This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016] See more...

Aliases for HNRNPUL1 Gene

Aliases for HNRNPUL1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein U Like 1 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 1 3 4
  • Adenovirus Early Region 1B-Associated Protein 5 3 4
  • E1B-55 KDa-Associated Protein 5 3 4
  • E1B 55kDa Associated Protein 5 2 3
  • HNRPUL1 3 4
  • E1B-AP5 3 4
  • E1BAP5 3 4

External Ids for HNRNPUL1 Gene

Previous HGNC Symbols for HNRNPUL1 Gene

  • HNRPUL1

Previous GeneCards Identifiers for HNRNPUL1 Gene

  • GC19P046463
  • GC19P041768
  • GC19P038200

Summaries for HNRNPUL1 Gene

Entrez Gene Summary for HNRNPUL1 Gene

  • This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]

GeneCards Summary for HNRNPUL1 Gene

HNRNPUL1 (Heterogeneous Nuclear Ribonucleoprotein U Like 1) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPU.

UniProtKB/Swiss-Prot Summary for HNRNPUL1 Gene

  • Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.

Gene Wiki entry for HNRNPUL1 Gene

Additional gene information for HNRNPUL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPUL1 Gene

Genomics for HNRNPUL1 Gene

GeneHancer (GH) Regulatory Elements for HNRNPUL1 Gene

Promoters and enhancers for HNRNPUL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPUL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPUL1

Top Transcription factor binding sites by QIAGEN in the HNRNPUL1 gene promoter:
  • NRSF form 1
  • p53

Genomic Locations for HNRNPUL1 Gene

Genomic Locations for HNRNPUL1 Gene
chr19:41,262,476-41,307,787
(GRCh38/hg38)
Size:
45,312 bases
Orientation:
Plus strand
chr19:41,768,391-41,813,811
(GRCh37/hg19)
Size:
45,421 bases
Orientation:
Plus strand

Genomic View for HNRNPUL1 Gene

Genes around HNRNPUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPUL1 Gene

Proteins for HNRNPUL1 Gene

  • Protein details for HNRNPUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUJ2-HNRL1_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 1
    Protein Accession:
    Q9BUJ2
    Secondary Accessions:
    • B3KMW7
    • O76022
    • Q6ZSZ0
    • Q7L8P4
    • Q8N6Z4
    • Q96G37
    • Q9HAL3
    • Q9UG75

    Protein attributes for HNRNPUL1 Gene

    Size:
    856 amino acids
    Molecular mass:
    95739 Da
    Quaternary structure:
    • Interacts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7.
    Miscellaneous:
    • Its methylation is enhanced in the late phase of adenoviral infection.
    • [Isoform 5]: May be due to intron retention.

    Alternative splice isoforms for HNRNPUL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPUL1 Gene

Post-translational modifications for HNRNPUL1 Gene

  • Methylated.
  • Ubiquitination at Lys117, Lys146, Lys270, Lys440, Lys517, and Lys527
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPUL1 Gene

Domains & Families for HNRNPUL1 Gene

Gene Families for HNRNPUL1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HNRNPUL1 Gene

Suggested Antigen Peptide Sequences for HNRNPUL1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56481, highly similar to Heterogeneous nuclear ribonucleoprotein U-like protein 1 (B7Z4B8_HUMAN)
  • E1B-55 kDa-associated protein 5 (HNRL1_HUMAN)
  • Heterogeneous nuclear ribonucleoprotein U-like 1 (Q9BTB7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BUJ2

UniProtKB/Swiss-Prot:

HNRL1_HUMAN :
  • The RGG-box domain is methylated.
Domain:
  • The RGG-box domain is methylated.
genes like me logo Genes that share domains with HNRNPUL1: view

Function for HNRNPUL1 Gene

Molecular function for HNRNPUL1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.

Phenotypes From GWAS Catalog for HNRNPUL1 Gene

Gene Ontology (GO) - Molecular Function for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA,TAS 21873635
GO:0005515 protein binding IPI,IEA 12489984
GO:0019899 enzyme binding IPI 11513728
genes like me logo Genes that share ontologies with HNRNPUL1: view
genes like me logo Genes that share phenotypes with HNRNPUL1: view

Animal Model Products

CRISPR Products

miRNA for HNRNPUL1 Gene

miRTarBase miRNAs that target HNRNPUL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPUL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPUL1 Gene

Localization for HNRNPUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPUL1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
cytoskeleton 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 11513728
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with HNRNPUL1: view

Pathways & Interactions for HNRNPUL1 Gene

genes like me logo Genes that share pathways with HNRNPUL1: view

Pathways by source for HNRNPUL1 Gene

1 KEGG pathway for HNRNPUL1 Gene

Gene Ontology (GO) - Biological Process for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing IEA,TAS 9733834
GO:0009615 response to virus IEA --
genes like me logo Genes that share ontologies with HNRNPUL1: view

No data available for SIGNOR curated interactions for HNRNPUL1 Gene

Drugs & Compounds for HNRNPUL1 Gene

No Compound Related Data Available

Transcripts for HNRNPUL1 Gene

mRNA/cDNA for HNRNPUL1 Gene

7 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPUL1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b ^
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: -
SP8:
SP9: -
SP10: -
SP11: -
SP12:
SP13:
SP14:

Relevant External Links for HNRNPUL1 Gene

GeneLoc Exon Structure for
HNRNPUL1

Expression for HNRNPUL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPUL1 Gene

Protein differential expression in normal tissues from HIPED for HNRNPUL1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.9) and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPUL1 Gene



Protein tissue co-expression partners for HNRNPUL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPUL1

SOURCE GeneReport for Unigene cluster for HNRNPUL1 Gene:

Hs.155218

Evidence on tissue expression from TISSUES for HNRNPUL1 Gene

  • Nervous system(5)
  • Eye(4.7)
  • Muscle(4.5)
  • Liver(4.4)
  • Skin(4.1)
  • Lung(4)
  • Intestine(3.6)
  • Pancreas(2.8)
  • Heart(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with HNRNPUL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPUL1 Gene

Orthologs for HNRNPUL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPUL1 31 30
  • 99.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPUL1 31 30
  • 93.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPUL1 31 30
  • 92.45 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpul1 17 31 30
  • 90.89 (n)
rat
(Rattus norvegicus)
Mammalia Hnrnpul1 30
  • 90.78 (n)
oppossum
(Monodelphis domestica)
Mammalia HNRNPUL1 31
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPUL1 31
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPUL1 31 30
  • 72.91 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPUL1 31
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100330645 30
  • 67.76 (n)
hnrnpul1 31
  • 55 (a)
OneToMany
FP085405.1 31
  • 55 (a)
OneToMany
wufb53d10 30
fruit fly
(Drosophila melanogaster)
Insecta CG30122 31
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.11 31
  • 10 (a)
OneToMany
Species where no ortholog for HNRNPUL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HNRNPUL1 Gene

ENSEMBL:
Gene Tree for HNRNPUL1 (if available)
TreeFam:
Gene Tree for HNRNPUL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPUL1: view image

Paralogs for HNRNPUL1 Gene

Paralogs for HNRNPUL1 Gene

(5) SIMAP similar genes for HNRNPUL1 Gene using alignment to 12 proteins:

  • HNRL1_HUMAN
  • B7Z4B8_HUMAN
  • L0R5B4_HUMAN
  • M0QYG9_HUMAN
  • M0QYI8_HUMAN
  • M0QYM5_HUMAN
  • M0QYZ0_HUMAN
  • M0QZV6_HUMAN
  • M0R0K8_HUMAN
  • M0R203_HUMAN
  • M0R247_HUMAN
  • M0R3F1_HUMAN
genes like me logo Genes that share paralogs with HNRNPUL1: view

Variants for HNRNPUL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPUL1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs17849624 - p.Gly91Cys

Additional dbSNP identifiers (rs#s) for HNRNPUL1 Gene