This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hn... See more...

Aliases for HNRNPH3 Gene

Aliases for HNRNPH3 Gene

  • Heterogeneous Nuclear Ribonucleoprotein H3 2 3 4 5
  • Heterogeneous Nuclear Ribonucleoprotein 2H9 2 3 4
  • HnRNP 2H9 3 4
  • HnRNP H3 3 4
  • HNRPH3 3 4
  • Heterogeneous Nuclear Ribonucleoprotein H3 (2H9) 2
  • 2H9 3

External Ids for HNRNPH3 Gene

Previous HGNC Symbols for HNRNPH3 Gene

  • HNRPH3

Previous GeneCards Identifiers for HNRNPH3 Gene

  • GC10P069762
  • GC10P070090
  • GC10P064093

Summaries for HNRNPH3 Gene

Entrez Gene Summary for HNRNPH3 Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPH3 Gene

HNRNPH3 (Heterogeneous Nuclear Ribonucleoprotein H3) is a Protein Coding gene. Diseases associated with HNRNPH3 include Reticulosarcoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH2.

UniProtKB/Swiss-Prot Summary for HNRNPH3 Gene

  • Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.

Gene Wiki entry for HNRNPH3 Gene

Additional gene information for HNRNPH3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPH3 Gene

Genomics for HNRNPH3 Gene

GeneHancer (GH) Regulatory Elements for HNRNPH3 Gene

Promoters and enhancers for HNRNPH3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J068327 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 529.9 +1.3 1291 9.5 RXRA HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 MYC TCF12 HNRNPH3 PBLD DNA2 SIRT1 DDX50 CCAR1 HERC4 TET1 RPS3AP38
GH10J068102 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 500.1 -222.9 -222941 10.7 ZSCAN5C TCF12 ZNF639 ZNF10 EP300 ZEB1 OSR2 BCL11A WT1 ZNF316 MYPN HNRNPH3 HERC4 ATOH7 lnc-HERC4-2
GH10J068899 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 20.3 +570.0 570013 3.6 ZBTB40 ZNF217 EP300 CTCF NRF1 POLR2G SP1 GTF2E2 PHF8 FOS DDX50 lnc-SLC25A16-5 piR-38995 CCAR1 HERC4 HNRNPH3 DDX21 RPL26P27 KIFBP ENSG00000285871
GH10J068071 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 20.4 -257.6 -257574 5.2 HNRNPK ZBTB40 EP300 SIN3A NRF1 POLR2G GTF2E2 PHF8 TEAD4 ZFX HERC4 lnc-ATOH7-3 SIRT1 DDX50 CCAR1 HNRNPH3 RPL12P8 RPL26P27 DDX21 ENSG00000221184
GH10J067763 Promoter/Enhancer 1.4 ENCODE CraniofacialAtlas 31.2 -566.8 -566819 2.6 ZBTB40 ZNF217 EP300 ZSCAN5C NRF1 TCF12 USF1 NCOR1 TEAD4 FOS CTNNA3 TRS-TGA1-1 HNRNPH3 CCAR1 SIRT1 RUFY2 HERC4 TET1 lnc-DNAJC12-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPH3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPH3

Top Transcription factor binding sites by QIAGEN in the HNRNPH3 gene promoter:
  • AML1a
  • Evi-1
  • MZF-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pax-2
  • Pbx1a

Genomic Locations for HNRNPH3 Gene

Genomic Locations for HNRNPH3 Gene
chr10:68,331,174-68,343,196
(GRCh38/hg38)
Size:
12,023 bases
Orientation:
Plus strand
chr10:70,090,931-70,102,953
(GRCh37/hg19)
Size:
12,023 bases
Orientation:
Plus strand

Genomic View for HNRNPH3 Gene

Genes around HNRNPH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPH3 Gene

Proteins for HNRNPH3 Gene

  • Protein details for HNRNPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31942-HNRH3_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein H3
    Protein Accession:
    P31942
    Secondary Accessions:
    • A8K682
    • B3KRE1
    • Q9BSX1
    • Q9NP53
    • Q9NP96
    • Q9NPA7
    • Q9NPI4
    • Q9UFU4
    • Q9Y4J5

    Protein attributes for HNRNPH3 Gene

    Size:
    346 amino acids
    Molecular mass:
    36926 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HNRNPH3 Gene

neXtProt entry for HNRNPH3 Gene

Post-translational modifications for HNRNPH3 Gene

  • Ubiquitination at Lys6 and Lys67
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for HNRNPH3
  • Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPH3

No data available for DME Specific Peptides for HNRNPH3 Gene

Domains & Families for HNRNPH3 Gene

Gene Families for HNRNPH3 Gene

Protein Domains for HNRNPH3 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HNRNPH3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57726, highly similar to Heterogeneous nuclear ribonucleoprotein H3 (B4DHY1_HUMAN)
  • Heterogeneous nuclear ribonucleoprotein 2H9 (HNRH3_HUMAN)
genes like me logo Genes that share domains with HNRNPH3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HNRNPH3 Gene

Function for HNRNPH3 Gene

Molecular function for HNRNPH3 Gene

UniProtKB/Swiss-Prot Function:
Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.

Phenotypes From GWAS Catalog for HNRNPH3 Gene

Gene Ontology (GO) - Molecular Function for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS,NAS 10858537
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with HNRNPH3: view
genes like me logo Genes that share phenotypes with HNRNPH3: view

Animal Model Products

CRISPR Products

miRNA for HNRNPH3 Gene

miRTarBase miRNAs that target HNRNPH3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPH3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPH3 Gene

Localization for HNRNPH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPH3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPH3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 22720776
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex TAS 8999868
genes like me logo Genes that share ontologies with HNRNPH3: view

Pathways & Interactions for HNRNPH3 Gene

PathCards logo

SuperPathways for HNRNPH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome NAS 10858537
GO:0006396 RNA processing TAS 8999868
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing TAS 8999868
GO:0030855 epithelial cell differentiation IEP 21492153
genes like me logo Genes that share ontologies with HNRNPH3: view

No data available for Pathways by source and SIGNOR curated interactions for HNRNPH3 Gene

Drugs & Compounds for HNRNPH3 Gene

(1) Drugs for HNRNPH3 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 236
genes like me logo Genes that share compounds with HNRNPH3: view

Transcripts for HNRNPH3 Gene

mRNA/cDNA for HNRNPH3 Gene

21 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPH3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPH3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ·
SP1: - - - - - - - - -
SP2: - - -
SP3:
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8:
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - -
SP19: - - - - - -
SP20: - -
SP21: - - -
SP22: - -
SP23: - - - - -

ExUns: 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8: -
SP9: -
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:

Relevant External Links for HNRNPH3 Gene

GeneLoc Exon Structure for
HNRNPH3

Expression for HNRNPH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HNRNPH3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPH3 Gene



Protein tissue co-expression partners for HNRNPH3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPH3

SOURCE GeneReport for Unigene cluster for HNRNPH3 Gene:

Hs.643472

Evidence on tissue expression from TISSUES for HNRNPH3 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Skin(4.4)
  • Eye(2.6)
  • Heart(2.5)
  • Spleen(2.5)
  • Kidney(2.4)
  • Lung(2.4)
  • Lymph node(2.4)
  • Muscle(2.4)
  • Bone marrow(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with HNRNPH3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPH3 Gene

Orthologs for HNRNPH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPH3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 31
  • 100 (a)
OneToMany
HNRNPH3 30
  • 97.48 (n)
-- 31
  • 95 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HNRNPH3 31 30
  • 99.71 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPH3 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPH3 31 30
  • 97.01 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPH3 31
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910795 30
  • 95.86 (n)
mouse
(Mus musculus)
Mammalia Hnrnph3 17 31 30
  • 94.99 (n)
chicken
(Gallus gallus)
Aves HNRNPH3 31 30
  • 84.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPH3 31
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5236 30
zebrafish
(Danio rerio)
Actinopterygii HNRNPH3 31
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14128 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToMany
Species where no ortholog for HNRNPH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPH3 Gene

ENSEMBL:
Gene Tree for HNRNPH3 (if available)
TreeFam:
Gene Tree for HNRNPH3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPH3: view image

Paralogs for HNRNPH3 Gene

Paralogs for HNRNPH3 Gene

(6) SIMAP similar genes for HNRNPH3 Gene using alignment to 2 proteins:

  • HNRH3_HUMAN
  • B4DHY1_HUMAN

Pseudogenes.org Pseudogenes for HNRNPH3 Gene

genes like me logo Genes that share paralogs with HNRNPH3: view

Variants for HNRNPH3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPH3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs16925347 - p.Gly284Ala
rs2273903 - p.Asn163Ser

Additional dbSNP identifiers (rs#s) for HNRNPH3 Gene

Structural Variations from Database of Genomic Variants (DGV) for HNRNPH3 Gene

Variant ID Type Subtype PubMed ID
nsv950972 CNV duplication 24416366

Variation tolerance for HNRNPH3 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPH3 Gene

Human Gene Mutation Database (HGMD)
HNRNPH3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPH3 Gene

Disorders for HNRNPH3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPH3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
reticulosarcoma
  • diffuse large b-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HNRNPH3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HNRNPH3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPH3 Gene

Publications for HNRNPH3 Gene

  1. Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest. (PMID: 8999868) Mahé D … Fuchs JP (The Journal of biological chemistry 1997) 2 3 4 23 54
  2. The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene. (PMID: 10858537) Honoré B (Biochimica et biophysica acta 2000) 3 4 23 54
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 54

Products for HNRNPH3 Gene

Sources for HNRNPH3 Gene