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The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]
HMGN4 (High Mobility Group Nucleosomal Binding Domain 4) is a Protein Coding gene. Diseases associated with HMGN4 include Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1. Gene Ontology (GO) annotations related to this gene include nucleosomal DNA binding. An important paralog of this gene is HMGN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 21044950 |
GO:0031492 | nucleosomal DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||
SP5: | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HMGN4 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HMGN4 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | LOC100856364 30 |
|
||
HMGN4 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Hmgn2 31 |
|
OneToMany | |
Gm10282 31 |
|
OneToMany | |||
Gm16494 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | HMGN4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | HMGN2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HMGN4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hmgn2 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 |
|
|