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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hn... See more...
Aliases for HNRNPC Gene
Aliases for HNRNPC Gene
External Ids for HNRNPC Gene
- HGNC: 5035
- Entrez Gene: 3183
- Ensembl: ENSG00000092199
- OMIM: 164020
- UniProtKB: P07910
Previous HGNC Symbols for HNRNPC Gene
- HNRPC
Previous GeneCards Identifiers for HNRNPC Gene
- GC14M020747
- GC14M021677
- GC14M001797
Summaries for HNRNPC Gene
-
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPC Gene
HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C) is a Protein Coding gene. Diseases associated with HNRNPC include Mixed Connective Tissue Disease and Oculopharyngeal Muscular Dystrophy. Among its related pathways are Telomere Extension by Telomerase and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is HNRNPCL1.
UniProtKB/Swiss-Prot Summary for HNRNPC Gene
-
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).
Additional gene information for HNRNPC Gene
- HGNC(5035)
- Entrez Gene(3183)
- Ensembl(ENSG00000092199)
- OMIM(164020)
- UniProtKB(P07910)
- Open Targets Platform(ENSG00000092199)
- Monarch Initiative
- Search for HNRNPC at DataMed
- Search for HNRNPC at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPC Gene
Genomics for HNRNPC Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HNRNPC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HNRNPC on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPC
- Top Transcription factor binding sites by QIAGEN in the HNRNPC gene promoter:
-
- AREB6
- Bach1
- Cdc5
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- ZID
Genomic Locations for HNRNPC Gene
Genomic Locations for HNRNPC Gene
- chr14:21,209,136-21,269,494
- (GRCh38/hg38)
- Size:
- 60,359 bases
- Orientation:
- Minus strand
- chr14:21,677,295-21,737,653
- (GRCh37/hg19)
- Size:
- 60,359 bases
- Orientation:
- Minus strand
Genomic View for HNRNPC Gene
Genes around HNRNPC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by HGNC
- 14q11.2 by Entrez Gene
- 14q11.2 by Ensembl
HNRNPC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPC Gene
Proteins for HNRNPC Gene
-
Protein details for HNRNPC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07910-HNRPC_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoproteins C1/C2
- Protein Accession:
- P07910
- D3DS19
- D3DS22
- P22628
- Q53EX2
- Q59FD3
- Q5FWE8
- Q86SF8
- Q86U45
- Q96HK7
- Q96HM4
- Q96IY5
- Q9BTS3
Protein attributes for HNRNPC Gene
- Size:
- 306 amino acids
- Molecular mass:
- 33670 Da
- Quaternary structure:
-
- Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with DHX9; this interaction is direct, enhanced probably by their concomitant binding to RNA and mediates the attachment to actin filaments (PubMed:11687588).
- SequenceCaution:
-
- Sequence=BAD92764.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for HNRNPC Gene
Protein Expression for HNRNPC Gene
Post-translational modifications for HNRNPC Gene
- Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
- Sumoylated. Sumoylation reduces affinity for mRNA.
-
Ubiquitination at Lys8 and Lys89
- NX_P07910 (NX_P07910-1)
- Modification sites at PhosphoSitePlus
Other Protein References for HNRNPC Gene
- ENSEMBL proteins:
-
- ENSP00000338095
- ENSP00000450725
- ENSP00000451187
- ENSP00000451291
- ENSP00000442816
- ENSP00000450548
- ENSP00000451708
- ENSP00000450790
- ENSP00000452599
- ENSP00000451652
- ENSP00000450629
- ENSP00000452214
- ENSP00000452276
- ENSP00000450544
- ENSP00000451176
- ENSP00000404848
- ENSP00000450601
- ENSP00000452545
- ENSP00000452021
- ENSP00000452213
- ENSP00000452185
- ENSP00000450467
- ENSP00000451292
- ENSP00000452573
- ENSP00000451892
- ENSP00000450669
- ENSP00000404559
- REFSEQ proteins:
Antibody Products
- GeneTex Anti-hnRNP C1/C2 antibody
-
Custom Antibody ServicesOriGene Antibodies for HNRNPC
- Novus Biologicals Antibodies for HNRNPC
-
Abcam antibodies for HNRNPC
- Invitrogen Antibodies for HNRNPC (AFLGC-HNRNPC)
-
Boster Bio Antibodies for HNRNPC
-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPC
- Sino Biological Antibodies for HNRNPC
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPC
- Origene Custom Protein Services for HNRNPC
- ProSpec Recombinant Proteins for HNRNPC
-
Abcam proteins for HNRNPC
Assay Products
No data available for DME Specific Peptides for HNRNPC Gene
Domains & Families for HNRNPC Gene
Gene Families for HNRNPC Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for HNRNPC Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPC Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92712, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein C (C1/C2) (HNRPC), transcript variant 1, mRNA (B2R603_HUMAN)
- cDNA FLJ52975, highly similar to Heterogeneous nuclear ribonucleoproteins C (B4DSU6_HUMAN)
- Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRPC_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P07910- Family:
-
- Belongs to the RRM HNRPC family. RALY subfamily.
Function for HNRNPC Gene
Molecular function for HNRNPC Gene
- UniProtKB/Swiss-Prot Function:
- Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).
Phenotypes From GWAS Catalog for HNRNPC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | HDA | 16217013 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,NAS | 9731529 |
| GO:0003730 | mRNA 3'-UTR binding | IDA | 16010978 |
| GO:0005515 | protein binding | IPI | 11546873 |
Phenotypes for HNRNPC Gene
- MGI mutant phenotypes for HNRNPC:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for HNRNPC:
-
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Reduced mammosphere formation
- Increased ionizing radiation sensitivity
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- FOXO1 nuclear localization
- Inconclusive
- Decreased homologous recombination repair frequency
- Downregulation of NFkappaB pathway
- Decreased viability after ionizing radiation
Animal Models for HNRNPC Gene
- MGI Knock Outs for HNRNPC:
-
- Hnrnpc Hnrnpc<tm1b(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HNRNPC - Select products 50% OFF >
- * HNRNPC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HNRNPC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HNRNPC
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPC
miRNA for HNRNPC Gene
- miRTarBase miRNAs that target HNRNPC
-
- hsa-miR-744-5p (MIRT037494)
- hsa-miR-455-3p (MIRT037890)
- hsa-miR-505-5p (MIRT037959)
- hsa-miR-615-3p (MIRT039991)
- hsa-miR-18a-3p (MIRT040851)
- hsa-miR-484 (MIRT042196)
- hsa-miR-342-3p (MIRT043694)
- hsa-miR-186-5p (MIRT045150)
- hsa-miR-30c-5p (MIRT047904)
- hsa-let-7e-5p (MIRT051596)
- hsa-miR-877-3p (MIRT277852)
- hsa-miR-485-3p (MIRT341160)
- hsa-miR-539-3p (MIRT341161)
- hsa-miR-136-3p (MIRT380416)
- hsa-miR-183-3p (MIRT475571)
- hsa-miR-5196-5p (MIRT475572)
- hsa-miR-4747-5p (MIRT475573)
- hsa-miR-4533 (MIRT475574)
- hsa-miR-6775-5p (MIRT475575)
- hsa-miR-5090 (MIRT475576)
- hsa-miR-4517 (MIRT475577)
- hsa-miR-202-3p (MIRT502260)
- hsa-miR-4698 (MIRT502261)
- hsa-miR-8063 (MIRT502262)
- hsa-miR-548p (MIRT502263)
- hsa-miR-583 (MIRT502264)
- hsa-miR-1276 (MIRT502265)
- hsa-miR-4311 (MIRT502266)
- hsa-miR-548e-5p (MIRT502267)
- hsa-miR-224-5p (MIRT502268)
- hsa-miR-3924 (MIRT511473)
- hsa-miR-4539 (MIRT511474)
- hsa-miR-4724-5p (MIRT511475)
- hsa-miR-4511 (MIRT511476)
- hsa-miR-3133 (MIRT511477)
- hsa-miR-365b-5p (MIRT557221)
- hsa-miR-8052 (MIRT557222)
- hsa-miR-365a-5p (MIRT557223)
- hsa-miR-3199 (MIRT557224)
- hsa-miR-6503-3p (MIRT557225)
- hsa-miR-606 (MIRT557226)
- hsa-miR-708-5p (MIRT557227)
- hsa-miR-28-5p (MIRT557228)
- hsa-miR-3139 (MIRT557229)
- hsa-miR-4699-5p (MIRT571997)
- hsa-miR-4773 (MIRT571998)
- hsa-miR-7850-5p (MIRT574674)
- hsa-miR-620 (MIRT574675)
- hsa-miR-1270 (MIRT574676)
- hsa-miR-4531 (MIRT574677)
- hsa-miR-139-3p (MIRT574678)
- hsa-miR-4524a-3p (MIRT574679)
- mmu-miR-1935 (MIRT600790)
- mmu-miR-298-5p (MIRT600791)
- mmu-miR-709 (MIRT600792)
- mmu-miR-1896 (MIRT600793)
- mmu-miR-1199-5p (MIRT600794)
- mmu-miR-1195 (MIRT600795)
- mmu-miR-3089-5p (MIRT600796)
- mmu-miR-5135 (MIRT600797)
- mmu-miR-665-3p (MIRT604933)
- hsa-miR-6738-3p (MIRT657339)
- hsa-miR-544a (MIRT657340)
- hsa-miR-6828-3p (MIRT657341)
- hsa-miR-6071 (MIRT657342)
- hsa-miR-1298-5p (MIRT657343)
- hsa-miR-3157-5p (MIRT657344)
- hsa-miR-627-3p (MIRT657345)
- hsa-miR-6515-3p (MIRT657346)
- hsa-miR-1-5p (MIRT657347)
- hsa-miR-5000-5p (MIRT657348)
- hsa-miR-6781-3p (MIRT667942)
- hsa-miR-2682-3p (MIRT667943)
- hsa-miR-6877-3p (MIRT667944)
- hsa-miR-6819-3p (MIRT667945)
- hsa-miR-6731-5p (MIRT754005)
- hsa-miR-6783-5p (MIRT755748)
- hsa-miR-6824-5p (MIRT756943)
- hsa-miR-8085 (MIRT760208)
- hsa-miR-1323 (MIRT762531)
- hsa-miR-2053 (MIRT763720)
- hsa-miR-4432 (MIRT768967)
- hsa-miR-495-3p (MIRT772775)
- hsa-miR-499a-5p (MIRT772883)
- hsa-miR-5095 (MIRT773281)
- hsa-miR-548o-3p (MIRT774461)
- hsa-miR-555 (MIRT774654)
- hsa-miR-5688 (MIRT774981)
- hsa-miR-6504-3p (MIRT776578)
- hsa-miR-7-1-3p (MIRT781492)
- hsa-miR-7151-3p (MIRT781511)
- hsa-miR-7-2-3p (MIRT781704)
- hsa-miR-8087 (MIRT782433)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HNRNPC
- Browse OriGene Inhibitory RNA Products For HNRNPC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPC
Clone Products
- Applied Biological Materials (abm): Clones for HNRNPC - Select products 50% OFF >
- * HNRNPC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204015
- MG204182
- MG220315
- MG220319
- MG220325
- MR204015
- MR204015L3
- MR204015L4
- MR204182
- MR204182L3
- MR204182L4
- MR220315
- MR220315L3
- MR220315L4
- MR220319
- MR220319L3
- MR220319L4
- MR220325
- MR220325L3
- MR220325L4
- RC201695
- RC201695L3
- RC201695L4
- RC202788
- RC202788L3
- RC202788L4
- RC215956
- RC215956L1
- RC215956L2
- RC215956L3
- RC215956L4
- RC216056
- RC216056L3
- RC216056L4
- RG201695
- RG202788
- RG215956
- RG216056
- RR206594
- RR206594L3
- RR206594L4
- RR216271
- RR216289
- RR216327
- MR204015L3V
- MR204015L4V
- MR204182L3V
- MR204182L4V
- MR220315L3V
- MR220315L4V
- MR220319L3V
- MR220319L4V
- MR220325L3V
- MR220325L4V
- RC201695L3V
- RC201695L4V
- RC202788L3V
- RC202788L4V
- RC215956L1V
- RC215956L2V
- RC215956L3V
- RC215956L4V
- RC216056L3V
- RC216056L4V
- RR206594L3V
- RR206594L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HNRNPC
- Addgene plasmids for HNRNPC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HNRNPC
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNRNPC Gene
Localization for HNRNPC Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPC Gene
- Nucleus. Note=Component of ribonucleosomes.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | HDA | 16217013 |
| GO:0005576 | extracellular region | HDA | 27068509 |
| GO:0005634 | nucleus | IBA,IDA | 11687588 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005681 | spliceosomal complex | IDA | 9731529 |
Pathways & Interactions for HNRNPC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.47
.41
|
| 2 | Metabolism of proteins | ||
| 3 | SUMOylation |
.95
|
|
| 4 | Chromatin Regulation / Acetylation | ||
| 5 | Translational Control | ||
Pathways by source for HNRNPC Gene
2 BioSystems pathways for HNRNPC Gene
9 Reactome pathways for HNRNPC Gene
1 KEGG pathway for HNRNPC Gene
1 Qiagen pathway for HNRNPC Gene
- Telomere Extension by Telomerase
2 Cell Signaling Technology pathways for HNRNPC Gene
Interacting Proteins for HNRNPC Gene
Selected Interacting proteins:
P07910-HNRPC_HUMAN
ENSP00000451291
for HNRNPC Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HNRNPC
SIGNOR curated interactions for HNRNPC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0001649 | osteoblast differentiation | HDA | 16210410 |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | TAS | 3110598 |
| GO:0016070 | RNA metabolic process | TAS | -- |
Transcripts for HNRNPC Gene
mRNA/cDNA for HNRNPC Gene
- 4 REFSEQ mRNAs :
- 30 NCBI additional mRNA sequence :
- 33 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000336053 3301 nts (view in UCSC)
- ENST00000420743 1559 nts (view in UCSC)
- ENST00000430246 4501 nts (view in UCSC)
- ENST00000449098 1599 nts (view in UCSC)
- ENST00000553300 1375 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HNRNPC - Select products 50% OFF >
- * HNRNPC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HNRNPC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HNRNPC
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPC
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HNRNPC
- Browse OriGene Inhibitory RNA Products For HNRNPC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPC
Clone Products
- Applied Biological Materials (abm): Clones for HNRNPC - Select products 50% OFF >
- * HNRNPC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204015
- MG204182
- MG220315
- MG220319
- MG220325
- MR204015
- MR204015L3
- MR204015L4
- MR204182
- MR204182L3
- MR204182L4
- MR220315
- MR220315L3
- MR220315L4
- MR220319
- MR220319L3
- MR220319L4
- MR220325
- MR220325L3
- MR220325L4
- RC201695
- RC201695L3
- RC201695L4
- RC202788
- RC202788L3
- RC202788L4
- RC215956
- RC215956L1
- RC215956L2
- RC215956L3
- RC215956L4
- RC216056
- RC216056L3
- RC216056L4
- RG201695
- RG202788
- RG215956
- RG216056
- RR206594
- RR206594L3
- RR206594L4
- RR216271
- RR216289
- RR216327
- MR204015L3V
- MR204015L4V
- MR204182L3V
- MR204182L4V
- MR220315L3V
- MR220315L4V
- MR220319L3V
- MR220319L4V
- MR220325L3V
- MR220325L4V
- RC201695L3V
- RC201695L4V
- RC202788L3V
- RC202788L4V
- RC215956L1V
- RC215956L2V
- RC215956L3V
- RC215956L4V
- RC216056L3V
- RC216056L4V
- RR206594L3V
- RR206594L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HNRNPC
- Addgene plasmids for HNRNPC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HNRNPC
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 12b | · | 12c | · | 12d | · | 12e | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: | |||||||||||
| SP13: | |||||||||||
| SP14: | |||||||||||
| SP15: | |||||||||||
| SP16: |
Relevant External Links for HNRNPC Gene
- GeneLoc Exon Structure for
- HNRNPC
Expression for HNRNPC Gene
This gene is overexpressed in Tlymphocyte (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPC Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPC
SOURCE GeneReport for Unigene cluster for HNRNPC Gene:
Hs.508848Evidence on tissue expression from TISSUES for HNRNPC Gene
- Nervous system(5)
- Liver(4.9)
- Blood(4.9)
- Eye(4.9)
- Bone marrow(4.6)
- Skin(4.6)
- Lung(4.5)
- Intestine(4.2)
- Kidney(4.2)
- Pancreas(4)
- Stomach(3.6)
- Heart(3.4)
- Muscle(3.2)
- Bone(3.1)
- Lymph node(3)
- Spleen(2.9)
- Thyroid gland(2.8)
- Adrenal gland(2.7)
- Gall bladder(2)
Primer Products
-
OriGene qPCR primer pairs for HNRNPC
-
OriGene qPCR primer pairs and template standards for HNRNPC
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPC Gene
Orthologs for HNRNPC Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HNRNPC 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HNRPC 31 |
|
OneToMany | |
| LOC510852 30 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | LOC475399 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Mouse (Mus musculus) |
Mammalia | Hnrnpc 30 17 |
|
||
| Ralyl 31 |
|
ManyToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Hnrnpc 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397793 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.6109 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:55733 31 |
|
ManyToMany | |
| hnrnpc 31 |
|
ManyToMany | |||
| zgc55733 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3917 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG42458 31 |
|
OneToMany |
- Species where no ortholog for HNRNPC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HNRNPC Gene
- ENSEMBL:
- Gene Tree for HNRNPC (if available)
- TreeFam:
- Gene Tree for HNRNPC (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HNRNPC: view image
Paralogs for HNRNPC Gene
(10) SIMAP similar genes for HNRNPC Gene using alignment to 16 proteins:
- HNRPC_HUMAN
- B4DSU6_HUMAN
- B4DY08_HUMAN
- G3V251_HUMAN
- G3V2D6_HUMAN
- G3V2H6_HUMAN
- G3V2Q1_HUMAN
- G3V3K6_HUMAN
- G3V4C1_HUMAN
- G3V4M8_HUMAN
- G3V4W0_HUMAN
- G3V555_HUMAN
- G3V575_HUMAN
- G3V576_HUMAN
- G3V5V7_HUMAN
- G3V5X6_HUMAN
Pseudogenes.org Pseudogenes for HNRNPC Gene
Variants for HNRNPC Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1560508 | CNV | insertion | 17803354 |
| esv2656744 | CNV | deletion | 23128226 |
| esv2748453 | CNV | deletion | 23290073 |
| esv3335931 | CNV | insertion | 20981092 |
| esv3633707 | CNV | loss | 21293372 |
| nsv1113621 | CNV | deletion | 24896259 |
| nsv509527 | CNV | insertion | 20534489 |
| nsv974313 | CNV | duplication | 23825009 |
| nsv983803 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.26;
5.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HNRNPC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HNRNPC
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPC Gene
Disorders for HNRNPC Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mixed connective tissue disease |
|
|
| oculopharyngeal muscular dystrophy |
|
|
| multisystem proteinopathy |
|
|
| endometrial stromal tumor |
|
|
| spinal muscular atrophy |
|
|
Search HNRNPC in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HNRNPC
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPC Gene
Publications for HNRNPC Gene
- Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells. (PMID: 16010978) Shetty S (Molecular and cellular biochemistry 2005) 3 4 23
- Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner. (PMID: 12509468) Kim JH … Jang SK (Molecular and cellular biology 2003) 3 4 23
- Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2. (PMID: 12564933) Stone JR … Collins T (Biochemistry 2003) 3 4 23
- 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins. (PMID: 1385725) Wittekind M … Mueller L (Biochemistry 1992) 3 4 23
- N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. (PMID: 25719671) Liu N … Pan T (Nature 2015) 3 4
ExternalLinks
Products for HNRNPC Gene
- Custom Antibody ServicesOriGene Antibodies for HNRNPC
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- VectorBuilder Custom and pre-made DNA vectors for HNRNPC (ie. gene expression, shRNA knockdown, CRISPR)
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