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Aliases for HNRNPR Gene

Aliases for HNRNPR Gene

  • Heterogeneous Nuclear Ribonucleoprotein R 2 3 3 5
  • HNRPR 3 4
  • HnRNP-R 3
  • HnRNP R 4

External Ids for HNRNPR Gene

Previous HGNC Symbols for HNRNPR Gene

  • HNRPR

Previous GeneCards Identifiers for HNRNPR Gene

  • GC01M023509
  • GC01M023630
  • GC01M021888

Summaries for HNRNPR Gene

Entrez Gene Summary for HNRNPR Gene

  • This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

GeneCards Summary for HNRNPR Gene

HNRNPR (Heterogeneous Nuclear Ribonucleoprotein R) is a Protein Coding gene. Diseases associated with HNRNPR include Spinal Muscular Atrophy. Among its related pathways are Translational Control and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SYNCRIP.

UniProtKB/Swiss-Prot for HNRNPR Gene

  • Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Gene Wiki entry for HNRNPR Gene

Additional gene information for HNRNPR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPR Gene

Genomics for HNRNPR Gene

GeneHancer (GH) Regulatory Elements for HNRNPR Gene

Promoters and enhancers for HNRNPR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J023339 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.6 1647 6.3 HDGF PKNOX1 SMAD1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B HNRNPR ZNF436-AS1 ZNF436 ZBTB40 KDM1A ENSG00000201405 SRSF10 ELOA ZBTB40-IT1 TCEA3
GH01J023691 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 45.9 -348.0 -347973 3.1 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 RPL11 SRSF10 SRRM1 LINC01355 HNRNPR PNRC2 KDM1A ELOA ASAP3 GC01M023708
GH01J023521 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.4 -184.0 -184034 13.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 E2F2 GC01P023526 SRSF10 LINC01355 KDM1A HNRNPR ASAP3 ID3 ZNF436 ELOA
GH01J023166 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.4 +176.3 176312 4.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 YY1 POLR2B ZNF213 ZNF548 LUZP1 GC01P023167 SRSF10 ZBTB40 PNRC2 RPL11 LINC01355 HNRNPR ELOA LACTBL1
GH01J023018 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.4 +324.6 324627 3.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 KDM1A SRSF10 ZBTB40 HNRNPR LINC01355 CDC42-IT1 LACTBL1 ELOA CDC42 ENSG00000271428
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HNRNPR gene promoter:
  • MRF-2
  • Nkx2-5
  • GR-beta
  • GR-alpha
  • GR
  • POU2F1
  • POU2F1a
  • SRY
  • USF-1:USF-2
  • USF1

Genomic Locations for HNRNPR Gene

Genomic Locations for HNRNPR Gene
chr1:23,303,771-23,344,650
(GRCh38/hg38)
Size:
40,880 bases
Orientation:
Minus strand
chr1:23,630,264-23,670,853
(GRCh37/hg19)
Size:
40,590 bases
Orientation:
Minus strand

Genomic View for HNRNPR Gene

Genes around HNRNPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPR Gene

Proteins for HNRNPR Gene

  • Protein details for HNRNPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43390-HNRPR_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein R
    Protein Accession:
    O43390
    Secondary Accessions:
    • Q2L7G6
    • Q5TEH1
    • Q9BV64
    • S4R3J4

    Protein attributes for HNRNPR Gene

    Size:
    633 amino acids
    Molecular mass:
    70943 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with GTPBP1.

    Three dimensional structures from OCA and Proteopedia for HNRNPR Gene

    Alternative splice isoforms for HNRNPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPR Gene

Post-translational modifications for HNRNPR Gene

  • Ubiquitination at isoforms=2, 3, 4359, isoforms=2, 3, 4187, and isoforms=2, 341
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPR Gene

Domains & Families for HNRNPR Gene

Gene Families for HNRNPR Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPR: view

No data available for UniProtKB/Swiss-Prot for HNRNPR Gene

Function for HNRNPR Gene

Molecular function for HNRNPR Gene

UniProtKB/Swiss-Prot Function:
Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Phenotypes From GWAS Catalog for HNRNPR Gene

Gene Ontology (GO) - Molecular Function for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding NAS 9421497
GO:0003730 mRNA 3-UTR binding IEA --
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with HNRNPR: view
genes like me logo Genes that share phenotypes with HNRNPR: view

Animal Model Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPR Gene

Localization for HNRNPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPR Gene

Nucleus. Microsome. Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). {ECO:0000250 UniProtKB:Q7TMK9, ECO:0000269 PubMed:17289661}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPR gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex NAS 9421497
GO:0005730 NOT nucleolus IDA 9421497
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HNRNPR: view

Pathways & Interactions for HNRNPR Gene

genes like me logo Genes that share pathways with HNRNPR: view

Pathways by source for HNRNPR Gene

1 Cell Signaling Technology pathway for HNRNPR Gene

Gene Ontology (GO) - Biological Process for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing NAS 9421497
GO:0007623 circadian rhythm IEA --
GO:0008380 RNA splicing IEA --
GO:0016070 RNA metabolic process TAS --
genes like me logo Genes that share ontologies with HNRNPR: view

No data available for SIGNOR curated interactions for HNRNPR Gene

Drugs & Compounds for HNRNPR Gene

No Compound Related Data Available

Transcripts for HNRNPR Gene

Unigene Clusters for HNRNPR Gene

Heterogeneous nuclear ribonucleoprotein R:
Representative Sequences:

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPR

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: - - - -
SP11: - - - -
SP12:
SP13:

Relevant External Links for HNRNPR Gene

GeneLoc Exon Structure for
HNRNPR
ECgene alternative splicing isoforms for
HNRNPR

Expression for HNRNPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPR Gene

Protein differential expression in normal tissues from HIPED for HNRNPR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2) and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPR Gene



Protein tissue co-expression partners for HNRNPR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPR Gene:

HNRNPR

SOURCE GeneReport for Unigene cluster for HNRNPR Gene:

Hs.373763

Evidence on tissue expression from TISSUES for HNRNPR Gene

  • Nervous system(5)
  • Liver(4.5)
  • Eye(2.7)
  • Skin(2.5)
  • Spleen(2.4)
  • Heart(2.2)
  • Lung(2.2)
  • Kidney(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with HNRNPR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPR Gene

Orthologs for HNRNPR Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPR 34 33
  • 99.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPR 34 33
  • 97.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPR 34 33
  • 96.31 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPR 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPR 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpr 33
  • 91.98 (n)
mouse
(Mus musculus)
Mammalia Hnrnpr 16 34 33
  • 91.46 (n)
chicken
(Gallus gallus)
Aves HNRNPR 34 33
  • 85.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPR 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpr 33
  • 75.27 (n)
Str.10730 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6623 33
zebrafish
(Danio rerio)
Actinopterygii hnrnpr 34
  • 79 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12332 33
fruit fly
(Drosophila melanogaster)
Insecta CG17838 34
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 34
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToMany
Species where no ortholog for HNRNPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPR Gene

ENSEMBL:
Gene Tree for HNRNPR (if available)
TreeFam:
Gene Tree for HNRNPR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPR: view image

Paralogs for HNRNPR Gene

Paralogs for HNRNPR Gene

(7) SIMAP similar genes for HNRNPR Gene using alignment to 4 proteins:

  • HNRPR_HUMAN
  • B4DT28_HUMAN
  • E7ETM7_HUMAN
  • S4R3J4_HUMAN

Pseudogenes.org Pseudogenes for HNRNPR Gene

genes like me logo Genes that share paralogs with HNRNPR: view

Variants for HNRNPR Gene

Sequence variations from dbSNP and Humsavar for HNRNPR Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000011953 -- 23,343,863(-) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000020640 -- 23,337,257(-) T/C intron_variant
rs1000055644 -- 23,343,214(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000076889 -- 23,337,556(-) C/G intron_variant
rs1000119317 -- 23,324,018(-) A/G intron_variant

Variation tolerance for HNRNPR Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPR Gene

Human Gene Mutation Database (HGMD)
HNRNPR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HNRNPR Gene

Disorders for HNRNPR Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPR Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spinal muscular atrophy
  • sma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HNRNPR

genes like me logo Genes that share disorders with HNRNPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPR Gene

Publications for HNRNPR Gene

  1. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. (PMID: 9421497) Hassfeld W … Tan EM (Nucleic acids research 1998) 2 3 4 22 58
  2. Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R. (PMID: 15858414) Huang J … Xu P (Neuroreport 2005) 3 4 22 58
  3. The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons. (PMID: 20167579) Glinka M … Sendtner M (Human molecular genetics 2010) 3 22 58
  4. Heterogeneous nuclear ribonucleoprotein R enhances transcription from the naturally configured c-fos promoter in vitro. (PMID: 19581295) Fukuda A … Hisatake K (The Journal of biological chemistry 2009) 3 22 58
  5. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4 58

Products for HNRNPR Gene

Sources for HNRNPR Gene

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