Aliases for HMHB1 Gene
Aliases for HMHB1 Gene
External Ids for HMHB1 Gene
- HGNC: 29677
- Entrez Gene: 57824
- Ensembl: ENSG00000158497
- OMIM: 609961
- UniProtKB: O97980
Previous GeneCards Identifiers for HMHB1 Gene
- GC05P143172
- GC05P138338
Summaries for HMHB1 Gene
-
This gene encodes one of the minor histocompatibility antigens, which play an important role in the induction of cytotoxic T lymphocyte (CTL) reactivity against leukemia after human histocompatibility leukocyte antigen (HLA)-identical allogeneic bone marrow transplantation (BMT). This gene is only expressed in B cell acute lymphoblastic leukemia cells and Epstein-Barr virus-transformed B cells. The translation of this mRNA initiates at a non-AUG (CUG) codon. [provided by RefSeq, Jul 2008]
GeneCards Summary for HMHB1 Gene
HMHB1 (Histocompatibility Minor HB-1) is a Protein Coding gene. Diseases associated with HMHB1 include Lymphoblastic Leukemia.
UniProtKB/Swiss-Prot for HMHB1 Gene
-
Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocomplatibility antigen in HLA-matched sibling marrow transplants. HB-1 is presented on the cell surface by MHC class I HLA-B44. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). It induces cell recognition and lysis by CTL. However, HB-1 restricted expression in B-ALL cells and not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMHB1 Gene
Genomics for HMHB1 Gene
GeneHancer (GH) Regulatory Elements for HMHB1 Gene
Promoters and enhancers for HMHB1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05I143812 | Promoter/Enhancer | 1.1 | EPDnew Ensembl | 550.8 | +0.2 | 240 | 0.8 | HDGF ZNF687 EBF1 POLR2A IKZF1 TARDBP NBN MLLT1 PRDM1 RUNX3 | HMHB1 GC05P144011 GC05P144012 GC05P144013 PIR62690 LOC105378210 | |
| GH05I143757 | Enhancer | 0.6 | ENCODE | 11 | -53.7 | -53733 | 2.8 | ZBED1 JUNB CEBPB DPF2 BATF ATF2 IRF4 ATF4 BCL11A IKZF1 | GC05M143659 HMHB1 LOC105378210 | |
| GH05I143836 | Enhancer | 0.4 | ENCODE | 11.3 | +25.4 | 25411 | 1.7 | POLR2A REST | HMHB1 NR3C1 PIR62690 GC05P144013 GC05P144012 GC05P144011 | |
| GH05I143806 | Enhancer | 0.7 | FANTOM5 | 3.4 | -5.4 | -5405 | 0.2 | USF1 NR2F1 ZBED1 EBF1 ELF1 ATF2 RELA IKZF1 ZNF143 ATF7 | NR3C1 HMHB1 GC05M143659 LOC105378210 | |
| GH05I143712 | Enhancer | 0.2 | ENCODE | 10.8 | -98.9 | -98905 | 1.5 | HMHB1 MIR5197 LOC100420513 GC05M143659 LOC105378210 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HMHB1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HMHB1 gene promoter:
Regulatory Element Products
Genomic Locations for HMHB1 Gene
Genomic Locations for HMHB1 Gene
- chr5:143,812,161-143,820,719
- (GRCh38/hg38)
- Size:
- 8,559 bases
- Orientation:
- Plus strand
- chr5:143,191,726-143,200,284
- (GRCh37/hg19)
Genomic View for HMHB1 Gene
Genes around HMHB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.3 by Ensembl
- 5q31.3 by Entrez Gene
- 5q31.3 by HGNC
HMHB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMHB1 Gene
Proteins for HMHB1 Gene
-
Protein details for HMHB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O97980-HMHB1_HUMAN
- Recommended name:
- Minor histocompatibility protein HB-1
- Protein Accession:
- O97980
- Q9MY25
Protein attributes for HMHB1 Gene
- Size:
- 41 amino acids
- Molecular mass:
- 4965 Da
- Quaternary structure:
-
- HB-1 forms a complex with MHC class I HLA-B44.
Post-translational modifications for HMHB1 Gene
Other Protein References for HMHB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for HMHB1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HMHB1
- Origene Custom Protein Services for HMHB1
- Search GeneTex for Proteins for HMHB1
Assay Products
No data available for DME Specific Peptides for HMHB1 Gene
Domains & Families for HMHB1 Gene
Gene Families for HMHB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for HMHB1 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for HMHB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HMHB1 Gene
Function for HMHB1 Gene
Molecular function for HMHB1 Gene
- UniProtKB/Swiss-Prot Function:
- Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocomplatibility antigen in HLA-matched sibling marrow transplants. HB-1 is presented on the cell surface by MHC class I HLA-B44. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). It induces cell recognition and lysis by CTL. However, HB-1 restricted expression in B-ALL cells and not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease.
Phenotypes From GWAS Catalog for HMHB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for HMHB1 Gene
- GenomeRNAi human phenotypes for HMHB1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMHB1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HMHB1 gene
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CRISPR Products
-
OriGene CRISPR knockouts for HMHB1
- genomics-online: gRNA clones - Search results for 33 available HMHB1 gene related products
- Overview of 33 available HMHB1 gene related products
- Applied Biological Materials CRISPR for HMHB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMHB1
miRNA Products
- Search ViGene Biosciences for HMHB1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for HMHB1
- Browse OriGene Inhibitory RNA Products For HMHB1
- genomics-online: shRNA clones - Search results for 33 available HMHB1 gene related products
- Overview of 33 available HMHB1 gene related products
- Search ViGene Biosciences for HMHB1
Clone Products
- VectorBuilder custom plasmid, inducible vectors for HMHB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMHB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for HMHB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HMHB1
-
ViGene Biosciences adenoviral particle packaged cDNA for HMHB1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HMHB1 gene
- Search ViGene Biosciences for HMHB1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HMHB1 Gene
Localization for HMHB1 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| nucleus | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for HMHB1 Gene
Pathways & Interactions for HMHB1 Gene
No Data Available
Interacting Proteins for HMHB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0010468 | regulation of gene expression | IDA | 8992968 |
| GO:0042268 | regulation of cytolysis | IMP | 9892612 |
| GO:0071356 | cellular response to tumor necrosis factor | IDA | 8992968 |
No data available for Pathways by source and SIGNOR curated interactions for HMHB1 Gene
Transcripts for HMHB1 Gene
mRNA/cDNA for HMHB1 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMHB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMHB1
- genomics-online: gRNA clones - Search results for 33 available HMHB1 gene related products
- Overview of 33 available HMHB1 gene related products
- Applied Biological Materials CRISPR for HMHB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMHB1
miRNA Products
- Search ViGene Biosciences for HMHB1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for HMHB1
- Browse OriGene Inhibitory RNA Products For HMHB1
- genomics-online: shRNA clones - Search results for 33 available HMHB1 gene related products
- Overview of 33 available HMHB1 gene related products
- Search ViGene Biosciences for HMHB1
Clone Products
- VectorBuilder custom plasmid, inducible vectors for HMHB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMHB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for HMHB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HMHB1 Gene
mRNA differential expression in normal tissues according to GTEx for HMHB1 Gene
This gene is overexpressed in Testis (x10.9).
NURSA nuclear receptor signaling pathways regulating expression of HMHB1 Gene:
HMHB1SOURCE GeneReport for Unigene cluster for HMHB1 Gene:
Hs.158320mRNA Expression by UniProt/SwissProt for HMHB1 Gene:
O97980-HMHB1_HUMAN
Tissue specificity:
Expressed in acute lymphoblastic leukemia B-cells and Epstein-Barr virus-transformed B-cells.
Primer Products
- genomics-online: primer clones - Search results for 33 available HMHB1 gene related products
- Overview of 33 available HMHB1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMHB1 Gene
Orthologs for HMHB1 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMHB1 34 |
|
OneToOne |
- Species where no ortholog for HMHB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HMHB1 Gene
No data available for Paralogs for HMHB1 Gene
Variants for HMHB1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000000116 | -- | 143,820,965(+) | G/C | downstream_transcript_variant | |
| rs1000074044 | -- | 143,820,080(+) | A/G | intron_variant | |
| rs1000292330 | -- | 143,813,978(+) | A/G | intron_variant | |
| rs1000541299 | -- | 143,820,722(+) | TGTGTGTGTGT/TGTGTGTGT | downstream_transcript_variant | |
| rs1000980595 | -- | 143,818,982(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3566747 | CNV | deletion | 23714750 |
Residual Variation Intolerance Score:
76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.23;
70.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HMHB1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMHB1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMHB1 Gene
Disorders for HMHB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoblastic leukemia |
|
|
Search HMHB1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HMHB1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HMHB1 Gene
Publications for HMHB1 Gene
- A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia. (PMID: 9892612) Dolstra H … van de Wiel-van Kemenade E (The Journal of experimental medicine 1999) 2 3 4 22 58
- Role of minor histocompatibility antigens in renal transplantation. (PMID: 18093280) Heinold A … Tran TH (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008) 3 22 44 58
- Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation. (PMID: 20353833) Larsen ME … Vindelov L (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010) 3 44 58
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
- Recognition of a B cell leukemia-associated minor histocompatibility antigen by CTL. (PMID: 8992968) Dolstra H … van de Wiel-van Kemenade E (Journal of immunology (Baltimore, Md. : 1950) 1997) 3 4 58
Products for HMHB1 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for HMHB1
- VectorBuilder custom plasmid, inducible vectors for HMHB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMHB1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available HMHB1 related products ranked by validation data
- antibodies-online: Search results for available HMHB1 related products ranked by validation data
- antibodies-online: Search results for available HMHB1 related products ranked by validation data
- Search GeneTex for Antibodies for HMHB1
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- ViGene Biosciences adenoviral particle packaged cDNA for HMHB1 gene
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- Search ViGene Biosciences for HMHB1
- Horizon Cell Lines for HMHB1
- genomics-online: cdna clones - Search results for 33 available HMHB1 gene related products
- Overview of 33 available HMHB1 gene related products
- orf clones - Search results for 33 available HMHB1 gene related products
- Overview of 33 available HMHB1 gene related products
- genomics-online: gRNA clones - Search results for 33 available HMHB1 gene related products
- Overview of 33 available HMHB1 gene related products
- genomics-online: primer clones - Search results for 33 available HMHB1 gene related products
- Overview of 33 available HMHB1 gene related products
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- Overview of 33 available HMHB1 gene related products
Sources for HMHB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems