Aliases for HNRNPA3 Gene

Aliases for HNRNPA3 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A3 2 3 4 5
  • HNRPA3 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • 2610510D13Rik 3
  • HnRNP A3 4
  • D10S102 3
  • FBRNP 3

External Ids for HNRNPA3 Gene

Previous HGNC Symbols for HNRNPA3 Gene

  • HNRPA3

Previous GeneCards Identifiers for HNRNPA3 Gene

  • GC02P177786
  • GC02P178077
  • GC02P169948

Summaries for HNRNPA3 Gene

GeneCards Summary for HNRNPA3 Gene

HNRNPA3 (Heterogeneous Nuclear Ribonucleoprotein A3) is a Protein Coding gene. Diseases associated with HNRNPA3 include X-Linked Hereditary Ataxia and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot Summary for HNRNPA3 Gene

  • Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

Gene Wiki entry for HNRNPA3 Gene

Additional gene information for HNRNPA3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPA3 Gene

Genomics for HNRNPA3 Gene

GeneHancer (GH) Regulatory Elements for HNRNPA3 Gene

Promoters and enhancers for HNRNPA3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J177210 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 556.9 +0.8 841 5.5 EP300 HNRNPK ZNF217 CTCF SIN3A NRF1 TCF12 MYC POLR2G USF1 HNRNPA3 ENSG00000229337 MIR4444-1 lnc-AGPS-6 DNAJC19P5 RBM45 NFE2L2 LOC100130691 ENSG00000272551 LOC105373759
GH02J177260 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 71.9 +53.2 53172 11 RXRA EP300 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A NRF1 NFE2L2 ENSG00000222043 RF02531 lnc-TTC30B-4 RBM45 HNRNPA3 DNAJC19P5 LOC100130691 ENSG00000272551 ENSG00000271825
GH02J177164 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.6 -43.7 -43662 9 RXRA EP300 CTCF MYC POLR2G SP1 NCOR1 JUND FOS ZFX HNRNPA3 NFE2L2 DNAJC19P5 ENSG00000222043 ENSG00000236501 LOC105373760 ENSG00000226273 lnc-HNRNPA3-13 ENSG00000229337
GH02J177228 Enhancer 0.9 Ensembl dbSUPER 33.3 +15.2 15186 3 ZSCAN5C POLR2G CEBPG CEBPB POLR2H RBM22 SPI1 XRCC3 SRSF4 POLR2A LOC105373759 HNRNPA3 DNAJC19P5 NFE2L2 ENSG00000222043 LOC100130691 TTC30A lnc-TTC30B-5
GH02J177237 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +30.2 30189 9.4 ZBTB40 ZNF217 ZSCAN5C TCF12 POLR2G JUND FOS ZNF639 REST AFF1 lnc-HNRNPA3-1 NFE2L2 HNRNPA3 ENSG00000222043 ENSG00000229337 ENSG00000237178 ENSG00000238295 LOC100130691 ENSG00000272551 lnc-TTC30B-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPA3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPA3

Top Transcription factor binding sites by QIAGEN in the HNRNPA3 gene promoter:
  • AREB6
  • FOXJ2
  • FOXJ2 (long isoform)
  • Pax-4a
  • Pax-5
  • POU6F1 (c2)
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for HNRNPA3 Gene

Genomic Locations for HNRNPA3 Gene
11,646 bases
Plus strand
11,396 bases
Plus strand

Genomic View for HNRNPA3 Gene

Genes around HNRNPA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA3 Gene

Proteins for HNRNPA3 Gene

  • Protein details for HNRNPA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A3
    Protein Accession:
    Secondary Accessions:
    • D3DPF4
    • Q53RW7
    • Q6URK5

    Protein attributes for HNRNPA3 Gene

    378 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Alternative splice isoforms for HNRNPA3 Gene


neXtProt entry for HNRNPA3 Gene

Post-translational modifications for HNRNPA3 Gene

  • Glycosylation at Asn334
  • Ubiquitination at Lys4, Lys36, Lys57, Lys73, and Lys151
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

No data available for DME Specific Peptides for HNRNPA3 Gene

Domains & Families for HNRNPA3 Gene

Gene Families for HNRNPA3 Gene

Protein Domains for HNRNPA3 Gene

  • RNA-binding region RNP-1 (RNA recognition motif)

Suggested Antigen Peptide Sequences for HNRNPA3 Gene

GenScript: Design optimal peptide antigens:
  • Heterogeneous nuclear ribonucleoprotein A3 (ROA3_HUMAN)
genes like me logo Genes that share domains with HNRNPA3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HNRNPA3 Gene

Function for HNRNPA3 Gene

Molecular function for HNRNPA3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

Phenotypes From GWAS Catalog for HNRNPA3 Gene

Gene Ontology (GO) - Molecular Function for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA,TAS 21873635
GO:0003729 mRNA binding IBA 21873635
GO:0005515 protein binding IPI 22720776
GO:0051033 RNA transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with HNRNPA3: view
genes like me logo Genes that share phenotypes with HNRNPA3: view

Animal Model Products

CRISPR Products

miRNA for HNRNPA3 Gene

miRTarBase miRNAs that target HNRNPA3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPA3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA3 Gene

Localization for HNRNPA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA3 Gene

Nucleus. Note=Component of ribonucleosomes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPA3 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with HNRNPA3: view

Pathways & Interactions for HNRNPA3 Gene

genes like me logo Genes that share pathways with HNRNPA3: view

Pathways by source for HNRNPA3 Gene

Gene Ontology (GO) - Biological Process for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0016070 RNA metabolic process TAS --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with HNRNPA3: view

No data available for SIGNOR curated interactions for HNRNPA3 Gene

Drugs & Compounds for HNRNPA3 Gene

No Compound Related Data Available

Transcripts for HNRNPA3 Gene

mRNA/cDNA for HNRNPA3 Gene

17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPA3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA3 Gene

No ASD Table

Relevant External Links for HNRNPA3 Gene

GeneLoc Exon Structure for

Expression for HNRNPA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPA3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPA3 Gene

Protein tissue co-expression partners for HNRNPA3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPA3

SOURCE GeneReport for Unigene cluster for HNRNPA3 Gene:


Evidence on tissue expression from TISSUES for HNRNPA3 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Lung(3.6)
  • Kidney(3.2)
  • Intestine(3)
  • Eye(2.5)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with HNRNPA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA3 Gene

Orthologs for HNRNPA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia HNRNPA3 31
  • 100 (a)
(Mus musculus)
Mammalia Gm6793 31
  • 99 (a)
Gm9242 31
  • 99 (a)
Gm8991 31
  • 97 (a)
(Bos Taurus)
Mammalia -- 31
  • 99 (a)
(Monodelphis domestica)
Mammalia HNRNPA3 31
  • 90 (a)
(Pan troglodytes)
Mammalia -- 31
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia HNRNPA3 31
  • 71 (a)
(Gallus gallus)
Aves HNRNPA3 31
  • 89 (a)
(Anolis carolinensis)
Reptilia HNRNPA3 31
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17064 30
(Danio rerio)
Actinopterygii hnrnpa3 31
  • 83 (a)
Species where no ortholog for HNRNPA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPA3 Gene

Gene Tree for HNRNPA3 (if available)
Gene Tree for HNRNPA3 (if available)
Evolutionary constrained regions (ECRs) for HNRNPA3: view image

Paralogs for HNRNPA3 Gene

(15) SIMAP similar genes for HNRNPA3 Gene using alignment to 2 proteins:

  • H7C1J8_HUMAN
genes like me logo Genes that share paralogs with HNRNPA3: view

Variants for HNRNPA3 Gene

Additional dbSNP identifiers (rs#s) for HNRNPA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA3 Gene

Variant ID Type Subtype PubMed ID
nsv834465 CNV loss 17160897
nsv963751 CNV duplication 23825009

Variation tolerance for HNRNPA3 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPA3 Gene

Disorders for HNRNPA3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HNRNPA3 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HNRNPA3

genes like me logo Genes that share disorders with HNRNPA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPA3 Gene

Publications for HNRNPA3 Gene

  1. Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. (PMID: 11886857) Ma AS … Smith R (The Journal of biological chemistry 2002) 2 3 4 23 54
  2. HnRNP A3 genes and pseudogenes in the vertebrate genomes. (PMID: 15776420) Makeyev AV … Bayarsaihan D (Journal of experimental zoology. Part A, Comparative experimental biology 2005) 2 3 23 54
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica MS … Moore MJ (RNA (New York, N.Y.) 2002) 3 4 54

Products for HNRNPA3 Gene

Sources for HNRNPA3 Gene