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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hn... See more...
Aliases for HNRNPC Gene
Aliases for HNRNPC Gene
External Ids for HNRNPC Gene
- HGNC: 5035
- Entrez Gene: 3183
- Ensembl: ENSG00000092199
- OMIM: 164020
- UniProtKB: P07910
Previous HGNC Symbols for HNRNPC Gene
- HNRPC
Previous GeneCards Identifiers for HNRNPC Gene
- GC14M020747
- GC14M021677
- GC14M001797
Summaries for HNRNPC Gene
-
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPC Gene
HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C) is a Protein Coding gene. Diseases associated with HNRNPC include Mixed Connective Tissue Disease and Rheumatic Disease. Among its related pathways are Telomere Extension by Telomerase and SUMOylation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is HNRNPCL1.
UniProtKB/Swiss-Prot Summary for HNRNPC Gene
-
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).
Additional gene information for HNRNPC Gene
- Monarch Initiative
- Search for HNRNPC at DataMed
- Search for HNRNPC at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPC Gene
Genomics for HNRNPC Gene
GeneHancer (GH) Regulatory Elements for HNRNPC Gene
Promoters and enhancers for HNRNPC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HNRNPC on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HNRNPC gene promoter:
-
- AREB6
- Bach1
- Cdc5
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- ZID
Genomic Locations for HNRNPC Gene
Genomic Locations for HNRNPC Gene
- chr14:21,209,136-21,269,494
- (GRCh38/hg38)
- Size:
- 60,359 bases
- Orientation:
- Minus strand
- chr14:21,677,295-21,737,653
- (GRCh37/hg19)
- Size:
- 60,359 bases
- Orientation:
- Minus strand
Genomic View for HNRNPC Gene
Genes around HNRNPC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by HGNC
- 14q11.2 by Entrez Gene
- 14q11.2 by Ensembl
HNRNPC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPC Gene
Proteins for HNRNPC Gene
-
Protein details for HNRNPC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07910-HNRPC_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoproteins C1/C2
- Protein Accession:
- P07910
- D3DS19
- D3DS22
- P22628
- Q53EX2
- Q59FD3
- Q5FWE8
- Q86SF8
- Q86U45
- Q96HK7
- Q96HM4
- Q96IY5
- Q9BTS3
Protein attributes for HNRNPC Gene
- Size:
- 306 amino acids
- Molecular mass:
- 33670 Da
- Quaternary structure:
-
- Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with DHX9; this interaction is direct, enhanced probably by their concomitant binding to RNA and mediates the attachment to actin filaments (PubMed:11687588).
- SequenceCaution:
-
- Sequence=BAD92764.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for HNRNPC Gene
Protein Expression for HNRNPC Gene
Post-translational modifications for HNRNPC Gene
- Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
- Sumoylated. Sumoylation reduces affinity for mRNA.
-
Ubiquitination at Lys8 and Lys89
- NX_P07910 (NX_P07910-1)
- Modification sites at PhosphoSitePlus
Other Protein References for HNRNPC Gene
- ENSEMBL proteins:
-
- ENSP00000404559
- ENSP00000452214
- ENSP00000452213
- ENSP00000442816
- ENSP00000450544
- ENSP00000450548
- ENSP00000450790
- ENSP00000404848
- ENSP00000451652
- ENSP00000451187
- ENSP00000452545
- ENSP00000452599
- ENSP00000450725
- ENSP00000450629
- ENSP00000451291
- ENSP00000451292
- ENSP00000451892
- ENSP00000452021
- ENSP00000452573
- ENSP00000452276
- ENSP00000452185
- ENSP00000450669
- ENSP00000450467
- ENSP00000451708
- ENSP00000450601
- ENSP00000451176
- ENSP00000338095
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-HNRNPC Antibody (HPA051075), Anti-HNRNPC Antibody (AMAb91012), and Anti-HNRNPC Antibody (AMAb91010)
-
Creative Biolabs
- Mouse Anti-HNRNPC Recombinant Antibody (CBFYH-1637)
- Rabbit Anti-HNRNPC Recombinant Antibody (CBFYH-1642)
- Recombinant Mouse anti-Human HNRNPC Monoclonal antibody (5G5)
- Mouse Anti-HNRNPC Recombinant Antibody (CBFYH-1641)
- Rabbit Anti-HNRNPC Recombinant Antibody (CBFYH-1643)
- Mouse Anti-HNRNPC Recombinant Antibody (CBFYH-1636)
- Mouse Anti-HNRNPC ( AA 1-250) Recombinant Antibody (CBFYH-1640)
- Mouse Anti-HNRNPC Recombinant Antibody (CL2596)
- Mouse Anti-HNRNPC Recombinant Antibody (CL2593)
- Mouse Anti-HNRNPC Recombinant Antibody (CBFYH-1639)
- Rabbit Anti-HNRNPC Recombinant Antibody (EPNCIR152)
- Hi-Affi™ Recombinant Rabbit Anti-HNRNPC Monoclonal Antibody (DS1646AB)
- Mouse Anti-HNRNPC Recombinant Antibody (CBFYH-3182)
- Mouse Anti-HNRNPC Recombinant Antibody (CBFYH-1638)
- GeneTex Anti-hnRNP C1/C2 antibody
-
Custom Antibody ServicesOriGene Antibodies for HNRNPC
- Novus Biologicals Antibodies for HNRNPC
-
Abcam antibodies for HNRNPC
- Invitrogen Antibodies for HNRNPC (AFLGC-HNRNPC)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPC
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPC
- Origene Custom Protein Services for HNRNPC
- ProSpec Recombinant Proteins for HNRNPC
-
Abcam proteins for HNRNPC
Assay Products
No data available for DME Specific Peptides for HNRNPC Gene
Domains & Families for HNRNPC Gene
Gene Families for HNRNPC Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for HNRNPC Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPC Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92712, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein C (C1/C2) (HNRPC), transcript variant 1, mRNA (B2R603_HUMAN)
- cDNA FLJ52975, highly similar to Heterogeneous nuclear ribonucleoproteins C (B4DSU6_HUMAN)
- Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRPC_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P07910- Family:
-
- Belongs to the RRM HNRPC family. RALY subfamily.
Function for HNRNPC Gene
Molecular function for HNRNPC Gene
- UniProtKB/Swiss-Prot Function:
- Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).
Phenotypes From GWAS Catalog for HNRNPC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | HDA | 16217013 |
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | HDA | 16217013 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,NAS | 9731529 |
| GO:0003730 | mRNA 3'-UTR binding | IDA | 16010978 |
Phenotypes for HNRNPC Gene
- MGI mutant phenotypes for HNRNPC:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for HNRNPC:
-
- Decreased homologous recombination repair frequency
- Increased homologous recombination repair frequency
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Reduced mammosphere formation
- Decreased viability after ionizing radiation
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Downregulation of NFkappaB pathway
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- Increased viability
- FOXO1 nuclear localization
Animal Models for HNRNPC Gene
- MGI Knock Outs for HNRNPC:
-
- Hnrnpc Hnrnpc<tm1b(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HNRNPC
- genomics-online: gRNA clones - Search results for available HNRNPC gene related products
- Applied Biological Materials (abm): CRISPR Clones for HNRNPC - Select products 50% OFF >
- * HNRNPC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * HNRNPC CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPC
miRNA for HNRNPC Gene
- miRTarBase miRNAs that target HNRNPC
-
- hsa-mir-744-5p (MIRT037494)
- hsa-mir-455-3p (MIRT037890)
- hsa-mir-505-5p (MIRT037959)
- hsa-mir-615-3p (MIRT039991)
- hsa-mir-18a-3p (MIRT040851)
- hsa-mir-484 (MIRT042196)
- hsa-mir-342-3p (MIRT043694)
- hsa-mir-186-5p (MIRT045150)
- hsa-mir-30c-5p (MIRT047904)
- hsa-let-7e-5p (MIRT051596)
- hsa-mir-877-3p (MIRT277852)
- hsa-mir-485-3p (MIRT341160)
- hsa-mir-539-3p (MIRT341161)
- hsa-mir-136-3p (MIRT380416)
- hsa-mir-183-3p (MIRT475571)
- hsa-mir-5196-5p (MIRT475572)
- hsa-mir-4747-5p (MIRT475573)
- hsa-mir-4533 (MIRT475574)
- hsa-mir-6775-5p (MIRT475575)
- hsa-mir-5090 (MIRT475576)
- hsa-mir-4517 (MIRT475577)
- hsa-mir-202-3p (MIRT502260)
- hsa-mir-4698 (MIRT502261)
- hsa-mir-8063 (MIRT502262)
- hsa-mir-548p (MIRT502263)
- hsa-mir-583 (MIRT502264)
- hsa-mir-1276 (MIRT502265)
- hsa-mir-4311 (MIRT502266)
- hsa-mir-548e-5p (MIRT502267)
- hsa-mir-224-5p (MIRT502268)
- hsa-mir-3924 (MIRT511473)
- hsa-mir-4539 (MIRT511474)
- hsa-mir-4724-5p (MIRT511475)
- hsa-mir-4511 (MIRT511476)
- hsa-mir-3133 (MIRT511477)
- hsa-mir-365b-5p (MIRT557221)
- hsa-mir-8052 (MIRT557222)
- hsa-mir-365a-5p (MIRT557223)
- hsa-mir-3199 (MIRT557224)
- hsa-mir-6503-3p (MIRT557225)
- hsa-mir-606 (MIRT557226)
- hsa-mir-708-5p (MIRT557227)
- hsa-mir-28-5p (MIRT557228)
- hsa-mir-3139 (MIRT557229)
- hsa-mir-4699-5p (MIRT571997)
- hsa-mir-4773 (MIRT571998)
- hsa-mir-7850-5p (MIRT574674)
- hsa-mir-620 (MIRT574675)
- hsa-mir-1270 (MIRT574676)
- hsa-mir-4531 (MIRT574677)
- hsa-mir-139-3p (MIRT574678)
- hsa-mir-4524a-3p (MIRT574679)
- hsa-mir-6738-3p (MIRT657339)
- hsa-mir-544a (MIRT657340)
- hsa-mir-6828-3p (MIRT657341)
- hsa-mir-6071 (MIRT657342)
- hsa-mir-1298-5p (MIRT657343)
- hsa-mir-3157-5p (MIRT657344)
- hsa-mir-627-3p (MIRT657345)
- hsa-mir-6515-3p (MIRT657346)
- hsa-mir-1-5p (MIRT657347)
- hsa-mir-5000-5p (MIRT657348)
- hsa-mir-6781-3p (MIRT667942)
- hsa-mir-2682-3p (MIRT667943)
- hsa-mir-6877-3p (MIRT667944)
- hsa-mir-6819-3p (MIRT667945)
- hsa-mir-6731-5p (MIRT754005)
- hsa-mir-6783-5p (MIRT755748)
- hsa-mir-6824-5p (MIRT756943)
- hsa-mir-8085 (MIRT760208)
- hsa-mir-1323 (MIRT762531)
- hsa-mir-2053 (MIRT763720)
- hsa-mir-4432 (MIRT768967)
- hsa-mir-495-3p (MIRT772775)
- hsa-mir-499a-5p (MIRT772883)
- hsa-mir-5095 (MIRT773281)
- hsa-mir-548o-3p (MIRT774461)
- hsa-mir-555 (MIRT774654)
- hsa-mir-5688 (MIRT774981)
- hsa-mir-6504-3p (MIRT776578)
- hsa-mir-7-1-3p (MIRT781492)
- hsa-mir-7151-3p (MIRT781511)
- hsa-mir-7-2-3p (MIRT781704)
- hsa-mir-8087 (MIRT782433)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HNRNPC
- Browse OriGene Inhibitory RNA Products For HNRNPC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPC
- genomics-online: shRNA clones - Search results for available HNRNPC gene related products
Clone Products
-
- MG204015
- MG204182
- MG220315
- MG220319
- MG220325
- MR204015
- MR204015L3
- MR204015L3V
- MR204015L4
- MR204015L4V
- MR204182
- MR204182L3
- MR204182L3V
- MR204182L4
- MR204182L4V
- MR220315
- MR220315L3
- MR220315L3V
- MR220315L4
- MR220315L4V
- MR220319
- MR220319L3
- MR220319L3V
- MR220319L4
- MR220319L4V
- MR220325
- MR220325L3
- MR220325L3V
- MR220325L4
- MR220325L4V
- RC201695
- RC201695L3
- RC201695L3V
- RC201695L4
- RC201695L4V
- RC202788
- RC202788L3
- RC202788L3V
- RC202788L4
- RC202788L4V
- RC215956
- RC215956L1
- RC215956L1V
- RC215956L2
- RC215956L2V
- RC215956L3
- RC215956L3V
- RC215956L4
- RC215956L4V
- RC216056
- RC216056L3
- RC216056L3V
- RC216056L4
- RC216056L4V
- RG201695
- RG202788
- RG215956
- RG216056
- RR206594
- RR206594L3
- RR206594L3V
- RR206594L4
- RR206594L4V
- RR216271
- RR216289
- RR216327
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HNRNPC
- Addgene plasmids for HNRNPC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HNRNPC
- genomics-online: cdna clones - Search results for available HNRNPC gene related products
- orf clones - Search results for available HNRNPC gene related products
- Applied Biological Materials (abm): Clones for HNRNPC - Select products 50% OFF >
- * HNRNPC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * HNRNPC tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNRNPC Gene
Localization for HNRNPC Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPC Gene
- Nucleus. Note=Component of ribonucleosomes.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | HDA | 16217013 |
| GO:0005576 | extracellular region | HDA | 27068509 |
| GO:0005634 | nucleus | IDA,IBA | 11687588 |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005681 | spliceosomal complex | IDA | 9731529 |
Pathways & Interactions for HNRNPC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.50
.41
|
| 2 | Metabolism of proteins | ||
| 3 | SUMOylation |
.95
|
|
| 4 | Chromatin Regulation / Acetylation | ||
| 5 | Translational Control | ||
Pathways by source for HNRNPC Gene
2 BioSystems pathways for HNRNPC Gene
9 Reactome pathways for HNRNPC Gene
1 KEGG pathway for HNRNPC Gene
1 Qiagen pathway for HNRNPC Gene
- Telomere Extension by Telomerase
2 Cell Signaling Technology pathways for HNRNPC Gene
Interacting Proteins for HNRNPC Gene
Selected Interacting proteins:
P07910-HNRPC_HUMAN
ENSP00000451291
for HNRNPC Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HNRNPC
SIGNOR curated interactions for HNRNPC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0001649 | osteoblast differentiation | HDA | 16210410 |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | TAS | 3110598 |
| GO:0016070 | RNA metabolic process | TAS | -- |
Transcripts for HNRNPC Gene
mRNA/cDNA for HNRNPC Gene
- (4) REFSEQ mRNAs :
- (30) Additional mRNA sequences :
- (1446) Selected AceView cDNA sequences:
- (33) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000336053 3301 bps (ENST00000336053.10)
- ENST00000554969 1924 bps (ENST00000554969.5)
- ENST00000556142 1599 bps (ENST00000556142.5)
- ENST00000554455 1784 bps (ENST00000554455.5)
- ENST00000430246 4501 bps (ENST00000430246.6)
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HNRNPC
- genomics-online: gRNA clones - Search results for available HNRNPC gene related products
- Applied Biological Materials (abm): CRISPR Clones for HNRNPC - Select products 50% OFF >
- * HNRNPC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * HNRNPC CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPC
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HNRNPC
- Browse OriGene Inhibitory RNA Products For HNRNPC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPC
- genomics-online: shRNA clones - Search results for available HNRNPC gene related products
Clone Products
-
- MG204015
- MG204182
- MG220315
- MG220319
- MG220325
- MR204015
- MR204015L3
- MR204015L3V
- MR204015L4
- MR204015L4V
- MR204182
- MR204182L3
- MR204182L3V
- MR204182L4
- MR204182L4V
- MR220315
- MR220315L3
- MR220315L3V
- MR220315L4
- MR220315L4V
- MR220319
- MR220319L3
- MR220319L3V
- MR220319L4
- MR220319L4V
- MR220325
- MR220325L3
- MR220325L3V
- MR220325L4
- MR220325L4V
- RC201695
- RC201695L3
- RC201695L3V
- RC201695L4
- RC201695L4V
- RC202788
- RC202788L3
- RC202788L3V
- RC202788L4
- RC202788L4V
- RC215956
- RC215956L1
- RC215956L1V
- RC215956L2
- RC215956L2V
- RC215956L3
- RC215956L3V
- RC215956L4
- RC215956L4V
- RC216056
- RC216056L3
- RC216056L3V
- RC216056L4
- RC216056L4V
- RG201695
- RG202788
- RG215956
- RG216056
- RR206594
- RR206594L3
- RR206594L3V
- RR206594L4
- RR206594L4V
- RR216271
- RR216289
- RR216327
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HNRNPC
- Addgene plasmids for HNRNPC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HNRNPC
- genomics-online: cdna clones - Search results for available HNRNPC gene related products
- orf clones - Search results for available HNRNPC gene related products
- Applied Biological Materials (abm): Clones for HNRNPC - Select products 50% OFF >
- * HNRNPC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * HNRNPC tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 12b | · | 12c | · | 12d | · | 12e | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: | |||||||||||
| SP13: | |||||||||||
| SP14: | |||||||||||
| SP15: | |||||||||||
| SP16: |
Expression for HNRNPC Gene
This gene is overexpressed in Tlymphocyte (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPC Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HNRNPC Gene:
HNRNPCSOURCE GeneReport for Unigene cluster for HNRNPC Gene:
Hs.508848Evidence on tissue expression from TISSUES for HNRNPC Gene
- Nervous system(5)
- Blood(4.8)
- Eye(4.8)
- Liver(4.8)
- Bone marrow(4.4)
- Lung(4.4)
- Skin(4.2)
- Intestine(3.8)
- Kidney(3.6)
- Pancreas(3.6)
- Stomach(3.1)
- Heart(2.5)
- Bone(2.3)
- Lymph node(2.2)
- Adrenal gland(2.1)
- Muscle(2.1)
- Spleen(2.1)
- Thyroid gland(2.1)
- Gall bladder(2)
Primer Products
-
OriGene qPCR primer pairs for HNRNPC
-
OriGene qPCR primer pairs and template standards for HNRNPC
- genomics-online: primer clones - Search results for available HNRNPC gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPC Gene
Orthologs for HNRNPC Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPC 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HNRPC 33 |
|
OneToMany | |
| LOC510852 32 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
ManyToMany | |
| dog (Canis familiaris) |
Mammalia | LOC475399 32 |
|
||
| -- 33 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Hnrnpc 17 32 |
|
||
| Ralyl 33 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Hnrnpc 32 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6109 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397793 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:55733 33 |
|
ManyToMany | |
| hnrnpc 33 |
|
ManyToMany | |||
| zgc55733 32 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3917 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG42458 33 |
|
OneToMany |
- Species where no ortholog for HNRNPC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for HNRNPC Gene
- ENSEMBL:
- Gene Tree for HNRNPC (if available)
- TreeFam:
- Gene Tree for HNRNPC (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HNRNPC: view image
Paralogs for HNRNPC Gene
(10) SIMAP similar genes for HNRNPC Gene using alignment to 16 proteins:
- HNRPC_HUMAN
- B4DSU6_HUMAN
- B4DY08_HUMAN
- G3V251_HUMAN
- G3V2D6_HUMAN
- G3V2H6_HUMAN
- G3V2Q1_HUMAN
- G3V3K6_HUMAN
- G3V4C1_HUMAN
- G3V4M8_HUMAN
- G3V4W0_HUMAN
- G3V555_HUMAN
- G3V575_HUMAN
- G3V576_HUMAN
- G3V5V7_HUMAN
- G3V5X6_HUMAN
Pseudogenes.org Pseudogenes for HNRNPC Gene
Variants for HNRNPC Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000034143 | -- | 21,253,416(-) | G/C | intron_variant | |
| rs1000066094 | -- | 21,258,209(-) | G/A | intron_variant | |
| rs1000067378 | -- | 21,259,758(-) | C/T | intron_variant | |
| rs1000077475 | -- | 21,257,969(-) | T/C | intron_variant | |
| rs1000102943 | -- | 21,208,836(-) | T/C | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1560508 | CNV | insertion | 17803354 |
| esv2656744 | CNV | deletion | 23128226 |
| esv2748453 | CNV | deletion | 23290073 |
| esv3335931 | CNV | insertion | 20981092 |
| esv3633707 | CNV | loss | 21293372 |
| nsv1113621 | CNV | deletion | 24896259 |
| nsv509527 | CNV | insertion | 20534489 |
| nsv974313 | CNV | duplication | 23825009 |
| nsv983803 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.26;
5.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HNRNPC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HNRNPC
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPC Gene
Disorders for HNRNPC Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mixed connective tissue disease |
|
|
| rheumatic disease |
|
|
| connective tissue disease |
|
|
| amyotrophic lateral sclerosis 1 |
|
|
Search HNRNPC in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HNRNPC
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPC Gene
Publications for HNRNPC Gene
- Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells. (PMID: 16010978) Shetty S (Molecular and cellular biochemistry 2005) 3 4 23 56
- Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2. (PMID: 12564933) Stone JR … Collins T (Biochemistry 2003) 3 4 23 56
- Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner. (PMID: 12509468) Kim JH … Jang SK (Molecular and cellular biology 2003) 3 4 23 56
- 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins. (PMID: 1385725) Wittekind M … Mueller L (Biochemistry 1992) 3 4 23 56
- N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. (PMID: 25719671) Liu N … Pan T (Nature 2015) 3 4 56
ExternalLinks
Products for HNRNPC Gene
- Custom Antibody ServicesOriGene Antibodies for HNRNPC
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPC
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- Browse OriGene Inhibitory RNA Products For HNRNPC
- OriGene qPCR primer pairs for HNRNPC
- OriGene qPCR primer pairs and template standards for HNRNPC
- OriGene CRISPR knockouts for HNRNPC
- MG204015
- MG204182
- MG220315
- MG220319
- MG220325
- MR204015
- MR204015L3
- MR204015L3V
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- MR204182
- MR204182L3
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- MR220315
- MR220315L3
- MR220315L3V
- MR220315L4
- MR220315L4V
- MR220319
- MR220319L3
- MR220319L3V
- MR220319L4
- MR220319L4V
- MR220325
- MR220325L3
- MR220325L3V
- MR220325L4
- MR220325L4V
- RC201695
- RC201695L3
- RC201695L3V
- RC201695L4
- RC201695L4V
- RC202788
- RC202788L3
- RC202788L3V
- RC202788L4
- RC202788L4V
- RC215956
- RC215956L1
- RC215956L1V
- RC215956L2
- RC215956L2V
- RC215956L3
- RC215956L3V
- RC215956L4
- RC215956L4V
- RC216056
- RC216056L3
- RC216056L3V
- RC216056L4
- RC216056L4V
- RG201695
- RG202788
- RG215956
- RG216056
- RR206594
- RR206594L3
- RR206594L3V
- RR206594L4
- RR206594L4V
- RR216271
- RR216289
- RR216327
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for HNRNPC
- antibodies-online: Show 38 available HNRNPC Antibodies ranked by validation data
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