HNRNPUL2 Gene (Protein Coding)

Heterogeneous Nuclear Ribonucleoprotein U Like 2

GC11M062712
GIFtS:
34
See more...

Aliases for HNRNPUL2 Gene

Aliases for HNRNPUL2 Gene

  • Heterogeneous Nuclear Ribonucleoprotein U Like 2 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 2 3 4
  • Scaffold-Attachment Factor A2 3 4
  • HNRPUL2 3 4
  • SAF-A2 3 4
  • Heterogeneous Nuclear Ribonucleoprotein U-Like 2 2
  • DKFZp762N1910 2
  • HNRNPUL2 5

External Ids for HNRNPUL2 Gene

Previous HGNC Symbols for HNRNPUL2 Gene

  • HNRPUL2

Previous GeneCards Identifiers for HNRNPUL2 Gene

  • GC11M062236
  • GC11M062482
  • GC11M058810
  • GC11M062493

Summaries for HNRNPUL2 Gene

GeneCards Summary for HNRNPUL2 Gene

HNRNPUL2 (Heterogeneous Nuclear Ribonucleoprotein U Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include kinase activity. An important paralog of this gene is HNRNPUL2-BSCL2.

Additional gene information for HNRNPUL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPUL2 Gene

Genomics for HNRNPUL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HNRNPUL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPUL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPUL2

Top Transcription factor binding sites by QIAGEN in the HNRNPUL2 gene promoter:
  • c-Myc
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GR
  • GR-alpha
  • Max

Genomic Locations for HNRNPUL2 Gene

Latest Assembly
chr11:62,712,630-62,727,457
(GRCh38/hg38)
Size:
14,828 bases
Orientation:
Minus strand

Previous Assembly
chr11:62,480,102-62,494,929
(GRCh37/hg19 by Entrez Gene)
Size:
14,828 bases
Orientation:
Minus strand

chr11:62,480,102-62,494,821
(GRCh37/hg19 by Ensembl)
Size:
14,720 bases
Orientation:
Minus strand

Genomic View for HNRNPUL2 Gene

Genes around HNRNPUL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HNRNPUL2 Gene

Proteins for HNRNPUL2 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for HNRNPUL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1KMD3-HNRL2_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 2
    Protein Accession:
    Q1KMD3
    Secondary Accessions:
    • Q8N3B3

    Protein attributes for HNRNPUL2 Gene

    Size:
    747 amino acids
    Molecular mass:
    85105 Da
    Quaternary structure:
    • Binds to MLF1 and retains it in the nucleus.

neXtProt entry for HNRNPUL2 Gene

Protein Expression for HNRNPUL2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HNRNPUL2 Gene

  • Ubiquitination at Lys273, Lys406, Lys471, Lys553, and Lys601
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPUL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for HNRNPUL2 Gene

Domains & Families for HNRNPUL2 Gene

Gene Families for HNRNPUL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HNRNPUL2 Gene

InterPro:
Blocks:
  • DNA-binding SAP
ProtoNet:

Suggested Antigen Peptide Sequences for HNRNPUL2 Gene

GenScript: Design optimal peptide antigens:
  • Scaffold-attachment factor A2 (HNRL2_HUMAN)
genes like me logo Genes that share domains with HNRNPUL2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Function for HNRNPUL2 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Gene Ontology (GO) - Molecular Function for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA 21873635
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with HNRNPUL2: view
genes like me logo Genes that share phenotypes with HNRNPUL2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPUL2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPUL2 Gene

Localization for HNRNPUL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPUL2 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IBA,IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with HNRNPUL2: view

Pathways & Interactions for HNRNPUL2 Gene

PathCards logo

SuperPathways for HNRNPUL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HNRNPUL2: view

No data available for Pathways by source and SIGNOR curated interactions for HNRNPUL2 Gene

Drugs & Compounds for HNRNPUL2 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for HNRNPUL2 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for HNRNPUL2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPUL2

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL2 Gene

No ASD Table

Relevant External Links for HNRNPUL2 Gene

GeneLoc Exon Structure for
HNRNPUL2

Expression for HNRNPUL2 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPUL2 Gene

mRNA expression in normal human tissues for HNRNPUL2 Gene
mRNA expression by GTEx for HNRNPUL2 GenemRNA expression by BioGPS for HNRNPUL2 Gene

Protein differential expression in normal tissues from HIPED for HNRNPUL2 Gene

This gene is overexpressed in Tlymphocyte (9.9), Peripheral blood mononuclear cells (7.1), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPUL2 Gene



Protein tissue co-expression partners for HNRNPUL2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPUL2

SOURCE GeneReport for Unigene cluster for HNRNPUL2 Gene:

Hs.657058

Evidence on tissue expression from TISSUES for HNRNPUL2 Gene

  • Heart(2.8)
  • Nervous system(2.8)
  • Intestine(2.6)
  • Spleen(2.5)
  • Liver(2.3)
  • Kidney(2.3)
  • Lung(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with HNRNPUL2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPUL2 Gene

Orthologs for HNRNPUL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia HNRNPUL2 30 31
  • 99.64 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia -- 31
  • 96 (a)
 OneToMany
HNRNPUL2 30
  • 94.96 (n)
Cow
(Bos Taurus)
 Mammalia HNRNPUL2 30 31
  • 94.33 (n)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Hnrnpul2 30
  • 92.26 (n)
Mouse
(Mus musculus)
 Mammalia Hnrnpul2 30 17 31
  • 92.13 (n)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 82 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 80 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 60 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia hnrnpul2 30
  • 61.47 (n)
Str.17711 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.11697 30
Zebrafish
(Danio rerio)
 Actinopterygii HNRNPUL2 31
  • 35 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG30122 31
  • 17 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea Y41E3.11 31
  • 8 (a)
 OneToMany
Species where no ortholog for HNRNPUL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HNRNPUL2 Gene

ENSEMBL:
Gene Tree for HNRNPUL2 (if available)
TreeFam:
Gene Tree for HNRNPUL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPUL2: view image

Paralogs for HNRNPUL2 Gene

Paralogs for HNRNPUL2 Gene

(4) SIMAP similar genes for HNRNPUL2 Gene using alignment to 2 proteins:

  • HNRL2_HUMAN
  • L8E7F7_HUMAN
genes like me logo Genes that share paralogs with HNRNPUL2: view

Variants for HNRNPUL2 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPUL2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1590900583 Uncertain Significance: not provided 62,724,323(-) G/T
NM_001079559.3(HNRNPUL2):c.642C>A (p.Tyr214Ter) 		NON_CODING_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HNRNPUL2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL2 Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855
nsv555174 CNV gain 21841781

Variation tolerance for HNRNPUL2 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPUL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPUL2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Disorders for HNRNPUL2 Gene

Additional Disease Information for HNRNPUL2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for HNRNPUL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPUL2 Gene

Publications for HNRNPUL2 Gene

  1. Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis. (PMID: 32838362) Li J … Liang Q (Med (New York, N.Y.) 2021) 3
  2. Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding. (PMID: 32457219) Tran DT … Itkin-Ansari P (Diabetes 2020) 3
  3. A High-Density Human Mitochondrial Proximity Interaction Network. (PMID: 32877691) Antonicka H … Shoubridge EA (Cell metabolism 2020) 3
  4. Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. (PMID: 32416067) Shu S … Polyak K (Molecular cell 2020) 3
  5. ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents. (PMID: 32780723) Lan W … Iovanna J (JCI insight 2020) 3

ExternalLinks

View latest publications for HNRNPUL2 gene in Mastermind

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