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Aliases for HMMR Gene

Aliases for HMMR Gene

  • Hyaluronan Mediated Motility Receptor 2 3 3 5
  • Intracellular Hyaluronic Acid-Binding Protein 3 4
  • Receptor For Hyaluronan-Mediated Motility 3 4
  • IHABP 3 4
  • RHAMM 3 4
  • Hyaluronan-Mediated Motility Receptor (RHAMM) 2
  • Hyaluronan-Mediated Motility Receptor 2
  • CD168 Antigen 4
  • CD168 3

External Ids for HMMR Gene

Previous GeneCards Identifiers for HMMR Gene

  • GC05P163090
  • GC05P162822
  • GC05P162868
  • GC05P162820
  • GC05P162887
  • GC05P157987

Summaries for HMMR Gene

Entrez Gene Summary for HMMR Gene

  • The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for HMMR Gene

HMMR (Hyaluronan Mediated Motility Receptor) is a Protein Coding gene. Diseases associated with HMMR include Breast Cancer and Fibrosarcoma. Among its related pathways are Cell Cycle, Mitotic and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include hyaluronic acid binding.

UniProtKB/Swiss-Prot for HMMR Gene

  • Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).

Gene Wiki entry for HMMR Gene

Additional gene information for HMMR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMMR Gene

Genomics for HMMR Gene

GeneHancer (GH) Regulatory Elements for HMMR Gene

Promoters and enhancers for HMMR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J163457 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.4 449 6 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D GLIS1 NBN NR2C1 NUDCD2 HMMR CCNG1 MAT2B HMMR-AS1 GC05P163387
GH05J163436 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.8 -22.2 -22176 3.8 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ENSG00000254186 LOC105377700 CCNG1 NUDCD2 HMMR HMMR-AS1 GC05M163448 GC05P163387
GH05J163502 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.6 +46.3 46292 8.7 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN NR2C1 MAT2B HMMR CCNG1 NUDCD2 GC05P163619 GC05P163387
GH05J163434 Enhancer 1 Ensembl ENCODE 11.7 -25.6 -25602 0.4 HDAC1 ATF1 YY1 ZNF335 TCF12 ATF7 ZEB2 ZNF592 NR2F2 NFIC HMMR NUDCD2 HMMR-AS1 ENSG00000254186 LOC105377700 ENSG00000250114 GC05P163387
GH05J163511 Enhancer 0.3 dbSUPER 4.9 +52.0 51981 1.4 SCRT1 CCNG1 HMMR MAT2B GC05P163619 GC05P163387
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HMMR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HMMR gene promoter:
  • c-Myb
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for HMMR Gene

Genomic Locations for HMMR Gene
chr5:163,460,203-163,491,945
(GRCh38/hg38)
Size:
31,743 bases
Orientation:
Plus strand
chr5:162,887,209-162,918,951
(GRCh37/hg19)
Size:
31,743 bases
Orientation:
Plus strand

Genomic View for HMMR Gene

Genes around HMMR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMMR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMMR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMMR Gene

Proteins for HMMR Gene

  • Protein details for HMMR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75330-HMMR_HUMAN
    Recommended name:
    Hyaluronan mediated motility receptor
    Protein Accession:
    O75330
    Secondary Accessions:
    • A8K3G2
    • B4E114
    • D3DQK9
    • D3DQL0
    • E9PCS0
    • Q32N02
    • Q92767

    Protein attributes for HMMR Gene

    Size:
    724 amino acids
    Molecular mass:
    84100 Da
    Quaternary structure:
    • Subunit of the HARC complex. Interacts with ANKRD26 (PubMed:22666460).

    Alternative splice isoforms for HMMR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMMR Gene

Post-translational modifications for HMMR Gene

  • Glycosylation at isoforms=2, 3, 4588, isoforms=2, 3, 4567, Asn477, and isoforms=2, 3, 4133
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HMMR Gene

Domains & Families for HMMR Gene

Gene Families for HMMR Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for HMMR Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HMMR: view

No data available for UniProtKB/Swiss-Prot for HMMR Gene

Function for HMMR Gene

Molecular function for HMMR Gene

UniProtKB/Swiss-Prot Function:
Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).
GENATLAS Biochemistry:
hyaluronan-mediated motility receptor,involved in signal transduction via Src tyrosine kinase family,expressed in the cytoplasm,nucleus,and cell surface,five isoforms (58,60,64,70,84kDa),regulating cell motility and cell cycle

Gene Ontology (GO) - Molecular Function for HMMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22110403
GO:0005540 hyaluronic acid binding IBA --
genes like me logo Genes that share ontologies with HMMR: view
genes like me logo Genes that share phenotypes with HMMR: view

Animal Models for HMMR Gene

MGI Knock Outs for HMMR:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HMMR Gene

Localization for HMMR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMMR Gene

Cell surface. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HMMR gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 3
extracellular 2
nucleus 2
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (4)
  • Cytosol (4)
  • Microtubules (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HMMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with HMMR: view

Pathways & Interactions for HMMR Gene

genes like me logo Genes that share pathways with HMMR: view

Pathways by source for HMMR Gene

2 Qiagen pathways for HMMR Gene

Gene Ontology (GO) - Biological Process for HMMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0030214 hyaluronan catabolic process TAS --
genes like me logo Genes that share ontologies with HMMR: view

No data available for SIGNOR curated interactions for HMMR Gene

Drugs & Compounds for HMMR Gene

(8) Drugs for HMMR Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target 535
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3113
Epirubicin Approved Pharma 426
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1970
HYALURONAN Pharma 0

(1) Additional Compounds for HMMR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HMMR: view

Transcripts for HMMR Gene

Unigene Clusters for HMMR Gene

Hyaluronan-mediated motility receptor (RHAMM):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMMR Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19
SP1: -
SP2: -
SP3: - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for HMMR Gene

GeneLoc Exon Structure for
HMMR
ECgene alternative splicing isoforms for
HMMR

Expression for HMMR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HMMR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HMMR Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for HMMR Gene

This gene is overexpressed in Heart (44.8) and Breast (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HMMR Gene



Protein tissue co-expression partners for HMMR Gene

NURSA nuclear receptor signaling pathways regulating expression of HMMR Gene:

HMMR

SOURCE GeneReport for Unigene cluster for HMMR Gene:

Hs.740467

mRNA Expression by UniProt/SwissProt for HMMR Gene:

O75330-HMMR_HUMAN
Tissue specificity: Expressed in breast cancer cell lines and in normal breast tissue.

Evidence on tissue expression from TISSUES for HMMR Gene

  • Nervous system(3.1)
  • Lymph node(2.2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with HMMR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HMMR Gene

Orthologs for HMMR Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMMR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMMR 34 33
  • 99.22 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HMMR 34 33
  • 88.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HMMR 34 33
  • 88.08 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmmr 33
  • 78.75 (n)
mouse
(Mus musculus)
Mammalia Hmmr 16 34 33
  • 74.52 (n)
oppossum
(Monodelphis domestica)
Mammalia HMMR 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves HMMR 33
  • 62.28 (n)
lizard
(Anolis carolinensis)
Reptilia HMMR 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmmr 33
  • 56.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22720 33
zebrafish
(Danio rerio)
Actinopterygii hmmr 34 33 33
  • 50.9 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10432 34
  • 21 (a)
OneToOne
Species where no ortholog for HMMR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMMR Gene

ENSEMBL:
Gene Tree for HMMR (if available)
TreeFam:
Gene Tree for HMMR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HMMR: view image

Paralogs for HMMR Gene

No data available for Paralogs for HMMR Gene

Variants for HMMR Gene

Sequence variations from dbSNP and Humsavar for HMMR Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000476811 -- 163,468,668(+) G/A intron_variant
rs1000533993 -- 163,469,948(+) A/G intron_variant
rs1000615303 -- 163,476,558(+) C/A intron_variant
rs1000656177 -- 163,473,780(+) C/G intron_variant
rs1000727247 -- 163,475,386(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HMMR Gene

Variant ID Type Subtype PubMed ID
nsv1017056 CNV gain 25217958
nsv1018494 CNV gain 25217958
nsv1029437 CNV gain 25217958
nsv473752 CNV novel sequence insertion 20440878
nsv519801 CNV loss 19592680
nsv524084 CNV loss 19592680
nsv830538 CNV gain+loss 17160897

Variation tolerance for HMMR Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.64; 89.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HMMR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HMMR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMMR Gene

Disorders for HMMR Gene

MalaCards: The human disease database

(2) MalaCards diseases for HMMR Gene - From: OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
fibrosarcoma
  • fibrocytic tumor
- elite association - COSMIC cancer census association via MalaCards
Search HMMR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HMMR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HMMR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HMMR Gene

Publications for HMMR Gene

  1. Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer. (PMID: 19064580) Kalmyrzaev B … SEARCH Team (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 22 44 58
  2. The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells. (PMID: 9601098) Assmann V … Hart IR (Journal of cell science 1998) 3 4 22 58
  3. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. (PMID: 22666460) Liu XF … Pastan I (PloS one 2012) 3 4 58
  4. The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia. (PMID: 19092852) Giannopoulos K … Schmitt M (Leukemia 2009) 3 22 58
  5. The tumor antigens RHAMM and G250/CAIX are expressed in head and neck squamous cell carcinomas and elicit specific CD8+ T cell responses. (PMID: 19212667) Schmitt A … Schmitt M (International journal of oncology 2009) 3 22 58

Products for HMMR Gene

Sources for HMMR Gene

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