This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hn... See more...

Aliases for HNRNPC Gene

Aliases for HNRNPC Gene

  • Heterogeneous Nuclear Ribonucleoprotein C 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) 2 3
  • Heterogeneous Nuclear Ribonucleoproteins C1/C2 3 4
  • HnRNP C1/C2 3 4
  • HNRPC 3 4
  • Nuclear Ribonucleoprotein Particle C1 Protein 3
  • Nuclear Ribonucleoprotein Particle C2 Protein 3
  • HNRNPC 5
  • HNRNP 3
  • SNRPC 3
  • C1 3
  • C2 3

External Ids for HNRNPC Gene

Previous HGNC Symbols for HNRNPC Gene

  • HNRPC

Previous GeneCards Identifiers for HNRNPC Gene

  • GC14M020747
  • GC14M021677
  • GC14M001797

Summaries for HNRNPC Gene

Entrez Gene Summary for HNRNPC Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPC Gene

HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C) is a Protein Coding gene. Diseases associated with HNRNPC include Mixed Connective Tissue Disease and Oculopharyngeal Muscular Dystrophy. Among its related pathways are Telomere Extension by Telomerase and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is HNRNPCL1.

UniProtKB/Swiss-Prot Summary for HNRNPC Gene

  • Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

Gene Wiki entry for HNRNPC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPC Gene

Genomics for HNRNPC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HNRNPC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPC

Top Transcription factor binding sites by QIAGEN in the HNRNPC gene promoter:
  • AREB6
  • Bach1
  • Cdc5
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • ZID

Genomic Locations for HNRNPC Gene

Genomic Locations for HNRNPC Gene
chr14:21,209,136-21,269,494
(GRCh38/hg38)
Size:
60,359 bases
Orientation:
Minus strand
chr14:21,677,295-21,737,653
(GRCh37/hg19)
Size:
60,359 bases
Orientation:
Minus strand

Genomic View for HNRNPC Gene

Genes around HNRNPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPC Gene

Proteins for HNRNPC Gene

  • Protein details for HNRNPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07910-HNRPC_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoproteins C1/C2
    Protein Accession:
    P07910
    Secondary Accessions:
    • D3DS19
    • D3DS22
    • P22628
    • Q53EX2
    • Q59FD3
    • Q5FWE8
    • Q86SF8
    • Q86U45
    • Q96HK7
    • Q96HM4
    • Q96IY5
    • Q9BTS3

    Protein attributes for HNRNPC Gene

    Size:
    306 amino acids
    Molecular mass:
    33670 Da
    Quaternary structure:
    • Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with DHX9; this interaction is direct, enhanced probably by their concomitant binding to RNA and mediates the attachment to actin filaments (PubMed:11687588).
    SequenceCaution:
    • Sequence=BAD92764.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPC Gene

    Alternative splice isoforms for HNRNPC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPC Gene

Post-translational modifications for HNRNPC Gene

  • Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
  • Sumoylated. Sumoylation reduces affinity for mRNA.
  • Ubiquitination at Lys8 and Lys89
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPC Gene

Domains & Families for HNRNPC Gene

Gene Families for HNRNPC Gene

Protein Domains for HNRNPC Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
ProtoNet:

Suggested Antigen Peptide Sequences for HNRNPC Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92712, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein C (C1/C2) (HNRPC), transcript variant 1, mRNA (B2R603_HUMAN)
  • cDNA FLJ52975, highly similar to Heterogeneous nuclear ribonucleoproteins C (B4DSU6_HUMAN)
  • Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRPC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P07910

UniProtKB/Swiss-Prot:

HNRPC_HUMAN :
  • Belongs to the RRM HNRPC family. RALY subfamily.
Family:
  • Belongs to the RRM HNRPC family. RALY subfamily.
genes like me logo Genes that share domains with HNRNPC: view

Function for HNRNPC Gene

Molecular function for HNRNPC Gene

UniProtKB/Swiss-Prot Function:
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

Phenotypes From GWAS Catalog for HNRNPC Gene

Gene Ontology (GO) - Molecular Function for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding HDA 16217013
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,NAS 9731529
GO:0003730 mRNA 3'-UTR binding IDA 16010978
GO:0005515 protein binding IPI 11546873
genes like me logo Genes that share ontologies with HNRNPC: view
genes like me logo Genes that share phenotypes with HNRNPC: view

Animal Models for HNRNPC Gene

MGI Knock Outs for HNRNPC:
  • Hnrnpc Hnrnpc<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for HNRNPC Gene

miRTarBase miRNAs that target HNRNPC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPC

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNRNPC Gene

Localization for HNRNPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPC Gene

Nucleus. Note=Component of ribonucleosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPC gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin HDA 16217013
GO:0005576 extracellular region HDA 27068509
GO:0005634 nucleus IBA,IDA 11687588
GO:0005654 nucleoplasm IDA,TAS --
GO:0005681 spliceosomal complex IDA 9731529
genes like me logo Genes that share ontologies with HNRNPC: view

Pathways & Interactions for HNRNPC Gene

genes like me logo Genes that share pathways with HNRNPC: view

Pathways by source for HNRNPC Gene

2 BioSystems pathways for HNRNPC Gene
1 KEGG pathway for HNRNPC Gene
1 Qiagen pathway for HNRNPC Gene
  • Telomere Extension by Telomerase
2 Cell Signaling Technology pathways for HNRNPC Gene

SIGNOR curated interactions for HNRNPC Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001649 osteoblast differentiation HDA 16210410
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing TAS 3110598
GO:0016070 RNA metabolic process TAS --
genes like me logo Genes that share ontologies with HNRNPC: view

Drugs & Compounds for HNRNPC Gene

(2) Drugs for HNRNPC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for HNRNPC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HNRNPC: view

Transcripts for HNRNPC Gene

mRNA/cDNA for HNRNPC Gene

4 REFSEQ mRNAs :
30 NCBI additional mRNA sequence :
33 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPC

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - -
SP10: - -
SP11: -
SP12: - - -
SP13: - -
SP14:
SP15: - - - - - - - - - - - -
SP16:

ExUns: 12b · 12c · 12d · 12e ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for HNRNPC Gene

GeneLoc Exon Structure for
HNRNPC

Expression for HNRNPC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPC Gene

Protein differential expression in normal tissues from HIPED for HNRNPC Gene

This gene is overexpressed in Tlymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPC Gene



Protein tissue co-expression partners for HNRNPC Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPC

SOURCE GeneReport for Unigene cluster for HNRNPC Gene:

Hs.508848

Evidence on tissue expression from TISSUES for HNRNPC Gene

  • Nervous system(5)
  • Liver(4.9)
  • Blood(4.9)
  • Eye(4.9)
  • Bone marrow(4.6)
  • Skin(4.6)
  • Lung(4.5)
  • Intestine(4.2)
  • Kidney(4.2)
  • Pancreas(4)
  • Stomach(3.6)
  • Heart(3.4)
  • Muscle(3.2)
  • Bone(3.1)
  • Lymph node(3)
  • Spleen(2.9)
  • Thyroid gland(2.8)
  • Adrenal gland(2.7)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with HNRNPC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPC Gene

Orthologs for HNRNPC Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HNRNPC 30 31
  • 99.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HNRPC 31
  • 98 (a)
OneToMany
LOC510852 30
  • 96.47 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 98 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 98 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC475399 30
  • 96.28 (n)
-- 31
  • 95 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Hnrnpc 30 17
  • 93.55 (n)
Ralyl 31
  • 71 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Hnrnpc 30
  • 93.33 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 89 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC397793 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.6109 30
Zebrafish
(Danio rerio)
Actinopterygii zgc:55733 31
  • 65 (a)
ManyToMany
hnrnpc 31
  • 59 (a)
ManyToMany
zgc55733 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3917 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG42458 31
  • 12 (a)
OneToMany
Species where no ortholog for HNRNPC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HNRNPC Gene

ENSEMBL:
Gene Tree for HNRNPC (if available)
TreeFam:
Gene Tree for HNRNPC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPC: view image

Paralogs for HNRNPC Gene

Paralogs for HNRNPC Gene

(10) SIMAP similar genes for HNRNPC Gene using alignment to 16 proteins:

  • HNRPC_HUMAN
  • B4DSU6_HUMAN
  • B4DY08_HUMAN
  • G3V251_HUMAN
  • G3V2D6_HUMAN
  • G3V2H6_HUMAN
  • G3V2Q1_HUMAN
  • G3V3K6_HUMAN
  • G3V4C1_HUMAN
  • G3V4M8_HUMAN
  • G3V4W0_HUMAN
  • G3V555_HUMAN
  • G3V575_HUMAN
  • G3V576_HUMAN
  • G3V5V7_HUMAN
  • G3V5X6_HUMAN
genes like me logo Genes that share paralogs with HNRNPC: view

Variants for HNRNPC Gene

Additional dbSNP identifiers (rs#s) for HNRNPC Gene

Structural Variations from Database of Genomic Variants (DGV) for HNRNPC Gene

Variant ID Type Subtype PubMed ID
esv1560508 CNV insertion 17803354
esv2656744 CNV deletion 23128226
esv2748453 CNV deletion 23290073
esv3335931 CNV insertion 20981092
esv3633707 CNV loss 21293372
nsv1113621 CNV deletion 24896259
nsv509527 CNV insertion 20534489
nsv974313 CNV duplication 23825009
nsv983803 CNV duplication 23825009

Variation tolerance for HNRNPC Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPC Gene

Disorders for HNRNPC Gene

MalaCards: The human disease database

(11) MalaCards diseases for HNRNPC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mixed connective tissue disease
  • connective tissue disease overlap syndrome
oculopharyngeal muscular dystrophy
  • opmd
multisystem proteinopathy
endometrial stromal tumor
  • endometrial stromal neoplasm
spinal muscular atrophy
  • progressive muscular atrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HNRNPC

genes like me logo Genes that share disorders with HNRNPC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPC Gene

Publications for HNRNPC Gene

  1. Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells. (PMID: 16010978) Shetty S (Molecular and cellular biochemistry 2005) 3 4 23
  2. Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner. (PMID: 12509468) Kim JH … Jang SK (Molecular and cellular biology 2003) 3 4 23
  3. Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2. (PMID: 12564933) Stone JR … Collins T (Biochemistry 2003) 3 4 23
  4. 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins. (PMID: 1385725) Wittekind M … Mueller L (Biochemistry 1992) 3 4 23
  5. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. (PMID: 25719671) Liu N … Pan T (Nature 2015) 3 4

Products for HNRNPC Gene