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The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011] See more...
Aliases for HMGN1 Gene
Aliases for HMGN1 Gene
- High Mobility Group Nucleosome Binding Domain 1 2 3 5
- High Mobility Group Nucleosome-Binding Domain-Containing Protein 1 3 4
- High-Mobility Group (Nonhistone Chromosomal) Protein 14 2 3
- High-Mobility Group Nucleosome Binding 1 2 3
- Non-Histone Chromosomal Protein HMG-14 3 4
- Nonhistone Chromosomal Protein HMG-14 2 3
External Ids for HMGN1 Gene
- HGNC: 4984
- Entrez Gene: 3150
- Ensembl: ENSG00000205581
- OMIM: 163920
- UniProtKB: P05114
Previous HGNC Symbols for HMGN1 Gene
- HMG14
Previous GeneCards Identifiers for HMGN1 Gene
- GC21M037290
- GC21M039634
- GC21M039637
- GC21M040714
- GC21M026182
Summaries for HMGN1 Gene
-
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
GeneCards Summary for HMGN1 Gene
HMGN1 (High Mobility Group Nucleosome Binding Domain 1) is a Protein Coding gene. Diseases associated with HMGN1 include Cockayne Syndrome and Down Syndrome. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include chromatin binding and nucleosomal DNA binding. An important paralog of this gene is HMGN2.
UniProtKB/Swiss-Prot Summary for HMGN1 Gene
-
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
Additional gene information for HMGN1 Gene
- HGNC(4984)
- Entrez Gene(3150)
- Ensembl(ENSG00000205581)
- OMIM(163920)
- UniProtKB(P05114)
- Open Targets Platform(ENSG00000205581)
- Search for HMGN1 at DataMed
- Search for HMGN1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HMGN1 Gene
Genomics for HMGN1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HMGN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HMGN1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HMGN1
- Top Transcription factor binding sites by QIAGEN in the HMGN1 gene promoter:
-
- AREB6
- FOXD3
- FOXF2
- HNF-4alpha2
- Sox9
- SRF
- SRF (504 AA)
- TBP
- TFIID
Genomic Locations for HMGN1 Gene
Genomic Locations for HMGN1 Gene
- chr21:39,342,315-39,349,647
- (GRCh38/hg38)
- Size:
- 7,333 bases
- Orientation:
- Minus strand
- chr21:40,714,241-40,721,573
- (GRCh37/hg19)
- Size:
- 7,333 bases
- Orientation:
- Minus strand
Genomic View for HMGN1 Gene
Genes around HMGN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.2 by HGNC
- 21q22.2 by Entrez Gene
- 21q22.2 by Ensembl
HMGN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGN1 Gene
Proteins for HMGN1 Gene
-
Protein details for HMGN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05114-HMGN1_HUMAN
- Recommended name:
- Non-histone chromosomal protein HMG-14
- Protein Accession:
- P05114
- Q3KQR8
Protein attributes for HMGN1 Gene
- Size:
- 100 amino acids
- Molecular mass:
- 10659 Da
- Quaternary structure:
- No Data Available
Protein Expression for HMGN1 Gene
Post-translational modifications for HMGN1 Gene
- Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
-
Ubiquitination at Lys5 and Lys14
- NX_P05114 (NX_P05114-1)
- Modification sites at PhosphoSitePlus
Other Protein References for HMGN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences HMGN1 / HMG14 Antibody (LS-B54) and HMGN1 / HMG14 Antibody (LS-B10268)
- G Biosciences Immunotag™ HMG14 Antibody
-
Custom Antibody ServicesOriGene Antibodies for HMGN1
- Novus Biologicals Antibodies for HMGN1
- Invitrogen Antibodies for HMGN1 (AFLGC-HMGN1)
- antibodies-online: Show 30 available HMGN1 Antibodies ranked by validation data
- Compare Top HMGN1 Antibodies
-
Recommended
- 69 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-mouse)
- 24 WB Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-rat)
- 18 WB Antibodies (anti-rat)
- 6 IHC Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMGN1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGN1
- Origene Custom Protein Services for HMGN1
- ProSpec Recombinant Proteins for HMGN1
-
Signalway Proteins for HMGN1
-
Abcam proteins for HMGN1
Assay Products
No data available for DME Specific Peptides for HMGN1 Gene
Domains & Families for HMGN1 Gene
Gene Families for HMGN1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for HMGN1 Gene
Suggested Antigen Peptide Sequences for HMGN1 Gene
- GenScript: Design optimal peptide antigens:
-
- High mobility group nucleosome-binding domain-containing protein 1 (HMGN1_HUMAN)
- High-mobility group nucleosome binding domain 1 (Q3B790_HUMAN)
- High-mobility group nucleosome binding domain 1 (Q6NSG7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P05114- Family:
-
- Belongs to the HMGN family.
Function for HMGN1 Gene
Molecular function for HMGN1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
Phenotypes From GWAS Catalog for HMGN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | 8047885 |
| GO:0031492 | nucleosomal DNA binding | IEA | -- |
Phenotypes for HMGN1 Gene
- MGI mutant phenotypes for HMGN1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HMGN1:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased gamma-H2AX phosphorylation
- Reduced mammosphere formation
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased cell number
- Inconclusive
- Increased shRNA abundance (Z-score > 2)
- Increased S DNA content
- Increased Nanog expression
- Decreased TP53 mRNA expression
Animal Models for HMGN1 Gene
- MGI Knock Outs for HMGN1:
-
- Hmgn1 Hmgn1<tm1Mbus>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HMGN1 - Select products 50% OFF >
- * HMGN1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for HMGN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMGN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGN1
miRNA for HMGN1 Gene
- miRTarBase miRNAs that target HMGN1
-
- hsa-miR-197-3p (MIRT004185)
- hsa-miR-484 (MIRT041871)
- hsa-miR-125b-5p (MIRT045927)
- hsa-miR-100-5p (MIRT048518)
- hsa-miR-16-5p (MIRT051195)
- hsa-miR-27b-3p (MIRT454703)
- hsa-miR-27a-3p (MIRT454704)
- hsa-miR-513a-5p (MIRT454705)
- hsa-miR-570-3p (MIRT454706)
- hsa-miR-802 (MIRT454707)
- hsa-miR-4496 (MIRT454708)
- hsa-miR-7-2-3p (MIRT454709)
- hsa-miR-7-1-3p (MIRT454710)
- hsa-miR-5688 (MIRT454711)
- hsa-miR-495-3p (MIRT454712)
- hsa-miR-548at-5p (MIRT454713)
- hsa-miR-548ax (MIRT523155)
- hsa-miR-548ao-5p (MIRT523156)
- hsa-miR-32-3p (MIRT523157)
- hsa-miR-3662 (MIRT523158)
- hsa-miR-607 (MIRT687929)
- hsa-miR-3686 (MIRT687930)
- hsa-miR-3671 (MIRT687931)
- hsa-miR-3607-3p (MIRT687932)
- hsa-miR-4762-5p (MIRT687933)
- hsa-miR-4759 (MIRT687934)
- hsa-miR-140-3p (MIRT687935)
- hsa-miR-4700-3p (MIRT687936)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HMGN1
- Browse OriGene Inhibitory RNA Products For HMGN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMGN1
Clone Products
- Applied Biological Materials (abm): Clones for HMGN1 - Select products 50% OFF >
- * HMGN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HMGN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMGN1
Cell Line Products
-
Horizon Cell Lines for HMGN1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HMGN1 Gene
Localization for HMGN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGN1 Gene
- Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IEA | -- |
| GO:0005634 | nucleus | IEA,HDA | 16780588 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for HMGN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 2 | P38 MAPK Signaling Pathway (sino) | ||
| 3 | Chromatin Regulation / Acetylation | ||
| 4 | MAPK Erk Pathway |
.32
|
|
| 5 | ERK Signaling |
ERK Signaling
.61
|
|
Pathways by source for HMGN1 Gene
2 Sino Biological pathways for HMGN1 Gene
2 BioSystems pathways for HMGN1 Gene
6 Reactome pathways for HMGN1 Gene
1 Qiagen pathway for HMGN1 Gene
- ERK Signaling
1 Cell Signaling Technology pathway for HMGN1 Gene
Interacting Proteins for HMGN1 Gene
GPS-Prot Interaction Network for HMGN1
SIGNOR curated interactions for HMGN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair | IEA | -- |
| GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0010224 | response to UV-B | IEA | -- |
Transcripts for HMGN1 Gene
mRNA/cDNA for HMGN1 Gene
- 1 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000288344 1303 nts (view in UCSC)
- ENST00000380747 709 nts (view in UCSC)
- ENST00000380748 829 nts (view in UCSC)
- ENST00000380749 1271 nts (view in UCSC)
- ENST00000419378 850 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HMGN1 - Select products 50% OFF >
- * HMGN1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HMGN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMGN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGN1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HMGN1
- Browse OriGene Inhibitory RNA Products For HMGN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMGN1
Clone Products
- Applied Biological Materials (abm): Clones for HMGN1 - Select products 50% OFF >
- * HMGN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HMGN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMGN1
Relevant External Links for HMGN1 Gene
- GeneLoc Exon Structure for
- HMGN1
Expression for HMGN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- S-shaped Body Cells S-shaped Body
- S-shaped Body
- Metanephros
- Brain (Nervous System)
-
Eye (Sensory Organs)
- Fetal Corneal Basal Epithelial Cells Corneal Epithelium
- Adult Corneal Basal Epithelial Cells Corneal Epithelium
-
Epithelial Cells
- Fetal Corneal Basal Epithelial Cells Corneal Epithelium
- Adult Corneal Basal Epithelial Cells Corneal Epithelium
- Neural Tube (Nervous System)
- Blood (Hematopoietic System)
- Umbilical Cord (Extraembryonic Tissues)
- Bone (Muscoskeletal System)
- Thymus (Hematopoietic System)
- Endoderm (Gastrulation Derivatives)
This gene is overexpressed in Stomach (13.4), Lavage (13.0), and Nasal epithelium (11.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HMGN1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HMGN1
SOURCE GeneReport for Unigene cluster for HMGN1 Gene:
Hs.356285Evidence on tissue expression from TISSUES for HMGN1 Gene
- Nervous system(5)
- Liver(4.6)
- Blood(4.6)
- Bone marrow(4.5)
- Lung(3.8)
- Eye(3.6)
- Intestine(3.2)
- Skin(2.9)
- Kidney(2.9)
- Lymph node(2.8)
- Spleen(2.8)
- Pancreas(2.7)
- Thyroid gland(2.6)
- Heart(2.3)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for HMGN1
-
OriGene qPCR primer pairs and template standards for HMGN1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGN1 Gene
Orthologs for HMGN1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HMGN1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HMGN1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HMGN1 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Hmgn1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hmgn1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | HMGN1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | HMGN1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HMGN1 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | hmgn1-prov 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | MGC75785 30 |
|
- Species where no ortholog for HMGN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for HMGN1 Gene
- ENSEMBL:
- Gene Tree for HMGN1 (if available)
- TreeFam:
- Gene Tree for HMGN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HMGN1: view image
Paralogs for HMGN1 Gene
(2) SIMAP similar genes for HMGN1 Gene using alignment to 9 proteins:
- HMGN1_HUMAN
- A6NEL0_HUMAN
- A6NGZ2_HUMAN
- A6NL93_HUMAN
- F2Z2W6_HUMAN
- F2Z2Y5_HUMAN
- H7BXJ5_HUMAN
- Q3B790_HUMAN
- Q6NSG7_HUMAN
Pseudogenes.org Pseudogenes for HMGN1 Gene
- PGOHUM00000290349
- PGOHUM00000290397
- PGOHUM00000290851
- PGOHUM00000291267
- PGOHUM00000291562
- PGOHUM00000292031
- PGOHUM00000292392
- PGOHUM00000292764
- PGOHUM00000292982
- PGOHUM00000293302
- PGOHUM00000294447
- PGOHUM00000294502
- PGOHUM00000294670
- PGOHUM00000294676
- PGOHUM00000295125
- PGOHUM00000295983
- PGOHUM00000297369
- PGOHUM00000298298
- PGOHUM00000306571
- PGOHUM00000299606
- PGOHUM00000300223
- PGOHUM00000300715
- PGOHUM00000300720
- PGOHUM00000302618
- PGOHUM00000302905
- PGOHUM00000304919
- PGOHUM00000305128
- PGOHUM00000288953
- PGOHUM00000288973
- PGOHUM00000290054
Variants for HMGN1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HMGN1 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 730941 | Likely Benign: not provided | 39,343,130(-) | T/C | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2389n106 | CNV | deletion | 24896259 |
| nsv1073129 | CNV | deletion | 25765185 |
| nsv587483 | CNV | loss | 21841781 |
| nsv979537 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.26;
62.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HMGN1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMGN1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGN1 Gene
Disorders for HMGN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cockayne syndrome |
|
|
| down syndrome |
|
|
| uv-sensitive syndrome |
|
|
| fanconi anemia, complementation group a |
|
|
Search HMGN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HMGN1
No data available for UniProtKB/Swiss-Prot and Genatlas for HMGN1 Gene
Publications for HMGN1 Gene
- Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry. (PMID: 10739259) Louie DF … Ahn NG (Protein science : a publication of the Protein Society 2000) 3 4 23
- Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family. (PMID: 2563381) Landsman D … Bustin M (The Journal of biological chemistry 1989) 2 3 4
- Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family. (PMID: 3782107) Landsman D … Bustin M (The Journal of biological chemistry 1986) 2 3 4
- Serine ADP-Ribosylation Depends on HPF1. (PMID: 28190768) Bonfiglio JJ … Matic I (Molecular cell 2017) 3 4
- HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. (PMID: 19524541) Rattner BP … Kadonaga JT (Molecular cell 2009) 3 23
ExternalLinks
Products for HMGN1 Gene
- Custom Antibody ServicesOriGene Antibodies for HMGN1
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- OriGene qPCR primer pairs for HMGN1
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- High-throughput Antibody Production Service
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- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for HMGN1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HMGN1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HMGN1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HMGN1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HMGN1
- antibodies-online: Show 30 available HMGN1 Antibodies ranked by validation data
- Compare Top HMGN1 Antibodies
- Recommended
- 69 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-mouse)
- 24 WB Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-rat)
- 18 WB Antibodies (anti-rat)
- 6 IHC Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- antibodies-online: Show 24 available HMGN1 Elisa Kits ranked by validation data
- Compare Top HMGN1 Elisa Kits
- antibodies-online: Show 13 available HMGN1 Proteins ranked by validation data
- Compare Top HMGN1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for HMGN1
- Search Santa Cruz Biotechnology (SCBT) for HMGN1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HMGN1
- Horizon Cell Lines for HMGN1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMGN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMGN1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HMGN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMGN1
Sources for HMGN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB