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Aliases for HNRNPM Gene

Aliases for HNRNPM Gene

  • Heterogeneous Nuclear Ribonucleoprotein M 2 3 5
  • CEA Receptor 2 3
  • HnRNP M 3 4
  • HNRPM 3 4
  • NAGR1 3 4
  • Heterogenous Nuclear Ribonucleoprotein M4 3
  • N-Acetylglucosamine Receptor 1 3
  • HnRNA-Binding Protein M4 3
  • HNRNPM4 3
  • HNRPM4 3
  • HTGR1 3
  • CEAR 3

External Ids for HNRNPM Gene

Previous HGNC Symbols for HNRNPM Gene

  • NAGR1
  • HNRPM

Previous GeneCards Identifiers for HNRNPM Gene

  • GC19P008416
  • GC19P008509
  • GC19P008165

Summaries for HNRNPM Gene

Entrez Gene Summary for HNRNPM Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for HNRNPM Gene

HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Signaling by FGFR2. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MYEF2.

UniProtKB/Swiss-Prot for HNRNPM Gene

  • Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

Additional gene information for HNRNPM Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPM Gene

Genomics for HNRNPM Gene

GeneHancer (GH) Regulatory Elements for HNRNPM Gene

Promoters and enhancers for HNRNPM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I008444 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 +1.6 1595 3.9 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 HNRNPM ENSG00000279827 MARCH2 PRAM1 GC19P008487
GH19I007521 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 80.5 -921.7 -921718 2 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC MCOLN1 GC19M007510 HNRNPM ELAVL1 XAB2 ZNF557 MAP2K7 ZNF414 TIMM44 SNAPC2
GH19I008361 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 67.9 -81.2 -81166 3.6 FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 FOS DEK ZC3H11A ANGPTL4 HNRNPM ZNF317 XAB2 ZNF699 ZNF558 MAP2K7 ELAVL1 ZNF559 ZNF414
GH19I008239 Enhancer 1.5 Ensembl ENCODE dbSUPER 94.2 -204.2 -204151 2 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B ZNF2 YY1 ENSG00000271717 ZNF558 HNRNPM ELAVL1 ZNF317 ENSG00000269300 XAB2 ZNF414 CERS4 ARHGEF18
GH19I008388 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 51.5 -51.7 -51731 10.3 MLX IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC GLIS1 RAB11B HNRNPM ELAVL1 ZNF699 ZNF558 XAB2 ZNF317 ENSG00000269300 MAP2K7 MARCH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HNRNPM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HNRNPM gene promoter:

Genomic Locations for HNRNPM Gene

Genomic Locations for HNRNPM Gene
chr19:8,444,575-8,489,118
(GRCh38/hg38)
Size:
44,544 bases
Orientation:
Plus strand
chr19:8,509,651-8,553,998
(GRCh37/hg19)

Genomic View for HNRNPM Gene

Genes around HNRNPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPM Gene

Proteins for HNRNPM Gene

  • Protein details for HNRNPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52272-HNRPM_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein M
    Protein Accession:
    P52272
    Secondary Accessions:
    • Q15584
    • Q8WZ44
    • Q96H56
    • Q9BWL9
    • Q9Y492

    Protein attributes for HNRNPM Gene

    Size:
    730 amino acids
    Molecular mass:
    77516 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for HNRNPM Gene

    Alternative splice isoforms for HNRNPM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPM Gene

Post-translational modifications for HNRNPM Gene

  • Sumoylated.
  • Ubiquitination at posLast=6969, isoforms=283, posLast=8888, posLast=110110, posLast=127127, posLast=345345, isoforms=2381, posLast=388388, isoforms=2651, posLast=667667, posLast=698698, and posLast=716716
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPM Gene

Domains & Families for HNRNPM Gene

Gene Families for HNRNPM Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HNRNPM Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPM: view

No data available for UniProtKB/Swiss-Prot for HNRNPM Gene

Function for HNRNPM Gene

Molecular function for HNRNPM Gene

UniProtKB/Swiss-Prot Function:
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

Phenotypes From GWAS Catalog for HNRNPM Gene

Gene Ontology (GO) - Molecular Function for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding NAS,IEA 9731529
GO:0005515 protein binding IPI 17435768
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with HNRNPM: view
genes like me logo Genes that share phenotypes with HNRNPM: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HNRNPM

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPM Gene

Localization for HNRNPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPM Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPM gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005730 nucleolus IEA --
GO:0005887 integral component of plasma membrane TAS 8088785
genes like me logo Genes that share ontologies with HNRNPM: view

Pathways & Interactions for HNRNPM Gene

genes like me logo Genes that share pathways with HNRNPM: view

Pathways by source for HNRNPM Gene

1 KEGG pathway for HNRNPM Gene

Gene Ontology (GO) - Biological Process for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IMP 19874820
GO:0000398 mRNA splicing, via spliceosome IEA,TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with HNRNPM: view

No data available for SIGNOR curated interactions for HNRNPM Gene

Drugs & Compounds for HNRNPM Gene

No Compound Related Data Available

Transcripts for HNRNPM Gene

Unigene Clusters for HNRNPM Gene

Heterogeneous nuclear ribonucleoprotein M:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for HNRNPM Gene

GeneLoc Exon Structure for
HNRNPM
ECgene alternative splicing isoforms for
HNRNPM

Expression for HNRNPM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPM Gene

Protein differential expression in normal tissues from HIPED for HNRNPM Gene

This gene is overexpressed in Bone (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPM Gene



Protein tissue co-expression partners for HNRNPM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPM Gene:

HNRNPM

SOURCE GeneReport for Unigene cluster for HNRNPM Gene:

Hs.465808

Evidence on tissue expression from TISSUES for HNRNPM Gene

  • Nervous system(4.7)
  • Liver(4.6)
  • Intestine(3.3)
  • Heart(3)
  • Eye(2.6)
  • Adrenal gland(2.5)
  • Bone marrow(2.5)
  • Gall bladder(2.5)
  • Kidney(2.5)
  • Lung(2.5)
  • Lymph node(2.5)
  • Muscle(2.5)
  • Pancreas(2.5)
  • Skin(2.5)
  • Spleen(2.5)
  • Stomach(2.5)
  • Thyroid gland(2.5)
genes like me logo Genes that share expression patterns with HNRNPM: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPM Gene

Orthologs for HNRNPM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPM 33 34
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 99 (a)
OneToMany
HNRNPM 33
  • 95.3 (n)
-- 34
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hnrnpm 33
  • 93.06 (n)
mouse
(Mus musculus)
Mammalia Hnrnpm 33 16 34
  • 93.02 (n)
dog
(Canis familiaris)
Mammalia HNRNPM 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves HNRNPM 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1972 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5477 33
zebrafish
(Danio rerio)
Actinopterygii hnrnpm 34
  • 52 (a)
OneToOne
wufa10g07 33
fruit fly
(Drosophila melanogaster)
Insecta rump 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C25A1.4 34
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GBP2 34 36
  • 23 (a)
ManyToMany
HRB1 34
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7224 34
  • 36 (a)
OneToMany
Species where no ortholog for HNRNPM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPM Gene

ENSEMBL:
Gene Tree for HNRNPM (if available)
TreeFam:
Gene Tree for HNRNPM (if available)

Paralogs for HNRNPM Gene

Paralogs for HNRNPM Gene

Pseudogenes.org Pseudogenes for HNRNPM Gene

genes like me logo Genes that share paralogs with HNRNPM: view

Variants for HNRNPM Gene

Sequence variations from dbSNP and Humsavar for HNRNPM Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs773444733 likely-benign, Long QT syndrome 8,445,074(+) G/A 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs483352729 uncertain-significance, not provided 8,488,790(+) G/A coding_sequence_variant, missense_variant
rs1000002876 -- 8,457,897(+) G/C intron_variant
rs1000055547 -- 8,461,354(+) A/G intron_variant
rs1000096369 -- 8,468,900(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPM Gene

Variant ID Type Subtype PubMed ID
dgv137n111 CNV deletion 26073780
dgv1708n106 CNV deletion 24896259
dgv396n27 CNV loss 19166990
dgv6258n54 CNV loss 21841781
esv1320041 CNV deletion 17803354
esv2335907 CNV deletion 18987734
esv2718124 CNV deletion 23290073
esv3098235 CNV deletion 24192839
esv3555991 CNV deletion 23714750
esv4060 CNV loss 18987735
esv7145 CNV loss 19470904
esv989310 CNV deletion 20482838
nsv1071142 CNV deletion 25765185
nsv1148644 CNV deletion 26484159
nsv458350 CNV loss 19166990
nsv578559 CNV loss 21841781
nsv956596 CNV deletion 24416366

Variation tolerance for HNRNPM Gene

Residual Variation Intolerance Score: 4.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPM Gene

Disorders for HNRNPM Gene

Additional Disease Information for HNRNPM

No disorders were found for HNRNPM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPM Gene

Publications for HNRNPM Gene

  1. The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins. (PMID: 8441656) Datar KV … Swanson MS (Nucleic acids research 1993) 2 3 4 58
  2. hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures. (PMID: 19874820) Marko M … Guialis A (Experimental cell research 2010) 3 22 58
  3. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. (PMID: 20467437) Llères D … Lamond AI (EMBO reports 2010) 3 22 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. (PMID: 15561718) Gocke CB … Kang J (The Journal of biological chemistry 2005) 3 4 58

Products for HNRNPM Gene

Sources for HNRNPM Gene

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