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Aliases for HNRNPLL Gene

Aliases for HNRNPLL Gene

  • Heterogeneous Nuclear Ribonucleoprotein L Like 2 3 5
  • HNRPLL 3 4
  • SRRF 3 4
  • Heterogeneous Nuclear Ribonucleoprotein L-Like 3
  • Stromal RNA Regulating Factor 3
  • Stromal RNA-Regulating Factor 4
  • HnRNPLL 4

External Ids for HNRNPLL Gene

Previous HGNC Symbols for HNRNPLL Gene

  • HNRPLL

Previous GeneCards Identifiers for HNRNPLL Gene

  • GC02M038790

Summaries for HNRNPLL Gene

Entrez Gene Summary for HNRNPLL Gene

  • HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

GeneCards Summary for HNRNPLL Gene

HNRNPLL (Heterogeneous Nuclear Ribonucleoprotein L Like) is a Protein Coding gene. Among its related pathways are Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPL.

UniProtKB/Swiss-Prot for HNRNPLL Gene

  • RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.

Additional gene information for HNRNPLL Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPLL Gene

Genomics for HNRNPLL Gene

GeneHancer (GH) Regulatory Elements for HNRNPLL Gene

Promoters and enhancers for HNRNPLL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I038598 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.3 2322 6.2 MLX ZFP64 FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SSRP1 ENSG00000235586 HNRNPLL PIR45803 SRSF7 DHX57 LOC101929596 GALM GC02M038560
GH02I038095 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +506.3 506280 4.6 PKNOX1 CLOCK ARNT NEUROD1 FEZF1 ZBTB7B GLIS2 ZNF213 KLF7 FOS ENSG00000272054 CYP1B1 CYP1B1-AS1 SRSF7 DHX57 ARHGEF33 RMDN2-AS1 HNRNPLL CEBPZ CDC42EP3
GH02I038540 Enhancer 1.5 FANTOM5 Ensembl ENCODE 11.5 +61.1 61146 3.4 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 DMAP1 CBX5 E2F8 SRSF7 SOS1 DHX57 ENSG00000235586 HNRNPLL ENSG00000232518 GALM MAP4K3 ENSG00000252473 CYP1B1
GH02I038689 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.6 -88.3 -88271 5.4 PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A ZNF48 NCOA2 TCF12 GALM SRSF7 ENSG00000232518 ENSG00000252473 HNRNPLL SOS1 ENSG00000235586 RPLP0P6
GH02I038701 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.4 -98.9 -98850 1 MEIS2 TEAD4 TAL1 TCF12 CBFA2T2 FOS TRIM24 HLF CBFA2T3 DPF2 GALM ENSG00000232518 HNRNPLL ENSG00000235586 SRSF7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HNRNPLL on UCSC Golden Path with GeneCards custom track

Genomic Locations for HNRNPLL Gene

Genomic Locations for HNRNPLL Gene
chr2:38,561,978-38,603,586
(GRCh38/hg38)
Size:
41,609 bases
Orientation:
Minus strand
chr2:38,789,120-38,830,728
(GRCh37/hg19)

Genomic View for HNRNPLL Gene

Genes around HNRNPLL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPLL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPLL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPLL Gene

Proteins for HNRNPLL Gene

  • Protein details for HNRNPLL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVV9-HNRLL_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein L-like
    Protein Accession:
    Q8WVV9
    Secondary Accessions:
    • Q53T80
    • Q5JB51
    • Q5JB52
    • Q659B9
    • Q8IVH5
    • Q8IVH6
    • Q96HR5

    Protein attributes for HNRNPLL Gene

    Size:
    542 amino acids
    Molecular mass:
    60083 Da
    Quaternary structure:
    • Interacts with HNRNPL.

    Alternative splice isoforms for HNRNPLL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPLL Gene

Post-translational modifications for HNRNPLL Gene

  • Ubiquitination at isoforms=2, 3, 4, 571

No data available for DME Specific Peptides for HNRNPLL Gene

Domains & Families for HNRNPLL Gene

Gene Families for HNRNPLL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HNRNPLL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPLL: view

No data available for UniProtKB/Swiss-Prot for HNRNPLL Gene

Function for HNRNPLL Gene

Molecular function for HNRNPLL Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
UniProtKB/Swiss-Prot Induction:
Up-regulated in stimulated T-cells.

Phenotypes From GWAS Catalog for HNRNPLL Gene

Gene Ontology (GO) - Molecular Function for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003729 mRNA binding IDA 18669861
GO:0005515 protein binding IPI 18669861
genes like me logo Genes that share ontologies with HNRNPLL: view
genes like me logo Genes that share phenotypes with HNRNPLL: view

Animal Model Products

CRISPR Products

miRNA for HNRNPLL Gene

miRTarBase miRNAs that target HNRNPLL

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPLL Gene

Localization for HNRNPLL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPLL gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IDA,HDA 19946888
GO:0019013 viral nucleocapsid IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPLL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HNRNPLL Gene

Pathways & Interactions for HNRNPLL Gene

SuperPathways for HNRNPLL Gene

SuperPathway Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with HNRNPLL: view

Pathways by source for HNRNPLL Gene

1 Cell Signaling Technology pathway for HNRNPLL Gene

Gene Ontology (GO) - Biological Process for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0033120 positive regulation of RNA splicing IDA 18669861
genes like me logo Genes that share ontologies with HNRNPLL: view

No data available for SIGNOR curated interactions for HNRNPLL Gene

Drugs & Compounds for HNRNPLL Gene

No Compound Related Data Available

Transcripts for HNRNPLL Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPLL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for HNRNPLL Gene

GeneLoc Exon Structure for
HNRNPLL
ECgene alternative splicing isoforms for
HNRNPLL

Expression for HNRNPLL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPLL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HNRNPLL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.9) and Fetal ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPLL Gene



Protein tissue co-expression partners for HNRNPLL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPLL Gene:

HNRNPLL

mRNA Expression by UniProt/SwissProt for HNRNPLL Gene:

Q8WVV9-HNRLL_HUMAN
Tissue specificity: Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.

Evidence on tissue expression from TISSUES for HNRNPLL Gene

  • Nervous system(4.7)
  • Lymph node(4.2)
genes like me logo Genes that share expression patterns with HNRNPLL: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPLL Gene

Orthologs for HNRNPLL Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPLL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPLL 34
  • 100 (a)
OneToOne
HNRPLL 33
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia HNRNPLL 34
  • 98 (a)
OneToOne
HNRPLL 33
  • 96 (n)
dog
(Canis familiaris)
Mammalia HNRNPLL 33 34
  • 96.31 (n)
oppossum
(Monodelphis domestica)
Mammalia HNRNPLL 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpll 33 16 34
  • 90.87 (n)
rat
(Rattus norvegicus)
Mammalia Hnrnpll 33
  • 90.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPLL 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPLL 34
  • 97 (a)
OneToOne
HNRPLL 33
  • 84.74 (n)
lizard
(Anolis carolinensis)
Reptilia HNRNPLL 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpll 33
  • 77.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta sm 34
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C44B7.2 34
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToMany
Species where no ortholog for HNRNPLL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HNRNPLL Gene

ENSEMBL:
Gene Tree for HNRNPLL (if available)
TreeFam:
Gene Tree for HNRNPLL (if available)

Paralogs for HNRNPLL Gene

Paralogs for HNRNPLL Gene

(2) SIMAP similar genes for HNRNPLL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HNRNPLL: view

Variants for HNRNPLL Gene

Sequence variations from dbSNP and Humsavar for HNRNPLL Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000120394 -- 38,564,020(-) G/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000137908 -- 38,597,754(-) T/A intron_variant
rs1000246726 -- 38,566,942(-) G/C intron_variant
rs1000295617 -- 38,579,448(-) T/A intron_variant
rs1000361751 -- 38,589,037(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPLL Gene

Variant ID Type Subtype PubMed ID
nsv9646 CNV loss 18304495
nsv953771 CNV duplication 24416366
nsv476487 CNV novel sequence insertion 20440878
nsv475399 CNV novel sequence insertion 20440878
dgv6789n54 CNV gain 21841781

Variation tolerance for HNRNPLL Gene

Residual Variation Intolerance Score: 9.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPLL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPLL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPLL Gene

Disorders for HNRNPLL Gene

Additional Disease Information for HNRNPLL

No disorders were found for HNRNPLL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPLL Gene

Publications for HNRNPLL Gene

  1. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. (PMID: 18669861) Oberdoerffer S … Rao A (Science (New York, N.Y.) 2008) 2 3 4 22 58
  2. Alternatively spliced isoforms of a novel stromal RNA regulating factor. (PMID: 15256261) Shur I … Benayahu D (Gene 2004) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for HNRNPLL Gene

Sources for HNRNPLL Gene

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