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Aliases for HNRNPUL1 Gene

Aliases for HNRNPUL1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein U Like 1 2 3 5
  • Adenovirus Early Region 1B-Associated Protein 5 3 4
  • E1B-55 KDa-Associated Protein 5 3 4
  • E1B 55kDa Associated Protein 5 2 3
  • HNRPUL1 3 4
  • E1B-AP5 3 4
  • E1BAP5 3 4
  • Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 1 3

External Ids for HNRNPUL1 Gene

Previous HGNC Symbols for HNRNPUL1 Gene

  • HNRPUL1

Previous GeneCards Identifiers for HNRNPUL1 Gene

  • GC19P046463
  • GC19P041768
  • GC19P038200

Summaries for HNRNPUL1 Gene

Entrez Gene Summary for HNRNPUL1 Gene

  • This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]

GeneCards Summary for HNRNPUL1 Gene

HNRNPUL1 (Heterogeneous Nuclear Ribonucleoprotein U Like 1) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPU.

UniProtKB/Swiss-Prot for HNRNPUL1 Gene

  • Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.

Gene Wiki entry for HNRNPUL1 Gene

Additional gene information for HNRNPUL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL1 Gene

Genomics for HNRNPUL1 Gene

GeneHancer (GH) Regulatory Elements for HNRNPUL1 Gene

Promoters and enhancers for HNRNPUL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I041261 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 619.3 +2.4 2374 7.3 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D HNRNPUL1 ZNF526 ZNF574 CCDC97 SNRPA ENSG00000269843 CYP2F2P NUMBL ITPKC SPTBN4
GH19I041294 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 146 +40.8 40821 16.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 CCDC97 ZNF526 HNRNPUL1 SNRPA ZNF574 ENSG00000269843 COQ8B TGFB1 AXL ITPKC
GH19I040747 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 123.2 -509.7 -509715 9.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF416 SNRPA C19orf54 HNRNPUL1 ENSG00000269843 CCDC97 COQ8B ZNF780A FBL AKT2 ZNF780B
GH19I040713 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 98.1 -544.1 -544128 9.2 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 ITPKC COQ8B SNRPA HNRNPUL1 ENSG00000269843 ZNF780B CCDC97 FBL AKT2 ZNF780A
GH19I040596 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 92.8 -660.8 -660780 10 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 LTBP4 HNRNPUL1 ZNF780B SNRPA ENSG00000269843 CCDC97 AKT2 FBL ZNF780A CYP2G1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HNRNPUL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HNRNPUL1 gene promoter:

Genomic Locations for HNRNPUL1 Gene

Genomic Locations for HNRNPUL1 Gene
chr19:41,262,476-41,307,693
(GRCh38/hg38)
Size:
45,218 bases
Orientation:
Plus strand
chr19:41,768,391-41,813,811
(GRCh37/hg19)

Genomic View for HNRNPUL1 Gene

Genes around HNRNPUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPUL1 Gene

Proteins for HNRNPUL1 Gene

  • Protein details for HNRNPUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUJ2-HNRL1_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 1
    Protein Accession:
    Q9BUJ2
    Secondary Accessions:
    • B3KMW7
    • O76022
    • Q6ZSZ0
    • Q7L8P4
    • Q8N6Z4
    • Q96G37
    • Q9HAL3
    • Q9UG75

    Protein attributes for HNRNPUL1 Gene

    Size:
    856 amino acids
    Molecular mass:
    95739 Da
    Quaternary structure:
    • Interacts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7.
    Miscellaneous:
    • Its methylation is enhanced in the late phase of adenoviral infection.

    Alternative splice isoforms for HNRNPUL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPUL1 Gene

Post-translational modifications for HNRNPUL1 Gene

  • Methylated.
  • Ubiquitination at posLast=146146, posLast=270270, isoforms=2, 3, 4440, isoforms=2, 3, 4517, and posLast=527527
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPUL1 Gene

Domains & Families for HNRNPUL1 Gene

Gene Families for HNRNPUL1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9BUJ2

UniProtKB/Swiss-Prot:

HNRL1_HUMAN :
  • The RGG-box domain is methylated.
Domain:
  • The RGG-box domain is methylated.
genes like me logo Genes that share domains with HNRNPUL1: view

Function for HNRNPUL1 Gene

Molecular function for HNRNPUL1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.

Phenotypes From GWAS Catalog for HNRNPUL1 Gene

Gene Ontology (GO) - Molecular Function for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,TAS 22658674
GO:0005515 protein binding IPI 12489984
GO:0019899 enzyme binding IPI 11513728
genes like me logo Genes that share ontologies with HNRNPUL1: view
genes like me logo Genes that share phenotypes with HNRNPUL1: view

Animal Model Products

miRNA for HNRNPUL1 Gene

miRTarBase miRNAs that target HNRNPUL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPUL1 Gene

Localization for HNRNPUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPUL1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 11513728
GO:0005654 nucleoplasm IDA,TAS --
GO:0019013 viral nucleocapsid IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPUL1: view

Pathways & Interactions for HNRNPUL1 Gene

genes like me logo Genes that share pathways with HNRNPUL1: view

Pathways by source for HNRNPUL1 Gene

1 KEGG pathway for HNRNPUL1 Gene

Gene Ontology (GO) - Biological Process for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing IEA,TAS 9733834
GO:0009615 response to virus IEA --
genes like me logo Genes that share ontologies with HNRNPUL1: view

No data available for SIGNOR curated interactions for HNRNPUL1 Gene

Drugs & Compounds for HNRNPUL1 Gene

No Compound Related Data Available

Transcripts for HNRNPUL1 Gene

Unigene Clusters for HNRNPUL1 Gene

Heterogeneous nuclear ribonucleoprotein U-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b ^
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: -
SP8:
SP9: -
SP10: -
SP11: -
SP12:
SP13:
SP14:

Relevant External Links for HNRNPUL1 Gene

GeneLoc Exon Structure for
HNRNPUL1
ECgene alternative splicing isoforms for
HNRNPUL1

Expression for HNRNPUL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPUL1 Gene

Protein differential expression in normal tissues from HIPED for HNRNPUL1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.9) and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPUL1 Gene



Protein tissue co-expression partners for HNRNPUL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPUL1 Gene:

HNRNPUL1

SOURCE GeneReport for Unigene cluster for HNRNPUL1 Gene:

Hs.155218

Evidence on tissue expression from TISSUES for HNRNPUL1 Gene

  • Nervous system(5)
  • Eye(4.7)
  • Muscle(4.5)
  • Liver(4.4)
  • Skin(4.1)
  • Lung(4)
  • Intestine(3.6)
  • Pancreas(2.8)
  • Heart(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with HNRNPUL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPUL1 Gene

Orthologs for HNRNPUL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPUL1 33 34
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia HNRNPUL1 33 34
  • 93.85 (n)
cow
(Bos Taurus)
Mammalia HNRNPUL1 33 34
  • 92.45 (n)
mouse
(Mus musculus)
Mammalia Hnrnpul1 33 16 34
  • 90.89 (n)
rat
(Rattus norvegicus)
Mammalia Hnrnpul1 33
  • 90.78 (n)
oppossum
(Monodelphis domestica)
Mammalia HNRNPUL1 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPUL1 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPUL1 33 34
  • 72.91 (n)
lizard
(Anolis carolinensis)
Reptilia HNRNPUL1 34
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100330645 33
  • 67.76 (n)
FP085405.1 34
  • 55 (a)
OneToMany
hnrnpul1 34
  • 55 (a)
OneToMany
wufb53d10 33
fruit fly
(Drosophila melanogaster)
Insecta CG30122 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.11 34
  • 10 (a)
OneToMany
Species where no ortholog for HNRNPUL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HNRNPUL1 Gene

ENSEMBL:
Gene Tree for HNRNPUL1 (if available)
TreeFam:
Gene Tree for HNRNPUL1 (if available)

Paralogs for HNRNPUL1 Gene

Paralogs for HNRNPUL1 Gene

genes like me logo Genes that share paralogs with HNRNPUL1: view

Variants for HNRNPUL1 Gene

Sequence variations from dbSNP and Humsavar for HNRNPUL1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000072986 -- 41,261,862(+) C/A upstream_transcript_variant
rs1000089279 -- 41,303,213(+) C/T intron_variant
rs1000104818 -- 41,292,943(+) C/G intron_variant
rs1000124895 -- 41,262,078(+) T/C upstream_transcript_variant
rs1000157054 -- 41,273,903(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL1 Gene

Variant ID Type Subtype PubMed ID
esv26941 CNV gain 19812545
esv3644375 CNV loss 21293372
esv3644376 CNV loss 21293372

Variation tolerance for HNRNPUL1 Gene

Residual Variation Intolerance Score: 5.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPUL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPUL1 Gene

Disorders for HNRNPUL1 Gene

Additional Disease Information for HNRNPUL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HNRNPUL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPUL1 Gene

Publications for HNRNPUL1 Gene

  1. E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs. (PMID: 9733834) Gabler S … Dobner T (Journal of virology 1998) 2 3 4 22 58
  2. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. (PMID: 18599554) van der Net JB … Sijbrands EJ (European heart journal 2008) 3 22 44 58
  3. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. (PMID: 12489984) Kzhyshkowska J … Dobner T (The Biochemical journal 2003) 2 3 4 58
  4. The role of hnRPUL1 involved in DNA damage response is related to PARP1. (PMID: 23577092) Hong Z … Yasui A (PloS one 2013) 2 3 58
  5. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PMID: 19056482) Yoshida T … Yamada Y (Genomics 2009) 3 44 58

Products for HNRNPUL1 Gene