 TTC9C HNRNPUL2 HNRNPUL2-BSCL2 AHNAK GANAB MN309261 BSCL2
GH11J062712 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 600.4 +13.4 13372 3.8 JUND PRDM1 RBFOX2 NR2C1 SP1 ZNF600 FOXA2 ZNF316 NR2C2 YY1 piR-45619 HNRNPUL2 TTC9C UBXN1 LBHD1 LRRN4CL POLR2G GANAB UQCC3 B3GAT3
GH11J062749 Enhancer 0.6 Ensembl ENCODE 12 -23.2 -23244 2.6 PRDM10 ZBTB33 ZNF362 ZNF384 SPI1 MN297053 piR-33614-038 piR-44930 TTC9C HNRNPUL2 HNRNPUL2-BSCL2 TAF6L SNORD22 SLC3A2 SNHG1
GH11J062851 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.6 -130.8 -130771 14.3 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 NXF1 SLC3A2 piR-40154-030 piR-40163-016 piR-52261-046 SNHG1 CSKMT MTA2 LOC105369332 GANAB
GH11J062957 Enhancer 0.3 Ensembl 5.3 -229.6 -229644 0.2 SCRT2 SCRT1 HNRNPUL2 ENSG00000285388 lnc-SLC22A6-1 RF00017-935 RN7SL259P SLC22A6 CHRM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPUL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPUL2

Top Transcription factor binding sites by QIAGEN in the HNRNPUL2 gene promoter:
  • c-Myc
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GR
  • GR-alpha
  • Max

Genomic Locations for HNRNPUL2 Gene

Genomic Locations for HNRNPUL2 Gene
chr11:62,712,630-62,727,457
(GRCh38/hg38)
Size:
14,828 bases
Orientation:
Minus strand
chr11:62,480,097-62,494,857
(GRCh37/hg19)
Size:
14,761 bases
Orientation:
Minus strand

Genomic View for HNRNPUL2 Gene

Genes around HNRNPUL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPUL2 Gene

Proteins for HNRNPUL2 Gene

  • Protein details for HNRNPUL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1KMD3-HNRL2_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 2
    Protein Accession:
    Q1KMD3
    Secondary Accessions:
    • Q8N3B3

    Protein attributes for HNRNPUL2 Gene

    Size:
    747 amino acids
    Molecular mass:
    85105 Da
    Quaternary structure:
    • Binds to MLF1 and retains it in the nucleus.

neXtProt entry for HNRNPUL2 Gene

Post-translational modifications for HNRNPUL2 Gene

  • Ubiquitination at Lys273, Lys406, Lys471, Lys553, and Lys601
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPUL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPUL2 Gene

Domains & Families for HNRNPUL2 Gene

Gene Families for HNRNPUL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HNRNPUL2 Gene

Suggested Antigen Peptide Sequences for HNRNPUL2 Gene

GenScript: Design optimal peptide antigens:
  • Scaffold-attachment factor A2 (HNRL2_HUMAN)
genes like me logo Genes that share domains with HNRNPUL2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Function for HNRNPUL2 Gene

Gene Ontology (GO) - Molecular Function for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA 21873635
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with HNRNPUL2: view
genes like me logo Genes that share phenotypes with HNRNPUL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPUL2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPUL2 Gene

Localization for HNRNPUL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPUL2 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IBA,IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with HNRNPUL2: view

Pathways & Interactions for HNRNPUL2 Gene

PathCards logo

SuperPathways for HNRNPUL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HNRNPUL2: view

No data available for Pathways by source and SIGNOR curated interactions for HNRNPUL2 Gene

Drugs & Compounds for HNRNPUL2 Gene

No Compound Related Data Available

Transcripts for HNRNPUL2 Gene

mRNA/cDNA for HNRNPUL2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPUL2

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL2 Gene

No ASD Table

Relevant External Links for HNRNPUL2 Gene

GeneLoc Exon Structure for
HNRNPUL2

Expression for HNRNPUL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPUL2 Gene

Protein differential expression in normal tissues from HIPED for HNRNPUL2 Gene

This gene is overexpressed in Tlymphocyte (9.9), Peripheral blood mononuclear cells (7.1), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPUL2 Gene



Protein tissue co-expression partners for HNRNPUL2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPUL2

SOURCE GeneReport for Unigene cluster for HNRNPUL2 Gene:

Hs.657058

Evidence on tissue expression from TISSUES for HNRNPUL2 Gene

  • Heart(2.8)
  • Nervous system(2.8)
  • Intestine(2.7)
  • Spleen(2.5)
  • Liver(2.4)
  • Kidney(2.3)
  • Lung(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with HNRNPUL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPUL2 Gene

Orthologs for HNRNPUL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HNRNPUL2 30 31
  • 99.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 96 (a)
OneToMany
HNRNPUL2 30
  • 94.96 (n)
Cow
(Bos Taurus)
Mammalia HNRNPUL2 30 31
  • 94.33 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Hnrnpul2 30
  • 92.26 (n)
Mouse
(Mus musculus)
Mammalia Hnrnpul2 30 17 31
  • 92.13 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 82 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 80 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 60 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hnrnpul2 30
  • 61.47 (n)
Str.17711 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.11697 30
Zebrafish
(Danio rerio)
Actinopterygii HNRNPUL2 31
  • 35 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG30122 31
  • 17 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y41E3.11 31
  • 8 (a)
OneToMany
Species where no ortholog for HNRNPUL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HNRNPUL2 Gene

ENSEMBL:
Gene Tree for HNRNPUL2 (if available)
TreeFam:
Gene Tree for HNRNPUL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPUL2: view image

Paralogs for HNRNPUL2 Gene

Paralogs for HNRNPUL2 Gene

(4) SIMAP similar genes for HNRNPUL2 Gene using alignment to 2 proteins:

  • HNRL2_HUMAN
  • L8E7F7_HUMAN
genes like me logo Genes that share paralogs with HNRNPUL2: view

Variants for HNRNPUL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPUL2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
690303 Uncertain Significance: not provided 62,724,323(-) G/T NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for HNRNPUL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL2 Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855
nsv555174 CNV gain 21841781

Variation tolerance for HNRNPUL2 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPUL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPUL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Disorders for HNRNPUL2 Gene

No disorders were found for HNRNPUL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPUL2 Gene

Publications for HNRNPUL2 Gene

  1. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  2. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (PMID: 30833792) Hubel P … Pichlmair A (Nature immunology 2019) 3
  3. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. (PMID: 30948266) Lee SH … Mayr C (Molecular cell 2019) 3
  4. Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. (PMID: 30462309) Ivanochko D … Arrowsmith CH (Nucleic acids research 2019) 3
  5. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. (PMID: 29911972) Lampert F … Peter M (eLife 2018) 3

Products for HNRNPUL2 Gene

Sources for HNRNPUL2 Gene