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Aliases for HMGN2 Gene

Aliases for HMGN2 Gene

  • High Mobility Group Nucleosomal Binding Domain 2 2 3 5
  • High Mobility Group Nucleosome-Binding Domain-Containing Protein 2 3 4
  • High-Mobility Group (Nonhistone Chromosomal) Protein 17 2 3
  • HMG17 3 4
  • High-Mobility Group Nucleosomal Binding Domain 2 2
  • Non-Histone Chromosomal Protein HMG-17 3
  • Nonhistone Chromosomal Protein HMG-17 3
  • High Mobility Group Protein N2 3

External Ids for HMGN2 Gene

Previous HGNC Symbols for HMGN2 Gene

  • HMG17

Previous GeneCards Identifiers for HMGN2 Gene

  • GC01M028726
  • GC01P025819
  • GC01P026031
  • GC01P026404
  • GC01P026406
  • GC01P026671
  • GC01P026800
  • GC01P025053

Summaries for HMGN2 Gene

Entrez Gene Summary for HMGN2 Gene

  • The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for HMGN2 Gene

HMGN2 (High Mobility Group Nucleosomal Binding Domain 2) is a Protein Coding gene. Diseases associated with HMGN2 include Limited Scleroderma. Among its related pathways are Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include nucleosomal DNA binding. An important paralog of this gene is HMGN4.

UniProtKB/Swiss-Prot for HMGN2 Gene

  • Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).

Gene Wiki entry for HMGN2 Gene

Additional gene information for HMGN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN2 Gene

Genomics for HMGN2 Gene

GeneHancer (GH) Regulatory Elements for HMGN2 Gene

Promoters and enhancers for HMGN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I026470 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 596.5 +0.2 244 4.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 HMGN2 GC01M026474 ARID1A GPN2 ACTG1P20 RPL17P9 LOC101928324 DHDDS MAN1C1 NPM1P39
GH01I026691 Promoter/Enhancer 3.3 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 78.1 +224.6 224647 12.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ARID1A LOC101928728 HMGN2 ACTG1P20 PIGV LOC101928324 GPN2 GPATCH3 TMEM222 RPL17P9
GH01I026618 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 112.3 +148.0 147985 4 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 ARID1A HMGN2 ACTG1P20 GPN2 ZNF593 GPATCH3 AHDC1 RPL17P9 LOC101928324 NPM1P39
GH01I026274 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 63.5 -188.5 -188517 19.1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 NBN SH3BGRL3 HMGN2 ARID1A CD52 LOC101928324 NPM1P39 UBXN11 CEP85 GPN2 LIN28A
GH01I025995 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 62.3 -474.5 -474458 4.4 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 PAFAH2 ARID1A HMGN2 LOC101928324 ENSG00000261349 SYF2 GPN2 ZNF593 LOC101928728 RPL17P9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HMGN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HMGN2 gene promoter:

Genomic Locations for HMGN2 Gene

Genomic Locations for HMGN2 Gene
4,232 bases
Plus strand

Genomic View for HMGN2 Gene

Genes around HMGN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGN2 Gene

Proteins for HMGN2 Gene

  • Protein details for HMGN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Non-histone chromosomal protein HMG-17
    Protein Accession:
    Secondary Accessions:
    • Q0VGD5
    • Q6FGI5
    • Q96C64

    Protein attributes for HMGN2 Gene

    90 amino acids
    Molecular mass:
    9393 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGN2 Gene

Post-translational modifications for HMGN2 Gene

  • Phosphorylation favors cytoplasmic localization.
  • Ubiquitination at posLast=5959, posLast=6464, and isoforms=82

Other Protein References for HMGN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HMGN2 Gene

Domains & Families for HMGN2 Gene

Gene Families for HMGN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HMGN2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HMGN family.
  • Belongs to the HMGN family.
genes like me logo Genes that share domains with HMGN2: view

Function for HMGN2 Gene

Molecular function for HMGN2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).

Phenotypes From GWAS Catalog for HMGN2 Gene

Gene Ontology (GO) - Molecular Function for HMGN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA,IDA 22681889
GO:0005515 protein binding IPI 21044950
GO:0031492 nucleosomal DNA binding IEA --
genes like me logo Genes that share ontologies with HMGN2: view
genes like me logo Genes that share phenotypes with HMGN2: view

Animal Model Products

miRNA for HMGN2 Gene

miRTarBase miRNAs that target HMGN2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGN2 Gene

Localization for HMGN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGN2 Gene

Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HMGN2 gene
Compartment Confidence
extracellular 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HMGN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005615 extracellular space IDA 16204630
GO:0005634 nucleus IDA 16204630
GO:0005737 cytoplasm IEA,IDA 16204630
genes like me logo Genes that share ontologies with HMGN2: view

Pathways & Interactions for HMGN2 Gene

genes like me logo Genes that share pathways with HMGN2: view

Pathways by source for HMGN2 Gene

1 Cell Signaling Technology pathway for HMGN2 Gene

SIGNOR curated interactions for HMGN2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HMGN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031640 killing of cells of other organism IMP 16204630
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IMP 16204630
genes like me logo Genes that share ontologies with HMGN2: view

Drugs & Compounds for HMGN2 Gene

(1) Drugs for HMGN2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HMGN2: view

Transcripts for HMGN2 Gene

Unigene Clusters for HMGN2 Gene

High mobility group nucleosomal binding domain 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMGN2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2: -
SP3: -

Relevant External Links for HMGN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HMGN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HMGN2 Gene

Protein differential expression in normal tissues from HIPED for HMGN2 Gene

This gene is overexpressed in Stomach (23.0), Peripheral blood mononuclear cells (18.4), and Urine (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMGN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HMGN2 Gene:


SOURCE GeneReport for Unigene cluster for HMGN2 Gene:


Evidence on tissue expression from TISSUES for HMGN2 Gene

  • Blood(4.7)
  • Lung(4.7)
  • Nervous system(4.7)
  • Eye(4.5)
  • Liver(4.3)
  • Skin(4.3)
  • Intestine(4.1)
  • Pancreas(3.9)
  • Muscle(3.7)
  • Kidney(3.4)
  • Bone(3.3)
  • Bone marrow(2.5)
  • Lymph node(2.3)
  • Stomach(2.3)
  • Spleen(2.1)
  • Adrenal gland(2)
  • Heart(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with HMGN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGN2 Gene

Orthologs for HMGN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HMGN2 33 34
  • 100 (n)
(Bos Taurus)
Mammalia -- 34
  • 99 (a)
(Mus musculus)
Mammalia Gm6594 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
(Canis familiaris)
Mammalia -- 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6669 33
Species where no ortholog for HMGN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HMGN2 Gene

Gene Tree for HMGN2 (if available)
Gene Tree for HMGN2 (if available)

Paralogs for HMGN2 Gene

Paralogs for HMGN2 Gene

(1) SIMAP similar genes for HMGN2 Gene using alignment to 2 proteins: Pseudogenes for HMGN2 Gene

genes like me logo Genes that share paralogs with HMGN2: view

Variants for HMGN2 Gene

Sequence variations from dbSNP and Humsavar for HMGN2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1055323 likely-benign, Retinitis Pigmentosa, Recessive 26,471,163(+) C/T upstream_transcript_variant
rs1057515508 uncertain-significance, Retinitis Pigmentosa, Recessive 26,470,836(+) G/A upstream_transcript_variant
rs12096239 likely-benign, Retinitis Pigmentosa, Recessive 26,470,431(+) G/C upstream_transcript_variant
rs182595109 uncertain-significance, Retinitis Pigmentosa, Recessive 26,471,235(+) A/T upstream_transcript_variant
rs2290588 likely-benign, Retinitis Pigmentosa, Recessive 26,471,017(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HMGN2 Gene

Variant ID Type Subtype PubMed ID
nsv947418 CNV duplication 23825009
nsv945842 CNV duplication 23825009

Variation tolerance for HMGN2 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HMGN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGN2 Gene

Disorders for HMGN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HMGN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
limited scleroderma
  • limited cutaneous systemic sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search HMGN2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HMGN2

genes like me logo Genes that share disorders with HMGN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HMGN2 Gene

Publications for HMGN2 Gene

  1. Serine ADP-Ribosylation Depends on HPF1. (PMID: 28190768) Bonfiglio JJ … Matic I (Molecular cell 2017) 3 4 58
  2. HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. (PMID: 19524541) Rattner BP … Kadonaga JT (Molecular cell 2009) 3 22 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Regional fine mapping of HMG17 to chromosomal band 1p35. (PMID: 10640150) Kazmierczak B … Bullerdiek J (Cancer genetics and cytogenetics 2000) 3 22 58

Products for HMGN2 Gene

Sources for HMGN2 Gene

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