HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008] See more...

Aliases for HNRNPLL Gene

Aliases for HNRNPLL Gene

  • Heterogeneous Nuclear Ribonucleoprotein L Like 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein L-Like 3 4
  • HNRPLL 3 4
  • SRRF 3 4
  • Stromal RNA Regulating Factor 3
  • Stromal RNA-Regulating Factor 4
  • HNRNPLL 5
  • HnRNPLL 4

External Ids for HNRNPLL Gene

Previous HGNC Symbols for HNRNPLL Gene

  • HNRPLL

Previous GeneCards Identifiers for HNRNPLL Gene

  • GC02M038790

Summaries for HNRNPLL Gene

Entrez Gene Summary for HNRNPLL Gene

  • HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

GeneCards Summary for HNRNPLL Gene

HNRNPLL (Heterogeneous Nuclear Ribonucleoprotein L Like) is a Protein Coding gene. Diseases associated with HNRNPLL include T Cell Deficiency and Type 1 Diabetes Mellitus 15. Among its related pathways are Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPL.

UniProtKB/Swiss-Prot Summary for HNRNPLL Gene

  • RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPLL Gene

Genomics for HNRNPLL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HNRNPLL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPLL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPLL

Genomic Locations for HNRNPLL Gene

Latest Assembly
chr2:38,561,969-38,603,586
(GRCh38/hg38)
Size:
41,618 bases
Orientation:
Minus strand

Previous Assembly
chr2:38,789,111-38,830,070
(GRCh37/hg19 by Entrez Gene)
Size:
40,960 bases
Orientation:
Minus strand

chr2:38,789,120-38,830,728
(GRCh37/hg19 by Ensembl)
Size:
41,609 bases
Orientation:
Minus strand

Genomic View for HNRNPLL Gene

Genes around HNRNPLL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPLL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPLL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPLL Gene

Proteins for HNRNPLL Gene

  • Protein details for HNRNPLL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVV9-HNRLL_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein L-like
    Protein Accession:
    Q8WVV9
    Secondary Accessions:
    • Q53T80
    • Q5JB51
    • Q5JB52
    • Q659B9
    • Q8IVH5
    • Q8IVH6
    • Q96HR5

    Protein attributes for HNRNPLL Gene

    Size:
    542 amino acids
    Molecular mass:
    60083 Da
    Quaternary structure:
    • Interacts with HNRNPL.

    Alternative splice isoforms for HNRNPLL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPLL Gene

Post-translational modifications for HNRNPLL Gene

  • Ubiquitination at Lys71 and Lys261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPLL Gene

Domains & Families for HNRNPLL Gene

Gene Families for HNRNPLL Gene

Protein Domains for HNRNPLL Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • Serine/threonine dehydratase, pyridoxal-phosphate attachment site

Suggested Antigen Peptide Sequences for HNRNPLL Gene

GenScript: Design optimal peptide antigens:
  • Heterogeneous nuclear ribonucleoprotein L-like, isoform CRA_d (D6W592_HUMAN)
  • Stromal RNA-regulating factor (HNRLL_HUMAN)
genes like me logo Genes that share domains with HNRNPLL: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HNRNPLL Gene

Function for HNRNPLL Gene

Molecular function for HNRNPLL Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
UniProtKB/Swiss-Prot Induction:
Up-regulated in stimulated T-cells.

Phenotypes From GWAS Catalog for HNRNPLL Gene

Gene Ontology (GO) - Molecular Function for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003729 mRNA binding IBA,IDA 18669861
GO:0005515 protein binding IPI 18669861
genes like me logo Genes that share ontologies with HNRNPLL: view
genes like me logo Genes that share phenotypes with HNRNPLL: view

miRNA for HNRNPLL Gene

miRTarBase miRNAs that target HNRNPLL

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPLL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPLL Gene

Localization for HNRNPLL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPLL gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with HNRNPLL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HNRNPLL Gene

Pathways & Interactions for HNRNPLL Gene

PathCards logo

SuperPathways for HNRNPLL Gene

SuperPathway Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with HNRNPLL: view

Pathways by source for HNRNPLL Gene

1 Cell Signaling Technology pathway for HNRNPLL Gene

Gene Ontology (GO) - Biological Process for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006417 regulation of translation IBA --
GO:0033120 positive regulation of RNA splicing IBA,IDA 18669861
GO:0043484 regulation of RNA splicing IBA 21873635
genes like me logo Genes that share ontologies with HNRNPLL: view

No data available for SIGNOR curated interactions for HNRNPLL Gene

Drugs & Compounds for HNRNPLL Gene

No Compound Related Data Available

Transcripts for HNRNPLL Gene

mRNA/cDNA for HNRNPLL Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPLL

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPLL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for HNRNPLL Gene

GeneLoc Exon Structure for
HNRNPLL

Expression for HNRNPLL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPLL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HNRNPLL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.9) and Fetal ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPLL Gene



Protein tissue co-expression partners for HNRNPLL Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPLL

mRNA Expression by UniProt/SwissProt for HNRNPLL Gene:

Q8WVV9-HNRLL_HUMAN
Tissue specificity: Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.

Evidence on tissue expression from TISSUES for HNRNPLL Gene

  • Nervous system(4.8)
  • Lymph node(4.3)
  • Blood(2.2)
  • Heart(2.1)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with HNRNPLL: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPLL Gene

Orthologs for HNRNPLL Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPLL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HNRNPLL 30
  • 100 (a)
OneToOne
HNRPLL 29
  • 99.31 (n)
Cow
(Bos Taurus)
Mammalia HNRNPLL 30
  • 98 (a)
OneToOne
HNRPLL 29
  • 96 (n)
Dog
(Canis familiaris)
Mammalia HNRNPLL 29 30
  • 96.31 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HNRNPLL 30
  • 95 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Hnrnpll 29 16 30
  • 90.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hnrnpll 29
  • 90.34 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPLL 30
  • 90 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HNRNPLL 30
  • 97 (a)
OneToOne
HNRPLL 29
  • 84.74 (n)
Lizard
(Anolis carolinensis)
Reptilia HNRNPLL 30
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hnrnpll 29
  • 77.12 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta sm 30
  • 33 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C44B7.2 30
  • 31 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 42 (a)
OneToMany
Species where no ortholog for HNRNPLL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for HNRNPLL Gene

ENSEMBL:
Gene Tree for HNRNPLL (if available)
TreeFam:
Gene Tree for HNRNPLL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPLL: view image
Alliance of Genome Resources:
Additional Orthologs for HNRNPLL

Paralogs for HNRNPLL Gene

Paralogs for HNRNPLL Gene

(2) SIMAP similar genes for HNRNPLL Gene using alignment to 6 proteins:

  • HNRLL_HUMAN
  • C9IYN3_HUMAN
  • C9JJZ7_HUMAN
  • H7BXH8_HUMAN
  • H7C464_HUMAN
  • Q5JB52_HUMAN
genes like me logo Genes that share paralogs with HNRNPLL: view

Variants for HNRNPLL Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HNRNPLL Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HNRNPLL Gene

Variant ID Type Subtype PubMed ID
dgv6789n54 CNV gain 21841781
nsv475399 CNV novel sequence insertion 20440878
nsv476487 CNV novel sequence insertion 20440878
nsv953771 CNV duplication 24416366
nsv9646 CNV loss 18304495

Variation tolerance for HNRNPLL Gene

Residual Variation Intolerance Score: 9.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPLL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPLL
Leiden Open Variation Database (LOVD)
HNRNPLL

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPLL Gene

Disorders for HNRNPLL Gene

MalaCards: The human disease database

(3) MalaCards diseases for HNRNPLL Gene - From: COP and GCD

Disorder Aliases PubMed IDs
t cell deficiency
  • t cell immunodeficiency
type 1 diabetes mellitus 15
  • t1d15
atrial septal defect 2
  • asd2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HNRNPLL

genes like me logo Genes that share disorders with HNRNPLL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPLL Gene

Publications for HNRNPLL Gene

  1. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. (PMID: 18669861) Oberdoerffer S … Rao A (Science (New York, N.Y.) 2008) 2 3 4 22
  2. Alternatively spliced isoforms of a novel stromal RNA regulating factor. (PMID: 15256261) Shur I … Benayahu D (Gene 2004) 3 4 22
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding. (PMID: 32457219) Tran DT … Itkin-Ansari P (Diabetes 2020) 3

Products for HNRNPLL Gene

Sources for HNRNPLL Gene