Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a consti... See more...

Aliases for HMOX1 Gene

Aliases for HMOX1 Gene

  • Heme Oxygenase 1 2 3 4 5
  • Heme Oxygenase (Decycling) 1 2 3
  • HO-1 3 4
  • Heat Shock Protein, 32-KD 3
  • EC 1.14.14.18 4
  • EC 1.14.99.3 54
  • BK286B10 3
  • HMOX1D 3
  • HSP32 3
  • HO1 4
  • HO 4

External Ids for HMOX1 Gene

Previous GeneCards Identifiers for HMOX1 Gene

  • GC22P032473
  • GC22P034101
  • GC22P035776
  • GC22P018737

Summaries for HMOX1 Gene

Entrez Gene Summary for HMOX1 Gene

  • Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

CIViC Summary for HMOX1 Gene

GeneCards Summary for HMOX1 Gene

HMOX1 (Heme Oxygenase 1) is a Protein Coding gene. Diseases associated with HMOX1 include Heme Oxygenase 1 Deficiency and Pulmonary Disease, Chronic Obstructive. Among its related pathways are Porphyrin and chlorophyll metabolism and Overview of nanoparticle effects. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity. An important paralog of this gene is HMOX2.

UniProtKB/Swiss-Prot Summary for HMOX1 Gene

  • Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

Tocris Summary for HMOX1 Gene

  • Heme oxygenase (HO) catalyzes the degradation of heme. It is a membrane-bound enzyme that cleaves the heme ring at the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form bilirubin), iron and carbon monoxide.

Gene Wiki entry for HMOX1 Gene

Additional gene information for HMOX1 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HMOX1 Gene

Genomics for HMOX1 Gene

GeneHancer (GH) Regulatory Elements for HMOX1 Gene

Promoters and enhancers for HMOX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J035376 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 764.6 -0.7 -720 7.1 ZNF785 SP1 ZBTB6 MLX RBPJ SMARCE1 POLR2A CTBP1 USF2 NR2F6 HMOX1 NONHSAG033802.2 HMGXB4 MCM5 TOM1 RBFOX2 APOL6 AB905429 ENSG00000282041
GH22J035371 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas 13.2 -7.9 -7919 2.1 ZNF785 SIN3A SP1 ZBTB6 MLX RBPJ SMARCE1 USF2 NR2F6 CREB1 AB905426 ENSG00000282602 HMGXB4 ENSG00000238153 MRPS16P3 ENSG00000235485 TOM1 HMOX1 MCM5 RBFOX2
GH22J035349 Promoter/Enhancer 1.5 ENCODE CraniofacialAtlas 6.5 -28.6 -28617 5.1 CTCF RBPJ SMARCE1 MIXL1 CC2D1A NFYC ETV6 L3MBTL2 MAX RAD21 HSALNG0135140 TOM1 HMOX1 piR-49793
GH22J035309 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.4 -67.1 -67052 6.7 RBPJ NR2F1 NR2F6 ETV6 MNT RELA RERE ELF3 SP1 CEBPG TOM1 APOL6 HMOX1 ENSG00000273176 MIR3909
GH22J035375 Enhancer 0.4 FANTOM5 ENCODE 14.8 -5.1 -5107 0.1 AB905429 ENSG00000282041 HMOX1 TOM1 APOL6 AB905426 ENSG00000282602
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HMOX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HMOX1 gene promoter:
  • AP-4
  • ARP-1
  • ATF6
  • Bach2
  • C/EBPbeta
  • CREB
  • deltaCREB
  • HSF2
  • p300
  • p53

Genomic Locations for HMOX1 Gene

Genomic Locations for HMOX1 Gene
chr22:35,380,361-35,394,214
(GRCh38/hg38)
Size:
13,854 bases
Orientation:
Plus strand
chr22:35,776,354-35,790,207
(GRCh37/hg19)
Size:
13,854 bases
Orientation:
Plus strand

Genomic View for HMOX1 Gene

Genes around HMOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMOX1 Gene

Proteins for HMOX1 Gene

  • Protein details for HMOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09601-HMOX1_HUMAN
    Recommended name:
    Heme oxygenase 1
    Protein Accession:
    P09601

    Protein attributes for HMOX1 Gene

    Size:
    288 amino acids
    Molecular mass:
    32819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HMOX1 Gene

neXtProt entry for HMOX1 Gene

Selected DME Specific Peptides for HMOX1 Gene

P09601:
  • GEGLAFFTF
  • YFPEELHR
  • QDLSEALKEATKEVH
  • PELLVAHAYTRY
  • ATKFKQLYRSRMN
  • GDLSGGQVLKK
  • YTRYLGDLSGGQ

Post-translational modifications for HMOX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMOX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for HMOX1 Gene

Gene Families for HMOX1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for HMOX1 Gene

Suggested Antigen Peptide Sequences for HMOX1 Gene

GenScript: Design optimal peptide antigens:
  • HMOX1 (D2K7W4_HUMAN)
  • Heme oxygenase 1 (E7BJU4_HUMAN)
  • Heme oxygenase 1 (F2YMD9_HUMAN)
  • Heme oxygenase 1 (HMOX1_HUMAN)
  • Heme oxygenase (Decycling) 1 (Q6FH11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P09601

UniProtKB/Swiss-Prot:

HMOX1_HUMAN :
  • Belongs to the heme oxygenase family.
Family:
  • Belongs to the heme oxygenase family.
genes like me logo Genes that share domains with HMOX1: view

Function for HMOX1 Gene

Molecular function for HMOX1 Gene

UniProtKB/Swiss-Prot Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:21764, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17245, ChEBI:CHEBI:29033, ChEBI:CHEBI:57618, ChEBI:CHEBI:57991, ChEBI:CHEBI:58210, ChEBI:CHEBI:60344; EC=1.14.14.18; Evidence=. ;.
UniProtKB/Swiss-Prot Induction:
Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.
GENATLAS Biochemistry:
heme oxygenase-1,rate limiting enzyme in the degradation of heme to biliverdin,inducible form,ubiquitously expressed following induction by several stresses,potent anti-inflammatory proteins whenever oxidation injury takes place

Enzyme Numbers (IUBMB) for HMOX1 Gene

Phenotypes From GWAS Catalog for HMOX1 Gene

Gene Ontology (GO) - Molecular Function for HMOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004392 heme oxygenase (decyclizing) activity TAS,IMP 19556236
GO:0004630 phospholipase D activity IEA --
GO:0005515 protein binding IPI 21044950
GO:0016491 oxidoreductase activity IEA --
GO:0019899 enzyme binding ISS,IEA 15516695
genes like me logo Genes that share ontologies with HMOX1: view
genes like me logo Genes that share phenotypes with HMOX1: view

Human Phenotype Ontology for HMOX1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HMOX1 Gene

MGI Knock Outs for HMOX1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMOX1

Clone Products

  • Addgene plasmids for HMOX1

No data available for Transcription Factor Targets and HOMER Transcription for HMOX1 Gene

Localization for HMOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMOX1 Gene

Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HMOX1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
extracellular 4
nucleus 4
cytosol 4
mitochondrion 3
cytoskeleton 2
peroxisome 2
golgi apparatus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HMOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 18307065
GO:0005634 nucleus IEA,ISS --
GO:0005730 nucleolus IEA --
GO:0005783 endoplasmic reticulum TAS,ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with HMOX1: view

Pathways & Interactions for HMOX1 Gene

genes like me logo Genes that share pathways with HMOX1: view

Pathways by source for HMOX1 Gene

SIGNOR curated interactions for HMOX1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for HMOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 12239590
GO:0001666 response to hypoxia IEA --
GO:0001935 endothelial cell proliferation TAS 12239590
GO:0002246 wound healing involved in inflammatory response IMP 9884342
GO:0002686 negative regulation of leukocyte migration TAS 14525760
genes like me logo Genes that share ontologies with HMOX1: view

Drugs & Compounds for HMOX1 Gene

(91) Drugs for HMOX1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Enzyme, inducer 504,508
Iron Approved, Experimental Pharma 1452
Oxygen Approved, Vet_approved Pharma 0
alpha-Tocopherol acetate Approved, Vet_approved Nutra Enzyme, inducer 0
alpha-Tocopherol succinate Approved, Vet_approved Nutra Enzyme, inducer 0

(63) Additional Compounds for HMOX1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
FADH
  • 1,5-dihydro-FAD
  • DIHYDROFLAVINE-adenine dinucleotide
  • Flavin adenine dinucleotide (reduced)
  • 1,5-dihydro-P-5-Ester with adenosine
  • 1,5-dihydro-Riboflavin 5'-(trihydrogen diphosphate) p'->5'-ester with adenosine
1910-41-4

(2) Tocris Compounds for HMOX1 Gene

Compound Action Cas Number
Tin protoporphyrin IX dichloride Heme oxygenase inhibitor 14325-05-4
Zinc protoporphyrin IX Heme oxygenase and guanylyl cyclase inhibitor 15442-64-5

(4) ApexBio Compounds for HMOX1 Gene

Compound Action Cas Number
Bifemelane hydrochloride 62232-46-6
Lazabemide hydrochloride 103878-83-7
Tin protoporphyrin IX dichloride 14325-05-4
Zinc protoporphyrin IX 15442-64-5
genes like me logo Genes that share compounds with HMOX1: view

Transcripts for HMOX1 Gene

mRNA/cDNA for HMOX1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMOX1

Clone Products

  • Addgene plasmids for HMOX1

Alternative Splicing Database (ASD) splice patterns (SP) for HMOX1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for HMOX1 Gene

GeneLoc Exon Structure for
HMOX1
ECgene alternative splicing isoforms for
HMOX1

Expression for HMOX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HMOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HMOX1 Gene

This gene is overexpressed in Spleen (x15.1) and Whole Blood (x6.3).

Protein differential expression in normal tissues from HIPED for HMOX1 Gene

This gene is overexpressed in Bone (29.3) and Spleen (21.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HMOX1 Gene



NURSA nuclear receptor signaling pathways regulating expression of HMOX1 Gene:

HMOX1

SOURCE GeneReport for Unigene cluster for HMOX1 Gene:

Hs.517581

mRNA Expression by UniProt/SwissProt for HMOX1 Gene:

P09601-HMOX1_HUMAN
Tissue specificity: Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).

Evidence on tissue expression from TISSUES for HMOX1 Gene

  • Liver(3.6)
  • Nervous system(3.6)
  • Kidney(3.5)
  • Lung(3.5)
  • Spleen(3.3)
  • Blood(3.2)
  • Heart(3.2)
  • Muscle(3.2)
  • Intestine(2.9)
  • Bone marrow(2.8)
  • Skin(2.8)
  • Adrenal gland(2.4)
  • Lymph node(2.4)
  • Eye(2.3)
  • Pancreas(2.2)
  • Stomach(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HMOX1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • urinary
Regions:
Abdomen:
  • kidney
  • liver
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with HMOX1: view

No data available for Protein tissue co-expression partners for HMOX1 Gene

Orthologs for HMOX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMOX1 33 32
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HMOX1 33 32
  • 87.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HMOX1 33 32
  • 85.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hmox1 17 33 32
  • 82.18 (n)
rat
(Rattus norvegicus)
Mammalia Hmox1 32
  • 81.48 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 67 (a)
OneToMany
-- 33
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HMOX1 33
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves HMOX1 33 32
  • 67.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMOX1 33
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmox1 32
  • 61.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68771 32
zebrafish
(Danio rerio)
Actinopterygii hmox1a 33 32
  • 56.59 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ho 33
  • 20 (a)
OneToMany
Species where no ortholog for HMOX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMOX1 Gene

ENSEMBL:
Gene Tree for HMOX1 (if available)
TreeFam:
Gene Tree for HMOX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HMOX1: view image

Paralogs for HMOX1 Gene

Paralogs for HMOX1 Gene

(2) SIMAP similar genes for HMOX1 Gene using alignment to 6 proteins:

  • HMOX1_HUMAN
  • B1AHA8_HUMAN
  • D2K7W4_HUMAN
  • F2YMD9_HUMAN
  • Q6FH11_HUMAN
  • Q96DI8_HUMAN
genes like me logo Genes that share paralogs with HMOX1: view

Variants for HMOX1 Gene

Sequence variations from dbSNP and Humsavar for HMOX1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs150515195 benign, not specified 35,386,870(+) C/T coding_sequence_variant, synonymous_variant
rs1000147902 -- 35,384,728(+) C/G intron_variant
rs1000558448 -- 35,390,788(+) G/A intron_variant
rs1001188574 -- 35,379,763(+) T/C upstream_transcript_variant
rs1001243905 -- 35,386,458(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HMOX1 Gene

Variant ID Type Subtype PubMed ID
nsv3611 CNV insertion 18451855

Variation tolerance for HMOX1 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HMOX1 Gene

Human Gene Mutation Database (HGMD)
HMOX1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HMOX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMOX1 Gene

Disorders for HMOX1 Gene

MalaCards: The human disease database

(40) MalaCards diseases for HMOX1 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search HMOX1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HMOX1_HUMAN
  • Heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. {ECO:0000269 PubMed:9884342}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for HMOX1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HMOX1: view

No data available for Genatlas for HMOX1 Gene

Publications for HMOX1 Gene

  1. Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome. (PMID: 19526221) Sheu CC … Christiani DC (Intensive care medicine 2009) 3 23 43 56
  2. Ozone, oxidant defense genes, and risk of asthma during adolescence. (PMID: 18048809) Islam T … Gilliland FD (American journal of respiratory and critical care medicine 2008) 3 23 43 56
  3. Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters. (PMID: 18502573) Sawa T … Ohshima H (Cancer letters 2008) 3 23 43 56
  4. Serum bilirubin and ferritin levels link heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients. (PMID: 18443197) Chen YH … Lin SJ (Diabetes care 2008) 3 23 43 56
  5. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. (PMID: 17991645) Arredondo M … Hertrampf E (The American journal of clinical nutrition 2007) 3 23 43 56

Products for HMOX1 Gene

  • Addgene plasmids for HMOX1

Sources for HMOX1 Gene