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Aliases for HNRNPL Gene

Aliases for HNRNPL Gene

  • Heterogeneous Nuclear Ribonucleoprotein L 2 3 5
  • HnRNP L 3 4
  • HNRPL 3 4
  • P/OKcl.14 3
  • HnRNP-L 3

External Ids for HNRNPL Gene

Previous HGNC Symbols for HNRNPL Gene

  • HNRPL

Previous GeneCards Identifiers for HNRNPL Gene

  • GC19M044022
  • GC19M039327
  • GC19M035773

Summaries for HNRNPL Gene

Entrez Gene Summary for HNRNPL Gene

  • Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPL Gene

HNRNPL (Heterogeneous Nuclear Ribonucleoprotein L) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPLL.

UniProtKB/Swiss-Prot for HNRNPL Gene

  • Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897).

Gene Wiki entry for HNRNPL Gene

Additional gene information for HNRNPL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPL Gene

Genomics for HNRNPL Gene

GeneHancer (GH) Regulatory Elements for HNRNPL Gene

Promoters and enhancers for HNRNPL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I038846 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 659.4 +2.2 2159 6.6 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 HNRNPL FBL ENSG00000269688 PLEKHG2 RN7SL566P RPS16 PAK4 PAF1 SUPT5H ENSG00000267892
GH19I039397 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 222 -554.7 -554728 20 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZFP36 PLEKHG2 HNRNPL ZNF780B FBL ZNF780A SUPT5H AKT2 RN7SL566P RPS16
GH19I038647 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 135.5 +192.6 192554 25.6 ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZC3H11A ACTN4 HNRNPL ZFP30 ZNF607 ZNF781 ZNF573 SUPT5H ENSG00000267152 PAK4 RN7SL566P
GH19I039427 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 120 -579.8 -579799 9.7 MLX ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF416 ZNF143 SP3 NFYC RPS16 HNRNPL FBL ZNF780B AKT2 PLEKHG2 RN7SL566P SUPT5H ENSG00000269688 EID2B
GH19I038336 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 156 +515.9 515922 2.5 CLOCK MLX DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 CATSPERG HNRNPL ZNF527 ZFP30 ZNF571 ZNF573 ZNF607 ZNF793 ENSG00000269688 C19orf33
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HNRNPL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HNRNPL gene promoter:

Genomic Locations for HNRNPL Gene

Genomic Locations for HNRNPL Gene
chr19:38,836,378-38,852,347
(GRCh38/hg38)
Size:
15,970 bases
Orientation:
Minus strand
chr19:39,327,028-39,342,987
(GRCh37/hg19)

Genomic View for HNRNPL Gene

Genes around HNRNPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPL Gene

Proteins for HNRNPL Gene

  • Protein details for HNRNPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14866-HNRPL_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein L
    Protein Accession:
    P14866
    Secondary Accessions:
    • A6ND69
    • A6NIT8
    • Q9H3P3

    Protein attributes for HNRNPL Gene

    Size:
    589 amino acids
    Molecular mass:
    64133 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with HNRNPLL (PubMed:18669861). Interacts with APEX1; the interaction is DNA-dependent (PubMed:11809897). Component of a complex with SETD2 (PubMed:19332550). Interacts with ELAVL1 (PubMed:18161049).
    Miscellaneous:
    • Excess hnRNP L activates NMD of its own mRNA by promoting the inclusion of a poison exon containing a premature stop codon and leading to nonsense-mediated decay. It also cross-regulates inclusion of an analogous poison exon in the hnRNP L-like pre-mRNA (PubMed:19124611).
    SequenceCaution:
    • Sequence=CAA34261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPL Gene

    Alternative splice isoforms for HNRNPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPL Gene

Post-translational modifications for HNRNPL Gene

  • Phosphorylation at Ser-544 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization.
  • Several isoelectric forms of the L protein are probably the results of post-translational modifications.
  • Ubiquitination at posLast=5959, posLast=9797, posLast=229229, isoforms=2248, isoforms=2264, posLast=277277, isoforms=2302, posLast=455455, isoforms=2493, isoforms=2533, and isoforms=2568
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPL Gene

Domains & Families for HNRNPL Gene

Gene Families for HNRNPL Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P14866

UniProtKB/Swiss-Prot:

HNRPL_HUMAN :
  • RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA (PubMed:23782695).
Domain:
  • RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA (PubMed:23782695).
genes like me logo Genes that share domains with HNRNPL: view

Function for HNRNPL Gene

Molecular function for HNRNPL Gene

UniProtKB/Swiss-Prot Function:
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897).

Phenotypes From GWAS Catalog for HNRNPL Gene

Gene Ontology (GO) - Molecular Function for HNRNPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IPI 11809897
GO:0044212 transcription regulatory region DNA binding IDA 11809897
GO:0097157 pre-mRNA intronic binding IDA 25623890
genes like me logo Genes that share ontologies with HNRNPL: view
genes like me logo Genes that share phenotypes with HNRNPL: view

Animal Models for HNRNPL Gene

MGI Knock Outs for HNRNPL:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNRNPL Gene

Localization for HNRNPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPL Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules. {ECO:0000269 PubMed:17289661}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPL gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 15798186
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA,HDA 19946888
GO:0019013 viral nucleocapsid IEA --
genes like me logo Genes that share ontologies with HNRNPL: view

Pathways & Interactions for HNRNPL Gene

genes like me logo Genes that share pathways with HNRNPL: view

Pathways by source for HNRNPL Gene

SIGNOR curated interactions for HNRNPL Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HNRNPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 25623890
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing TAS 2687284
GO:0006397 mRNA processing IEA --
GO:0016070 RNA metabolic process TAS --
genes like me logo Genes that share ontologies with HNRNPL: view

Drugs & Compounds for HNRNPL Gene

(1) Drugs for HNRNPL Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202

(1) Additional Compounds for HNRNPL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HNRNPL: view

Transcripts for HNRNPL Gene

Unigene Clusters for HNRNPL Gene

Heterogeneous nuclear ribonucleoprotein L:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPL Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for HNRNPL Gene

GeneLoc Exon Structure for
HNRNPL
ECgene alternative splicing isoforms for
HNRNPL

Expression for HNRNPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPL Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPL Gene



Protein tissue co-expression partners for HNRNPL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPL Gene:

HNRNPL

SOURCE GeneReport for Unigene cluster for HNRNPL Gene:

Hs.644906

Evidence on tissue expression from TISSUES for HNRNPL Gene

  • Nervous system(4.7)
  • Liver(4.6)
  • Skin(4.6)
  • Intestine(3.2)
  • Lung(3.2)
  • Kidney(3.1)
  • Muscle(3.1)
  • Heart(3)
  • Adrenal gland(2.8)
  • Bone marrow(2.8)
  • Gall bladder(2.8)
  • Lymph node(2.8)
  • Pancreas(2.8)
  • Spleen(2.8)
  • Stomach(2.8)
  • Thyroid gland(2.8)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with HNRNPL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPL Gene

Orthologs for HNRNPL Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPL 33 34
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia HNRNPL 33 34
  • 94.84 (n)
dog
(Canis familiaris)
Mammalia HNRNPL 33 34
  • 94.51 (n)
rat
(Rattus norvegicus)
Mammalia Hnrnpl 33
  • 91.87 (n)
mouse
(Mus musculus)
Mammalia Hnrnpl 33 16 34
  • 91.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 98 (a)
ManyToMany
-- 34
  • 89 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpl 33
  • 77.71 (n)
Str.5918 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1324 33
zebrafish
(Danio rerio)
Actinopterygii hnrnpl2 34
  • 77 (a)
ManyToMany
hnrpl 33 34
  • 73.6 (n)
CABZ01100304.1 34
  • 52 (a)
ManyToMany
zgc55429 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8682 33
fruit fly
(Drosophila melanogaster)
Insecta sm 33 34
  • 54.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012054 33
  • 54 (n)
worm
(Caenorhabditis elegans)
Secernentea C44B7.2 33 34
  • 48.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2266 33
Species where no ortholog for HNRNPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPL Gene

ENSEMBL:
Gene Tree for HNRNPL (if available)
TreeFam:
Gene Tree for HNRNPL (if available)

Paralogs for HNRNPL Gene

Paralogs for HNRNPL Gene

(4) SIMAP similar genes for HNRNPL Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for HNRNPL Gene

genes like me logo Genes that share paralogs with HNRNPL: view

Variants for HNRNPL Gene

Sequence variations from dbSNP and Humsavar for HNRNPL Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000113012 -- 38,843,275(-) T/C intron_variant
rs1000219686 -- 38,851,631(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000355165 -- 38,851,918(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000417755 -- 38,851,795(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000523865 -- 38,843,775(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPL Gene

Variant ID Type Subtype PubMed ID
esv29388 CNV loss 19812545
nsv1160616 CNV duplication 26073780

Variation tolerance for HNRNPL Gene

Residual Variation Intolerance Score: 6.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPL Gene

Disorders for HNRNPL Gene

Additional Disease Information for HNRNPL

No disorders were found for HNRNPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPL Gene

Publications for HNRNPL Gene

  1. Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. (PMID: 19332550) Yuan W … Reinberg D (The Journal of biological chemistry 2009) 3 4 22 58
  2. Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. (PMID: 11809897) Kuninger DT … Mitra S (Nucleic acids research 2002) 3 4 22 58
  3. A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts. (PMID: 2687284) Piñol-Roma S … Dreyfuss G (The Journal of cell biology 1989) 2 3 4 58
  4. hnRNP L inhibits CD44 V10 exon splicing through interacting with its upstream intron. (PMID: 25623890) Loh TJ … Shen H (Biochimica et biophysica acta 2015) 3 4 58
  5. The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein. (PMID: 26051023) Blatter M … Allain FH (Journal of molecular biology 2015) 3 4 58

Products for HNRNPL Gene