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This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]
HMGN5 (High Mobility Group Nucleosome Binding Domain 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleosomal DNA binding.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ081120 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.2 | +80.8 | 80812 | 3 | TBP SP1 IKZF1 CTCF IRF3 MAX TRIM22 MAFF RAD21 RFX5 | HMGN5 SH3BGRL piR-55194-447 RF00017-8550 lnc-BRWD3-1 BRWD3 | |
GH0XJ081200 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.7 | -2.4 | -2388 | 7 | CHD2 TBP IKZF1 SMAD5 BRCA1 ELF1 SIN3A VEZF1 REST ZNF341 | SH3BGRL BRWD3 HMGN5 HSALNG0138810 lnc-BRWD3-1 piR-32407-003 | |
GH0XJ081213 | Enhancer | 0.2 | Ensembl | 4.9 | -11.2 | -11188 | 2.6 | HMGN5 HSALNG0138810 SH3BGRL piR-32407-003 | ||
GH0XJ081194 | Enhancer | 0.5 | Ensembl | 0.4 | +6.5 | 6512 | 1.6 | CTCF TRIM22 SMC3 RAD21 TCF7L2 ZNF660 ZNF143 ZNF654 | HMGN5 lnc-BRWD3-1 piR-55194-447 BRWD3 | |
GH0XJ081198 | Enhancer | 0.3 | Ensembl | 0.7 | +3.9 | 3912 | 0.8 | PRDM1 | HMGN5 lnc-BRWD3-1 piR-55194-447 BRWD3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003682 | chromatin binding | IEA,NAS | 11161810 |
GO:0003723 | RNA binding | HDA | 22681889 |
GO:0031492 | nucleosomal DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | IEA | -- |
GO:0005634 | nucleus | IEA,NAS | 11161810 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005739 | mitochondrion | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | NAS | 11161810 |
GO:0008284 | positive regulation of cell proliferation | IMP | 20531280 |
GO:0010628 | positive regulation of gene expression | IMP | 20531280 |
GO:0043066 | negative regulation of apoptotic process | IMP | 20531280 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HMGN5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HMGN5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HMGN5 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hmgn5 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs142173136 | Likely Benign: not provided | 81,119,810(-) |
C/A NM_030763.3(HMGN5):c.23G>T (p.Gly8Val) |
MISSENSE | |
rs144502161 | Benign: not provided | 81,115,003(-) |
C/G NM_030763.3(HMGN5):c.495G>C (p.Glu165Asp) |
MISSENSE | |
rs73231013 | Benign: not provided | 81,118,462(-) |
C/T NM_030763.3(HMGN5):c.99G>A (p.Glu33=) |
SYNONYMOUS | |
rs73631719 | Benign: not provided | 81,118,482(-) |
G/A NM_030763.3(HMGN5):c.79C>T (p.Leu27Phe) |
MISSENSE |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv24043 | CNV | loss | 19812545 |
esv2671958 | CNV | deletion | 23128226 |
esv3307397 | CNV | mobile element insertion | 20981092 |
esv33127 | CNV | loss | 17666407 |
esv3335197 | CNV | insertion | 20981092 |
No disorders were found for HMGN5 Gene.