This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While ... See more...

Aliases for HNRNPAB Gene

Aliases for HNRNPAB Gene

  • Heterogeneous Nuclear Ribonucleoprotein A/B 2 3 4 5
  • APOBEC1-Binding Protein 1 3 4
  • HnRNP A/B 3 4
  • HNRPAB 3 4
  • ABBP-1 3 4
  • ABBP1 3 4
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 1-Binding Protein 1 3
  • Apobec-1 Binding Protein 1 3
  • HnRNP Type A/B Protein 3

External Ids for HNRNPAB Gene

Previous HGNC Symbols for HNRNPAB Gene

  • HNRPAB

Previous GeneCards Identifiers for HNRNPAB Gene

  • GC05P177565
  • GC05P177631
  • GC05P172357

Summaries for HNRNPAB Gene

Entrez Gene Summary for HNRNPAB Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPAB Gene

HNRNPAB (Heterogeneous Nuclear Ribonucleoprotein A/B) is a Protein Coding gene. Diseases associated with HNRNPAB include Wells Syndrome. Among its related pathways are Telomere Extension by Telomerase and Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is HNRNPD.

UniProtKB/Swiss-Prot Summary for HNRNPAB Gene

  • Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Gene Wiki entry for HNRNPAB Gene

Additional gene information for HNRNPAB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPAB Gene

Genomics for HNRNPAB Gene

GeneHancer (GH) Regulatory Elements for HNRNPAB Gene

Promoters and enhancers for HNRNPAB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPAB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HNRNPAB gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • CREB
  • deltaCREB
  • NF-Y
  • Nkx2-5

Genomic Locations for HNRNPAB Gene

Genomic Locations for HNRNPAB Gene
chr5:178,204,507-178,211,183
(GRCh38/hg38)
Size:
6,677 bases
Orientation:
Plus strand
chr5:177,631,508-177,638,184
(GRCh37/hg19)
Size:
6,677 bases
Orientation:
Plus strand

Genomic View for HNRNPAB Gene

Genes around HNRNPAB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPAB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPAB Gene

Proteins for HNRNPAB Gene

  • Protein details for HNRNPAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99729-ROAA_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A/B
    Protein Accession:
    Q99729
    Secondary Accessions:
    • B3KNN5
    • D3DWP7
    • Q04150
    • Q8N7U3
    • Q9BQ99

    Protein attributes for HNRNPAB Gene

    Size:
    332 amino acids
    Molecular mass:
    36225 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1.
    SequenceCaution:
    • Sequence=AAC50956.1; Type=Frameshift; Positions=296, 307, 330; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPAB Gene

    Alternative splice isoforms for HNRNPAB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPAB Gene

Post-translational modifications for HNRNPAB Gene

  • Dimethylation at Arg-322 is probably asymmetric.
  • Ubiquitination at Lys86, Lys91, Lys101, Lys118, Lys125, Lys130, and Lys232
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for HNRNPAB Gene

No data available for DME Specific Peptides for HNRNPAB Gene

Domains & Families for HNRNPAB Gene

Gene Families for HNRNPAB Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HNRNPAB Gene

GenScript: Design optimal peptide antigens:
  • APOBEC1-binding protein 1 (ROAA_HUMAN)
genes like me logo Genes that share domains with HNRNPAB: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HNRNPAB Gene

Function for HNRNPAB Gene

Molecular function for HNRNPAB Gene

UniProtKB/Swiss-Prot Function:
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Phenotypes From GWAS Catalog for HNRNPAB Gene

Gene Ontology (GO) - Molecular Function for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 contributes_to DNA-binding transcription factor activity ISS --
GO:0003723 RNA binding IBA,TAS 21873635
GO:0003729 mRNA binding TAS 8999813
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with HNRNPAB: view
genes like me logo Genes that share phenotypes with HNRNPAB: view

Animal Models for HNRNPAB Gene

MGI Knock Outs for HNRNPAB:
  • Hnrnpab Hnrnpab<tm2b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNRNPAB Gene

Localization for HNRNPAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPAB Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPAB gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IBA,IDA --
GO:0005737 cytoplasm ISS --
GO:0090575 RNA polymerase II transcription factor complex ISS --
GO:1990904 ribonucleoprotein complex IDA 17289661
genes like me logo Genes that share ontologies with HNRNPAB: view

Pathways & Interactions for HNRNPAB Gene

PathCards logo

SuperPathways for HNRNPAB Gene

SuperPathway Contained pathways
1 Telomere Extension by Telomerase
-
2 mRNA Splicing - Major Pathway
3 Preimplantation Embryo
genes like me logo Genes that share pathways with HNRNPAB: view

Pathways by source for HNRNPAB Gene

2 BioSystems pathways for HNRNPAB Gene
1 Qiagen pathway for HNRNPAB Gene
  • Telomere Extension by Telomerase

Gene Ontology (GO) - Biological Process for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with HNRNPAB: view

No data available for SIGNOR curated interactions for HNRNPAB Gene

Drugs & Compounds for HNRNPAB Gene

No Compound Related Data Available

Transcripts for HNRNPAB Gene

mRNA/cDNA for HNRNPAB Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPAB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3:
SP4:
SP5: - - - -

Relevant External Links for HNRNPAB Gene

GeneLoc Exon Structure for
HNRNPAB
ECgene alternative splicing isoforms for
HNRNPAB

Expression for HNRNPAB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPAB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPAB Gene



Protein tissue co-expression partners for HNRNPAB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPAB Gene:

HNRNPAB

SOURCE GeneReport for Unigene cluster for HNRNPAB Gene:

Hs.591731

mRNA Expression by UniProt/SwissProt for HNRNPAB Gene:

Q99729-ROAA_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for HNRNPAB Gene

  • Skin(4.6)
  • Liver(4.4)
  • Nervous system(4.2)
  • Lung(3)
  • Intestine(2.6)
genes like me logo Genes that share expression patterns with HNRNPAB: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPAB Gene

Orthologs for HNRNPAB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPAB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPAB 33
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPAB 33 32
  • 91.11 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPAB 33
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910156 32
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Hnrnpab 17 33 32
  • 88.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPAB 33
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPAB 33
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPAB 33 32
  • 77.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPAB 33
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpab 32
  • 71.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia hnrpab-prov 32
zebrafish
(Danio rerio)
Actinopterygii hnrnpabb 33 32
  • 69.83 (n)
OneToMany
hnrnpaba 33
  • 67 (a)
OneToMany
Dr.18836 32
fruit fly
(Drosophila melanogaster)
Insecta sqd 33
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 33
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5495 33
  • 40 (a)
ManyToMany
CSA.10292 33
  • 40 (a)
ManyToMany
Species where no ortholog for HNRNPAB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPAB Gene

ENSEMBL:
Gene Tree for HNRNPAB (if available)
TreeFam:
Gene Tree for HNRNPAB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPAB: view image

Paralogs for HNRNPAB Gene

(17) SIMAP similar genes for HNRNPAB Gene using alignment to 4 proteins:

  • ROAA_HUMAN
  • D6R9P3_HUMAN
  • D6RBZ0_HUMAN
  • D6RD18_HUMAN

Pseudogenes.org Pseudogenes for HNRNPAB Gene

genes like me logo Genes that share paralogs with HNRNPAB: view

Variants for HNRNPAB Gene

Sequence variations from dbSNP and Humsavar for HNRNPAB Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000294138 -- 178,210,965(+) T/C 3_prime_UTR_variant
rs1000559336 -- 178,210,000(+) G/A intron_variant
rs1000899703 -- 178,211,555(+) G/T downstream_transcript_variant
rs1001508270 -- 178,204,397(+) GCGCGCGCGC/GCGCGCGCGCGCGC upstream_transcript_variant
rs1001636041 -- 178,208,764(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPAB Gene

Variant ID Type Subtype PubMed ID
dgv1679e212 CNV loss 25503493
nsv1017664 CNV gain 25217958
nsv1019404 CNV gain 25217958
nsv1120062 OTHER inversion 24896259
nsv1144126 CNV deletion 24896259
nsv820182 CNV gain 19587683

Variation tolerance for HNRNPAB Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPAB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPAB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPAB Gene

Disorders for HNRNPAB Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPAB Gene - From: GeneCards

Disorder Aliases PubMed IDs
wells syndrome
  • bullous cellulitis with eosinophilia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HNRNPAB

genes like me logo Genes that share disorders with HNRNPAB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPAB Gene

Publications for HNRNPAB Gene

  1. Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PMID: 8999813) Lau PP … Chan L (The Journal of biological chemistry 1997) 3 4 23 56
  2. Cloning and sequence analysis of a human type A/B hnRNP protein. (PMID: 1717314) Khan FA … Szer W (FEBS letters 1991) 2 3 4 56
  3. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4 56
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for HNRNPAB Gene

Sources for HNRNPAB Gene