This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hn... See more...

Aliases for HNRNPM Gene

Aliases for HNRNPM Gene

  • Heterogeneous Nuclear Ribonucleoprotein M 2 3 4 5
  • CEA Receptor 2 3
  • HNRNPM4 2 3
  • HnRNP M 3 4
  • HNRPM4 2 3
  • HNRPM 3 4
  • HTGR1 2 3
  • NAGR1 3 4
  • CEAR 2 3
  • Heterogenous Nuclear Ribonucleoprotein M4 3
  • N-Acetylglucosamine Receptor 1 3
  • HnRNA-Binding Protein M4 3
  • HNRNPM 5

External Ids for HNRNPM Gene

Previous HGNC Symbols for HNRNPM Gene

  • NAGR1
  • HNRPM

Previous GeneCards Identifiers for HNRNPM Gene

  • GC19P008416
  • GC19P008509
  • GC19P008165

Summaries for HNRNPM Gene

Entrez Gene Summary for HNRNPM Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for HNRNPM Gene

HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M) is a Protein Coding gene. Diseases associated with HNRNPM include Bladder Clear Cell Adenocarcinoma and Contagious Pustular Dermatitis. Among its related pathways are Signaling by GPCR and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MYEF2.

UniProtKB/Swiss-Prot Summary for HNRNPM Gene

  • Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

Additional gene information for HNRNPM Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPM Gene

Genomics for HNRNPM Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HNRNPM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPM on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPM

Top Transcription factor binding sites by QIAGEN in the HNRNPM gene promoter:
  • ER-alpha
  • MyoD
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pax-5
  • RFX1
  • ZIC2

Genomic Locations for HNRNPM Gene

Genomic Locations for HNRNPM Gene
chr19:8,444,575-8,489,114
(GRCh38/hg38)
Size:
44,540 bases
Orientation:
Plus strand
chr19:8,509,651-8,553,998
(GRCh37/hg19)
Size:
44,348 bases
Orientation:
Plus strand

Genomic View for HNRNPM Gene

Genes around HNRNPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPM Gene

Proteins for HNRNPM Gene

  • Protein details for HNRNPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52272-HNRPM_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein M
    Protein Accession:
    P52272
    Secondary Accessions:
    • Q15584
    • Q8WZ44
    • Q96H56
    • Q9BWL9
    • Q9Y492

    Protein attributes for HNRNPM Gene

    Size:
    730 amino acids
    Molecular mass:
    77516 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for HNRNPM Gene

    Alternative splice isoforms for HNRNPM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPM Gene

Post-translational modifications for HNRNPM Gene

  • Sumoylated.
  • Ubiquitination at Lys69, Lys83, Lys88, Lys110, Lys127, Lys345, Lys381, Lys388, Lys651, Lys667, Lys698, and Lys716
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPM Gene

Domains & Families for HNRNPM Gene

Gene Families for HNRNPM Gene

Protein Domains for HNRNPM Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
ProtoNet:

Suggested Antigen Peptide Sequences for HNRNPM Gene

GenScript: Design optimal peptide antigens:
  • Heterogeneous nuclear ribonucleoprotein M (HNRPM_HUMAN)
  • HNRPM protein (Q6P2D7_HUMAN)
genes like me logo Genes that share domains with HNRNPM: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HNRNPM Gene

Function for HNRNPM Gene

Molecular function for HNRNPM Gene

UniProtKB/Swiss-Prot Function:
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

Phenotypes From GWAS Catalog for HNRNPM Gene

Gene Ontology (GO) - Molecular Function for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,NAS 9731529
GO:0003729 mRNA binding IBA 21873635
GO:0005515 protein binding IPI 17435768
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with HNRNPM: view
genes like me logo Genes that share phenotypes with HNRNPM: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HNRNPM

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPM

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPM Gene

Localization for HNRNPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPM Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPM gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 2
cytoskeleton 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA,TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with HNRNPM: view

Pathways & Interactions for HNRNPM Gene

genes like me logo Genes that share pathways with HNRNPM: view

Pathways by source for HNRNPM Gene

1 KEGG pathway for HNRNPM Gene

SIGNOR curated interactions for HNRNPM Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IBA,IMP 19874820
GO:0000398 mRNA splicing, via spliceosome IEA,TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with HNRNPM: view

Drugs & Compounds for HNRNPM Gene

No Compound Related Data Available

Transcripts for HNRNPM Gene

mRNA/cDNA for HNRNPM Gene

3 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPM

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for HNRNPM Gene

GeneLoc Exon Structure for
HNRNPM

Expression for HNRNPM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPM Gene

Protein differential expression in normal tissues from HIPED for HNRNPM Gene

This gene is overexpressed in Bone (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPM Gene



Protein tissue co-expression partners for HNRNPM Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPM

SOURCE GeneReport for Unigene cluster for HNRNPM Gene:

Hs.465808

Evidence on tissue expression from TISSUES for HNRNPM Gene

  • Nervous system(4.8)
  • Liver(4.7)
  • Blood(4.5)
  • Intestine(3.5)
  • Heart(3.4)
  • Skin(3.4)
  • Kidney(3.3)
  • Muscle(3.1)
  • Lymph node(3.1)
  • Spleen(3)
  • Pancreas(3)
  • Lung(3)
  • Stomach(3)
  • Bone marrow(2.9)
  • Thyroid gland(2.9)
  • Eye(2.6)
  • Adrenal gland(2.5)
  • Gall bladder(2.5)
genes like me logo Genes that share expression patterns with HNRNPM: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPM Gene

Orthologs for HNRNPM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPM Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HNRNPM 30 31
  • 99.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 99 (a)
OneToMany
HNRNPM 30
  • 95.3 (n)
-- 31
  • 78 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Hnrnpm 30
  • 93.06 (n)
Mouse
(Mus musculus)
Mammalia Hnrnpm 30 17 31
  • 93.02 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 92 (a)
OneToMany
-- 31
  • 87 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia HNRNPM 31
  • 92 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 90 (a)
OneToMany
-- 31
  • 83 (a)
OneToMany
Chicken
(Gallus gallus)
Aves HNRNPM 31
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5477 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.1972 30
Zebrafish
(Danio rerio)
Actinopterygii hnrnpm 31
  • 52 (a)
OneToOne
wufa10g07 30
Fruit Fly
(Drosophila melanogaster)
Insecta rump 31
  • 28 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C25A1.4 31
  • 33 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GBP2 31 33
  • 23 (a)
ManyToMany
HRB1 31
  • 20 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7224 31
  • 36 (a)
OneToMany
Species where no ortholog for HNRNPM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HNRNPM Gene

ENSEMBL:
Gene Tree for HNRNPM (if available)
TreeFam:
Gene Tree for HNRNPM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPM: view image

Paralogs for HNRNPM Gene

Paralogs for HNRNPM Gene

(5) SIMAP similar genes for HNRNPM Gene using alignment to 10 proteins:

  • HNRPM_HUMAN
  • M0QY96_HUMAN
  • M0QYL3_HUMAN
  • M0QYQ7_HUMAN
  • M0QZM1_HUMAN
  • M0R019_HUMAN
  • M0R0N3_HUMAN
  • M0R0Y6_HUMAN
  • M0R2I7_HUMAN
  • M0R2T0_HUMAN

Pseudogenes.org Pseudogenes for HNRNPM Gene

genes like me logo Genes that share paralogs with HNRNPM: view

Variants for HNRNPM Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPM Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
727869 Benign: not provided 8,468,767(+) C/G INTRON_VARIANT
754952 Likely Benign: not provided 8,488,776(+) C/A SYNONYMOUS_VARIANT
768964 Benign: not provided 8,486,087(+) C/T SYNONYMOUS_VARIANT
788016 Benign: not provided 8,486,231(+) C/T SYNONYMOUS_VARIANT
789662 Benign: not provided 8,474,177(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for HNRNPM Gene

Structural Variations from Database of Genomic Variants (DGV) for HNRNPM Gene

Variant ID Type Subtype PubMed ID
dgv137n111 CNV deletion 26073780
dgv1708n106 CNV deletion 24896259
dgv396n27 CNV loss 19166990
dgv6258n54 CNV loss 21841781
esv1320041 CNV deletion 17803354
esv2335907 CNV deletion 18987734
esv2718124 CNV deletion 23290073
esv3098235 CNV deletion 24192839
esv3555991 CNV deletion 23714750
esv4060 CNV loss 18987735
esv7145 CNV loss 19470904
esv989310 CNV deletion 20482838
nsv1071142 CNV deletion 25765185
nsv1148644 CNV deletion 26484159
nsv458350 CNV loss 19166990
nsv578559 CNV loss 21841781
nsv956596 CNV deletion 24416366

Variation tolerance for HNRNPM Gene

Residual Variation Intolerance Score: 4.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPM Gene

Disorders for HNRNPM Gene

MalaCards: The human disease database

(3) MalaCards diseases for HNRNPM Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bladder clear cell adenocarcinoma
  • bladder mesonephric adenocarcinoma
contagious pustular dermatitis
  • ecthyma contagiosum
spinal muscular atrophy
  • progressive muscular atrophy
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with HNRNPM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPM Gene

Publications for HNRNPM Gene

  1. The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins. (PMID: 8441656) Datar KV … Swanson MS (Nucleic acids research 1993) 2 3 4
  2. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. (PMID: 20467437) Llères D … Lamond AI (EMBO reports 2010) 3 23
  3. hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures. (PMID: 19874820) Marko M … Guialis A (Experimental cell research 2010) 3 23
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. (PMID: 15561718) Gocke CB … Kang J (The Journal of biological chemistry 2005) 3 4

Products for HNRNPM Gene

  • Boster Bio Antibodies for HNRNPM
  • Boster Bio ELISA Kits for HNRNPM
  • Signalway Proteins for HNRNPM

Sources for HNRNPM Gene