The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008] See more...

Aliases for HMMR Gene

Aliases for HMMR Gene

  • Hyaluronan Mediated Motility Receptor 2 3 4 5
  • RHAMM 2 3 4
  • Intracellular Hyaluronic Acid-Binding Protein 3 4
  • Receptor For Hyaluronan-Mediated Motility 3 4
  • CD168 2 3
  • IHABP 3 4
  • Hyaluronan-Mediated Motility Receptor (RHAMM) 2
  • Hyaluronan-Mediated Motility Receptor 2
  • CD168 Antigen 4
  • HMMR 5

External Ids for HMMR Gene

Previous GeneCards Identifiers for HMMR Gene

  • GC05P163090
  • GC05P162822
  • GC05P162868
  • GC05P162820
  • GC05P162887
  • GC05P157987

Summaries for HMMR Gene

Entrez Gene Summary for HMMR Gene

  • The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for HMMR Gene

HMMR (Hyaluronan Mediated Motility Receptor) is a Protein Coding gene. Diseases associated with HMMR include Breast Cancer and Fibrosarcoma. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include hyaluronic acid binding.

UniProtKB/Swiss-Prot Summary for HMMR Gene

  • Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).

Gene Wiki entry for HMMR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HMMR Gene

Genomics for HMMR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HMMR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J163457 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.4 422 6 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 TFE3 RFX1 LEF1 NUDCD2 HMMR lnc-GABRB2-6 CCNG1 MAT2B HMMR-AS1
GH05J163436 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 -21.9 -21927 4.3 BRCA1 ARHGAP35 SP1 CREB1 GATAD2A PRDM10 ZNF629 REST IKZF1 ZNF692 CCNG1 ENSG00000254186 LOC105377700 lnc-CCNG1-1 NUDCD2 HMMR HMMR-AS1 MN298233
GH05J163502 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 5.6 +46.3 46292 8.7 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 REST ZNF629 TFE3 MAT2B HMMR CCNG1 NUDCD2 MN298678-071
GH05J163434 Enhancer 1 Ensembl ENCODE 11.8 -25.5 -25502 1 LEF1 IKZF1 MTA2 ZNF24 HDAC1 SOX6 MCM7 MTA3 CTBP1 FOXK2 HMMR NUDCD2 HMMR-AS1 CCNG1 ENSG00000254186 LOC105377700 piR-42694-131
GH05J164354 Enhancer 0.8 Ensembl 11.9 +894.7 894723 1.5 CEBPG ZNF512 LEF1 JUND PKNOX1 ZNF24 MTA1 BRD9 DPF2 HDAC1 HMMR RF00017-5072 lnc-NUDCD2-10 ENSG00000241956 LOC102546299 LOC105377703 MAT2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HMMR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HMMR

Top Transcription factor binding sites by QIAGEN in the HMMR gene promoter:
  • c-Myb
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for HMMR Gene

Genomic Locations for HMMR Gene
chr5:163,460,203-163,491,941
(GRCh38/hg38)
Size:
31,739 bases
Orientation:
Plus strand
chr5:162,887,209-162,918,951
(GRCh37/hg19)
Size:
31,743 bases
Orientation:
Plus strand

Genomic View for HMMR Gene

Genes around HMMR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMMR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMMR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMMR Gene

Proteins for HMMR Gene

  • Protein details for HMMR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75330-HMMR_HUMAN
    Recommended name:
    Hyaluronan mediated motility receptor
    Protein Accession:
    O75330
    Secondary Accessions:
    • A8K3G2
    • B4E114
    • D3DQK9
    • D3DQL0
    • E9PCS0
    • Q32N02
    • Q92767

    Protein attributes for HMMR Gene

    Size:
    724 amino acids
    Molecular mass:
    84100 Da
    Quaternary structure:
    • Subunit of the HARC complex. Interacts with ANKRD26 (PubMed:22666460).

    Alternative splice isoforms for HMMR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMMR Gene

Post-translational modifications for HMMR Gene

  • Glycosylation at Asn133, Asn477, Asn567, and Asn588
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HMMR Gene

Domains & Families for HMMR Gene

Gene Families for HMMR Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for HMMR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HMMR Gene

GenScript: Design optimal peptide antigens:
  • Hyaluronan-mediated motility receptor (B9UCQ3_HUMAN)
  • Receptor for hyaluronan-mediated motility (HMMR_HUMAN)
  • HMMR protein (Q05D84_HUMAN)
  • HMMR protein (Q05DM0_HUMAN)
  • HMMR protein (Q6NSC0_HUMAN)
genes like me logo Genes that share domains with HMMR: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HMMR Gene

Function for HMMR Gene

Molecular function for HMMR Gene

UniProtKB/Swiss-Prot Function:
Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).
GENATLAS Biochemistry:
hyaluronan-mediated motility receptor,involved in signal transduction via Src tyrosine kinase family,expressed in the cytoplasm,nucleus,and cell surface,five isoforms (58,60,64,70,84kDa),regulating cell motility and cell cycle

Phenotypes From GWAS Catalog for HMMR Gene

Gene Ontology (GO) - Molecular Function for HMMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22110403
GO:0005540 hyaluronic acid binding IEA --
genes like me logo Genes that share ontologies with HMMR: view
genes like me logo Genes that share phenotypes with HMMR: view

Human Phenotype Ontology for HMMR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HMMR Gene

MGI Knock Outs for HMMR:
  • Hmmr Hmmr<tm1Baa>
  • Hmmr Hmmr<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMMR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HMMR Gene

Localization for HMMR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMMR Gene

Cell surface. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HMMR gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 3
extracellular 2
golgi apparatus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (4)
  • Cytosol (4)
  • Microtubules (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HMMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with HMMR: view

Pathways & Interactions for HMMR Gene

genes like me logo Genes that share pathways with HMMR: view

Pathways by source for HMMR Gene

2 Qiagen pathways for HMMR Gene
  • FAK1 Signaling
  • Glioma Invasiveness

Gene Ontology (GO) - Biological Process for HMMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0030214 hyaluronan catabolic process TAS --
genes like me logo Genes that share ontologies with HMMR: view

No data available for SIGNOR curated interactions for HMMR Gene

Drugs & Compounds for HMMR Gene

(8) Drugs for HMMR Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target 717
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3670
Epirubicin Approved Pharma 483
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 2338
HYALURONAN Pharma 0

(1) Additional Compounds for HMMR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HMMR: view

Transcripts for HMMR Gene

mRNA/cDNA for HMMR Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMMR

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMMR Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19
SP1: -
SP2: -
SP3: - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for HMMR Gene

GeneLoc Exon Structure for
HMMR

Expression for HMMR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HMMR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HMMR Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for HMMR Gene

This gene is overexpressed in Heart (44.8) and Breast (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HMMR Gene



Protein tissue co-expression partners for HMMR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HMMR

SOURCE GeneReport for Unigene cluster for HMMR Gene:

Hs.740467

mRNA Expression by UniProt/SwissProt for HMMR Gene:

O75330-HMMR_HUMAN
Tissue specificity: Expressed in breast cancer cell lines and in normal breast tissue.

Evidence on tissue expression from TISSUES for HMMR Gene

  • Nervous system(3.5)
  • Lymph node(2.6)
  • Eye(2.5)
  • Blood(2.5)
  • Bone marrow(2.4)
  • Intestine(2.3)
  • Spleen(2.3)
  • Heart(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with HMMR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HMMR Gene

Orthologs for HMMR Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMMR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HMMR 30 31
  • 99.22 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HMMR 30 31
  • 88.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HMMR 30 31
  • 88.08 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hmmr 30
  • 78.75 (n)
Mouse
(Mus musculus)
Mammalia Hmmr 30 17 31
  • 74.52 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HMMR 31
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 52 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
Chicken
(Gallus gallus)
Aves HMMR 30
  • 62.28 (n)
Lizard
(Anolis carolinensis)
Reptilia HMMR 31
  • 46 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hmmr 30
  • 56.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22720 30
Zebrafish
(Danio rerio)
Actinopterygii hmmr 30 31
  • 50.9 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10432 31
  • 21 (a)
OneToOne
Species where no ortholog for HMMR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HMMR Gene

ENSEMBL:
Gene Tree for HMMR (if available)
TreeFam:
Gene Tree for HMMR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HMMR: view image

Paralogs for HMMR Gene

No data available for Paralogs for HMMR Gene

Variants for HMMR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HMMR Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
792019 Benign: not provided 163,483,130(+) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
792020 Benign: not provided 163,483,159(+) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs2303077 -. - p.Asn305Lysp.Asn320Lys
rs2230362 - p.Asp557His
rs2230363 - p.Leu595Ile

Additional dbSNP identifiers (rs#s) for HMMR Gene

Structural Variations from Database of Genomic Variants (DGV) for HMMR Gene

Variant ID Type Subtype PubMed ID
nsv1017056 CNV gain 25217958
nsv1018494 CNV gain 25217958
nsv1029437 CNV gain 25217958
nsv473752 CNV novel sequence insertion 20440878
nsv519801 CNV loss 19592680
nsv524084 CNV loss 19592680
nsv830538 CNV gain+loss 17160897

Variation tolerance for HMMR Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.64; 89.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HMMR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HMMR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMMR Gene

Disorders for HMMR Gene

MalaCards: The human disease database

(6) MalaCards diseases for HMMR Gene - From: OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
fibrosarcoma
  • fibrocytic tumor
nodular basal cell carcinoma
  • basal cell carcinoma, nodular
urachus cancer
  • malignant tumor of urachus
myelodysplastic syndrome
  • mds
- elite association - COSMIC cancer census association via MalaCards
Search HMMR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HMMR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HMMR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HMMR Gene

Publications for HMMR Gene

  1. Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer. (PMID: 19064580) Kalmyrzaev B … SEARCH Team (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 23 41
  2. The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells. (PMID: 9601098) Assmann V … Hart IR (Journal of cell science 1998) 3 4 23
  3. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. (PMID: 22666460) Liu XF … Pastan I (PloS one 2012) 3 4
  4. RHAMM (CD168) is overexpressed at the protein level and may constitute an immunogenic antigen in advanced prostate cancer disease. (PMID: 19724689) Gust KM … Ringhoffer M (Neoplasia (New York, N.Y.) 2009) 3 23
  5. The tumor antigens RHAMM and G250/CAIX are expressed in head and neck squamous cell carcinomas and elicit specific CD8+ T cell responses. (PMID: 19212667) Schmitt A … Schmitt M (International journal of oncology 2009) 3 23

Products for HMMR Gene

Sources for HMMR Gene