This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of th... See more...

Aliases for HNRNPA0 Gene

Aliases for HNRNPA0 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A0 2 3 4 5
  • HnRNP A0 3 4
  • HNRPA0 3 4
  • HnRNA Binding Protein 3

External Ids for HNRNPA0 Gene

Previous HGNC Symbols for HNRNPA0 Gene

  • HNRPA0

Previous GeneCards Identifiers for HNRNPA0 Gene

  • GC05M137114
  • GC05M132277

Summaries for HNRNPA0 Gene

Entrez Gene Summary for HNRNPA0 Gene

  • This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPA0 Gene

HNRNPA0 (Heterogeneous Nuclear Ribonucleoprotein A0) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA3.

UniProtKB/Swiss-Prot Summary for HNRNPA0 Gene

  • mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.

Gene Wiki entry for HNRNPA0 Gene

Additional gene information for HNRNPA0 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNRNPA0 Gene

Genomics for HNRNPA0 Gene

GeneHancer (GH) Regulatory Elements for HNRNPA0 Gene

Promoters and enhancers for HNRNPA0 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNRNPA0 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNRNPA0

Top Transcription factor binding sites by QIAGEN in the HNRNPA0 gene promoter:
  • AML1a
  • CUTL1
  • HFH-1
  • N-Myc
  • p300
  • Pax-4a
  • SRF
  • SRF (504 AA)
  • Zic1

Genomic Locations for HNRNPA0 Gene

Genomic Locations for HNRNPA0 Gene
chr5:137,745,651-137,754,363
(GRCh38/hg38)
Size:
8,713 bases
Orientation:
Minus strand
chr5:137,087,073-137,090,039
(GRCh37/hg19)
Size:
2,967 bases
Orientation:
Minus strand

Genomic View for HNRNPA0 Gene

Genes around HNRNPA0 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA0 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA0 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA0 Gene

Proteins for HNRNPA0 Gene

  • Protein details for HNRNPA0 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13151-ROA0_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A0
    Protein Accession:
    Q13151
    Secondary Accessions:
    • Q6IB18

    Protein attributes for HNRNPA0 Gene

    Size:
    305 amino acids
    Molecular mass:
    30841 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPA0 Gene

Post-translational modifications for HNRNPA0 Gene

  • Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.
  • Arg-291 is dimethylated, probably to asymmetric dimethylarginine.
  • Ubiquitination at Lys45, Lys80, Lys106, Lys133, and Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPA0 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPA0 Gene

Domains & Families for HNRNPA0 Gene

Gene Families for HNRNPA0 Gene

Protein Domains for HNRNPA0 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HNRNPA0 Gene

GenScript: Design optimal peptide antigens:
  • Heterogeneous nuclear ribonucleoprotein A0 (ROA0_HUMAN)
genes like me logo Genes that share domains with HNRNPA0: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HNRNPA0 Gene

Function for HNRNPA0 Gene

Molecular function for HNRNPA0 Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.

Phenotypes From GWAS Catalog for HNRNPA0 Gene

Gene Ontology (GO) - Molecular Function for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS,IBA 21873635
GO:0003729 mRNA binding IBA 21873635
GO:0019901 protein kinase binding IPI 20932473
GO:0035925 mRNA 3'-UTR AU-rich region binding IEA,IDA 20932473
genes like me logo Genes that share ontologies with HNRNPA0: view
genes like me logo Genes that share phenotypes with HNRNPA0: view

Animal Model Products

CRISPR Products

miRNA for HNRNPA0 Gene

miRTarBase miRNAs that target HNRNPA0

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPA0

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA0 Gene

Localization for HNRNPA0 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA0 Gene

Nucleus. Note=Component of ribonucleosomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPA0 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS 21873635
GO:0005654 nucleoplasm TAS --
GO:1990904 ribonucleoprotein complex IBA 21873635
genes like me logo Genes that share ontologies with HNRNPA0: view

Pathways & Interactions for HNRNPA0 Gene

genes like me logo Genes that share pathways with HNRNPA0: view

Pathways by source for HNRNPA0 Gene

Gene Ontology (GO) - Biological Process for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS,IBA 21873635
GO:0006954 inflammatory response ISS,IEA --
GO:0016070 RNA metabolic process TAS --
GO:0032496 response to lipopolysaccharide IEA,ISS --
genes like me logo Genes that share ontologies with HNRNPA0: view

No data available for SIGNOR curated interactions for HNRNPA0 Gene

Drugs & Compounds for HNRNPA0 Gene

No Compound Related Data Available

Transcripts for HNRNPA0 Gene

mRNA/cDNA for HNRNPA0 Gene

1 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNRNPA0

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA0 Gene

No ASD Table

Relevant External Links for HNRNPA0 Gene

GeneLoc Exon Structure for
HNRNPA0

Expression for HNRNPA0 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPA0 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HNRNPA0 Gene

This gene is overexpressed in Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPA0 Gene



Protein tissue co-expression partners for HNRNPA0 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNRNPA0

SOURCE GeneReport for Unigene cluster for HNRNPA0 Gene:

Hs.96996

Evidence on tissue expression from TISSUES for HNRNPA0 Gene

  • Nervous system(4.7)
  • Lung(4.6)
  • Muscle(4.5)
  • Eye(4.4)
  • Liver(4.4)
  • Skin(4.4)
  • Stomach(2.3)
  • Heart(2.2)
  • Intestine(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with HNRNPA0: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA0 Gene

Orthologs for HNRNPA0 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPA0 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPA0 31
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRPA0 31
  • 98 (a)
OneToOne
HNRNPA0 30
  • 94.3 (n)
dog
(Canis familiaris)
Mammalia HNRNPA0 31
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPA0 31
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC681410 30
  • 85.19 (n)
mouse
(Mus musculus)
Mammalia Hnrnpa0 17 31 30
  • 83.21 (n)
oppossum
(Monodelphis domestica)
Mammalia HNRNPA0 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPA0 31 30
  • 78.86 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPA0 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpa0 30
  • 68.43 (n)
MGC75874 30
African clawed frog
(Xenopus laevis)
Amphibia hnrpa0-prov 30
zebrafish
(Danio rerio)
Actinopterygii hnrnpa0a 31
  • 60 (a)
OneToMany
hnrnpa0b 31
  • 59 (a)
OneToMany
hnrnpa0l 31
  • 58 (a)
OneToMany
wufc01g05 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6239 30
fruit fly
(Drosophila melanogaster)
Insecta Hrb87F 31
  • 36 (a)
ManyToMany
Hrb98DE 31
  • 35 (a)
ManyToMany
Rb97D 31
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-1 31
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 31
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10370 31
  • 27 (a)
OneToMany
Species where no ortholog for HNRNPA0 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPA0 Gene

ENSEMBL:
Gene Tree for HNRNPA0 (if available)
TreeFam:
Gene Tree for HNRNPA0 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HNRNPA0: view image

Paralogs for HNRNPA0 Gene

(17) SIMAP similar genes for HNRNPA0 Gene using alignment to 1 proteins:

  • ROA0_HUMAN
genes like me logo Genes that share paralogs with HNRNPA0: view

Variants for HNRNPA0 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNRNPA0 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
709391 Benign: not provided 137,753,551(-) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for HNRNPA0 Gene

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA0 Gene

Variant ID Type Subtype PubMed ID
nsv819360 CNV gain 19587683
nsv830500 CNV loss 17160897

Variation tolerance for HNRNPA0 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPA0 Gene

Human Gene Mutation Database (HGMD)
HNRNPA0
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPA0

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA0 Gene

Disorders for HNRNPA0 Gene

Additional Disease Information for HNRNPA0

No disorders were found for HNRNPA0 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPA0 Gene

Publications for HNRNPA0 Gene

  1. Isolation and characterization of a novel, low abundance hnRNP protein: A0. (PMID: 7585247) Myer VE … Steitz JA (RNA (New York, N.Y.) 1995) 2 3 4 54
  2. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. (PMID: 20932473) Reinhardt HC … Yaffe MB (Molecular cell 2010) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. (PMID: 12456657) Rousseau S … Cohen P (The EMBO journal 2002) 3 4 54
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. (PMID: 30196744) Arbogast F … Gros F (Autophagy 2019) 3 54

Products for HNRNPA0 Gene

Sources for HNRNPA0 Gene