Aliases for HNF4G Gene

Aliases for HNF4G Gene

  • Hepatocyte Nuclear Factor 4 Gamma 2 3 5
  • NR2A2 2 3 4
  • Nuclear Receptor Subfamily 2 Group A Member 2 3 4
  • Hepatocyte Nuclear Factor 4-Gamma 3 4
  • HNF-4-Gamma 3 4
  • NR2A3 3
  • HNF4G 5

External Ids for HNF4G Gene

Previous GeneCards Identifiers for HNF4G Gene

  • GC08P075350
  • GC08P076308
  • GC08P076043
  • GC08P076370
  • GC08P076502
  • GC08P076482
  • GC08P076614
  • GC08P071939

Summaries for HNF4G Gene

GeneCards Summary for HNF4G Gene

HNF4G (Hepatocyte Nuclear Factor 4 Gamma) is a Protein Coding gene. Diseases associated with HNF4G include Maturity-Onset Diabetes Of The Young and Hyperuricemia. Among its related pathways are Gene Expression and Regulation of beta-cell development. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and steroid hormone receptor activity. An important paralog of this gene is HNF4A.

UniProtKB/Swiss-Prot Summary for HNF4G Gene

  • Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Gene Wiki entry for HNF4G Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HNF4G Gene

Genomics for HNF4G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HNF4G Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J075402 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 257.2 +0.2 195 11.7 ZNF207 ZNF654 SSRP1 ZNF580 KLF9 CEBPA POLR2A ZIC2 YY1 MXD4 HNF4G lnc-HNF4G-2 lnc-JPH1-11 HSALNG0066268 MK280607-122
GH08J075324 Promoter 1.2 EPDnew Ensembl 250.2 -83.5 -83467 1.8 ZNF10 ZBTB10 ZNF341 KLF7 ZBTB48 ZNF189 EGR1 TAF7 ZNF561 KLF1 CASC9 piR-33432-516 piR-33605-456 piR-45012-495 piR-46002-564 piR-55361-549 HNF4G HSALNG0066261 KF773848 MK280607-122
GH08J075538 Promoter/Enhancer 0.7 EPDnew ENCODE 254.2 +133.6 133588 5.3 ZNF133 RAD51 MLLT1 HNF4G HSALNG0066275 HSALNG0066278 MK280607-122
GH08J075418 Enhancer 0.9 ENCODE dbSUPER 5.2 +13.3 13316 4.9 ATF2 YY1 MAFF RXRA CUX1 ZNF316 JUND FOXP1 MAFK HNF4A HNF4G lnc-HNF4G-2 lnc-JPH1-11 MK280607-122
GH08J075552 Enhancer 0.4 ENCODE 4.2 +146.3 146338 3.2 CEBPB HDGF IKZF1 HNF4G HSALNG0066275 HSALNG0066278 MK280607-122
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HNF4G on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HNF4G

Top Transcription factor binding sites by QIAGEN in the HNF4G gene promoter:
  • GATA-6
  • Gfi-1
  • HFH-1
  • HNF-1
  • HNF-1A
  • MRF-2
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for HNF4G Gene

Latest Assembly
159,268 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
159,186 bases
Plus strand

(GRCh37/hg19 by Ensembl)
158,930 bases
Plus strand

Genomic View for HNF4G Gene

Genes around HNF4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNF4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNF4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNF4G Gene

Proteins for HNF4G Gene

  • Protein details for HNF4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatocyte nuclear factor 4-gamma
    Protein Accession:
    Secondary Accessions:
    • Q7Z2V9
    • Q9UH81
    • Q9UIS6

    Protein attributes for HNF4G Gene

    408 amino acids
    Molecular mass:
    45877 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAE11875.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNF4G Gene

    Alternative splice isoforms for HNF4G Gene


neXtProt entry for HNF4G Gene

Post-translational modifications for HNF4G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HNF4G Gene

Domains & Families for HNF4G Gene

Gene Families for HNF4G Gene

Human Protein Atlas (HPA):
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HNF4G Gene

  • Steroid hormone receptor signature
  • Retinoic acid receptor signature

Suggested Antigen Peptide Sequences for HNF4G Gene

GenScript: Design optimal peptide antigens:
  • Hepatocyte nuclear factor 4, gamma (B6ZGT4_HUMAN)
  • Hepatocyte nuclear factor 4 gamma (F1D8Q4_HUMAN)
  • Nuclear receptor subfamily 2 group A member 2 (HNF4G_HUMAN)
  • HNF4G protein (Q6FGL6_HUMAN)
  • HNF4G protein (Q7Z5U9_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with HNF4G: view

Function for HNF4G Gene

Molecular function for HNF4G Gene

UniProtKB/Swiss-Prot Function:
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
GENATLAS Biochemistry:
hepatocyte nuclear factor 4 gamma,steroid/thyroid receptor superfamily,expressed in kidney,pancreas,small intestine,testis,colon,not in the liver,involved in differential transcriptional regulation,not playing a major role in the etiology of early onst autosomal dominant,non insulin dependent type 2,diabetes

Phenotypes From GWAS Catalog for HNF4G Gene

Gene Ontology (GO) - Molecular Function for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 12220531
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 23896584
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 8622695
genes like me logo Genes that share ontologies with HNF4G: view
genes like me logo Genes that share phenotypes with HNF4G: view

Animal Models for HNF4G Gene

MGI Knock Outs for HNF4G:

Animal Models for research

  • Taconic Biosciences Mouse Models for HNF4G

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNF4G

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNF4G Gene

Localization for HNF4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNF4G Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNF4G gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
  • Cytokinetic bridge (2)
  • Mitotic spindle (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with HNF4G: view

Pathways & Interactions for HNF4G Gene

genes like me logo Genes that share pathways with HNF4G: view

Pathways by source for HNF4G Gene

SIGNOR curated interactions for HNF4G Gene


Gene Ontology (GO) - Biological Process for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS,IBA 21873635
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0030154 cell differentiation IBA 21873635
GO:0030522 intracellular receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with HNF4G: view

Drugs & Compounds for HNF4G Gene

(1) Drugs for HNF4G Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved Pharma Target 27
genes like me logo Genes that share compounds with HNF4G: view

Transcripts for HNF4G Gene

mRNA/cDNA for HNF4G Gene

9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HNF4G

Alternative Splicing Database (ASD) splice patterns (SP) for HNF4G Gene

No ASD Table

Relevant External Links for HNF4G Gene

GeneLoc Exon Structure for

Expression for HNF4G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNF4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HNF4G Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.9), Colon - Transverse (x10.9), and Liver (x5.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNF4G Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HNF4G

SOURCE GeneReport for Unigene cluster for HNF4G Gene:


mRNA Expression by UniProt/SwissProt for HNF4G Gene:

Tissue specificity: Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen.

Evidence on tissue expression from TISSUES for HNF4G Gene

  • Liver(4.5)
  • Kidney(4.4)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with HNF4G: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNF4G Gene

Orthologs for HNF4G Gene

This gene was present in the common ancestor of animals.

Orthologs for HNF4G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HNF4G 29 30
  • 99.7 (n)
(Canis familiaris)
Mammalia HNF4G 29 30
  • 92.88 (n)
(Bos Taurus)
Mammalia HNF4G 29 30
  • 92.06 (n)
(Monodelphis domestica)
Mammalia HNF4G 30
  • 89 (a)
(Mus musculus)
Mammalia Hnf4g 29 16 30
  • 87.02 (n)
(Rattus norvegicus)
Mammalia Hnf4g 29
  • 86.7 (n)
(Ornithorhynchus anatinus)
Mammalia HNF4G 30
  • 74 (a)
(Gallus gallus)
Aves HNF4G 29 30
  • 80.93 (n)
(Anolis carolinensis)
Reptilia HNF4G 30
  • 80 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hnf4g 29
  • 74.74 (n)
(Danio rerio)
Actinopterygii hnf4g 29 30
  • 65.13 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Hnf4 30 31
  • 34 (a)
(Caenorhabditis elegans)
Secernentea nhr-64 29 30 31
  • 48.89 (n)
nhr-69 30 31
  • 38 (a)
nhr-14 31
  • 32 (a)
nhr-35 30
  • 25 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 50 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3727 29
Species where no ortholog for HNF4G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HNF4G Gene

Gene Tree for HNF4G (if available)
Gene Tree for HNF4G (if available)
Evolutionary constrained regions (ECRs) for HNF4G: view image
Alliance of Genome Resources:
Additional Orthologs for HNF4G

Paralogs for HNF4G Gene

Paralogs for HNF4G Gene Pseudogenes for HNF4G Gene

genes like me logo Genes that share paralogs with HNF4G: view

Variants for HNF4G Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HNF4G Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs1805098 -- p.Met190Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HNF4G Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HNF4G Gene

Variant ID Type Subtype PubMed ID
esv3891416 CNV gain 25118596
nsv465718 CNV loss 19166990
nsv465719 CNV loss 19166990
nsv611561 CNV gain 21841781
nsv611562 CNV loss 21841781
nsv611563 CNV loss 21841781
nsv611564 CNV loss 21841781
nsv831357 CNV loss 17160897

Variation tolerance for HNF4G Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNF4G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNF4G Gene

Disorders for HNF4G Gene

MalaCards: The human disease database

(4) MalaCards diseases for HNF4G Gene - From: COP and GCD

Disorder Aliases PubMed IDs
maturity-onset diabetes of the young
  • mody
  • blood urate raized
chromosome 8q21.11 deletion syndrome
  • 8q21.11 microdeletion syndrome
maturity-onset diabetes of the young, type 1
  • mody1
- elite association - COSMIC cancer census association via MalaCards
Search HNF4G in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HNF4G

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HNF4G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNF4G Gene

Publications for HNF4G Gene

  1. Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. (PMID: 12220494) Wisely GB … Williams SP (Structure (London, England : 1993) 2002) 2 3 4
  2. Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. (PMID: 10512380) Plengvidhya N … Doria A (Diabetes 1999) 3 4 22
  3. Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. (PMID: 8622695) Drewes T … Ryffel GU (Molecular and cellular biology 1996) 2 3 4
  4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 40
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 3 4

Products for HNF4G Gene

Sources for HNF4G Gene