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Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
HMOX1 (Heme Oxygenase 1) is a Protein Coding gene. Diseases associated with HMOX1 include Heme Oxygenase 1 Deficiency and Pulmonary Disease, Chronic Obstructive. Among its related pathways are Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling and Validated transcriptional targets of AP1 family members Fra1 and Fra2. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity. An important paralog of this gene is HMOX2.
Heme oxygenase (HO) catalyzes the degradation of heme. It is a membrane-bound enzyme that cleaves the heme ring at the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form bilirubin), iron and carbon monoxide.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004392 | heme oxygenase (decyclizing) activity | TAS,IMP | 19556236 |
GO:0004630 | phospholipase D activity | IEA | -- |
GO:0005198 | structural molecule activity | IMP | 19556236 |
GO:0005515 | protein binding | IPI | 21044950 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | TAS | 18307065 |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IEA,ISS | -- |
GO:0005730 | nucleolus | IEA | -- |
GO:0005783 | endoplasmic reticulum | TAS,ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Porphyrin and chlorophyll metabolism |
.01
|
.01
|
2 | Metabolism |
.40
|
|
3 | Cytokine Signaling in Immune system | ||
4 | Angiogenesis (CST) | ||
5 | NF-kappaB Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IEA,TAS | 12239590 |
GO:0001666 | response to hypoxia | IEA | -- |
GO:0001935 | endothelial cell proliferation | TAS | 12239590 |
GO:0002246 | wound healing involved in inflammatory response | IMP | 9884342 |
GO:0002686 | negative regulation of leukocyte migration | TAS | 14525760 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Vitamin E | Approved, Vet_approved | Nutra | Enzyme, inducer | 526,534 | ||
Iron | Approved, Experimental | Pharma | 1560 | |||
Oxygen | Approved, Vet_approved | Pharma | 0 | |||
alpha-Tocopherol acetate | Approved, Vet_approved | Nutra | Enzyme, inducer | 0 | ||
alpha-Tocopherol succinate | Approved, Vet_approved | Nutra | Enzyme, inducer | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
FADH |
|
1910-41-4 |
|
Compound | Action | Cas Number |
---|---|---|
Tin protoporphyrin IX dichloride | Heme oxygenase inhibitor | 14325-05-4 |
Zinc protoporphyrin IX | Heme oxygenase and guanylyl cyclase inhibitor | 15442-64-5 |
Compound | Action | Cas Number |
---|---|---|
Bifemelane hydrochloride | 62232-46-6 | |
Lazabemide hydrochloride | 103878-83-7 | |
Tin protoporphyrin IX dichloride | 14325-05-4 | |
Zinc protoporphyrin IX | 15442-64-5 |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||
SP2: | - | ||||||||||||||||||||
SP3: | |||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HMOX1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HMOX1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HMOX1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hmox1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hmox1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | HMOX1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HMOX1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HMOX1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hmox1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68771 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | hmox1a 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Ho 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710830 | Likely Benign: not provided | 35,386,762(+) | C/T | SYNONYMOUS_VARIANT | |
712414 | Benign: not provided | 35,386,831(+) | C/T | SYNONYMOUS_VARIANT | |
717053 | Benign: not provided | 35,393,571(+) | A/G | SYNONYMOUS_VARIANT | |
756404 | Likely Benign: not provided | 35,386,906(+) | G/A | SYNONYMOUS_VARIANT | |
775454 | Benign: not provided | 35,387,143(+) | A/G | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
heme oxygenase 1 deficiency |
|
|
pulmonary disease, chronic obstructive |
|
|
toxic encephalopathy |
|
|
hepatopulmonary syndrome |
|
|
neonatal jaundice |
|