Aliases for HNRNPA1 Gene
- Heterogeneous Nuclear Ribonucleoprotein A1 2 3 4 5
- Single-Strand RNA-Binding Protein 3 4
- Helix-Destabilizing Protein 3 4
- HnRNP A1 3 4
- HnRNP-A1 2 3
- HNRPA1 3 4
- ALS20 2 3
- Putative Heterogeneous Nuclear Ribonucleoprotein A1-Like 3 3
- Heterogeneous Nuclear Ribonucleoprotein Core Protein A1 3
- Heterogeneous Nuclear Ribonucleoprotein A1B Protein 3
External Ids for HNRNPA1 Gene
Previous HGNC Symbols for HNRNPA1 Gene
Previous GeneCards Identifiers for HNRNPA1 Gene
This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016]
GeneCards Summary for HNRNPA1 Gene
HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) is a Protein Coding gene. Diseases associated with HNRNPA1 include Inclusion Body Myopathy With Early-Onset Paget Disease With Or Without Frontotemporal Dementia 3 and Amyotrophic Lateral Sclerosis 20. Among its related pathways are Signaling by GPCR and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA1L2.
UniProtKB/Swiss-Prot Summary for HNRNPA1 Gene
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791).
(Microbial infection) May play a role in HCV RNA replication.
(Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis.