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Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a consti... See more...
Aliases for HMOX1 Gene
Aliases for HMOX1 Gene
External Ids for HMOX1 Gene
- HGNC: 5013
- Entrez Gene: 3162
- Ensembl: ENSG00000100292
- OMIM: 141250
- UniProtKB: P09601
Previous GeneCards Identifiers for HMOX1 Gene
- GC22P032473
- GC22P034101
- GC22P035776
- GC22P018737
Summaries for HMOX1 Gene
-
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
GeneCards Summary for HMOX1 Gene
HMOX1 (Heme Oxygenase 1) is a Protein Coding gene. Diseases associated with HMOX1 include Heme Oxygenase 1 Deficiency and Pulmonary Disease, Chronic Obstructive. Among its related pathways are Mineral absorption and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity. An important paralog of this gene is HMOX2.
UniProtKB/Swiss-Prot Summary for HMOX1 Gene
-
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
-
Heme oxygenase (HO) catalyzes the degradation of heme. It is a membrane-bound enzyme that cleaves the heme ring at the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form bilirubin), iron and carbon monoxide.
Additional gene information for HMOX1 Gene
- Monarch Initiative
- Search for HMOX1 at DataMed
- Search for HMOX1 at HumanCyc
No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HMOX1 Gene
Genomics for HMOX1 Gene
GeneHancer (GH) Regulatory Elements for HMOX1 Gene
Promoters and enhancers for HMOX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HMOX1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HMOX1
- Top Transcription factor binding sites by QIAGEN in the HMOX1 gene promoter:
-
- AP-4
- ARP-1
- ATF6
- Bach2
- C/EBPbeta
- CREB
- deltaCREB
- HSF2
- p300
- p53
Genomic Locations for HMOX1 Gene
Genomic Locations for HMOX1 Gene
- chr22:35,380,361-35,394,214
- (GRCh38/hg38)
- Size:
- 13,854 bases
- Orientation:
- Plus strand
- chr22:35,776,354-35,790,207
- (GRCh37/hg19)
- Size:
- 13,854 bases
- Orientation:
- Plus strand
Genomic View for HMOX1 Gene
Genes around HMOX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.3 by HGNC
- 22q12.3 by Entrez Gene
- 22q12.3 by Ensembl
HMOX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMOX1 Gene
Proteins for HMOX1 Gene
-
Protein details for HMOX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09601-HMOX1_HUMAN
- Recommended name:
- Heme oxygenase 1
- Protein Accession:
- P09601
Protein attributes for HMOX1 Gene
- Size:
- 288 amino acids
- Molecular mass:
- 32819 Da
- Quaternary structure:
- No Data Available
Protein Expression for HMOX1 Gene
Selected DME Specific Peptides for HMOX1 Gene
- P09601:
-
- GEGLAFFTF
- YFPEELHR
- QDLSEALKEATKEVH
- PELLVAHAYTRY
- ATKFKQLYRSRMN
- GDLSGGQVLKK
- YTRYLGDLSGGQ
Post-translational modifications for HMOX1 Gene
Other Protein References for HMOX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HMOX1 Antibody and Immunotag™ HO-1 Antibody
- NSJ Bioreagents Heme Oxygenase 1 Antibody / HMOX1 (Rabbit Monoclonal)
- Creative Diagnostics Anti-HMOX1 monoclonal antibody, clone IP-2-2
-
Custom Antibody ServicesOriGene Antibodies for HMOX1
- Novus Biologicals Antibodies for HMOX1
-
Abcam antibodies for HMOX1
- Invitrogen Antibodies for HMOX1 (AFLGC-HMOX1)
- antibodies-online: Show 196 available HMOX1 Antibodies ranked by validation data
- Compare Top HMOX1 Antibodies
-
Recommended
- 349 WB Antibodies (anti-human)
- 23 IHC (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 299 WB Antibodies (anti-mouse)
- 23 IHC (p) Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 297 WB Antibodies (anti-rat)
- 12 IHC (p) Antibodies (anti-rat)
- 3 IF Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMOX1
Protein Products
- G Biosciences Human HO-1/HMOX1/HSP32, Liquid
- Creative Biomart Recombinant Human Heme Oxygenase 1, His-tagged
- Search Origene for MassSpec and Protein Over-expression Lysates for HMOX1
- Origene Custom Protein Services for HMOX1
- ProSpec Recombinant Proteins for HMOX1
-
ProSci Proteins for HMOX1
-
Abcam proteins for HMOX1
Assay Products
- Creative Diagnostics Human HO-1 ELISA Kit, Hmox1 (Rat) ELISA Kit, and HMOX1 (Human) ELISA Kit
- Aviva Systems Biology HMOX1 ELISA Kit (Human) : 96 Wells (OKEH02774) and HMOX1 ELISA Kit (Human) (OKCD06543)
-
Custom Assay ServicesOriGene ELISA Kits for HMOX1
- Novus Biologicals ELISA Kits for HMOX1
- antibodies-online: Show 77 available HMOX1 Elisa Kits ranked by validation data
- Compare Top HMOX1 Elisa Kits
-
Quality Products:
- ABIN1115379
- ABIN2964833
- ABIN416738
- ABIN366536
- ABIN2859305
- ABIN1028803
- ABIN5524628
- ABIN6720268
- ABIN5526865
- ABIN510481
- ABIN1115377
- ABIN424042
- ABIN367833
- ABIN5524629
- ABIN5670218
- ABIN1570329
- ABIN627959
- ABIN5594644
- ABIN5692099
- ABIN5655012
- ABIN1115378
- ABIN416094
- ABIN368210
- ABIN579692
- ABIN1570330
- ABIN5524630
- ABIN2684484
- ABIN5670900
- ABIN627144
- ABIN1136295
- ABIN992649
-
Abcam assays for HMOX1
Domains & Families for HMOX1 Gene
Gene Families for HMOX1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for HMOX1 Gene
- Blocks:
-
- Heme oxygenase
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMOX1 Gene
- GenScript: Design optimal peptide antigens:
-
- HMOX1 (D2K7W4_HUMAN)
- Heme oxygenase 1 (E7BJU4_HUMAN)
- Heme oxygenase 1 (F2YMD9_HUMAN)
- Heme oxygenase 1 (HMOX1_HUMAN)
- Heme oxygenase (Decycling) 1 (Q6FH11_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P09601- Family:
-
- Belongs to the heme oxygenase family.
Function for HMOX1 Gene
Molecular function for HMOX1 Gene
- UniProtKB/Swiss-Prot Function:
- Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:21764, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17245, ChEBI:CHEBI:29033, ChEBI:CHEBI:57618, ChEBI:CHEBI:57991, ChEBI:CHEBI:58210, ChEBI:CHEBI:60344; EC=1.14.14.18; Evidence=. ;.
- UniProtKB/Swiss-Prot Induction:
- Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.
- GENATLAS Biochemistry:
- heme oxygenase-1,rate limiting enzyme in the degradation of heme to biliverdin,inducible form,ubiquitously expressed following induction by several stresses,potent anti-inflammatory proteins whenever oxidation injury takes place
Enzyme Numbers (IUBMB) for HMOX1 Gene
Phenotypes From GWAS Catalog for HMOX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004392 | heme oxygenase (decyclizing) activity | IMP,TAS | 19556236 |
| GO:0004630 | phospholipase D activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 21044950 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0019899 | enzyme binding | IEA,ISS | 15516695 |
Phenotypes for HMOX1 Gene
- MGI mutant phenotypes for HMOX1:
-
inferred from 6 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- homeostasis/metabolism phenotype
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for HMOX1:
Animal Models for HMOX1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HMOX1 - Select products 50% OFF >
- * HMOX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HMOX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMOX1
- genomics-online: gRNA clones - Search results for available HMOX1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMOX1
miRNA for HMOX1 Gene
- miRTarBase miRNAs that target HMOX1
-
- hsa-mir-16-5p (MIRT001455)
- hsa-mir-196a-5p (MIRT004719)
- hsa-mir-335-5p (MIRT017714)
- hsa-mir-148b-3p (MIRT019368)
- hsa-mir-128-3p (MIRT021967)
- hsa-mir-124-3p (MIRT022531)
- hsa-mir-122-5p (MIRT023272)
- hsa-mir-1-3p (MIRT023697)
- hsa-mir-26b-5p (MIRT029307)
- hsa-mir-24-3p (MIRT054754)
- hsa-mir-3180-5p (MIRT462650)
- hsa-mir-4443 (MIRT462651)
- hsa-mir-6749-3p (MIRT462652)
- hsa-mir-6792-3p (MIRT462653)
- hsa-mir-4691-5p (MIRT462654)
- hsa-mir-525-5p (MIRT462655)
- hsa-mir-520a-5p (MIRT462656)
- hsa-mir-762 (MIRT462657)
- hsa-mir-5001-5p (MIRT462658)
- hsa-mir-4498 (MIRT462659)
- hsa-mir-4492 (MIRT462660)
- hsa-mir-4430 (MIRT462661)
- hsa-mir-3652 (MIRT462662)
- hsa-mir-6775-3p (MIRT462663)
- hsa-mir-1291 (MIRT462664)
- hsa-mir-650 (MIRT462665)
- hsa-mir-3612 (MIRT462666)
- hsa-mir-3135b (MIRT462667)
- hsa-mir-7976 (MIRT462668)
- hsa-mir-4721 (MIRT462669)
- hsa-mir-6875-5p (MIRT462670)
- hsa-mir-3126-5p (MIRT462671)
- hsa-mir-5008-5p (MIRT462672)
- hsa-mir-3667-3p (MIRT462673)
- hsa-mir-6734-3p (MIRT462674)
- hsa-mir-660-3p (MIRT462675)
- hsa-mir-5193 (MIRT462676)
- hsa-mir-3681-3p (MIRT462677)
- hsa-mir-216a-3p (MIRT462678)
- hsa-mir-4446-3p (MIRT462679)
- hsa-mir-7845-5p (MIRT462680)
- hsa-mir-6873-5p (MIRT462681)
- hsa-mir-6856-5p (MIRT462682)
- hsa-mir-6758-5p (MIRT462683)
- hsa-mir-5590-5p (MIRT650815)
- hsa-mir-4448 (MIRT650816)
- hsa-mir-218-5p (MIRT732641)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HMOX1
- Browse OriGene Inhibitory RNA Products For HMOX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMOX1
- genomics-online: shRNA clones - Search results for available HMOX1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for HMOX1 - Select products 50% OFF >
- * HMOX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HMOX1
- Addgene plasmids for HMOX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMOX1
- genomics-online: cdna clones - Search results for available HMOX1 gene related products
- orf clones - Search results for available HMOX1 gene related products
Cell Line Products
-
Horizon Cell Lines for HMOX1
No data available for Transcription Factor Targets and HOMER Transcription for HMOX1 Gene
Localization for HMOX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMOX1 Gene
- Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| cytosol | 4 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| peroxisome | 3 |
| golgi apparatus | 3 |
| endosome | 2 |
| lysosome | 2 |
- Golgi apparatus (1)
- Plasma membrane (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | TAS | 18307065 |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IEA,ISS | -- |
| GO:0005730 | nucleolus | IEA | -- |
| GO:0005783 | endoplasmic reticulum | TAS,ISS | -- |
Pathways & Interactions for HMOX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Porphyrin and chlorophyll metabolism |
.01
|
.01
|
| 2 | Metabolism |
.40
|
|
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Angiogenesis (CST) | ||
| 5 | NF-kappaB Signaling | ||
Pathways by source for HMOX1 Gene
9 BioSystems pathways for HMOX1 Gene
9 Reactome pathways for HMOX1 Gene
9 KEGG pathways for HMOX1 Gene
1 GeneGo (Thomson Reuters) pathway for HMOX1 Gene
- Immune response IL-1 signaling pathway
1 Qiagen pathway for HMOX1 Gene
- IL-10 Pathway
2 Cell Signaling Technology pathways for HMOX1 Gene
Interacting Proteins for HMOX1 Gene
Selected Interacting proteins:
P09601-HMOX1_HUMAN
ENSP00000216117
for HMOX1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HMOX1
SIGNOR curated interactions for HMOX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | TAS | 12239590 |
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001935 | endothelial cell proliferation | TAS | 12239590 |
| GO:0002246 | wound healing involved in inflammatory response | IMP | 9884342 |
| GO:0002686 | negative regulation of leukocyte migration | TAS | 14525760 |
Drugs & Compounds for HMOX1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Vitamin E | Approved, Vet_approved | Nutra | Enzyme, inducer | 521,525 | ||
| Iron | Approved, Experimental | Pharma | 1496 | |||
| Oxygen | Approved, Vet_approved | Pharma | 0 | |||
| alpha-Tocopherol acetate | Approved, Vet_approved | Nutra | Enzyme, inducer | 0 | ||
| alpha-Tocopherol succinate | Approved, Vet_approved | Nutra | Enzyme, inducer | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| nadph |
|
53-57-6 | ||||
| FADH |
|
1910-41-4 |
|
(2) Tocris Compounds for HMOX1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Tin protoporphyrin IX dichloride | Heme oxygenase inhibitor | 14325-05-4 |
| Zinc protoporphyrin IX | Heme oxygenase and guanylyl cyclase inhibitor | 15442-64-5 |
(4) ApexBio Compounds for HMOX1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bifemelane hydrochloride | 62232-46-6 | |
| Lazabemide hydrochloride | 103878-83-7 | |
| Tin protoporphyrin IX dichloride | 14325-05-4 | |
| Zinc protoporphyrin IX | 15442-64-5 |
Drug Products
- G Biosciences Human HO-1/HMOX1/HSP32, Liquid
- Creative Biomart Recombinant Human Heme Oxygenase 1, His-tagged
- ApexBio compounds for HMOX1
Transcripts for HMOX1 Gene
mRNA/cDNA for HMOX1 Gene
- 1 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000216117 1554 bps (ENST00000216117.9)
- ENST00000412893 921 bps (ENST00000412893.5)
- ENST00000481190 582 bps (ENST00000481190.1)
- ENST00000494998 567 bps (ENST00000494998.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HMOX1 - Select products 50% OFF >
- * HMOX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HMOX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMOX1
- genomics-online: gRNA clones - Search results for available HMOX1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMOX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HMOX1
- Browse OriGene Inhibitory RNA Products For HMOX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMOX1
- genomics-online: shRNA clones - Search results for available HMOX1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for HMOX1 - Select products 50% OFF >
- * HMOX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HMOX1
- Addgene plasmids for HMOX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMOX1
- genomics-online: cdna clones - Search results for available HMOX1 gene related products
- orf clones - Search results for available HMOX1 gene related products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: |
Relevant External Links for HMOX1 Gene
- GeneLoc Exon Structure for
- HMOX1
Expression for HMOX1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Conventional Dendritic Cells I Spleen
- Hematopoietic Bone Marrow
- Brain (Nervous System)
- Adipose (Muscoskeletal System)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Spleen (Hematopoietic System)
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Placenta (Extraembryonic Tissues)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Kidney (Urinary System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for HMOX1 Gene
This gene is overexpressed in Spleen (x15.1) and Whole Blood (x6.3).
This gene is overexpressed in Bone (29.3) and Spleen (21.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HMOX1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HMOX1
SOURCE GeneReport for Unigene cluster for HMOX1 Gene:
Hs.517581mRNA Expression by UniProt/SwissProt for HMOX1 Gene:
P09601-HMOX1_HUMAN
Tissue specificity:
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Evidence on tissue expression from TISSUES for HMOX1 Gene
- Liver(3.6)
- Nervous system(3.6)
- Kidney(3.5)
- Lung(3.5)
- Spleen(3.3)
- Blood(3.2)
- Heart(3.2)
- Muscle(3.2)
- Intestine(2.9)
- Bone marrow(2.8)
- Skin(2.8)
- Adrenal gland(2.4)
- Lymph node(2.4)
- Eye(2.3)
- Pancreas(2.2)
- Stomach(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HMOX1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- urinary
Regions:
Abdomen:
- kidney
- liver
General:
- blood
- blood vessel
- coagulation system
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for HMOX1
-
OriGene qPCR primer pairs and template standards for HMOX1
- genomics-online: primer clones - Search results for available HMOX1 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for HMOX1 Gene
Orthologs for HMOX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMOX1 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HMOX1 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HMOX1 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hmox1 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hmox1 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HMOX1 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HMOX1 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HMOX1 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hmox1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68771 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hmox1a 31 30 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Ho 31 |
|
OneToMany |
- Species where no ortholog for HMOX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for HMOX1 Gene
- ENSEMBL:
- Gene Tree for HMOX1 (if available)
- TreeFam:
- Gene Tree for HMOX1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HMOX1: view image
Paralogs for HMOX1 Gene
Variants for HMOX1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HMOX1 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710830 | Likely Benign: not provided | 35,386,762(+) | C/T | SYNONYMOUS_VARIANT | |
| 712414 | Benign: not provided | 35,386,831(+) | C/T | SYNONYMOUS_VARIANT | |
| 717053 | Benign: not provided | 35,393,571(+) | A/G | SYNONYMOUS_VARIANT | |
| 756404 | Likely Benign: not provided | 35,386,906(+) | G/A | SYNONYMOUS_VARIANT | |
| 775454 | Benign: not provided | 35,387,143(+) | A/G | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.42;
54.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HMOX1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMOX1 Gene
Disorders for HMOX1 Gene
(71) MalaCards diseases for HMOX1 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| heme oxygenase 1 deficiency |
|
|
| pulmonary disease, chronic obstructive |
|
|
| toxic encephalopathy |
|
|
| central retinal artery occlusion |
|
|
| hepatopulmonary syndrome |
|
Search HMOX1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HMOX1_HUMAN- Heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. {ECO:0000269 PubMed:9884342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for HMOX1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for HMOX1 Gene
Publications for HMOX1 Gene
- Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome. (PMID: 19526221) Sheu CC … Christiani DC (Intensive care medicine 2009) 3 23 41 54
- Ozone, oxidant defense genes, and risk of asthma during adolescence. (PMID: 18048809) Islam T … Gilliland FD (American journal of respiratory and critical care medicine 2008) 3 23 41 54
- Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters. (PMID: 18502573) Sawa T … Ohshima H (Cancer letters 2008) 3 23 41 54
- Serum bilirubin and ferritin levels link heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients. (PMID: 18443197) Chen YH … Lin SJ (Diabetes care 2008) 3 23 41 54
- Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. (PMID: 17991645) Arredondo M … Hertrampf E (The American journal of clinical nutrition 2007) 3 23 41 54
ExternalLinks
Products for HMOX1 Gene
- View all 7 R&D Systems HMOX1 (HO-1/HMOX1/HSP32) Products
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for HMOX1
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- Browse Primary Antibodies
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- ApexBio compounds for HMOX1
- VectorBuilder Custom and pre-made DNA vectors for HMOX1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HMOX1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HMOX1 (ie. knockout, knockin, CRISPRa, CRISPRi)
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- Addgene plasmids for HMOX1
- antibodies-online: Show 196 available HMOX1 Antibodies ranked by validation data
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- 349 WB Antibodies (anti-human)
- 23 IHC (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 299 WB Antibodies (anti-mouse)
- 23 IHC (p) Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 297 WB Antibodies (anti-rat)
- 12 IHC (p) Antibodies (anti-rat)
- 3 IF Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 77 available HMOX1 Elisa Kits ranked by validation data
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- antibodies-online: Show 37 available HMOX1 Proteins ranked by validation data
- Compare Top HMOX1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for HMOX1
- Search Santa Cruz Biotechnology (SCBT) for HMOX1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HMOX1
- Search for HMOX1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for HMOX1
- Horizon Cell Lines for HMOX1
- genomics-online: cdna clones - Search results for available HMOX1 gene related products
- orf clones - Search results for available HMOX1 gene related products
- genomics-online: gRNA clones - Search results for available HMOX1 gene related products
- genomics-online: primer clones - Search results for available HMOX1 gene related products
- genomics-online: shRNA clones - Search results for available HMOX1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMOX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMOX1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HMOX1
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Sources for HMOX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28)