Aliases for HMOX2 Gene
External Ids for HMOX2 Gene
Previous GeneCards Identifiers for HMOX2 Gene
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
GeneCards Summary for HMOX2 Gene
HMOX2 (Heme Oxygenase 2) is a Protein Coding gene. Diseases associated with HMOX2 include Type 1 Diabetes Mellitus 7 and Microcephaly 16, Primary, Autosomal Recessive. Among its related pathways are Porphyrin and chlorophyll metabolism and Innate Immune System. Gene Ontology (GO) annotations related to this gene include heme oxygenase (decyclizing) activity. An important paralog of this gene is HMOX1.
UniProtKB/Swiss-Prot Summary for HMOX2 Gene
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
Heme oxygenase (HO) catalyzes the degradation of heme. It is a membrane-bound enzyme that cleaves the heme ring at the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form bilirubin), iron and carbon monoxide.