Aliases for HNMT Gene
External Ids for HNMT Gene
Previous GeneCards Identifiers for HNMT Gene
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNMT Gene
HNMT (Histamine N-Methyltransferase) is a Protein Coding gene. Diseases associated with HNMT include Mental Retardation, Autosomal Recessive 51 and Asthma. Among its related pathways are Histidine metabolism and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include N-methyltransferase activity and histamine N-methyltransferase activity.
UniProtKB/Swiss-Prot Summary for HNMT Gene
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.