Aliases for HNRNPF Gene
External Ids for HNRNPF Gene
Previous HGNC Symbols for HNRNPF Gene
Previous GeneCards Identifiers for HNRNPF Gene
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPF Gene
HNRNPF (Heterogeneous Nuclear Ribonucleoprotein F) is a Protein Coding gene. Diseases associated with HNRNPF include Atrial Septal Defect 1 and Kidney Hypertrophy. Among its related pathways are Signaling by GPCR and Signaling by FGFR2. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH1.
UniProtKB/Swiss-Prot Summary for HNRNPF Gene
Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.