This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014] See more...

Aliases for HNRNPR Gene

Aliases for HNRNPR Gene

  • Heterogeneous Nuclear Ribonucleoprotein R 2 3 4 5
  • HnRNP-R 2 3
  • HNRPR 3 4
  • HnRNP R 4
  • HNRNPR 5

External Ids for HNRNPR Gene

Previous HGNC Symbols for HNRNPR Gene

  • HNRPR

Previous GeneCards Identifiers for HNRNPR Gene

  • GC01M023509
  • GC01M023630
  • GC01M021888

Summaries for HNRNPR Gene

Entrez Gene Summary for HNRNPR Gene

  • This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

GeneCards Summary for HNRNPR Gene

HNRNPR (Heterogeneous Nuclear Ribonucleoprotein R) is a Protein Coding gene. Diseases associated with HNRNPR include Spinal Muscular Atrophy. Among its related pathways are Translational Control and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SYNCRIP.

UniProtKB/Swiss-Prot Summary for HNRNPR Gene

  • Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Gene Wiki entry for HNRNPR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPR Gene

Genomics for HNRNPR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HNRNPR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPR

Top Transcription factor binding sites by QIAGEN in the HNRNPR gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • MRF-2
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • SRY
  • USF-1:USF-2
  • USF1

Genomic Locations for HNRNPR Gene

Latest Assembly
chr1:23,303,771-23,344,336
(GRCh38/hg38)
Size:
40,566 bases
Orientation:
Minus strand

Previous Assembly
chr1:23,631,181-23,670,777
(GRCh37/hg19 by Entrez Gene)
Size:
39,597 bases
Orientation:
Minus strand

chr1:23,630,264-23,670,829
(GRCh37/hg19 by Ensembl)
Size:
40,566 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr1(PATCHES):74,667-114,263 (-)

Genomic View for HNRNPR Gene

Genes around HNRNPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPR Gene

Proteins for HNRNPR Gene

  • Protein details for HNRNPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43390-HNRPR_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein R
    Protein Accession:
    O43390
    Secondary Accessions:
    • Q2L7G6
    • Q5TEH1
    • Q9BV64
    • S4R3J4

    Protein attributes for HNRNPR Gene

    Size:
    633 amino acids
    Molecular mass:
    70943 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with GTPBP1.
    Miscellaneous:
    • [Isoform 3]: Expression is low and neural-specific.

    Three dimensional structures from OCA and Proteopedia for HNRNPR Gene

    Alternative splice isoforms for HNRNPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPR Gene

Post-translational modifications for HNRNPR Gene

  • Ubiquitination at Lys41, Lys187, Lys359, and Lys366
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPR Gene

Domains & Families for HNRNPR Gene

Gene Families for HNRNPR Gene

Protein Domains for HNRNPR Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)

Suggested Antigen Peptide Sequences for HNRNPR Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54544, highly similar to Heterogeneous nuclear ribonucleoprotein R (B4DT28_HUMAN)
  • Heterogeneous nuclear ribonucleoprotein R (HNRPR_HUMAN)
  • HNRPR protein (Q0VGD6_HUMAN)
genes like me logo Genes that share domains with HNRNPR: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HNRNPR Gene

Function for HNRNPR Gene

Molecular function for HNRNPR Gene

UniProtKB/Swiss-Prot Function:
Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Phenotypes From GWAS Catalog for HNRNPR Gene

Gene Ontology (GO) - Molecular Function for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA,NAS 9421497
GO:0003729 mRNA binding IBA 21873635
GO:0003730 mRNA 3'-UTR binding IEA --
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with HNRNPR: view
genes like me logo Genes that share phenotypes with HNRNPR: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPR

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPR Gene

Localization for HNRNPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPR Gene

Nucleus. Microsome. Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). {ECO:0000250 UniProtKB:Q7TMK9, ECO:0000269 PubMed:17289661}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPR gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytoskeleton 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex NAS 9421497
GO:0005730 NOT nucleolus IDA 9421497
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HNRNPR: view

Pathways & Interactions for HNRNPR Gene

genes like me logo Genes that share pathways with HNRNPR: view

Pathways by source for HNRNPR Gene

1 Cell Signaling Technology pathway for HNRNPR Gene

Gene Ontology (GO) - Biological Process for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing NAS 9421497
GO:0007623 circadian rhythm IEA --
GO:0008380 RNA splicing IEA --
GO:0016070 RNA metabolic process TAS --
genes like me logo Genes that share ontologies with HNRNPR: view

No data available for SIGNOR curated interactions for HNRNPR Gene

Drugs & Compounds for HNRNPR Gene

No Compound Related Data Available

Transcripts for HNRNPR Gene

mRNA/cDNA for HNRNPR Gene

7 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPR

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: - - - -
SP11: - - - -
SP12:
SP13:

Relevant External Links for HNRNPR Gene

GeneLoc Exon Structure for
HNRNPR

Expression for HNRNPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPR Gene

Protein differential expression in normal tissues from HIPED for HNRNPR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2) and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPR Gene



Protein tissue co-expression partners for HNRNPR Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPR

SOURCE GeneReport for Unigene cluster for HNRNPR Gene:

Hs.373763

Evidence on tissue expression from TISSUES for HNRNPR Gene

  • Nervous system(5)
  • Liver(4.6)
  • Skin(3.1)
  • Eye(3)
  • Kidney(2.8)
  • Muscle(2.7)
  • Heart(2.5)
  • Lung(2.5)
  • Spleen(2.4)
  • Intestine(2.2)
  • Adrenal gland(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with HNRNPR: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPR Gene

Orthologs for HNRNPR Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HNRNPR 29 30
  • 99.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HNRNPR 29 30
  • 97.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HNRNPR 29 30
  • 96.31 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HNRNPR 30
  • 94 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPR 30
  • 92 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hnrnpr 29
  • 91.98 (n)
Mouse
(Mus musculus)
Mammalia Hnrnpr 29 16 30
  • 91.46 (n)
OneToOne
Chicken
(Gallus gallus)
Aves HNRNPR 29 30
  • 85.81 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HNRNPR 30
  • 93 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hnrnpr 29
  • 75.27 (n)
Str.10730 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.6623 29
Zebrafish
(Danio rerio)
Actinopterygii hnrnpr 30
  • 79 (a)
ManyToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12332 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG17838 30
  • 46 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea hrp-2 30
  • 41 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 54 (a)
OneToMany
Species where no ortholog for HNRNPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HNRNPR Gene

ENSEMBL:
Gene Tree for HNRNPR (if available)
TreeFam:
Gene Tree for HNRNPR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPR: view image
Alliance of Genome Resources:
Additional Orthologs for HNRNPR

Paralogs for HNRNPR Gene

(7) SIMAP similar genes for HNRNPR Gene using alignment to 4 proteins:

  • HNRPR_HUMAN
  • B4DT28_HUMAN
  • E7ETM7_HUMAN
  • S4R3J4_HUMAN

Pseudogenes.org Pseudogenes for HNRNPR Gene

genes like me logo Genes that share paralogs with HNRNPR: view

Variants for HNRNPR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPR Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1553153365 Likely Pathogenic: Inborn genetic diseases 23,310,702(-) G/A
NM_005826.5(HNRNPR):c.1654C>T (p.Gln552Ter)
NONSENSE
rs202076745 Likely Benign: not provided 23,311,326(-) T/C
NM_005826.5(HNRNPR):c.1168-4A>G
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HNRNPR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for HNRNPR Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPR Gene

Human Gene Mutation Database (HGMD)
HNRNPR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPR
Leiden Open Variation Database (LOVD)
HNRNPR

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HNRNPR Gene

Disorders for HNRNPR Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPR Gene - From: COP and GCD

Disorder Aliases PubMed IDs
spinal muscular atrophy
  • sma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HNRNPR

genes like me logo Genes that share disorders with HNRNPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPR Gene

Publications for HNRNPR Gene

  1. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. (PMID: 9421497) Hassfeld W … Tan EM (Nucleic acids research 1998) 2 3 4 22
  2. Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R. (PMID: 15858414) Huang J … Xu P (Neuroreport 2005) 3 4 22
  3. The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons. (PMID: 20167579) Glinka M … Sendtner M (Human molecular genetics 2010) 3 22
  4. Heterogeneous nuclear ribonucleoprotein R enhances transcription from the naturally configured c-fos promoter in vitro. (PMID: 19581295) Fukuda A … Hisatake K (The Journal of biological chemistry 2009) 3 22
  5. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4

Products for HNRNPR Gene

Sources for HNRNPR Gene