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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of th... See more...
Aliases for HNRNPF Gene
Aliases for HNRNPF Gene
External Ids for HNRNPF Gene
- HGNC: 5039
- Entrez Gene: 3185
- Ensembl: ENSG00000169813
- OMIM: 601037
- UniProtKB: P52597
Previous HGNC Symbols for HNRNPF Gene
- HNRPF
Previous GeneCards Identifiers for HNRNPF Gene
- GC10M043202
- GC10M043881
- GC10M040407
Summaries for HNRNPF Gene
-
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPF Gene
HNRNPF (Heterogeneous Nuclear Ribonucleoprotein F) is a Protein Coding gene. Diseases associated with HNRNPF include Postsurgical Hypothyroidism and Atrial Septal Defect 1. Among its related pathways are Signaling by GPCR and Telomere Extension by Telomerase. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH1.
UniProtKB/Swiss-Prot Summary for HNRNPF Gene
-
Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.
Additional gene information for HNRNPF Gene
- HGNC(5039)
- Entrez Gene(3185)
- Ensembl(ENSG00000169813)
- OMIM(601037)
- UniProtKB(P52597)
- Open Targets Platform(ENSG00000169813)
- Search for HNRNPF at DataMed
- Search for HNRNPF at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPF Gene
Genomics for HNRNPF Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HNRNPF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HNRNPF on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPF
- Top Transcription factor binding sites by QIAGEN in the HNRNPF gene promoter:
-
- c-Ets-1
- Elk-1
- Meis-1
Genomic Locations for HNRNPF Gene
Genomic Locations for HNRNPF Gene
- chr10:43,385,617-43,409,248
- (GRCh38/hg38)
- Size:
- 23,632 bases
- Orientation:
- Minus strand
- chr10:43,881,065-43,904,696
- (GRCh37/hg19)
- Size:
- 23,632 bases
- Orientation:
- Minus strand
Genomic View for HNRNPF Gene
Genes around HNRNPF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q11.21 by HGNC
- 10q11.21 by Entrez Gene
- 10q11.21 by Ensembl
HNRNPF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPF Gene
Proteins for HNRNPF Gene
-
Protein details for HNRNPF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P52597-HNRPF_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein F
- Protein Accession:
- P52597
- B3KM84
- Q5T0N2
- Q96AU2
Protein attributes for HNRNPF Gene
- Size:
- 415 amino acids
- Molecular mass:
- 45672 Da
- Quaternary structure:
-
- Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1.
Protein Expression for HNRNPF Gene
Post-translational modifications for HNRNPF Gene
- Sumoylated.
-
Ubiquitination at Lys14, Lys87, Lys98, Lys167, Lys185, Lys200, Lys224, and Lys299
- NX_P52597 (NX_P52597-1)
- Modification sites at PhosphoSitePlus
Other Protein References for HNRNPF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HNRNPF Antibody and Immunotag™ hnRNP F Antibody
- GeneTex Anti-hnRNP F antibody [N1N3]
- NSJ Bioreagents hnRNP F Antibody
-
Custom Antibody ServicesOriGene Antibodies for HNRNPF
- Novus Biologicals Antibodies for HNRNPF
- Invitrogen Antibodies for HNRNPF (AFLGC-Hnrnpf)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPF
Protein Products
-
OriGene Purified Proteins for HNRNPF
- NM_004966
- NM_001098205
- NM_001098204
- NM_001098207
- NM_001098206
- NM_004966
- NM_001098204
- NM_001098205
- NM_001098206
- NM_001098207
- NM_001098208
- NM_001098204
- NM_001098205
- NM_001098206
- NM_001098207
- NM_001098208
- NM_004966
- NM_001098204
- NM_001098205
- NM_001098206
- NM_001098207
- NM_001098208
- NM_001098204
- NM_001098205
- NM_001098206
- NM_001098207
- NM_001098208
- NM_004966
- NM_001098205
- NM_001098204
- NM_001098207
- NM_001098206
- BC089313
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPF
- Origene Custom Protein Services for HNRNPF
- antibodies-online: Show 13 available HNRNPF Proteins ranked by validation data
- Compare Top HNRNPF Proteins
-
Quality Products:
-
Signalway Proteins for HNRNPF
-
Abcam proteins for HNRNPF
Assay Products
-
Signalway ELISA kits for HNRNPF
No data available for DME Specific Peptides for HNRNPF Gene
Domains & Families for HNRNPF Gene
Gene Families for HNRNPF Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for HNRNPF Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
- Zinc finger, CHHC
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPF Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57121, highly similar to Heterogeneous nuclear ribonucleoprotein F (B4DKS8_HUMAN)
- Nucleolin-like protein mcs94-1 (HNRPF_HUMAN)
- Heterogeneous nuclear ribonucleoprotein F (Q8NI96_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P52597UniProtKB/Swiss-Prot:
HNRPF_HUMAN :- The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.
- Domain:
-
- The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.
Function for HNRNPF Gene
Molecular function for HNRNPF Gene
- UniProtKB/Swiss-Prot Function:
- Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.
Phenotypes From GWAS Catalog for HNRNPF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | TAS,IBA | 21873635 |
| GO:0003727 | single-stranded RNA binding | IDA | 20526337 |
| GO:0005515 | protein binding | IPI | 9111328 |
| GO:0008134 | transcription factor binding | IEA | -- |
Phenotypes for HNRNPF Gene
- MGI mutant phenotypes for HNRNPF:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HNRNPF:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HNRNPF - Select products 50% OFF >
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OriGene CRISPR knockouts for HNRNPF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HNRNPF
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPF
miRNA for HNRNPF Gene
- miRTarBase miRNAs that target HNRNPF
-
- hsa-miR-874-3p (MIRT037762)
- hsa-miR-615-3p (MIRT040073)
- hsa-miR-18a-3p (MIRT040847)
- hsa-miR-505-3p (MIRT041015)
- hsa-miR-339-5p (MIRT042766)
- hsa-miR-328-3p (MIRT043767)
- hsa-miR-27b-3p (MIRT046236)
- hsa-miR-10b-5p (MIRT047469)
- hsa-miR-10a-5p (MIRT047662)
- hsa-miR-92a-3p (MIRT049243)
- hsa-miR-16-5p (MIRT051089)
- hsa-let-7b-5p (MIRT052092)
- hsa-miR-590-3p (MIRT056644)
- hsa-miR-4709-3p (MIRT126944)
- hsa-miR-27a-3p (MIRT177532)
- hsa-miR-216a-3p (MIRT177533)
- hsa-miR-128-3p (MIRT177534)
- hsa-miR-3681-3p (MIRT177537)
- hsa-miR-507 (MIRT177539)
- hsa-miR-557 (MIRT177540)
- hsa-miR-888-5p (MIRT262609)
- hsa-miR-1468-3p (MIRT330541)
- hsa-miR-548f-5p (MIRT330542)
- hsa-miR-548g-5p (MIRT330543)
- hsa-miR-548x-5p (MIRT330544)
- hsa-miR-548aj-5p (MIRT330545)
- hsa-miR-4698 (MIRT330548)
- hsa-miR-548aw (MIRT330549)
- hsa-miR-3685 (MIRT475555)
- hsa-miR-592 (MIRT475556)
- hsa-miR-514b-5p (MIRT475557)
- hsa-miR-513c-5p (MIRT475558)
- hsa-miR-155-3p (MIRT475559)
- hsa-miR-4711-3p (MIRT475560)
- hsa-miR-372-5p (MIRT475561)
- hsa-miR-371a-5p (MIRT475562)
- hsa-miR-616-5p (MIRT475563)
- hsa-miR-373-5p (MIRT475564)
- hsa-miR-371b-5p (MIRT475565)
- hsa-miR-5571-5p (MIRT475566)
- hsa-miR-16-1-3p (MIRT475567)
- hsa-miR-139-5p (MIRT475568)
- hsa-miR-101-3p (MIRT475569)
- hsa-miR-144-3p (MIRT475570)
- hsa-miR-3680-3p (MIRT502248)
- hsa-miR-450b-5p (MIRT502249)
- hsa-miR-4666b (MIRT502250)
- hsa-miR-5011-3p (MIRT502251)
- hsa-miR-4775 (MIRT502252)
- hsa-miR-6076 (MIRT502253)
- hsa-miR-6797-3p (MIRT502254)
- hsa-miR-539-5p (MIRT502255)
- hsa-miR-570-3p (MIRT502256)
- hsa-miR-488-5p (MIRT502257)
- hsa-miR-141-3p (MIRT502258)
- hsa-miR-200a-3p (MIRT502259)
- hsa-miR-6842-3p (MIRT511455)
- hsa-miR-647 (MIRT511456)
- hsa-miR-1273e (MIRT511457)
- hsa-miR-6514-3p (MIRT511458)
- hsa-miR-573 (MIRT511459)
- hsa-miR-3616-5p (MIRT511460)
- hsa-miR-6762-3p (MIRT511461)
- hsa-miR-604 (MIRT511462)
- hsa-miR-6882-3p (MIRT511463)
- hsa-miR-6811-3p (MIRT511464)
- hsa-miR-5585-5p (MIRT511465)
- hsa-miR-548ax (MIRT511466)
- hsa-miR-548ao-5p (MIRT511467)
- hsa-miR-302f (MIRT511468)
- hsa-miR-580-5p (MIRT511469)
- hsa-miR-6750-3p (MIRT511470)
- hsa-miR-3662 (MIRT511471)
- hsa-miR-214-5p (MIRT511472)
- hsa-miR-6780a-3p (MIRT557204)
- hsa-miR-6881-3p (MIRT557205)
- hsa-miR-7111-3p (MIRT557206)
- hsa-miR-7162-5p (MIRT557207)
- hsa-miR-516b-3p (MIRT557208)
- hsa-miR-516a-3p (MIRT557209)
- hsa-miR-361-3p (MIRT557210)
- hsa-miR-4506 (MIRT557211)
- hsa-miR-19a-3p (MIRT557212)
- hsa-miR-19b-3p (MIRT557213)
- hsa-miR-524-5p (MIRT562179)
- hsa-miR-3922-5p (MIRT562180)
- hsa-miR-520d-5p (MIRT562181)
- hsa-miR-651-3p (MIRT562182)
- hsa-miR-561-3p (MIRT562183)
- hsa-miR-224-5p (MIRT562184)
- hsa-miR-7856-5p (MIRT571996)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HNRNPF
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Clone Products
- Applied Biological Materials (abm): Clones for HNRNPF - Select products 50% OFF >
- * HNRNPF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206178
- MG206554
- MG206567
- MG217094
- MG217106
- MG217114
- MG217122
- MG218542
- MR206178
- MR206178L3
- MR206178L4
- MR206554
- MR206554L3
- MR206554L4
- MR206567
- MR206567L3
- MR206567L4
- MR217094
- MR217094L3
- MR217094L4
- MR217106
- MR217106L3
- MR217106L4
- MR217114
- MR217114L3
- MR217114L4
- MR217122
- MR217122L3
- MR217122L4
- MR218542
- MR218542L3
- MR218542L4
- RC205100
- RC205100L1
- RC205100L2
- RC205100L3
- RC205100L4
- RC212568
- RC212568L3
- RC212568L4
- RC212612
- RC212612L3
- RC212612L4
- RC212850
- RC212850L1
- RC212850L2
- RC212850L3
- RC212850L4
- RC213874
- RC213874L3
- RC213874L4
- RC217995
- RC217995L3
- RC217995L4
- RG205100
- RG212568
- RG212612
- RG212850
- RG213874
- RG217995
- RR200320
- RR200320L3
- RR200320L4
- RR216606
- RR216607
- RR216608
- MR206178L3V
- MR206178L4V
- MR206554L3V
- MR206554L4V
- MR206567L3V
- MR206567L4V
- MR217094L3V
- MR217094L4V
- MR217106L3V
- MR217106L4V
- MR217114L3V
- MR217114L4V
- MR217122L3V
- MR217122L4V
- MR218542L3V
- MR218542L4V
- RC205100L1V
- RC205100L2V
- RC205100L3V
- RC205100L4V
- RC212568L3V
- RC212568L4V
- RC212612L3V
- RC212612L4V
- RC212850L1V
- RC212850L2V
- RC212850L3V
- RC212850L4V
- RC213874L3V
- RC213874L4V
- RC217995L3V
- RC217995L4V
- RR200320L3V
- RR200320L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HNRNPF
- Addgene plasmids for HNRNPF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HNRNPF
Cell Line Products
-
Horizon Cell Lines for HNRNPF
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPF Gene
Localization for HNRNPF Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPF Gene
- Nucleus, nucleoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 4 |
| cytosol | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| extracellular | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 7499401 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for HNRNPF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
|
| 2 | Signaling by FGFR2 | ||
| 3 | Telomere Extension by Telomerase |
Telomere Extension by Telomerase
-
|
|
| 4 | HIV Transcription Elongation | ||
| 5 | Gene Expression |
.48
|
|
Pathways by source for HNRNPF Gene
1 BioSystems pathway for HNRNPF Gene
8 Reactome pathways for HNRNPF Gene
1 Qiagen pathway for HNRNPF Gene
- Telomere Extension by Telomerase
Interacting Proteins for HNRNPF Gene
Selected Interacting proteins:
P52597-HNRPF_HUMAN
ENSP00000400433
for HNRNPF Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HNRNPF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006396 | RNA processing | TAS | 7499401 |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | TAS | -- |
No data available for SIGNOR curated interactions for HNRNPF Gene
Drugs & Compounds for HNRNPF Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Phenethyl isothiocyanate | Investigational | Pharma | Target | 12 |
Transcripts for HNRNPF Gene
mRNA/cDNA for HNRNPF Gene
- 6 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000337970 2186 nts (view in UCSC)
- ENST00000356053 2670 nts (view in UCSC)
- ENST00000357065 2617 nts (view in UCSC)
- ENST00000443950 2755 nts (view in UCSC)
- ENST00000477108 636 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HNRNPF - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HNRNPF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HNRNPF
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HNRNPF
- Browse OriGene Inhibitory RNA Products For HNRNPF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPF
Clone Products
- Applied Biological Materials (abm): Clones for HNRNPF - Select products 50% OFF >
- * HNRNPF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206178
- MG206554
- MG206567
- MG217094
- MG217106
- MG217114
- MG217122
- MG218542
- MR206178
- MR206178L3
- MR206178L4
- MR206554
- MR206554L3
- MR206554L4
- MR206567
- MR206567L3
- MR206567L4
- MR217094
- MR217094L3
- MR217094L4
- MR217106
- MR217106L3
- MR217106L4
- MR217114
- MR217114L3
- MR217114L4
- MR217122
- MR217122L3
- MR217122L4
- MR218542
- MR218542L3
- MR218542L4
- RC205100
- RC205100L1
- RC205100L2
- RC205100L3
- RC205100L4
- RC212568
- RC212568L3
- RC212568L4
- RC212612
- RC212612L3
- RC212612L4
- RC212850
- RC212850L1
- RC212850L2
- RC212850L3
- RC212850L4
- RC213874
- RC213874L3
- RC213874L4
- RC217995
- RC217995L3
- RC217995L4
- RG205100
- RG212568
- RG212612
- RG212850
- RG213874
- RG217995
- RR200320
- RR200320L3
- RR200320L4
- RR216606
- RR216607
- RR216608
- MR206178L3V
- MR206178L4V
- MR206554L3V
- MR206554L4V
- MR206567L3V
- MR206567L4V
- MR217094L3V
- MR217094L4V
- MR217106L3V
- MR217106L4V
- MR217114L3V
- MR217114L4V
- MR217122L3V
- MR217122L4V
- MR218542L3V
- MR218542L4V
- RC205100L1V
- RC205100L2V
- RC205100L3V
- RC205100L4V
- RC212568L3V
- RC212568L4V
- RC212612L3V
- RC212612L4V
- RC212850L1V
- RC212850L2V
- RC212850L3V
- RC212850L4V
- RC213874L3V
- RC213874L4V
- RC217995L3V
- RC217995L4V
- RR200320L3V
- RR200320L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HNRNPF
- Addgene plasmids for HNRNPF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HNRNPF
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | - | - | - |
| ExUns: | 10d | · | 10e | · | 10f | · | 10g | · | 10h | · | 10i | · | 10j | · | 10k | · | 10l | · | 10m | · | 10n |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
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| SP20: |
Relevant External Links for HNRNPF Gene
- GeneLoc Exon Structure for
- HNRNPF
Expression for HNRNPF Gene
This gene is overexpressed in Peripheral blood mononuclear cells (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPF Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPF
SOURCE GeneReport for Unigene cluster for HNRNPF Gene:
Hs.808mRNA Expression by UniProt/SwissProt for HNRNPF Gene:
P52597-HNRPF_HUMAN
Tissue specificity:
Expressed ubiquitously.
Evidence on tissue expression from TISSUES for HNRNPF Gene
- Lung(4.9)
- Nervous system(4.8)
- Blood(4.8)
- Liver(4.8)
- Intestine(4.5)
- Bone marrow(4.5)
- Skin(4.3)
- Kidney(3.9)
- Eye(3.4)
- Pancreas(3.2)
- Spleen(2.9)
- Muscle(2.5)
- Lymph node(2.4)
- Thyroid gland(2.4)
- Heart(2.4)
- Stomach(2.4)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for HNRNPF
-
OriGene qPCR primer pairs and template standards for HNRNPF
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPF Gene
Orthologs for HNRNPF Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HNRNPF 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gm6430 31 |
|
OneToMany | |
| Hnrnpf 30 17 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | HNRNPF 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hnrnpf 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | HNRNPF 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | HNRNPF 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HNRNPH1 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | hnrnph1l 31 |
|
ManyToMany | |
| hnrnph1 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | hrpf-1 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for HNRNPF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for HNRNPF Gene
- ENSEMBL:
- Gene Tree for HNRNPF (if available)
- TreeFam:
- Gene Tree for HNRNPF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HNRNPF: view image
Paralogs for HNRNPF Gene
(5) SIMAP similar genes for HNRNPF Gene using alignment to 1 proteins:
- HNRPF_HUMAN
Pseudogenes.org Pseudogenes for HNRNPF Gene
Variants for HNRNPF Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPF Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs17851426 | - | p.Lys87Arg |
Residual Variation Intolerance Score:
22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.04;
21.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HNRNPF Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HNRNPF
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPF Gene
Disorders for HNRNPF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| postsurgical hypothyroidism |
|
|
| atrial septal defect 1 |
|
|
| kidney hypertrophy |
|
|
Search HNRNPF in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HNRNPF
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPF Gene
Publications for HNRNPF Gene
- Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. (PMID: 7499401) Honoré B … Celis JE (The Journal of biological chemistry 1995) 2 3 4
- Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. (PMID: 20526337) Dominguez C … Allain FH (Nature structural & molecular biology 2010) 3 4
- Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. (PMID: 17932509) Höck J … Meister G (EMBO reports 2007) 3 4
- NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition. (PMID: 16885237) Dominguez C … Allain FH (Nucleic acids research 2006) 3 4
- Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer. (PMID: 16424007) Balasubramani M … Getzenberg RH (Cancer research 2006) 3 23
ExternalLinks
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